Diagnostic value of breast cancer with 2D ultrasound features combined with ultrasonic elastic strain rate ratio and correlation analysis with pathological prognostic indicators / 中国医学物理学杂志

Objective To analyze the diagnostic value of two-dimensional(2D)ultrasound features combined with ultrasonic elastic strain rate ratio(SR)for breast cancer and discuss their correlations with pathological prognostic indicators.Methods The clinical data of 265 patients with breast cancer admitted to the 2nd Affiliated Hospital of Chengdu Medical College from January 2020 to December 2021 were analyzed retrospectively.Through pathological examination,171 cases were diagnosed with benign lesions(benign group)and 94 cases with malignant lesions(malignant group).The 2D ultrasound and ultrasound elastography imaging data were collected and compared for the two groups in terms of ultrasound appearance and SR.The positive rates of estrogen receptor(ER),progesterone receptor(PR),and proto-oncogene(CerbB-2)were recorded.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficiency of 2D ultrasound and SR for breast cancer;and Pearman correlation analysis was conducted to assess the correlations between 2D ultrasound features/SR and ER/PR/CerbB-2.Results The 2D ultrasound features such as spicule sign,posterior echo attenuation,microcalcification,lymph node metastasis,and abundant blood flow were more common in malignant group,and the SR was significantly higher than that in benign group(P<0.05).The positive rates of ER,PR and CerbB-2 in malignant group were 59.57%,75.53%and 47.87%,respectively,significantly higher than those in benign group(P<0.05).ROC curve analysis showed that the AUC values of 2D ultrasound,SR,and their combination for breast cancer diagnosis were 0.586,0.743,and 0.761,respectively,indicating a significantly higher diagnostic efficiency of the combined detection than 2D ultrasound or SR alone(P<0.05).The occurrences of spicule sign and posterior echo attenuation and SR were higher in ER-positive patients than in ER-negative patients(P<0.05);lymph node metastasis was more prevalent in PR-positive patients,and their SR was higher than PR-negative patients(P<0.05);CerbB-2 positive patients had more microcalcifications and higher SR value as compared with CerbB-2 negative patients(P<0.05).Pearman correlation analysis revealed that there were positive correlations between 2D ultrasound features such as spicule sign/posterior echo attenuation and ER,lymph node metastasis and PR,microcalcification and CerbB-2,SR and ER/PR/CerbB-2(P<0.05).Conclusion The combination of 2D ultrasound features and SR provides reliable imaging information for the diagnosis of breast cancer.The spicule sign,posterior echo attenuation,lymph node metastasis,microcalcification and SR are correlated to the pathological prognostic indicators(ER,PR,and CerbB-2).

Differential diagnosis of diffuse sclerotic thyroid papillary carcinoma and Hashimoto's thyroiditis using fine-needle aspiration cytology, BRAFV600E , and ultrasound elastography.

BACKGROUND: The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) has ultrasound findings that are similar to Hashimoto's thyroiditis (HT), resulting in under-diagnosis. DSV-PTC combined with HT is also common, so early and accurate diagnosis of DSV-PTC using a variety of diagnostic techniques, including FNAC, BRAFV600E mutation detection, and ultrasound elastography, is critical. OBJECTIVE: To assess the diagnostic value of fine-needle aspiration cytology (FNAC) and BRAFV600E detection in combination with ultrasound elastography in the diagnosis of DSV-PTC. METHODS: We performed a retrospective analysis of 40 patients with pathologically confirmed DSV-PTC and 43 patients with HT admitted to our hospital's ultrasound department between January 2015 and December 2020. Preoperative FNAC, BRAFV600E mutation detection, and ultrasound elastography imaging were all performed on all patients. For a definitive diagnosis, the results of these tests were compared to postoperative pathological findings. The diagnostic value of FNAC, BRAFV600E mutation detection, ultrasound elasticity imaging, and their combination for DSV-PTC diagnosis was assessed. RESULTS: The mean elastic strain rate ratio (E1/E2) of the 40 DSV-PTC cases was 5.75 ± 2.14, while that of the 43 HT cases was 2.81 ± 1.20. The receiver operating characteristic (ROC) curve was generated using the average value of E2/E1. The area under the ROC curve was 0.910, and the optimal E2/E1 cut-off value was 4.500. When FNAC, BRAFV600E mutation detection, and ultrasound elasticity imaging detection were combined, the diagnostic sensitivity, specificity, negative predictive value, positive predictive value, and accuracy of DSV-PTC diagnosis were 92.5%, 95.3%, 93.2%, 94.9%, and 94.0%, respectively, which were significantly higher than the single technique (p < 0.05). CONCLUSIONS: The use of FNAC, BRAFV600E mutation detection, and ultrasound elastography in combination is more helpful in establishing an accurate diagnosis of DSV-PTC than using a single diagnostic technique alone.

The value of TI-RADS,ultrasonic elastic strain rate and VTQ in identity of benign and malignant thyroid nodule / 安徽医科大学学报

Objective To explore the value of ultrsound tyorid imaige reporing and systerm (TI-RADS ), ultrasonic elastic strain rate (SR) and virtual touch tissue quantification (VTQ) three methods diagnosis of benign and malignant thyroid nodule. Methods 128 patients with thyroid nodule which need surgical treatment were selected as research objective. Before surgical treatment, all thyroid nodules detection with two-dimensional and color doppler ultrasoundand and classification by TI-RADS; All thyroid nodules measuring the SR of thyroid nodule as referenced of sternocleidomastoid; All thyroid nodules conducted with VTQ detection and recorded by shear wave velocity. Receiver operator characteristic curve (ROC) was used to evaluate TI-RADS, SR and VTQ in identifying benign and malignant thyroid nodule which by surgery pathology as the gold standard. Results TI-RADS, SR and VTQ had statistically significant (P < 0. 05 ) in benign and malignant thyroid nodules, the area under the ROC curve of TI-RADS, SR and VTQ were respectively 0. 83, 0. 87, 0. 92. Conclusion VTQ could improve the accuracy of ultrasonography in identifying benign and malignant thyroid nodule.

Diagnostic value of ultrasonic elastic strain rate and conventional ultrasound for thyroid nodules / 中国基层医药

Objective To investigate the diagnostic value of ultrasonic elastic strain rate and conventional ultrasound for thyroid nodules,and to guide the clinical treatment.Methods 72 cases,a total of 86 nodules,were treated with ultrasound examination for thyroid nodules and operation were given conventional and ultrasonic elastic strain rate echocardiography before operation, after operation they had a pathological examination for tubercle.The accuracy,specificity and sensitivity of ultrasonic elastic strain rate combined with ultrasound to check the benign and malignant thyroid nodules were analyzed.Results The accuracy of ultrasonic elastic strain rate combined with con-ventional ultrasound was 93.41%,which was significantly higher than 73.67%of the conventional ultrasound (χ2 =12.0,P<0.05) .Conclusion Ultrasound elasticity strain rate combined with conventional ultrasound can effectively differentiate benign and malignant thyroid nodules and improve the accuracy of diagnosis of malignant thyroid nodules, which is conducive to the treatment and prognosis.