Neural processing of audiovisual and painful analogue trauma and its relationship with subsequent audiovisual and pain intrusions.

Background: Posttraumatic stress disorder and medically unexplained pain frequently co-occur. While pain is common during traumatic events, the processing of pain during trauma and its relation to audiovisual and pain intrusions is poorly understood.Objective: Here we investigate neural activations during painful analogue trauma, focusing on areas that have been related to threat and pain processing, and how they predict intrusion formation. We also examine the moderating role of cumulative lifetime adversity.Methods: Sixty-five healthy women were assessed using functional magnetic resonance imaging. An analogue trauma was induced by an adaptation of the trauma-film paradigm extended by painful electrical stimulation in a 2 (film: aversive, neutral) x 2 (pain: pain, no-pain) design, followed by 7-day audiovisual and pain intrusion assessment using event-based ecological momentary assessment. Intrusions were fitted with Bayesian multilevel regression and a hurdle lognormal distribution.Results: Conjunction analysis confirmed a wide network including anterior insula (AI) and dorsal anterior cingulate cortex (dACC) being active both, during aversive films and pain. Pain resulted in activation in areas amongst posterior insula and deactivation in a network around ventromedial prefrontal cortex (VMPFC). Higher AI and dACC activity during aversive>neutral film predicted greater audiovisual intrusion probability over time and predicted greater audiovisual intrusion frequency particularly for participants with high lifetime adversity. Lower AI, dACC, hippocampus, and VMPFC activity during pain>no-pain predicted greater pain intrusion probability particularly for participants with high lifetime adversity. Weak regulatory VMPFC activation was associated with both increased audiovisual and pain intrusion frequency.Conclusions: Enhanced AI and dACC processing during aversive films, poor pain vs. no-pain discrimination in AI and dACC, as well as weak regulatory VMPFC processing may be driving factors for intrusion formation, particularly in combination with high lifetime adversity. Results shed light on a potential path for the etiology of PTSD and medically unexplained pain.

AI and dACC play a common role for both trauma- and pain-processing.In combination with high lifetime adversity, higher AI and dACC aversive film processing was associated with higher audiovisual intrusion frequency, whereas weaker AI and dACC pain discrimination enhanced the chance for pain intrusions.Weak regulatory VMPFC activity in aversive situations increased both audiovisual and pain intrusion formation.

Emotion Regulation, Relationship and Therapeutic Change in Analytical Psychology and Contemporary Psychodynamic Approaches.

All contemporary psychotherapies agree that (failing) emotion regulation is central to psychological disorders and that psychotherapy is about improving emotion regulation. In his research on the "emotion-laden" complex Jung put an emphasis on the role of failing emotion regulation in contributing to psychological disorders as well as to change in the process of psychotherapy, but he left this field of research and took a very different direction in favour of his archetype concept. Psychodynamic approaches generally argue that changes in emotion regulation are accomplished through corrective emotional experiences in the therapeutic relationship. Insights from affective neurosciences and attachment research have had a major influence on how the therapeutic relationship is constructed in contemporary psychodynamic approaches. There is a lack of similar developments in analytical psychology, which leads to substantial differences between the models of Jungian psychotherapy in contrast to other contemporary psychodynamic approaches. The implications of these differences for the practice of psychotherapy and especially the role of the therapeutic relationship are pointed out.

Toutes les psychothérapies actuelles s'accordent sur le fait que la régulation (défaillante) de l'émotion est au centre des désordres psychologiques et que la psychothérapie vise à améliorer la régulation de l'émotion. Dans sa recherche sur le « complexe à haute charge émotionnelle ¼, Jung a mis l'accent sur le rôle de la régulation défaillante de l'émotion comme participant aux désordres psychologiques ainsi qu'au changement dans le processus de psychothérapie. Mais il a abandonné ce champ de recherche et pris une direction très différente, y préférant son concept de l'archétype. Les approches psychodynamiques plaident généralement en faveur de l'idée que les changements dans la régulation de l'émotion sont atteints par les expériences émotionnelles corrective dans la relation thérapeutique. Des apports venant des neurosciences affectives et des recherches sur l'attachement ont eu une influence majeure sur comment la relation thérapeutique est construite dans les approches psychodynamiques actuelles. De tels développements font défaut dans la psychologie analytique, ce qui conduit à des différences considérables entre les modèles de psychothérapie jungienne en contraste avec les autres approches psychodynamiques actuelles. L'article souligne les conséquences de ces différences dans la pratique de la psychothérapie, tout particulièrement en ce qui concerne le rôle de la relation thérapeutique.

Todas las psicoterapias contemporáneas coinciden en que la regulación (fallida) de las emociones es central a los trastornos psicológicos y que la psicoterapia consiste en mejorar la regulación de las emociones. En su investigación sobre el complejo "de tonalidad afectiva", Jung hizo hincapié en el rol de una fallida regulación emocional en el desarrollo de los trastornos psicológicos, así como al cambio en el proceso de psicoterapia, pero abandonó este campo de investigación y tomó una dirección muy diferente en favor de su concepto de arquetipo. En general, los enfoques Psicodinámicos sostienen que los cambios en la regulación de las emociones se logran a través de experiencias emocionales correctivas en la relación terapéutica. Los conocimientos de las neurociencias afectivas y la investigación sobre el apego han tenido una gran influencia en cómo comprender la conformación de la relación terapéutica en los abordajes psicodinámicos contemporáneos. Faltan desarrollos similares en la psicología analítica, lo que conduce a diferencias sustanciales entre los modelos de la psicoterapia Junguiana en contraste con otros enfoques psicodinámicos contemporáneos. Se señalan las implicaciones de estas diferencias para la práctica de la psicoterapia y se destaca especialmente el rol de la relación terapéutica.

