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1.
Heliyon ; 10(12): e32286, 2024 Jun 30.
Artículo en Inglés | MEDLINE | ID: mdl-38975188

RESUMEN

Sports organizations have deemed sports entrepreneurship crucial in helping them overcome difficult times. The purpose of this research is to find out how the COVID-19 issue affected sports entrepreneurs and whether there are any variations in how non-profit sporting organizations anticipate entrepreneurs' effect on service excellence. This goal was achieved by comparing 145 sports organizations before and after the viral epidemic. The factors evaluated before (Time 1) and after (Time 2) the COVID-19 epidemic were compared using paired sample-t tests. Associations and multilevel linear declines were utilized to examine the link between the factors discussed in the two phases. After the emergence of COVID-19, the findings suggest that risk-taking and creativity are much more significant, although initiative has mostly stayed the same. Lastly, a favourable and statistically substantial correlation exists between sports entrepreneurial and service excellence during pre- and post-crisis periods.

2.
Adv Pharmacol ; 100: 39-117, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39034055

RESUMEN

Academic and other non-profit institutions have a long-term vision to improve human health where commercial interests can be limited for profit organizations. Medicinal chemistry to these diseases with no commercial benefit needs is well suited in the academic environment and this chapter outlines some work conducted at Calibr-Skaggs around antibiotic drug development that has led to initiation of multiple clinical trials over the last decade.


Asunto(s)
Antiinfecciosos , Descubrimiento de Drogas , Humanos , Antiinfecciosos/farmacología , Antiinfecciosos/uso terapéutico , Antiinfecciosos/química , Animales , Antibacterianos/farmacología , Antibacterianos/química , Antibacterianos/uso terapéutico
3.
BMC Health Serv Res ; 24(1): 659, 2024 May 24.
Artículo en Inglés | MEDLINE | ID: mdl-38783301

RESUMEN

BACKGROUND: Healthcare facility characteristics, such as ownership, size, and location, have been associated with patient outcomes. However, it is not known whether the outcomes of healthcare workers are associated with the characteristics of their employing healthcare facilities, particularly during the COVID-19 pandemic. METHODS: This was an analysis of a nationwide registry of healthcare workers (the Healthcare Worker Exposure Response and Outcomes (HERO) registry). Participants were surveyed on their personal, employment, and medical characteristics, as well as our primary study outcomes of COVID-19 infection, access to personal protective equipment, and burnout. Participants from healthcare sites with at least ten respondents were included, and these sites were linked to American Hospital Association data to extract information about sites, including number of beds, teaching status, urban/rural location, and for-profit status. Generalized estimating equations were used to estimate linear regression models for the unadjusted and adjusted associations between healthcare facility characteristics and outcomes. RESULTS: A total of 8,941 healthcare workers from 97 clinical sites were included in the study. After adjustment for participant demographics, healthcare role, and medical comorbidities, facility for-profit status was associated with greater odds of COVID-19 diagnosis (aOR 1.76, 95% CI 1.02-3.03, p = .042). Micropolitan location was associated with decreased odds of COVID-19 infection after adjustment (aOR = 0.42, 95% CI 0.24, 0.71, p = .002. For-profit facility status was associated with decreased odds of burnout after adjustment (aOR = 0.53, 95% CI 0.29-0.98), p = .044). CONCLUSIONS: For-profit status of employing healthcare facilities was associated with greater odds of COVID-19 diagnosis but decreased odds of burnout after adjustment for demographics, healthcare role, and medical comorbidities. Future research to understand the relationship between facility ownership status and healthcare outcomes is needed to promote wellbeing in the healthcare workforce. TRIAL REGISTRATION: The registry was prospectively registered: ClinicalTrials.gov Identifier (trial registration number) NCT04342806, submitted April 8, 2020.


