Association of ambient temperature with intentional self-harm and suicide death in Seoul: a case-crossover design with a distributed lag nonlinear model.

Previous epidemiological studies have reported a short-term association between ambient temperature and suicide risk. To gain a clearer understanding of this association, it is essential to differentiate the risk factors for intentional self-harm (ISH) from those specifically associated with suicide deaths. Therefore, this study aims to examine whether the association between daily temperature and ISH or suicide deaths differs by age and sex. Between 2014 and 2019, cases of emergency room visits related to ISH and suicide deaths in Seoul were identified. A time-stratified case-crossover design was used to adjust for temporal trends and seasonal variation. A distributed lag nonlinear model was used to analyze the nonlinear and time-delayed effect of ambient temperature on ISH and suicide deaths. Positive associations were observed between temperature and both ISH and suicide deaths. For ISH, the relative risk (RR) was high at 1.17 (95% confidence interval (CI): 1.03, 1.34) for a temperature of 25.7 °C compared with 14.8 °C. The RR for suicide death was higher than those for ISH, at 1.43 (95% CI: 1.03, 2.00) for a temperature of 33.7 °C. These associations varied by age and sex, with males and females aged 35-64 years showing increased susceptibility to suicide deaths. This study provides detailed evidence that unusually high temperatures, both anomalous and out of season, may trigger suicidal behaviors, including both ISH and suicide deaths.

An Experiential Approach to Training Medical Faculty to Coach: "The Total Experience was Much More Than the Sum of Its Parts".

Coaching in academic medicine may be used for performance improvement as well as personal and professional growth and development. Medical faculty used to advising and mentoring learners may find it challenging to transition to coaching. Limited information is available about educating physicians to take on the role of coaching. We investigated a faculty coach training program at an academic medical center, using qualitative methods to explore how participants' perceptions of the training aligned with the elements of Self-Determination Theory (SDT) and Intentional Change Theory (ICT) that were taught using the principles of Experiential Learning Theory (ELT). Based on findings that illuminated understanding and practice of coaching, it may be summarized that the application of experiential learning may be an effective approach in helping faculty embrace the principles of SDT and ICT and make the shift to transformational coaching.

EFSA statement on the requirements for whole genome sequence analysis of microorganisms intentionally used in the food chain.

Microorganisms, genetically modified or not, may be used in the food chain either as active agents, biomasses or as production organisms of substances of interest. The placement of such microorganisms or their derived substances/products in the European market may be subject to a premarket authorisation process. The authorisation process requires a risk assessment in order to establish the safety and/or the efficacy of the microorganism(s) when used in the food chain as such, as biomasses or as production strains. This includes a full molecular characterisation of the microorganism(s) under assessment. For certain regulated products, the use of whole genome sequence (WGS) data of the microorganism is established as a requirement for the risk assessment. In this regard, data obtained from WGS analysis can provide information on the unambiguous taxonomic identification of the strains, on the presence of genes of concern (e.g. those encoding virulence factors, resistance to antimicrobials of clinical relevance for humans and animals, production of harmful metabolites or of clinically relevant antimicrobials) and on the characterisation of genetic modification(s) (where relevant). This document provides recommendations to applicants on how to describe and report the results of WGS analyses in the context of an application for market authorisation of a regulated product. Indications are given on how to perform genome sequencing and the quality criteria/thresholds that should be reached, as well as the data and relevant information that need to be reported, if required. This updated document replaces the EFSA 2021 Statement and reflects the current knowledge in technologies and methodologies to be used to generate and analyse WGS data for the risk assessment of microorganisms.

Effect of Dental Implant System-Assisted Tooth Intentional Replantation in the Treatment of Anterior Teeth with Pathological Tooth Flaring, Drifting and Elongation in Patients with Stage III/IV Periodontitis: a Case Series.