Integrating neuroscience and humanities in healthcare evolution: a multidisciplinary perspective / Integração das neurociências e das ciências humanas na evolução dos cuidados de saúde: uma perspetiva multidisciplinar

The trajectory of healthcare has evolved from ancient holistic practices to the present biomedical model, reflecting the dynamic interplay between scientific progress, technological advancements, and the integration of humanistic values. While biomedical advancements have revolutionized medical treatments, there is an emerging recognition of the importance of integrating neuroscience and humanities to foster holistic patient care and understanding. This paper aims to explore the historical development of medicine, emphasizing the convergence of neuroscience, psychiatry, and neurology within the biomedical framework. Additionally, it investigates the resurgence of humanities in healthcare and its role in promoting patientcentered care. Through a comprehensive review of literature, this study traces the historical roots of medicine and examines the interdisciplinary intersections of neuroscience, psychiatry, neurology, and medical humanities. The exploration reveals the significant contributions of interdisciplinary approaches in enhancing patient-centered care, fostering a comprehensive understanding of health and well-being, and shaping modern healthcare practices. The integration of neuroscience and humanities offers valuable insights into the complexities of human health, bridging legacy practices with innovative approaches. Embracing this interdisciplinary perspective is crucial for promoting holistic healthcare, emphasizing patient-centered care, and enriching the understanding of health and well-being in contemporary healthcare settings.

A trajetória dos cuidados de saúde evoluiu das antigas práticas holísticas para o atual modelo biomédico, reflectindo a interação dinâmica entre o progresso científico, os avanços tecnológicos e a integração de valores humanísticos. Embora os avanços biomédicos tenham revolucionado os tratamentos médicos, há um reconhecimento emergente da importância de integrar as neurociências e as humanidades para promover a compreensão e os cuidados holísticos dos doentes. Este artigo tem como objetivo explorar o desenvolvimento histórico da medicina, salientando a convergência da neurociência, da psiquiatria e da neurologia no quadro biomédico. Além disso, investiga o ressurgimento das humanidades nos cuidados de saúde e o seu papel na promoção de cuidados centrados no doente. Através de uma revisão exaustiva da literatura, este estudo traça as raízes históricas da medicina e examina as intersecções interdisciplinares da neurociência, psiquiatria, neurologia e humanidades médicas. A exploração revela os contributos significativos das abordagens interdisciplinares para melhorar os cuidados centrados no doente, promover uma compreensão abrangente da saúde e do bem-estar e moldar as práticas modernas de cuidados de saúde. A integração das neurociências e das humanidades oferece conhecimentos valiosos sobre as complexidades da saúde humana, fazendo a ponte entre práticas antigas e abordagens inovadoras. A adoção desta perspetiva interdisciplinar é crucial para promover cuidados de saúde holísticos, enfatizando os cuidados centrados no doente e enriquecendo a compreensão da saúde e do bem-estar nos contextos de cuidados de saúde contemporâneos.

La relación entre afecto y cognición: perspectivas teóricas afecto y cognición / A relação entre afeto e cognição: perspectivas teóricas / The relation between affection and cognition: theoretical perspectives

O presente artigo pretende apresentar a relação entre afetividade e cognição nas perspectivas teóricas de Jean Piaget, da neurociência e de Lev Vygotsky. Na perspectiva teórica de Piaget, confere ênfase aos conceitos de interesse e assimilação. Já na perspectiva teórica da neurociência, a ênfase é colocada nas bases biológicas da aprendizagem. Ademais, problematiza o lugar da perspectiva histórico-cultural de Vygotsky, enfatizando os conceitos de significado e sentido no contexto conceitual da relação entre afeto e cognição. A partir do recorte feito, apresenta algumas possíveis contribuições de tais leituras dentro do tema trabalhado concernentes à relação entre afeto e cognição. Argumenta ainda que embora comportem diferenças, as três perspectivas explicitam a importância do afeto para a cognição. Nessa direção, conclui pela relevância das contribuições dadas pelas leituras de Piaget, Vygotsky e da neurociência. As fontes utilizadas são da literatura disponível sobre o tema.

En el presente artículo se pretende presentar la relación entre afectividad y cognición en las perspectivas teóricas de Jean Piaget, de la neurociencia y de Lev Vygotsky. En la perspectiva teórica de Piaget, confiere énfasis a los conceptos de interés y asimilación. En la perspectiva teórica de la neurociencia, el énfasis está colocado en las bases biológicas del aprendizaje. Además, problematiza el lugar de la perspectiva histórico-cultural de Vygotsky, enfatizando los conceptos de significado y sentido en el contexto conceptual de la relación entre afecto y cognición. A partir del recorte, presenta algunas posibles contribuciones de tales lecturas dentro del tema estudiado concernientes a la relación entre afecto y cognición. Argumenta que, aunque comporten diferencias, las tres perspectivas explicitan la importancia del afecto para la cognición. En esa dirección, se concluye por la relevancia de las contribuciones dadas por las lecturas de Piaget, Vygotsky y de la neurociencia. Las fuentes utilizadas son de la literatura disponible sobre el tema.