Asunto(s)
Agotamiento Profesional , COVID-19 , Instituciones de Salud , Personal de Salud , SARS-CoV-2 , Humanos , COVID-19/epidemiología , COVID-19/psicología , COVID-19/prevención & control , Personal de Salud/psicología , Personal de Salud/estadística & datos numéricos , Femenino , Masculino , Adulto , Persona de Mediana Edad , Agotamiento Profesional/epidemiología , Instituciones de Salud/estadística & datos numéricos , Estados Unidos/epidemiología , Pandemias , Equipo de Protección Personal , Sistema de Registros
4.
Heliyon ; 10(7): e28170, 2024 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-38560144

RESUMEN

Focusing on the research scenario that integrates value-based healthcare objectives with the pharmaceutical group purchasing model, this study delineates value-based healthcare objectives in pharmaceutical group purchasing from three perspectives: drug sales price, drug quality, and service level. We construct a three-level pharmaceutical group purchasing supply chain consisting of drug manufacturers, medical institutions, and non-profit drug group purchasing organisations. Under centralised and decentralised decision-making, we introduce cost-sharing contracts and "cost-sharing-quantity-discount" contracts to analyse the impact of factors such as drug sales price, quality, and sensitivity of the service level. The study found that: (1) Compared with centralised decision-making, the optimal drug quality and service level in decentralised decision-making and the optimal profits of drug manufacturers and medical institutions will decrease. However, the optimal drug sales price in decentralised decision-making always deviates from that in centralised decision-making, leading to higher or lower drug sales prices. (2) The incorporation of value-based healthcare objectives in the pharmaceutical group purchasing through cost-sharing contracts depends on changes in the proportion of drug quality costs borne by medical institutions. If the proportion is too high, medical institutions will suffer greater losses because they bear too much of the cost. (3) Under certain conditions, cost-sharing contracts can improve supply chain efficiency but cannot achieve supply chain coordination, while the combination of "cost-sharing-quantity-discount" contracts can achieve supply chain coordination in pharmaceutical group purchasing.

5.
Artículo en Ruso | MEDLINE | ID: mdl-38640208

RESUMEN

According to the International Labor Organization, health protection and access to medical treatment are to be guaranteed to seamen in the same way as to people working ashore. However, in practice, formal measures and mechanisms do not always make it possible to provide medical care to crew members of civil vessels due to peculiarities of legal systems of the States in whose territorial waters the vessel is located, remoteness of the vessel from coastline and objective situation that permits to receiving medical care from the shore. As far as possible these problems are resolved by non-profit organizations of seamen. The overview of their activities is presented in this article.


Asunto(s)
Medicina Naval , Navíos , Humanos
6.
Sci Justice ; 64(2): 210-215, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38431378

RESUMEN

The age progression technique allows to update identification photos of individuals who have been missing for years. This method is based on the study of the facial variation and on the dynamics of facial growth. Knowledge about changes in the distribution of facial fat and the tone of the cartilage allows realistic predictions of the facial appearance after many years. Beside these elements, age progression is also supported by similar characters between family members. This is why photos of the missing and family members are used to create an age progression, making the new identikit accurate. Non-profit associations are crucial for the dissemination of information on the problem of missing persons. In Italy, the Italian Missing Children association provides for free an age progression service with the support of forensic anthropology. With the activation of a protocol, consisting of guidelines, and a form for the request for age progression by family members, the Italian Missing Children has started a collaboration with Missing Child Kenya. It allowed to disseminate up-to-date photos of the presumed current appearance of the missing children in Kenya. Thus, in the present study some cases are reported, in which age progression technique was applied. The photos provided by Italian Missing Children were shown in video documentaries made by Missing Child Kenya, allowing to continue the dissemination of age progression photo during the Covid quarantines and to keep the population active in the search for the missing.