OBJECTIVE: To investigate the clinical effect of implant-assisted dental intentional replantation (IR) for the treatment of "drifted" anterior periodontally hopeless teeth (PHT). METHODS: The present authors recruited 22 patients with stage III/IV periodontitis who suffered drifting of the maxillary anterior teeth, with a total of 25 teeth. The PHT were extracted for in vitro root canal treatment (RCT). The root surface was smoothed and the shape was trimmed, and the alveolar socket was scratched. The dental implant system was used to prepare the alveolar socket according to the direction, depth and shape of the tooth implantation. The PHT were reimplanted into the prepared alveolar socket. The periodontal indicators were analysed statistically before and after surgery. RESULT: Twenty-two patients who completed the full course of treatment, with a total of 25 PHT, had a successful retention rate of 88%. Mean periodontal probing depth (PPD) decreased by 2.880 ± 0.556 mm and 3.390 ± 0.634 mm at 6 months and 1 year, respectively, and clinical attachment loss (CAL) decreased by 2.600 ± 0.622 mm and 2.959 ± 0.731 mm at the same time points, respectively, showing significant improvement (P < 0.05). CONCLUSION: Dental implant system-assisted IR can effectively preserve "drifted" natural PHT in patients with stage III/IV periodontitis.

Instantaneous phase of rhythmic behaviour under volitional control.

The phase of signals representing cyclic behavioural patterns provides valuable information for understanding the mechanisms driving the observed behaviours. Methods usually adopted to estimate the phase, which are based on projecting the signal onto the complex plane, have strict requirements on its frequency content, which limits their application. To overcome these limitations, input signals can be processed using band-pass filters or decomposition techniques. In this paper, we briefly review these approaches and propose a new one. Our approach is based on the principles of Empirical Mode Decomposition (EMD), but unlike EMD, it does not aim to decompose the input signal. This avoids the many problems that can occur when extracting a signal's components one by one. The proposed approach estimates the phase of experimental signals that have one main oscillatory component modulated by slower activity and perturbed by weak, sparse, or random activity at faster time scales. We illustrate how our approach works by estimating the phase dynamics of synthetic signals and real-world signals representing knee angles during flexion/extension activity, heel height during gait, and the activity of different organs involved in speech production.

Sex differences among patients with intentional poisoning presenting to the emergency Department at a Tertiary Care Centre in Beirut, Lebanon.

Poisoning poses a worldwide public health challenge and recent data from Lebanon in 2020 revealed that over half patients presenting with acute toxicological exposure intentionally poisoned themselves, primarily with suspected suicidal intent. This study aims to assess sex disparities in intentional toxicological exposures among patients presenting to the Emergency Department, at a tertiary care centre in Lebanon. This was a secondary analysis of an existing toxicological database, including patients aged 6 years and older admitted due to acute overdose from March 2015 to August 2022. A total of 444 cases of intentional poisoning were analysed, with 302 (68.0%) women. The primary cause of intentional poisoning was suspected suicide in both sexes, significantly more common in women (85.1% versus 65.5%, P < 0.001). Specific agents exposed to patients varied by sex; sedatives/hypnotics/antipsychotics, antihistamines, and melitracen/flupentixol were significantly more prevalent in women (P < 0.001) while men showed higher prevalence for ethanol (P = 0.02), stimulants, street drugs and opioids (P < 0.001). Our study underscores substantial sex differences in intentional poisoning cases in Lebanon. Women exhibited a higher likelihood of exposures to sedatives/hypnotics/antipsychotics, antihistamines and melitracen/flupentixol, while stimulant drugs, ethanol, and opioids were prevalent in men. Developing proper and effective sex-specific measures may mitigate potential physical and psychological consequences.

Common intentional binding effects across diverse sensory modalities in touch-free voluntary actions.

The intentional binding effect refers to the phenomenon where the perceived temporal interval between a voluntary action and its sensory consequence is subjectively compressed. Prior research revealed the importance of tactile feedback from the keyboard on this effect. Here we examined the necessity of such tactile feedback by utilizing a touch-free key-press device without haptic feedback, and explored how initial/outcome sensory modalities (visual/auditory/tactile) and their consistency influence the intentional binding effect. Participants estimated three delay lengths (250, 550, or 850 ms) between the initial and outcome stimuli. Results showed that regardless of the combinations of sensory modalities between the initial and the outcome stimuli (i.e., modal consistency), the intentional binding effect was only observed in the 250 ms delay condition. This findings indicate a stable intentional binding effect both within and across sensory modalities, supporting the existence of a shared mechanism underlying the binding effect in touch-free voluntary actions.