This article aims to present the relation between affection and cognition from the Jean Piaget, neuroscience and Lev Vygotsky's theoretical perspectives. From Piaget's theoretical perspective, it emphasizes the concepts of interest and assimilation. From the neuroscience theoretical perspective, emphasis is placed on the biological bases of learning. Furthermore, it problematizes the place of Vygotsky's historical-cultural perspective, emphasizing the concepts of meaning and sense in the conceptual context of the relation between affection and cognition. Based on the selection made, it presents some possible contributions of such readings within the theme discussed regarding the relation between affect and cognition. It also argues that although they have differences, the three perspectives explain the importance of affect for cognition. In this direction, it concludes that the contributions made by reading Piaget, Vygotsky and neuroscience are relevant. The sources used are from the available literature about the topic.

Predisposing and precipitating factors for the development of postoperative delirium in critically ill patients in a university intensive care unit / Fatores predisponentes e precipitantes para o desenvolvimento de delirium pós-operatório em pacientes críticos de uma unidade intensiva universitária / Factores predisponentes y precipitantes para el desarrollo del delirium postoperatorio en pacientes críticos de una unidad intensiva universitaria

Abstract Objective: to detect the incidence of postoperative delirium in critically ill patients admitted to a surgical intensive care unit and to evaluate the predisposing and precipitating factors associated with postoperative delirium in critically ill patients admitted to a surgical intensive care unit. Method: this is a prospective cohort study of 157 critically ill surgical patients. Fisher's exact test and Chi-square test were used for the association between factors and the occurrence of delirium, the Wilcoxon test for numerical variables, and the logistic regression model for the analysis of predisposing and precipitating factors. Results: the incidence of delirium was 28% (n=44). Age was a significant predisposing factor (p=0.001), followed by the length of surgery (p<0.001), blood transfusion (p=0.043), administration of crystalloids (p=0.008), and anti-inflammatory drugs (p=0.037), which were the precipitating factors identified. The best-adjusted models were: age, length of surgery, non-administration of anti-emetics, use of sufentanil, and blood transfusion. Conclusion: delirium is a frequent condition in critically ill adults undergoing surgery and the existence of precipitating and predisposing factors is relevant to the outcome, with the anesthetic-surgical procedure as the catalyst event.

Resumo Objetivo: detectar a incidência de delirium pós-operatório em pacientes críticos internados em uma unidade de terapia intensiva cirúrgica e avaliar os fatores predisponentes e precipitantes associados ao delirium pós-operatório em pacientes críticos internados em uma unidade de terapia intensiva cirúrgica. Método: trata-se de um estudo de coorte prospectivo com 157 pacientes críticos cirúrgicos. Utilizou-se teste Exato de Fisher e qui-quadrado para a associação entre os fatores e ocorrência de delirium, teste de Wilcoxon para as variáveis numéricas e o modelo de Regressão Logística para a análise dos fatores predisponentes e precipitantes. Resultados: a incidência de delirium foi 28% (n=44). O fator idade apresentou-se predisponente significativo (p=0,001), seguido do tempo de cirurgia (p<0,001), a transfusão sanguínea (p=0,043), a administração de cristaloides (p=0,008) e anti-inflamatórios (p=0,037), estes foram os fatores precipitantes identificados. Obteve-se como melhor modelo ajustado: idade, tempo de cirurgia, a não administração de antieméticos, o uso de sufentanil e a transfusão sanguínea. Conclusão: o delirium consiste em acometimento frequente para adultos críticos cirúrgicos e a existência de fatores precipitantes e predisponentes tornam-se relevantes para o desfecho, tendo-se o procedimento anestésico-cirúrgico como evento catalisador.

Resumen Objetivo: detectar la incidencia de delirium postoperatorio en pacientes críticos internados en una unidad de terapia intensiva quirúrgica y evaluar los factores predisponentes y precipitantes asociados al delirium postoperatorio en pacientes críticos internados en una unidad de terapia intensiva quirúrgica. Método: se trata de un estudio de cohorte prospectivo con 157 pacientes críticos quirúrgicos. Se utilizó la prueba exacta de Fisher y chi-cuadrado para la asociación entre los factores y ocurrencia de delirium, prueba de Wilcoxon para las variables numéricas y el modelo de regresión logística para el análisis de los factores predisponentes y precipitantes. Resultados: la incidencia de delirium fue 28% (n=44). El factor edad se presentó como predisponente significativo (p=0,001), seguido del tiempo de cirugía (p<0,001), la transfusión sanguínea (p=0,043), la administración de cristaloides (p=0,008) y antiinflamatorios (p=0,037), estos fueron los factores precipitantes identificados. Se obtuvo como mejor modelo ajustado: edad, tiempo de cirugía, la no administración de antieméticos, el uso de sufentanilo y la transfusión sanguínea. Conclusión: el delirium es un acometimiento frecuente para adultos críticos quirúrgicos y la existencia de factores precipitantes y predisponentes se vuelven relevantes para el desenlace, teniendo el procedimiento anestésico-quirúrgico como evento catalizador.

