Imaging technologies for presurgical margin assessment of basal cell carcinoma.

Basal cell carcinoma is the most common cancer worldwide, necessitating the development of techniques to decrease treatment costs through efficiency and efficacy. Mohs micrographic surgery, a specialized surgical technique involving staged resection of the tumor with complete histologic evaluation of the peripheral margins, is highly utilized. Reducing stages by even 5% to 10% would result in significant improvement in care and economic benefits. Noninvasive imaging could aid in both establishing the diagnosis of suspicious skin lesions and streamlining the surgical management of skin cancers by improving presurgical estimates of tumor sizes. Herein, we review the current state of imaging techniques in dermatology and their applications for diagnosis and tumor margin assessment of basal cell carcinoma prior to Mohs micrographic surgery.

Mediciones de imágenes fotográficas del pie como una metodología no invasiva y válida en la exploración clínica / Photographic imaging measurements of the foot as a non-invasive and valid methodology for clinical examination

Introducción: La evaluación anatómica musculoesquelética por imagen en la exploración clínica del pie es la fotografía digital que evalúa la morfología superficial. Objetivos: Validar la obtención de las imágenes fotográficas del pie, calcular las mediciones longitudinales, angulares y el índice del arco plantar de las imágenes mencionadas usando un podoscopio y fotogrametría en sujetos sanos y categorizar la normalidad de las mediciones. Métodos: Este estudio fue exploratorio y se realizó utilizando un prototipo de cámaras alrededor de un podoscopio y un software de análisis de imágenes. La imagen fotográfica fue evaluada por mediciones longitudinales, angulares y el índice plantar. Resultados: Los 30 sujetos sanos evaluados tenían una edad media de 25,06 ± 11,95 años, predominaban las mujeres con un 53,3 por ciento. La longitud total del pie, anchura del metatarso y altura del empeine media para el lado derecho en 226,55 ± 36,49mm, 98,99 ± 22,71 mm, y 36,32 ± 4,07 mm respectivamente; y para el lado izquierdo en 229,81 ± 42,25 mm, 104,49 ± 16,84mm y 36,31 ± 3,32 mm, respectivamente. El ángulo intermetatarsal del 1-2 rayo, ángulo intermetatarsal del 4-5 rayo y ángulo del retropié para el lado derecho fueron 14 ± 4º, 11 ± 3º y 2 ± 2º respectivamente, para el lado Izquierdo 14 ± 3º, 9 ± 3º y 2 ± 2º respectivamente y el índice plantar del arco derecho e izquierdo fueron 0,23 ± 0,2 y 0,22 ± 0,1, respectivamente. La variabilidad solo se presentó en el antepié en 20 por ciento. Conclusiones: La obtención de las imágenes fotográficas del pie fueron válidas, las mediciones fueron menores o similares a otros estudios. La variabilidad de normalidad solo se presentó en antepié(AU)

Introduction: Musculoskeletal anatomical assessment by imaging in clinical examination of the foot is digital photography assessing surface morphology. Objectives: To validate the acquisition of photographic images of the foot, to calculate the longitudinal, angular and plantar arch index measurements of the above images using a podoscope and photogrammetry in healthy subjects and to categorize the normality of the measurements. Methods: This study was exploratory and was performed using a prototype camera around a podoscope and image analysis software. The photographic image was evaluated by longitudinal, angular and plantar index measurements. Results: The 30 healthy subjects evaluated had a mean age of 25.06 ± 11.95 years, females predominated with 53.3 percent. The mean total foot length, metatarsal width and instep height for the right side at 226 55 ± 36.49mm, 98.99 ± 22.71 mm, and 36.32 ± 4.07 mm respectively; and for the left side at 229.81 ± 42.25 mm, 104.49 ± 16.84mm and 36.31 ± 3.32mm respectively. The 1-2 ray intermetatarsal angle, 4-5 ray intermetatarsal angle and rearfoot angle for the right side were 14 ± 4º, 11 ± 3º and 2 ± 2º respectively; for the Left side 14 ± 3º, 9 ± 3º and 2 ± 2º respectively and the plantar index of the right and left arch were 0.23 ± 0.2 and 0.22 ± 0.1 respectively. Variability was only present in the forefoot at 20 percent. Conclusions: The photographic images of the foot were valid, the measurements were lower or similar to other studies. The variability of normality was only present in the forefoot(AU)

Emerging imaging technologies in dermatology: Part II: Applications and limitations.