Explicit and implicit sense of agency in depersonalisation experiences.

The sense of agency, the feeling of controlling one's bodily actions and the world is altered in Depersonalisation (DP), a condition that makes people feel detached from one's self and body. To investigate the link between depersonalisation and both implicit and explicit sense of agency, an online study was conducted using the influential Intentional Binding paradigm in a sample of non-clinical DP participants. The results did not reveal significant differences between individuals with low and high occurrences of DP experiences on the implicit and explicit sense of agency. However, participants with high occurrences of DP experiences showed a more time-sensitive explicit sense of agency and greater temporal distortions for short intervals in the absence of self-initiated motion. These results suggest that there is a discrepancy between implicit and explicit sense of agency in people with high levels of depersonalisation. Altogether, these findings call for further investigations of the key role of time perception on altered sense of self and agency in both non-clinical and clinical populations, to disentangle the mechanisms associated with the explicit and implicit sense of agency.

Dynamic of Fire Deaths: Two Emblematic Cases of Intentional Burning.

Background: Homicide by burning is rare, involving victims exposed to direct flames, often with accelerants. This demonstrates excessive force by the assaulter. A thorough investigation is vital as fire can conceal pathological findings. This study presents two emblematic cases of intentional burning. Case report: Two cases of homicide by fire are detailed. The first involves a male found dead in a fire-damaged apartment, doused with flammable liquid and set on fire by his partner. The autopsy showed heat hematoma and soot in the trachea and large bronchi. The second case involves a female set on fire with gasoline by an acquaintance, sustaining burns over 90% of her body and dying from hypovolemic shock. The autopsy revealed effusions in pleural and peritoneal cavities and a hyperaemic trachea. Conclusions: Intentional burnings are sporadic and difficult to classify without testimonial evidence. The difference between homicide and accidental burns relies on circumstantial evidence and antemortem injuries. Vital reactions to thermal lesions include red-base blisters, dilated capillaries, leukocyte infiltration, coagulative necrosis, heat hematoma, and soot in the airways. High carboxyhemoglobin levels indicate vitality. The first case showed heat hematoma and tracheal soot, while the second exhibited severe burns leading to hypovolemic shock. Testimonial evidence and crime scene examination were crucial in determining the homicidal nature. Forensic investigation of charred corpses requires a comprehensive evaluation of all available data. Crime scene analysis, combined with autopsy, toxicological tests, and post-mortem CT scans, helps establish the cause of death and differentiate between ante- and postmortem injuries.

Facilitating and hindering factors for routine adaptations in manufacturing and effects on human performance- unexpected insights from three experimental studies in a special purpose setting.

Consumer behaviour changes and strategic management decisions are driving adaptations in manufacturing routines. Based on the theory of situational strength, we investigated how contextual and person-related factors influence workers' adaptation in a two-worker position routine. Contextual factors, like retrieval cues (Study 1), time pressure (Study 2), and convenience (Study 3), were varied. Person-related factors included retentivity, general and routine-specific self-efficacy, and perceived adaptation costs. Dependent variables included various error types and production time before and after adaptation. In each study, 148 participants were trained in a production routine at t1 and executed an adapted routine at t2, one week later. Repeated measures ANOVA for performance at t1 and t2, and MANOVA for performance at t2, revealed that time increased for all groups at t2. For participants in Studies 1 & 2, error rates remained consistent. Retentivity significantly impacted errors at both t1 and t2, emphasising that routine changes in a 'running business' take time, regardless of contextual factors. Workers with lower retentivity may require additional support.

When production routines are changed while daily business operations continue, and on-the-job training is the sole method, a slowdown in production speed should be anticipated. Workers, particularly those with low retentivity, require additional support and training to minimise errors when executing the adapted routine.