Asunto(s)
Antropología Forense , Imagen Forense , Niño , Humanos , Kenia , Antropología Forense/métodos , Cara/anatomía & histología , Italia/epidemiología
7.
Autism ; 28(9): 2232-2243, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38332664

RESUMEN

LAY ABSTRACT: In low-resource settings, non-profit organisations play an essential role in providing services and support for families with young children with autism, including in Africa. However, non-profit organisation service providers may not have access to quality training in proven intervention methods. Web-based or online courses may help to meet this need. In this study, we invited a group of specialist (10) and non-specialist (16) non-profit organisation providers in South Africa to complete a web-based course, Autism Navigator® JumpStart to Coaching in Everyday Activities, a 20-h self-paced course that provides training in an evidence-based parent coaching intervention called Early Social Interaction. We evaluated acceptability, appropriateness, and feasibility of the training. Of the 26 who enrolled, 16 completed the course (7 specialists and 9 non-specialists). All providers found it difficult to find time to do the course until the lockdown restrictions due to COVID-19, when most completed the course. Those whose first language was not English experienced more difficulties with two of six learner assessments and those who were not clinical specialists had more difficulty with the coaching strategies learner assessment. Most providers rated the course highly feasible, acceptable, and appropriate stating that the course content was very valuable and helpful in equipping them to serve their families. They felt the extensive video clips and regular meetings with a local trainer helped them engage with and understand the material. They suggested that including South African video clips would make the course more relatable. The fact that the course was web-based was identified as a strong benefit, especially during COVID-19 restrictions.


Asunto(s)
Trastorno Autístico , COVID-19 , Estudios de Factibilidad , Tutoría , Humanos , Sudáfrica , Tutoría/métodos , Femenino , Masculino , Trastorno Autístico/terapia , Adulto , Padres/educación , Interacción Social , SARS-CoV-2 , Organizaciones sin Fines de Lucro
8.
Work ; 77(1): 49-59, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-37483050

RESUMEN

BACKGROUND: While mental illness (e.g., depression, anxiety) has been examined frequently in the workplace, the COVID-19 pandemic has only increased the attention towards mental illness. Mental well-being views mental health as a continuum from ill health to thriving. Few studies have examined factors associated with mental well-being in the workplace. Public stigma for mental illness, the general population's negative attitude towards mental illness, and occupational burnout are examined. OBJECTIVE: The purpose of this study was to examine the relationship between burnout and public stigma on mental well-being in a sample of employees across industries in the United States. METHODS: Employees surveyed from 16 companies from various industries were assessed. Room Here, a non-profit organization whose goal is to improve employee mental fitness, gathered data from these companies located in the western mountain region of the U.S. Data were collected during the pandemic. Across this portfolio of companies, 259 employees were included in the sample. Survey assesses respondents' mental well-being, stigma towards mental illness, and occupational burnout. Ordinary least squares (OLS) regression was used in this cross-sectional study on secondary data. RESULTS: Results suggested occupational burnout was associated with a decrease in mental well-being, while public stigma was associated with an improvement in mental well-being. CONCLUSION: This study sought to examine the relationship between mental well-being, burnout, and public stigma. Employee burnout and public stigma were related to mental well-being. Implications for burnout and stigma reduction programs are discussed as well as future research.


Asunto(s)
Agotamiento Profesional , COVID-19 , Humanos , Salud Mental , Agotamiento Profesional/psicología , Estudios Transversales , Pandemias , COVID-19/epidemiología
9.
Sante Publique ; 35(HS1): 153-155, 2023 12 01.
Artículo en Francés | MEDLINE | ID: mdl-38040638

RESUMEN

The first Dental Public Health Day, in 2001, was not only the starting point for the creation of the Association des Acteurs de la Santé Publique Bucco-Dentaire (ASPBD), but also for the recognition of this specialty in France, even though it had already been recognized by the American Dental Association as early as 1950. Every year, the ASPBD organizes a national oral health day. The ASPBD brings together the vast majority of French odontologists and academic researchers in the field, as well as other French-speaking academics. Throughout the year, we work to bring together the dental and non-dental worlds, mainly the institutional and non-profit sectors with users, freelancers, and employees, the World Health Organization, and the French Public Health Society. This is in keeping with the partnership approach taken by the association for the past twenty-two years. Our aim is to bring together all the actors concerned to work toward integrating oral health into all health policies and health promotion and prevention schemes. We believe it is vital to provide oral health training for medical and paramedical staff, as well as for those working in education and outreach. Likewise, we are working to ensure that prevention is organized on a territorial level, involving local people as closely as possible and focusing on their needs. This is why we are actively involved in the fight against social and territorial inequalities in health, oral health being a strong indicator of these inequalities.


