Aging and binding in short-term memory: processes involved in conjunctive and relational binding.

In visual short-term binding memory tasks, some studies suggested that aging disrupts relational binding more than conjunctive binding, whereas others report equivalent age-related differences in both types of binding. Yet, demands in controlled resources are potentially the greatest for relational short-term binding. In order to test the hypothesis that aging would affect preferentially tasks demanding in controlled processes, we assessed the contribution of controlled and automatic memory processes to relational and conjunctive short-term binding. Groups of young and older adults studied shape-colour (Exp.1 and 3) or object-colour (Exp.2) pairs in a relational condition in which items were linked to colour patches and a conjunctive condition where colour was integrated into the items. Memory for bindings was tested with a reconstruction task (Exp. 1 and 2) or with a recognition memory task (Exp. 3) under inclusion and exclusion instructions (Process Dissociation Procedure). The three experiments showed that the retrieval of both relational and conjunctive bindings relied primarily on controlled memory processes, the use of which was diminished in older participants. This study brings additional evidence that age-related differences in top-down control processes explain at least partly decreased short-term binding capacities.

Assessment of Conjunctive Binding in Aging: A Promising Approach for Alzheimer's Disease Detection.

The visual experience of objects lies in the ability to perceive and integrate their constitutive features. Conjunctive binding (CB) is the cognitive function that integrates the features of objects as wholes. This review covers the main findings (over the last 10 years) concerning the role of CB in visual working memory (VWM) and cognitive theory, its neural correlates, as well as perspectives for future work. First, we discuss the theoretical cognitive models of CB and how these relate to other cognitive functions. We then integrate neuroimaging evidence with cognitive theory to identify the neural functional network of CB for encoding and maintenance. Also, we describe the field's transition from experimental to clinical research, which paves the way for work in the area of VWM binding and aging. Finally, we expose the challenges faced by this field of research and analyze its role in the study of dementia and the construction of neuro-cognitive models of conjunctive binding.

Differential age-related effects on conjunctive and relational visual short-term memory binding.

An age-related associative deficit has been described in visual short-term binding memory tasks. However, separate studies have suggested that ageing disrupts relational binding (to associate distinct items or item and context) more than conjunctive binding (to integrate features within an object). The current study directly compared relational and conjunctive binding with a short-term memory task for object-colour associations in 30 young and 30 older adults. Participants studied a number of object-colour associations corresponding to their individual object span level in a relational task in which objects were associated to colour patches and a conjunctive task where colour was integrated into the object. Memory for individual items and for associations was tested with a recognition memory test. Evidence for an age-related associative deficit was observed in the relational binding task, but not in the conjunctive binding task. This differential impact of ageing on relational and conjunctive short-term binding is discussed by reference to two underlying age-related cognitive difficulties: diminished hippocampally dependent binding and attentional resources.

Relational and conjunctive binding functions dissociate in short-term memory.

Remembering complex events requires binding features within unified objects (conjunctions) and holding associations between objects (relations). Recent studies suggest that the two functions dissociate in long-term memory (LTM). Less is known about their functional organization in short-term memory (STM). The present study investigated this issue in patient AE affected by a stroke which caused damage to brain regions known to be relevant for relational functions both in LTM and in STM (i.e., the hippocampus). The assessment involved a battery of standard neuropsychological tasks and STM binding tasks. One STM binding task (Experiment 1) presented common objects and common colors forming either pairs (relations) or integrated objects (conjunctions). Free recall of relations or conjunctions was assessed. A second STM binding task used random polygons and non-primary colors instead (Experiment 2). Memory was assessed by selecting the features that made up the relations or the conjunctions from a set of single polygons and a set of single colors. The neuropsychological assessment revealed impaired delayed memory in AE. AE's pronounced relational STM binding deficits contrasted with his completely preserved conjunctive binding functions in both Experiments 1 and 2. Only 2.35% and 1.14% of the population were expected to have a discrepancy more extreme than that presented by AE in Experiments 1 and 2, respectively. Processing relations and conjunctions of very elementary nonspatial features in STM led to dissociating performances in AE. These findings may inform current theories of memory decline such as those linked to cognitive aging.