Correlatos neuroanatómicos y neuropsicológicos del comportamiento de adicción a las compras. Una revisión sistemática / Neuroanatomical and neuropsychological correlates of shopping addiction behaviour. A systematic review

Introducción: La incidencia de la compra compulsiva ha aumentado en las últimas dos décadas y supone un impacto negativo sustancial en el funcionamiento general de los consumidores. No obstante, a pesar de su relevancia clínica, todavía se desconocen los mecanismos neuropsicológicos y los correlatos neurales subyacentes a este fenómeno. Asimismo, el comportamiento de compra compulsiva continúa sin reconocerse como una categoría diagnóstica perteneciente a los trastornos adictivos. Objetivo El objetivo del estudio es analizar de forma sistemática la evidencia empírica disponible sobre la compra compulsiva con la finalidad de identificar las variables neuropsicológicas y los correlatos neurales subyacentes. Materiales y métodos Se realizó una búsqueda en PubMed, Scopus y ScienceDirect sobre los mecanismos subyacentes a este fenómeno. Resultados Los resultados muestran únicamente 11 estudios recientes que indagan sobre estos mecanismos. Además, se realizó un registro previo del protocolo de esta revisión sistemática en el registro internacional PROSPERO (número de registro CRD42023427497). Conclusiones Los estudios analizados aluden a una alteración en la función ejecutiva, en la toma de decisiones y en la sensibilidad a la recompensa, y una tendencia a la reactividad de señales relacionadas con las compras. Este patrón conductual parece implicar una pérdida del control del comportamiento vinculado a la desregulación de estructuras como el estriado y las regiones frontales. Se examinan los resultados obtenidos y se analizan las similitudes existentes con los mecanismos subyacentes a otras adicciones. (AU)

INTRODUCTION: The incidence of compulsive buying has increased over the last two decades and it has a substantial negative impact on consumers’ overall functioning. However, despite its clinical relevance, the neuropsychological mechanisms and neural correlates underlying this phenomenon are still unknown. Also, compulsive buying behaviour remains unrecognised as a diagnostic category belonging to addictive disorders. AIM The aim of the study is to systematically analyse the available empirical evidence on compulsive buying in order to identify the underlying neuropsychological variables and neural correlates. MATERIALS AND METHODS PubMed, Scopus and ScienceDirect were searched for the mechanisms behind this phenomenon. RESULTS The results show only 11 recent studies that investigate these mechanisms. In addition, the protocol of this systematic review was pre-registered in the international PROSPERO register (registration number CRD42023427497). CONCLUSIONS The studies reviewed refer to impaired executive functions, decision-making and sensitivity to rewards, and a tendency to reactivity to purchase-related cues. This pattern of behaviour appears to involve a loss of behavioural control linked to dysregulation of structures such as the striatum and frontal regions. The results obtained are examined and similarities with the mechanisms underlying other addictions are discussed. (AU)

Neuroculture and aesthetics: exploring the multidisciplinary ambiance of art, beauty and the human brain / Neurocultura e estética: explorando o ambiente multidisciplinar da arte, da beleza e do cérebro humano

This narrative review addresses the intersection between neuroculture and aesthetics, exploring the intricate relationship between neuroscience and the perception of beauty. The presentation begins by mentioning the philosophical foundations of aesthetics and moves on to the neural basis behind the sensory and emotional processing of beauty. Progressing further, it presents the intricate networks involved in interactions and responses to art, elucidating the brain's mechanisms for appreciating artistic stimuli. Finally, it investigates the neural networks associated with deriving personal and symbolic meaning from art forms, shedding light on how our brains deduce meaning and value from aesthetic experiences. Thus, there is an integration of studies based on the connectome with neuroaesthetics, on how the complete network of neural connections in the brain influences and shapes the way we perceive, interpret, and appreciate beauty. Furthermore, the article addresses the impact of virtual reality and artificial intelligence on traditional concepts of creativity, challenging existing paradigms. Concluding, it explores the potential educational and therapeutic applications of 'Visual Thinking Strategies' in promoting artistic engagement with potential educational and therapeutic applications.

Esta revisão narrativa aborda a intersecção entre neurocultura e estética, explorando a intrincada relação entre neurociência e a percepção da beleza. A apresentação começa mencionando os fundamentos filosóficos da estética e avança para a base neural por trás do processamento sensorial e emocional da beleza. Progredindo ainda mais, apresenta as intrincadas redes envolvidas nas interações e respostas à arte, elucidando os mecanismos do cérebro para apreciar estímulos artísticos. Por fim, investiga as redes neurais associadas à obtenção de significado pessoal e simbólico das formas de arte, esclarecendo como nossos cérebros deduzem significado e valor de experiências estéticas. Assim, há uma integração de estudos baseados no conectoma com a neuroestética, sobre como a rede completa de conexões neurais cerebrais influencia e molda a maneira como percebemos, interpretamos e apreciamos a beleza. Além disso, o artigo aborda o impacto da realidade virtual e da inteligência artificial nos conceitos tradicionais de criatividade, desafiando os paradigmas existentes. Concluindo, explora as potenciais aplicações educativas e terapêuticas das 'Estratégias de Pensamento Visual' na promoção do envolvimento artístico com potenciais aplicações educativas e terapêuticas.

