The lunar dust environment: concerns for Moon-based astronomy.

The Moon has no atmosphere, hence, it offers a unique opportunity to place telescopes on its surface for astronomical observations. It is phase-locked with Earth, and its far side remains free from ground-based interference, enabling the optimal use of radio telescopes. However, the surface of the Moon, as any other airless planetary object in the solar system, is continually bombarded by interplanetary dust particles that cause impact damage and generate secondary ejecta particles that continually overturn the top layer of the lunar regolith. In addition, there is evidence, that small particles comprising the lunar regolith can be electrically charged, mobilized and transported, also representing a hazard for covering sensitive surfaces and interfering with exposed mechanical structures. In addition to the naturally occurring dust transport, rocket firings during landings and take-offs, pedestrian and motorized vehicle traffic will also liberate copious amounts of dust, representing a potential hazard for the safe and optimal use of optical platforms. This article is part of a discussion meeting issue 'Astronomy from the Moon: the next decades (part 2)'.

Comprehensive Evaluation of the Toxicity and Biosafety of Plasma Polymerized Nanoparticles.

The rapid growth of nanoparticle-based therapeutics has underpinned significant developments in nanomedicine, which aim to overcome the limitations imposed by conventional therapies. Establishing the safety of new nanoparticle formulations is the first important step on the pathway to clinical translation. We have recently shown that plasma-polymerized nanoparticles (PPNs) are highly efficient nanocarriers and a viable, cost-effective alternative to conventional chemically synthesized nanoparticles. Here, we present the first comprehensive toxicity and biosafety study of PPNs using both established in vitro cell models and in vivo models. Overall, we show that PPNs were extremely well tolerated by all the cell types tested, significantly outperforming commercially available lipid-based nanoparticles (lipofectamine) used at the manufacturer's recommended dosage. Supporting the in vitro data, the systemic toxicity of PPNs was negligible in BALB/c mice following acute and repeated tail-vein intravenous injections. PPNs were remarkably well tolerated in mice without any evidence of behavioral changes, weight loss, significant changes to the hematological profile, or signs of histological damage in tissues. PPNs were tolerated at extremely high doses without animal mortality observed at 6000 mg/kg and 48,000 mg/kg for acute and repeated-injection regimens, respectively. Our findings demonstrate the safety of PPNs in biological systems, adding to their future potential in biomedical applications.

Image Registration with Particles, Examplified with the Complex Plasma Laboratory PK-4 on Board the International Space Station.

Often, in complex plasmas and beyond, images of particles are recorded with a side-by-side camera setup. These images ideally need to be joined to create a large combined image. This is, for instance, the case in the PK-4 Laboratory on board the International Space Station (the next generation of complex plasma laboratories in space). It enables observations of microparticles embedded in an elongated low temperature DC plasma tube. The microparticles acquire charges from the surrounding plasma and interact strongly with each other. A sheet of laser light illuminates the microparticles, and two cameras record the motion of the microparticles inside this laser sheet. The fields of view of these cameras slightly overlap. In this article, we present two methods to combine the associated image pairs into one image, namely the SimpleElastix toolkit based on comparing the mutual information and a method based on detecting the particle positions. We found that the method based on particle positions performs slightly better than that based on the mutual information, and conclude with recommendations for other researchers wanting to solve a related problem.

Three-Dimensional Reconstruction of Individual Particles in Dense Dust Clouds: Benchmarking Camera Orientations and Reconstruction Algorithms.

In dusty plasmas, determining the three-dimensional particle positions and trajectories of individual particles is often required. This paper benchmarks two approaches capable of reconstructing the trajectories of particles in three dimensions. The influences of the particle number, the particle number density, and the orientation of the individual cameras are studied. Additionally, the demands on the desired image quality, required for these algorithms, are discussed. The reader is given practical information for the appropriate reconstruction approach and camera positioning that should/could be used in a specific application.