La première Journée de santé publique dentaire, en 2001, a été non seulement le point de départ de la création de l'association des Acteurs de la santé publique bucco-dentaire (ASPBD), mais aussi celui de l'identification en France de cette spécialité, alors qu'elle était déjà reconnue comme telle par l'Association dentaire américaine dès 1950. L'ASPBD organise, depuis annuellement une journée nationale de santé publique bucco-dentaire. L'ASPBD rassemble la grande majorité des odontologistes, enseignants-chercheurs hospitalo-universitaires français, mais aussi les autres hospitalo-universitaires francophones. Nous œuvrons tout au long de l'année à faire travailler ensemble le dentaire et le non-dentaire, principalement le monde institutionnel et associatif avec les usagers, les libéraux et les salariés, l'Organisation mondiale de la santé et la Société française de santé publique. À l'image du binôme qui préside chacune de nos journées depuis vingt-deux ans. Notre association a pour vocation de rassembler tous les acteurs concernés pour œuvrer à l'intégration de la santé orale dans toutes les politiques de santé et dispositifs de promotion de la santé et de prévention. Nous pensons qu'il est indispensable de former à la santé orale tant les personnels médicaux et paramédicaux que ceux de l'éducation et de l'animation. De même, nous agissons pour que la prévention s'organise à l'échelon territorial, au plus près des populations en fonction de leurs besoins. C'est le sens de notre participation active à la lutte contre les inégalités sociales et territoriales de santé, la santé orale étant un marqueur fort d'inégalités sociales de santé.


Asunto(s)
Salud Bucal , Salud Pública , Humanos , Promoción de la Salud , Francia
10.
Front Psychol ; 14: 1042722, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37496791

RESUMEN

Introduction: Non-profit organizations (NPOs) are a complex working context whose main characteristic resides in the dichotomy between paid staff and volunteers. Despite its benefits for goal achievement, this circumstance can be also a challenge, for both groups' interaction, for their comprehension of their own role and to HR management. The aim of this study was to explore factors that may contribute to promote job satisfaction among NPOs' members. Methods: Combining two different data analyses, serial multiple mediation analyses and cluster analyses, first we analyze whether there are differences between paid staff and volunteers in perceived intrapersonal conflict and performance and its effect on job satisfaction, and second, we analyze whether there is an additional profiles distribution that reflects more adequately the reality of NPOs, despite the formal roles that coexist in these organizations (paid staff and volunteers). Results: Results confirm that paid staff and volunteers differ on their perceived job satisfaction level, with volunteers being more satisfied. This relationship is serially mediated by role conflict, role ambiguity, and performance. Another characteristic of the NPOs is that the dichotomy between paid staff and volunteers does not capture well the reality of the labor relations between members of both groups and the organization. To explore this phenomenon, we perform a cluster analysis based on paid staff and volunteers' perceptions. Cluster analyses demonstrate the existence of three rather homogenous profiles. Discussion: Additionally, practical implications for HR management in NPOs and future research lines to understand this organizational context dynamics are also discussed.

11.
Front Sports Act Living ; 5: 1200246, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37383065

RESUMEN

Sports federations as non-profit organizations play a crucial role for organized sports activities of the population. However, one key responsibility of sports federations is providing needs-based support services to affiliated member sports clubs. Due to limited resources and simultaneously increasing heterogeneous expectations from their member sports clubs, designing an appropriate service portfolio poses increasing difficulties for sports federations. This study addresses these challenges by analyzing member clubs' expectations and identifying distinct expectation types to enable more individually designed services. To analyze the expectations of member clubs (n = 354), the explorative case study was carried out in a regional sports federation in Germany. The findings reveal that member clubs' expectations can be represented using six reliable factors. The subsequent cluster analysis indicates four different expectation-based club types with heterogenous profiles. Based on the z-standardized factor values, the identified club types were labelled as follows: (1) "People Promoters" (32%), (2) "Undemanding" (22%), (3) "Competition-oriented Self-administrators" (23%) and (4) "Demanding Communicators" (23%). The extracted clusters were also reflected and validated by other structural and organizational characteristics of the sports clubs. The extracted types provide a first empirical step to identify different expectation schemes regarding services of sports federations. These schemes enable managers of sports federations to professionalize their service portfolios and, at the same time, to design services contributing to the development of sports clubs in a more targeted manner.