From the breakdown of psychiatry during nazism and the Nuremberg Code, to the materialist neuropsychological model in contemporary science and society: A bioethical analysis / De la quiebra de la psiquiatría durante el nazismo y el Código de Nüremberg al modelo neuropsicológico materialista en la ciencia y la sociedad contemporáneas: Un análisis en clave bioética

Abstract The breakdown of German psychiatry with the coming to power of the National Socialist regime in 1933 resulted in a revival after the war of bioethical issues, the immediate effect of which was the enactment of the Nuremberg Code. In many ways, this breakdown was the result of the historical evolution of psychomedical knowledge and the mass dissemination of reductionist discourses and ideas that created a breeding ground for tragedy. The cyclical discourse of psychic materialism, which has been repeated for centuries in the history of science in different formulations, can, if not properly interpreted, lead to far-reaching appropriations and risks, to which due attention must be paid. The latest manifestation of this issue, the view of mental life as basically cerebral, neurological, biochemical, and determinist, a view that has not been managed or presented adequately to the public, could become the basis for perverse new perspectives and applications in the current context of research and academic activity.

Resumen La llamada "quiebra" de la psiquiatría alemana en 1933, tras la llegada al poder del régimen nacionalsocialista, tuvo como resultado una reactivación de la cuestión bioética, cuyo efecto inmediato fue la promulgación del famoso Código de Nuremberg. En más de un sentido, tal ruptura fue el resultado del devenir histórico del conocimiento psicomédico, así como de la difusión masiva de discursos e ideas reduccionistas que terminaron por generar un caldo de cultivo propicio para la tragedia. El discurso cíclico del materialismo psíquico, que se reedita en la historia de la ciencia, en diferentes formatos y formulaciones, desde hace siglos, no bien interpretado, puede inducir apropiaciones y riesgos de largo alcance a los que se debe prestar la debida atención. Así, el último episodio de este asunto, la visión de la vida mental como vida básicamente cerebral, neurológica, bioquímica y determinista, no bien gestionado y presentado a la opinión pública, aunado a las condiciones actuales de la actividad investigadora y académica, podría convertirse en piedra angular de nuevas perspectivas y aplicaciones perversas de este asunto.

El abrazo, de las bases a su expresión en la vida y el arte / The embrace of the people to their expression in life and art

Resumen: El confinamiento y aislamiento social durante la pandemia por COVID-19 limitaron el contacto físico estrecho, en especial los de cercanía, del que destacan los abrazos. El impacto social del vacío y aislamiento afectivo aún perdura. El abrazo es una respuesta innata afectiva del ser humano que se expresa en diferentes circunstancias. Tiene su origen en diferentes regiones cerebrales, que van de las límbicas a las corticales, en las que se entrelaza una compleja interacción entre aferencias, sistemas de señalización y neurotransmisores que condicionan una respuesta neurohormonal con impacto multisistémico. El abrazo va más allá de este complejo sustrato, representa la sublimación de lo meramente anatómico y fisiológico, a la manifestación afectiva del espíritu humano. El objetivo de este breve ensayo es poner a su consideración las bases neurocientíficas del abrazo y su expresión en la complejidad de la vida y el arte.

Abstract: Confinement and social isolation during the COVID-19 pandemic limited close physical contact, especially close ones, of which hugs stand out. The social impact of emptiness and affective isolation still endures. The hug is an innate affective response of the human being that is expressed in different circumstances. It originates from different brain regions, ranging from limbic to cortical, in which a complex interaction between afferents, signaling systems, and neurotransmitters is intertwined, conditioning a neurohormonal response with multisystem impact. The hug goes beyond this complex substrate, it represents the sublimation of the merely anatomical and physiological, to the affective manifestation of the human spirit. The objective of this brief essay is to put to your consideration the neuroscientific bases of the hug and its expression in the complexity of life and art.

Christofredo Jakob, los cimientos de la neurociencia argentina / Christofredo Jakob, the foundations of argentine neuroscience

El presente artículo es una reseña biográfica de la vida del Dr. Christofredo Jakob, desde su formación en Alemania, las personalidades que acompañaron su desarrollo y las publicaciones científicas en suelo germano. Luego llegarían los inicios de su trabajo en la Argentina y los principales alcances de sus investigaciones. A través de esta reseña recorremos los comienzos del estudio sistemático del sistema nervioso en el país y recordamos el Día del Neurocientífico argentino. (AU)

This article is a biographical review of the life of Dr. Christofredo Jakob, from his training in Germany, the personalities who accompanied his development and the scientific publications on German soil. Then came the beginnings of his work in Argentina and the main achievements of his research. Through this review, we retrace the beginnings of the systematic study of the nervous system in the country and we remember the Day of the Argentine Neuroscientist. (AU)

Una mirada actual a la caracterización de datos y ficheros de neurociencias / A Current Look at Characterization of Neuroscience Data and Files