Intentional replantation for a Class 4/Stage C cemental tear: Etiology, choice and outcomes of treatment.

Cemental tears, root cracks, and associated periapical-periodontal lesions may occur simultaneously in one tooth, and can be effectively managed by intentional replantation and etiological control. A durable splint, along with occlusal and periodontal monitoring, is required as healing progresses slowly and may be insufficient.

Intonation words in initial intentional communication of Mandarin-speaking children.

Intonation words play a very important role in early childhood language development and serve as a crucial entry point for studying children's language acquisition. Utilizing a natural conversation corpus, this paper thoroughly examines the intentional communication scenes of five Mandarin-speaking children before the age of 1;05 (17 months). We found that children produced a limited yet high-frequency set of intonation words such as " [a], [æ], [ε], [ən], [ə], eng [əŋ], [o], and [i]." These intonation words do not express the children's emotional attitudes toward propositions or events; rather, they are utilized within the frameworks of imperative, declarative, and interrogative intents. The children employ non-verbal, multimodal means such as pointing, gesturing, and facial expressions to actively convey or receive commands, provide or receive information, and inquire or respond. The data suggests that the function of intonation words is essentially equivalent to holophrases, indicating the initial stage of syntactic acquisition, which is a milestone in early syntactic development. Based on the cross-linguistic universality of intonation word acquisition and its inherited relationship with pre-linguistic intentional vocalizations, this paper proposes that children's syntax is initiated by the prosodic features of intonation. The paper also contends that intonation words, as the initial form of human vocal language in individual development, naturally extend from early babbling, emotional vocalizations, or sound expressions for changing intentions. They do not originate from spontaneous gesturing, which seems to have no necessary evolutionary relationship with the body postures that chimpanzees use to change intentions, as suggested by existing research. Human vocal language and non-verbal multimodal means are two parallel and non-contradictory forms of communication, with no apparent evidence of the former inheriting from the latter.

The animacy (bias) effect in recognition: testing the influence of intentionality of learning and retrieval quality.

The animacy effect, a memory advantage for animate/living over inanimate/non-living items, is well-documented in free recall, but unclear in recognition memory. This might relate to the encoding tasks that have been used and/or to an unequal influence of animacy on the processes underlying recognition (recollection or familiarity). This study reports a recognition memory experiment, coupled with a remember/know procedure. An intentional and two incidental learning conditions (one animacy-related and one animacy-unrelated) were used. No animacy effect was found in discriminability (A') irrespectively of the encoding condition. Still, different mechanisms in incidental and intentional conditions conducted to said result. Overall, animates (vs. inanimates) elicited more hits and also more false alarms. Moreover, participants tended to assign more remember responses to animate (vs. inanimate) hits, denoting higher recollection for the former. These findings are suggestive of an animacy bias in recognition, which was stronger in the animacy-related encoding condition. Ultimate and proximate mechanisms underlying the animacy effect are examined.

Intentional Dural Resection during en bloc Spinal Resection Could Provide a Secure Surgical Margin for Patients with Recurrent Spinal Tumors.

OBJECTIVE: It is always difficult to obtain a comfortable surgical margin for patients with recurrent malignant or invasive benign spinal tumors. Tumor intraspinal invasion and dural adhesion are the essential reasons. There are always residual tumor cells maintained at the edge of dura. Dural resection is a key point to obtain a comfortable surgical margin for such cases. Whether such patients benefit from this risky surgical procedure is unknown. This study aims to understand better the oncological results, associated risks, and neurological function of this risky surgical procedure. METHODS: We retrospectively reviewed clinical data from six consecutive patients who registered spinal tumors in our institute and underwent dural resection during en bloc spinal resection from June 2013 to May 2020. The demographic and perioperative data, oncological outcomes, complications, and neurological status were collected and analyzed. RESULTS: All six patients were followed up for 24 to 46 months (mean follow-up time: 32.8 months). Local recurrence was detected in one patient (1/6, 16.7%) at 36 months postoperatively and in five patients with no evidence of disease at the last follow up (survival rate 83.3%). Eleven complications occurred in four patients (66.7%), and the dural resection-related complications included only four cases of cerebrospinal fluid leakage (CSFL), which accounted for 36.4% (4/11) of all complications. Neurologic status evaluated by the Frankel grade showed improvement of one grade in one case and deterioration of one to two grades in five patients immediately after surgery. All deterioration cases recovered to the preoperative level 6 months after the operation. CONCLUSION: Dural resection is significant for patients with dura matter invaded by recurrent primary malignant or invasive benign spinal tumors with the purpose of clinical cure. This study demonstrated that in strictly selected cases, intentional dural resection could provide satisfying local control and long-term disease-free survival with acceptable complications and satisfying neurological function.