12.
Int J Offender Ther Comp Criminol ; : 306624X231165428, 2023 Apr 13.
Artículo en Inglés | MEDLINE | ID: mdl-37057305

RESUMEN

In order to prevent and fight terrorism, a new research area has developed called terrorist financing. An important aspect is the financing of terrorism by Non-Profit Organization (NPO), through transfer funds, terrorist alliances, abuse of NPOs, terrorist recruitment, and false NPOs and agents. Therefore, the NPO counter-terrorist financing strategy was established, considering four major aspects: warning information indicators, internal management mechanisms, international cooperation and information sharing, and counter-terrorist Financing legislation. This paper provides a new way to supervise the terrorist financing of NPOs. First, actual cases should be collected, and viable warning indicators for regulatory agencies and NPOs should be established. Second, internal management mechanisms should be strengthened to actively prevent terrorist activities within NPOs. Third, given the global activity of NPOs and terrorist organizations, information-led international cooperation must be emphasized. Fourth, from the angle of independent counter-terrorist Financing legislation, the gap should be filled in NPO counter-terrorist Financing legislation.

13.
J Environ Manage ; 326(Pt B): 116731, 2023 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-36402017

RESUMEN

Arts and Cultural Organisations (ACOs) have received significant attention over the last few years regarding their environmental performance. ACOs are often non-profit organisations, relying on government funding to implement various programmes to support societal development. Funding dependence can shift ACOs' focus from creating socio-cultural value to being more commercially driven. This paper explores factors influencing organisational changes in ACOs related to environmental performance measurement. Stakeholders in ACOs based in Nottingham, England, were interviewed and participated in a workshop to validate and collect additional data. Our research uncovered five interrelated factors that influence organisational change: the role of funding bodies; local policies and networks; organisational culture and leadership; lack of resources; and building proprietary-tenant relationships. This paper contributes to understanding ACOs responses to measuring environmental performance and the challenges they face as they move from measuring to implementation. Implications are explored for how funding is allocated and understood in terms of moving beyond merely measuring the carbon footprint of activities. ACOs' funding dependence indicates a focus on carbon measurement, omitting a more holistic approach towards the environment and sustainability.


Asunto(s)
Liderazgo , Innovación Organizacional , Inglaterra
14.
J Community Health ; 48(2): 199-209, 2023 04.
Artículo en Inglés | MEDLINE | ID: mdl-36346404

RESUMEN

Non-profit hospitals are expected to provide charity care and other community benefits to adjust their tax exemption status. Using the Medicare Hospital Cost Report, American Hospital Association Annual Survey, and the American Community Survey datasets, we examined if church-affiliated hospitals spent more on charity care and community benefit. For this analysis, we defined five main categories of community benefits were measured: total community benefit; charity care; Medicaid shortfall; unreimbursed other means-tested services; and the total of unreimbursed education and unfunded research. Multiple regression was used to examine the effect of church ownership, controlling for other factors, on the level of community benefit in 2644 general acute care non-profit hospitals. Descriptive analyses and multiple regression were used to show the relationship between the provision of community benefits and church affiliation including Catholic (CH), other church-affiliated hospitals (OCAH), and non-church affiliated hospitals (NCAH). The non-profit hospital on average spent 6.5% of its total expenses on community benefits. NCAH spent 6.09%, CH spent 7.5%, and OCAH spent 9.4%. Non-profits spent 2.8% of their total expenses on charity care, with the highest charity care spending for OCAH (5.2%), followed by CH (3.9%), and NCAH (2.4%). Regression results showed that CH and OCAH, on average, spent 1.08% and 2.16% more on community benefits than NCAHs. In addition, CH and OCAH spent more on other categories of community benefits except for education and research. Church-affiliated hospitals spend more on community benefits and charity care than non-church affiliated nonprofit hospitals.