Clinical examination is critical for the diagnosis and identification of response to treatment. It is fortunate that technologies are continuing to evolve, enabling augmentation of classical clinical examination with noninvasive imaging modalities. This article discusses emerging technologies with a focus on digital photographic imaging, confocal microscopy, optical coherence tomography, and high-frequency ultrasound, as well as several additional developing modalities. The most readily adopted technologies to date include total-body digital photography and dermoscopy, with some practitioners beginning to use confocal microscopy. In this article, applications and limitations are addressed. For a detailed discussion of the principles involved in these technologies, please refer to the first part of this review article.

Emerging imaging technologies in dermatology: Part I: Basic principles.

Dermatologists rely primarily on clinical examination in combination with histopathology to diagnose conditions; however, clinical examination alone might not be sufficient for accurate diagnosis and skin biopsies have associated morbidity. With continued technological advancement, there are emerging ancillary imaging technologies available to dermatologists to aid in diagnosis and management. This 2-part review article will discuss these emerging technologies including: digital photographic imaging, confocal microscopy, optical coherence tomography, and high-frequency ultrasound, as well as several additional modalities in development. In this first installment, the authors describe the breadth of technologies available and the science behind them. Then, in the second article, the authors discuss the applications and limitations of these technologies and future directions.

Methods and reproducibility of grading optimized digital color fundus photographs in the Age-Related Eye Disease Study 2 (AREDS2 Report Number 2).

PURPOSE: To establish continuity with the grading procedures and outcomes from the historical data of the Age-Related Eye Disease Study (AREDS), color photographic imaging and evaluation procedures for the assessment of age-related macular degeneration (AMD) were modified for digital imaging in the AREDS2. The reproducibility of the grading of index AMD lesion components and for the AREDS severity scale was tested at the AREDS2 reading center. METHODS: Digital color stereoscopic fundus photographs from 4203 AREDS2 subjects collected at baseline and annual follow-up visits were optimized for tonal balance and graded according to a standard protocol slightly modified from AREDS. The reproducibility of digital grading of AREDS2 images was assessed by reproducibility exercises, temporal drift (regrading a subset of baseline annually, n = 88), and contemporaneous masked regrading (ongoing, monthly regrade on 5% of submissions, n = 1335 eyes). RESULTS: In AREDS2, 91% and 96% of images received replicate grades within two steps of the baseline value on the AREDS severity scale for temporal drift and contemporaneous assessment, respectively (weighted Kappa of 0.73 and 0.76). Historical data for temporal drift in replicate gradings on the AREDS film-based images were 88% within two steps (weighted Kappa = 0.88). There was no difference in AREDS2-AREDS concordance for temporal drift (exact P = 0.57). CONCLUSIONS: Digital color grading has nearly the same reproducibility as historical film grading. There is substantial agreement for testing the predictive utility of the AREDS severity scale in AREDS2 as a clinical trial outcome. (ClinicalTrials.gov number, NCT00345176.)

Development and Current Status of Skull-Image Superimposition - Methodology and Instrumentation.

This article presents a review of the literature and an evaluation on the development and application of skull-image superimposition technology - both instrumentation and methodology - contributed by a number of scholars since 1935. Along with a comparison of the methodologies involved in the two superimposition techniques - photographic and video - the author characterized the techniques in action and the recent advances in computer image superimposition processing technology. The major disadvantage of conventional approaches is its relying on subjective interpretation. Through painstaking comparison and analysis, computer image processing technology can make more conclusive identifications by direct testing and evaluating the various programmed indices.