Para los neurocientíficos constituye un desafío realizar un seguimiento de los datos y metadatos generados en cada investigación y extraer con precisión toda la información relevante, hecho crucial para interpretar resultados y requisito mínimo para que los investigadores construyan sus investigaciones sobre los hallazgos anteriores. Se debe mantener tanta información como sea posible desde el inicio, incluso si esta pudiera parece ser irrelevante, además de registrar y almacenar los datos con sus metadatos de forma clara y concisa. Un análisis preliminar sobre la literatura especializada arrojó ausencia de una investigación detallada sobre cómo incorporar la gestión de datos y metadatos en las investigaciones clínicas del cerebro, en términos de organizar datos y metadatos completamente en repositorios digitales, recopilar e ingresar estos teniendo en cuenta su completitud, y sacar provecho de dicha recopilación en el proceso de análisis de los datos. Esta investigación tiene como objetivo caracterizar conceptual y técnicamente los datos y metadatos de neurociencias para facilitar el desarrollo de soluciones informáticas para su gestión y procesamiento. Se consultaron diferentes fuentes bibliográficas, así como bases de datos y repositorios tales como: Pubmed, Scielo, Nature, Researchgate, entre otros. El análisis sobre la recopilación, organización, procesamiento y almacenamiento de los datos y metadatos de neurociencias para cada técnica de adquisición de datos (EEG, iEEG, MEG, PET), así como su vínculo a la estructura de datos de imágenes cerebrales (BIDS) permitió obtener una caracterización general de cómo gestionar y procesar la información contenida en los mismos(AU)

For neuroscientists, it is a challenge to keep track of the data and metadata generated in each investigation and accurately extract all the relevant information, a crucial fact to interpret results and a minimum requirement for researchers to build their investigations on previous findings. Keep as much information as possible from the start, even if it may seem irrelevant and record and store the data with its metadata clearly and concisely. A preliminary analysis of the specialized literature revealed an absence of detailed research on how to incorporate data and metadata management in clinical brain research, in terms of organizing data and metadata completely in digital repositories, collecting and inputting them taking into account their completeness. , and take advantage of such collection in the process of data analysis. This research aims to conceptually and technically characterize neuroscience data and metadata to facilitate the development of computer solutions for its management and processing. Different bibliographic sources were consulted, as well as databases and repositories such as: Pubmed, Scielo, Nature, Researchgate, among others. The analysis on the collection, organization, processing and storage of neuroscience data and metadata for each data acquisition technique (EEG, iEEG, MEG, PET), as well as its link to the brain imaging data structure (BIDS) allowed to obtain a general characterization of how to manage and process the information contained in them(AU)

Neuroética: comienza el reinado de las neurociencias en la fundamentación de la ética / Neuroethics: the reign of neuroscience begins in the foundation of the ethics / Neuroética: começa o reinado das neurociências na fundamentação da ética

Resumen: 1] La neurociencia de la ética constituye un progreso al aplicar la ciencia empírica en la investigación del fenómeno moral. 2] Resaltar la importancia de afectos y sentimientos representa una compensación a la excesiva importancia dada a la razón en la formación de los juicios morales. 3] Existen graves dificultades metodológicas al no precisar los conceptos de "intuición", "afectos", "deber" y especialmente qué se entiende por "ética". 4] Pero la investigación científica aprehende al hombre como una "entidad" en sí (presente) y no como una "existencia" (futuro), vale decir, ser-en-el-mundo. 5] En lugar de "tener" una moral el ser humano "es" moral y, como tal, es un proyecto lanzado hacia su más auténtica posibilidad que consiste en apropiarse de su ser-para-la-muerte.

Abstract: 1] The Neuroscience of Ethics constitutes a progress when applying empirical science in the investigation of the moral phenomenon. 2] Emphasizing the importance of affects and feelings represents a compensation for the excessive importance given to reason in the formation of moral judgments. 3] There are serious methodological difficulties by not specifying the concepts of intuition, affections, duty and especially what is understood by ethics. 4] But scientific research apprehends man as an "entity" in himself (present) and not as an "existence" (future), that is, being-in-the-world. 5] Instead of "having" a moral, the human being "is" moral and as such is a project thrown towards its most authentic possibility that consists of appropriating its being-for-death.

Resumo: 1] A neurociência da ética constitui um progresso ao aplicar a ciência empírica na investigação do fenômeno moral. 2] Ressaltar a importância de afetos e sentimentos representa uma compensação à excessiva importância dada à razão na formação dos juízos morais. 3] Existem graves dificuldades metodológicas ao não precisar os conceitos de "intuição", "afetos", "dever" e especialmente o que se entende por "ética". 4] Porém a investigação científica apreende o homem como uma "entidade" em si (presente) e não como una "existência" (futuro), vale dizer, ser-no-mundo. 5] Em lugar de "ter" uma moral o ser humano "é" moral e, como tal, é um projeto lançado à sua mais autêntica possibilidade, que consiste em apropriar-se de seu ser-para-a-morte.

Neuroética en fotogramas / Neuroethics in frames

El auge de la neurociencia y la neurotecnología parece imparable. Cada vez sus posibilidades terapéuticas y el sueño de la neuromejora se hacen más evidentes. En este ensayo hacemos un recorrido descriptivo de una disciplina híbrida relativamente nueva, como es la neuroética, disciplina capaz de servir como marco deontológico de las profesiones «neuro», capaz también de investigar aspectos de la condición humana tradicionalmente reservados a otras áreas de conocimiento. Además, teniendo en cuenta que este «neuroesencialismo» también ha impregnado al séptimo arte, utilizamos el cine de ciencia-ficción como herramienta divulgadora de algunos de los hitos más destacados en la agenda investigadora de la neurociencia de la ética, como es el origen neurobiológico del libre albedrío y de la responsabilidad moral. (AU)

The rise of neuroscience and neurotechnology seems unstoppable. Each time its therapeutic possibilities and the desire of neuroenhancement become more evident. In this essay we make a descriptive tour of a relatively new hybrid discipline, such as neuroethics, a discipline capable of serving as a deontological framework of the «neuro» professions, also capable of investigating aspects of the human condition traditionally reserved for other areas of knowledge. In addition, taking into account that this «neuro-essentialism» has also reached the film industry, we use science-fiction movies to explain the most important milestones in the neuroscience of ethics, such as the neurobiological origin of free will and moral responsibility. (AU)

The Self and alien self in psyche and soma.