Asunto(s)
Organizaciones de Beneficencia , Hospitales Filantrópicos , Anciano , Humanos , Estados Unidos , Atención no Remunerada , Propiedad , Medicare , Hospitales , Exención de Impuesto
15.
Int J Community Wellbeing ; 6(1): 21-41, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36467590

RESUMEN

The present study contributes to the existing literature by highlighting the ways in which non-profit community literacy organizations can benefit individuals and communities in ways that transcend their stated missions. We employed a qualitative research design whereby data were collected via in-depth individual interviews and focus groups with program users (n = 72), staff (n = 11), and program leads (n = 8). Findings revealed that, in addition to supporting traditionally defined notions of literacy, programs presented participants with opportunities to cultivate bridging and bonding social capital. By way of the conditions created and programmatic measures employed within programs, bridging social capital often strengthened into deeper bonding ties between and amongst service users and, in many cases, staff and volunteers. Administrators and staff described efforts to create program cultures conducive to the development of social capital. The research illuminates how non-profit community entities can empower individual service users and their communities beyond their stated missions by fostering social and organizational connectedness, promoting communal cohesion and social trust, and cultivating typically unacknowledged talents, strengths and assets within marginalized communities.

16.
Front Psychol ; 13: 982102, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36204735

RESUMEN

In contemporary Japanese society, it is difficult to find a marriage partner, and therefore, "Konkatsu," the search for a marriage partner, has become a socially accepted activity in Japan. In response to this social challenge, in addition to private companies, governments and non-profit organizations are supporting individuals in their search for a marriage partner. This paper reviews statistical information related to marriage hunting published in Japan. In addition, some of the authors' collaborative activities and academic publications based on these activities are reviewed. Subsequently, the paper discusses and highlights the importance of helping individuals have confidence in their physical attractiveness.

17.
Front Vet Sci ; 9: 895532, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35978709

RESUMEN

Analyzing a dataset of payment plans disassociated with traditional credit scoring, this research, for the first time, offers insights into the mitigation of cash flow and credit ineligibility challenges in access to veterinary care. Specifically, this paper explores financial fragility among pet families and whether payment options offer substantial bridges in access to care challenges for veterinarians and clients. Researchers introduce a veterinary care multiplier to estimate the potential increase in veterinary care that may be provided by for-profit and non-profit clinics from additional payment options. The implications for non-profits working to address access to care is that by directing donor dollars to cover the 6.9% that is potentially left unpaid in meeting pet families simply facing cash flow challenges, a non-profit clinic could provide 14.5 times the veterinary care vs. full subsidies. In for-profit clinics, allocating some of a clinic's discount budget may similarly yield 14.5 times the care for clients likely to be declined by the traditional credit options. Further research is recommended to explore how deeply these options penetrate all financially fragile pet owners and outcomes in the absence of these tools for credit-declined clients. Additional research to determine the levels at which payment options reduce economic euthanasia decisions, reduce the client and staff stress, increase the value perception and compliance with suggested care, enable better outcomes for patients, and increase clinic revenue is also recommended. The researchers conclude that payment options that are independent of traditional credit scoring mitigate financial barriers to obtaining veterinary care.

18.
J Bus Ethics ; 180(4): 1075-1095, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35855697

RESUMEN

The role to be played by multi-stakeholder partnerships in addressing the 'wicked problems' of sustainable development is made explicit by the seventeenth Sustainable Development Goal. But how do these partnerships really work? Based on the analysis of four sustainability-oriented innovation initiatives implemented in Belgium, Italy, Germany, and France, this study explores the roles and mechanisms that collaborating actors may enact to facilitate the pursuit of sustainable development, with a particular focus on non-profit organizations. The results suggest that collaborative innovations for sustainability contribute simultaneously to the fulfilment of different Sustainable Development Goals, reaching beyond their original intent, and that the value being created has the potential to reinforce such roles and mechanisms. These partnerships are prompted and managed by non-profit organizations that act as metagovernors of collaborative innovation processes as they play the roles of cultural spreaders, enablers, relational brokers, service provides, and influencers. These findings will help policy-makers and practitioners in the public and non-profit sector to identify and utilize emerging opportunities for value creation through collaborative innovation, and to better design existing and prospective collaborative efforts aimed at sustainable objectives, thereby supporting progress towards the implementation of Agenda 2030.

19.
Epilepsia Open ; 7(3): 532-540, 2022 09.
Artículo en Inglés | MEDLINE | ID: mdl-35833327

RESUMEN

OBJECTIVE: To discuss the results of the KETASER01 trial and the reasons for its failure, particularly in view of future studies. METHODS: KETASER01 is a multicenter, randomized, controlled, open-label, sequentially designed, non-profit Italian study that aimed to assess the efficacy of ketamine compared with conventional anesthetics in the treatment of refractory convulsive status epilepticus (RCSE) in children. RESULTS: During the 5-year recruitment phase, a total of 76 RCSEs treated with third-line therapy were observed in five of the 10 participating Centers; only 10 individuals (five for each study arm; five females, mean age 6.5 ± 6.3 years) were enrolled in the KETASER01 study. Two of the five patients (40%) in the experimental arm were successfully treated with ketamine and two of the five (40%) children in the control arm, where successfully treated with thiopental. In the remaining six (60%) enrolled patients, RCSE was not controlled by the randomized anesthetic(s). SIGNIFICANCE: The KETASER01 study was prematurely halted due to low eligibility of patients and no successful recruitment. No conclusions can be drawn regarding the objectives of the study. Here, we discuss the KETASER01 results and critically analyze the reasons for its failure in view of future trials.


Asunto(s)
Anestésicos , Ketamina , Estado Epiléptico , Niño , Preescolar , Protocolos Clínicos , Femenino , Humanos , Lactante , Ketamina/uso terapéutico , Masculino , Estudios Multicéntricos como Asunto , Ensayos Clínicos Controlados Aleatorios como Asunto , Estado Epiléptico/tratamiento farmacológico , Tiopental
20.
Health Promot Int ; 37(3)2022 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-35901173

RESUMEN

While the non-profit sector has an integral role in health promotion, it is unclear whether these organisations have the capacity for health promotion activities. This study aims to explore and describe capacity changes of a non-profit organisation during a 3-year community-based nutrition intervention. The non-profit organisation, with 3800 members throughout the state of Queensland, Australia, implemented a 3-year food literacy community-based intervention. A team of qualified nutritionists delivered the program in partnership with community-based volunteers. A separate aim of the intervention was to build capacity of the non-profit organisation for health promotion. A qualitative study was undertaken, using a social constructivist approach to explore organisational capacity changes longitudinally. All relevant participants including non-profit executive managers and nutritionists were included in the study (100% response rate). Data collection included semi-structured interviews (n = 17) at multiple intervention time points and document analysis of program newsletters (n = 21). Interview transcripts and documents were analysed separately using thematic and content analysis. Codes and categories between the two data sources were then compared and contrasted to build themes. Organisational capacity was predominantly influenced by four themes; 'communicating', 'changing relationships', 'limited organisational learning' and 'adaptability and resistance to change'. Developing non-profit organisational health promotion capacity appears to require focusing on fostering communication processes and building positive relationships over time. Capacity changes of the non-profit organisation were not linear, fluctuating across various levels over time. Assessing non-profit organisational capacity to implement community interventions by describing adaptive capacity, may help researchers focus on the processes that influence capacity development.


Asunto(s)
Creación de Capacidad , Promoción de la Salud , Australia , Comunicación , Humanos , Organizaciones sin Fines de Lucro
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