This paper compares presentations of disorders of the sense of body ownership and agency from psychoanalytic and neurological perspectives to demonstrate similarities in symptomatology proposing these similarities arise from adjustments in Friston's generative model of self-organization and selfhood. The implications for the analytic model of the Self, for clinical practice and for neuroscience research are considered. Patients with narcissistic disorders use projective defences resulting in a disordered sense of what belongs to whom. This applies to mind and body of self and other and is central to understanding transference and countertransference. Clinical observations of this disordered sense of ownership and agency mirror findings in neurological disorders. This paper proposes that in both neurological and psychological disorders Friston's 'internal generative model' of selfhood is adjusted. Further to this whilst this adjustment may be either neurogenic or psychogenic, the final neural mechanism and symptomatic outcome are similar. On the basis of these observations the paper compares the concept of the Self from Jungian and psychoanalytic perspectives. Finally, the implications for the concept of the death instinct and Britton's concept of Xenophobia are explored along with the implications of these observations for clinical practice.

Cet article compare les présentations des troubles du sens de la propriété du corps et de la capacité d'action selon les perspectives psychanalytiques et neurologiques afin de montrer les similarités dans la symptomatologie. L'article suggère que ces similarités proviennent d'ajustements dans le modèle générateur de Friston de l'organisation et du sentiment de soi. L'article s'intéresse aux implications pour le modèle analytique du soi, pour la pratique clinique et pour la recherche en neurosciences. Les patients qui ont des troubles narcissiques utilisent des défenses projectives qui produisent un sentiment troublé de « quoi appartient à qui ¼. Ceci s'applique à l'esprit et au corps - de soi et de l'autre - et est central dans la compréhension du transfert et du contretransfert. Les observations cliniques de ce sentiment troublé d'appartenance et de capacité d'action reflètent les découvertes sur les troubles neurologiques. Cet article suggère que dans les troubles neurologiques et dans les troubles psychologiques le 'modèle générateur interne' du sentiment de soi de Friston est ajusté. De plus, bien que cet ajustement puisse être soit neurogène soit psychogène, le mécanisme neural final et le résultat symptomatique sont similaires. Sur la base de ces observations l'article compare le concept du Soi des points de vue Jungien et psychanalytique. Enfin les implications en ce qui concerne le concept de pulsion de mort et le concept de Britton de Xénophobie sont étudiées aux côtés des conséquences de ces observations pour la pratique clinique.

El presente trabajo compara presentaciones de trastornos de la sensación de agencia y posesión del propio cuerpo desde perspectivas psicoanalíticas y neurológicas para demostrar similitudes en sintomatología, proponiendo que estas similitudes emergen de ajustes según el modelo de autoorganización e identidad de Friston. Se consideran las implicancias de la práctica clínica y de investigaciones en neurociencias para un modelo analítico del self. Pacientes con trastornos narcisistas utilizan defensas proyectivas que resultan en un sentido desordenado de qué pertenece a quién. Esto aplica a la mente y al cuerpo de uno mismo y del otro y es central para la comprensión de la transferencia y contratransferencia. Las observaciones clínicas de este trastorno del sentido de agencia y posesión reflejan hallazgos en trastornos neurológicos. El artículo propone que, tanto en trastornos neurológicos como psicológicos, el 'modelo generativo interno' de la identidad de Friston es adaptativo. Además, mientras esta adaptación puede ser neurogénica o psicogénica, el resultado sintomático y el mecanismo final neural son similares. Sobre la base de estas observaciones, el trabajo compara el concepto de Self desde las perspectivas Junguiana y psicoanalítica. Finalmente, se exploran las implicaciones del concepto de instinto de muerte y el concepto de Xenofobia de Britton, junto a las consecuencias de estas observaciones para la práctica clínica.

Investigación de mindfulness en neurociencia cognitiva / Mindfulness Research in Cognitive Neuroscience

Mindfulness es un término que ha pasado a formar parte del vocabulario en nuestra sociedad, y su práctica se ha instalado en el contexto educativo, terapéutico, clínico y como herramienta de bienestar o crecimiento personal. En este artículo hacemos un repaso de los trabajos de investigación más relevantes en neurociencia cognitiva del mindfulness clasificándolos en tres grandes áreas: a) cambios diferenciales en la actividad de la red por defecto debidas a la práctica del mindfulness; b) cambios funcionales o estructurales de la red atencional, y c) cambios funcionales o estructurales de la red frontolímbica y la amígdala, relacionados con la regulación emocional. Hay suficiente bibliografía para afirmar el efecto cerebral que conlleva la práctica de mindfulness, pero todavía necesitamos generar mejores diseños experimentales que nos permitan encontrar los mecanismos de acción de prácticas específicas.(AU)

Mindfulness is a term that has become part of our society’s vocabulary and its practice has become firmly established in educational, therapeutic and clinical contexts and as a tool for fostering well-being and personal growth. In this article we review the most relevant research conducted on mindfulness in cognitive neuroscience, classifying it in three broad areas: a) differential changes in default network activity due to the practice of mindfulness; b) functional or structural changes in the attentional network, and c) functional or structural changes in the frontal limbic network and the amygdala, related to emotion regulation. There is enough evidence in the literature to affirm the effect of mindfulness practice on the brain, but we still need to produce better experimental designs that allow us to find the mechanisms of action underlying specific practices.(AU)

Fetal psychism: neurodynamic and psychoanalytic bases / Psiquismo fetal: bases neurodinâmicas e psicanalíticas

Backgroung: Neuroscientific research has provided great discoveries regarding the understanding of the brain functioning and its neural circuits. With advances in studies on fetal behavior, new discussions have arisen about the existence of a possible rudimentary psychic apparatus. Questioning the existence of a psychism in the fetus becomes doubly challenging. First, because of the controversy that exists in the field of neuroscience about the studies of epiphenomena. Second, because of the difficulty that psychoanalysis has in accepting the existence of a psychic structure before birth. This study was carried out considering all these controversies and scientific limitations, and for this reason it should be understood as a theoretical hypothesis and an invitation to a broad and transdisciplinary view on the complexity of human behavior. From an extensive review on the development of the nervous system and fetal synaptogenesis, and combining neurophysiological and neurophysical research, it was possible to create a link with the Freudian theory of psychic energy described in the Project for a scientific psychology. From these joints, questions were raised about fetal development, especially in the preterm phase, which would be composed of intense synaptic activities, especially in the somatosensory and thalamocortical regions that would receive exogenous and endogenous stimuli, both acting to generate an accumulation of psychic energy. Thus, it was hypothesized that this intense flow of energy would be the first sign of the development of the primitive psychic apparatus in the fetus. Thus, it was possible to assume that during the preterm period this cathected energy discharge could project directly onto the limbic and motor brain structures and leave unconscious memory traces of intrauterine life experiences. These influences of a psychic nature, together with epigenetic factors, would contribute to the appearance of certain behavioral and neurodevelopmental disorders. Therefore, suggesting an early transdisciplinary approach in at-risk infants exposed to environmental or epigenetic stressors during the gestational period, especially during the synaptic plasticity window, will provide a therapeutic opportunity through psychic reorganization and sensorimotor integration.

Introdução: As pesquisas neurocientíficas têm proporcionado grandes descobertas no que concerne ao entendimento sobre o funcionamento cerebral e seus circuitos neurais. Com os avanços nos estudos sobre o comportamento fetal novas discussões têm surgido acerca da existência de um possível aparelho psíquico rudimentar. Questionar a existência de um psiquismo no feto, torna-se duplamente desafiador. Primeiro pela controvérsia que existe no âmbito da neurociência sobre os estudos dos epifenômenos. Segundo, pela própria dificuldade que a psicanálise tem em aceitar a existência de uma estrutura psíquica antes do nascimento. Este estudo foi realizado considerando todas estas controvérsias e limitações científicas, e por este motivo deve ser entendido como uma hipótese teórica e um convite para uma ampla e transdisciplinar visão sobre a complexidade do comportamento humano. A partir de uma extensa revisão sobre o desenvolvimento do sistema nervoso e da sinaptogênese fetal, e associando as pesquisas neurofisiológicas e da neurofísica, foi possível criar uma articulação com a teoria Freudiana da energia psíquica descrita no Projeto para uma psicologia científica. A partir destas articulações, levantou-se questionamentos sobre o desenvolvimento fetal, especialmente na fase pré-termo, o qual seria composto por atividades sinápticas intensas, especialmente nas regiões somatossensoriais e talamocorticais que receberiam estímulos exógenos e endógenos, ambos atuando para gerar um acúmulo de energia psíquica. Desta forma, criou-se uma hipótese de que este intenso fluxo de energia seria o primeiro sinal do desenvolvimento do aparelho psíquico primitivo no feto. Assim, foi possível supor que durante o período pré-termo esta descarga de energia catexizada poderia se projetar diretamente sobre as estruturas cerebrais límbicas e motoras e deixar traços de memória inconscientes das experiências da vida intrauterina. Seriam estas influências de natureza psíquica em conjunto com os fatores epigenéticos, que contribuiriam para o aparecimento de certos transtornos comportamentais e do neurodesenvolvimento. Sendo assim, sugerir uma abordagem transdisciplinar precoce em bebês de risco expostos a fatores estressores ambientais ou epigenéticos durante o período gestacional, especialmente durante a janela de plasticidade sináptica, proporcionará uma oportunidade terapêutica através da reorganização psíquica e da integração sensoriomotora.

As Regionais que queremos / The Regions we want

O pioneirismo em regionalização no Estado de Goiás é demonstrado através da abordagem dos tópicos regionalização, regionais e suas divisões, matriciamento, gestão, planejamento, coordenação, neuroliderança e fortalecimento

Pioneering in regionalization in the State of Goiás is demonstrated through the approach of the topics regionalization, regions and their divisions, matrix support, management, planning, coordination, neuro-leadership and strengthening