Sense of agency in schizophrenia: A reconciliation of conflicting findings through a theory-driven literature review.

The sense of agency is the experience of being the author of self-generated actions and their outcomes. Both clinical manifestations and experimental evidence suggest that the agency experience and the mechanisms underlying agency attribution may be dysfunctional in schizophrenia. Yet, studies investigating the sense of agency in these patients show seemingly conflicting results: some indicated under-attribution of self-agency (coherently with certain positive symptoms), while others suggested over-attribution of self-agency. In this review, we assess whether recent theoretical frameworks can reconcile these divergent results. We examine whether the identification of agency abnormalities in schizophrenia might depend on the measure of self-agency considered (depending on the specific task requirements) and the available agency-related cues. We conclude that all these aspects are relevant to predict and characterize the type of agency misattribution that schizophrenia patients might show. We argue that one particular model, based on the predictive coding theory, can reconcile the interpretation of the multifarious phenomenology of agency manifestations in schizophrenia, paving the way for testing agency disorders in novel ways.

Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses.

To evaluate the suitability of an analytical instrument, essential figures of merit such as the limit of detection (LOD) and the limit of quantification (LOQ) can be employed. However, as the definitions k nown in the literature are mostly applicable to one signal per sample, estimating the LOD for substances with instruments yielding multidimensional results like electronic noses (eNoses) is still challenging. In this paper, we will compare and present different approaches to estimate the LOD for eNoses by employing commonly used multivariate data analysis and regression techniques, including principal component analysis (PCA), principal component regression (PCR), as well as partial least squares regression (PLSR). These methods could subsequently be used to assess the suitability of eNoses to help control and steer processes where volatiles are key process parameters. As a use case, we determined the LODs for key compounds involved in beer maturation, namely acetaldehyde, diacetyl, dimethyl sulfide, ethyl acetate, isobutanol, and 2-phenylethanol, and discussed the suitability of our eNose for that dertermination process. The results of the methods performed demonstrated differences of up to a factor of eight. For diacetyl, the LOD and the LOQ were sufficiently low to suggest potential for monitoring via eNose.

Exploring the influence of self-identification on perceptual judgments of physical and social causality.

People tend to overestimate the causal contribution of the self to the observed outcome in various situations, a cognitive bias known as the 'illusion of control.' This study delves into whether this cognitive bias impacts causality judgments in animations depicting physical and social causal interactions. In two experiments, participants were instructed to associate themselves and a hypothetical stranger identity with two geometrical shapes (a circle and a square). Subsequently, they viewed animations portraying these shapes assuming the roles of agent and patient in causal interactions. Within one block, the shape related to the self served as the agent, while the shape associated with the stranger played the role of the patient. Conversely, in the other block, the identity-role association was reversed. We posited that the perception of the self as a causal agent might influence explicit judgments of physical and social causality. Experiment 1 demonstrated that physical causality ratings were solely shaped by kinematic cues. In Experiment 2, emphasising social causality, the dominance of kinematic parameters was confirmed. Therefore, contrary to the hypothesis anticipating diminished causality ratings with specific identity-role associations, results indicated negligible impact of our manipulation. The study contributes to understanding the interplay between kinematic and non-kinematic cues in human causal reasoning. It suggests that explicit judgments of causality in simple animations primarily rely on low-level kinematic cues, with the cognitive bias of overestimating the self's contribution playing a negligible role.

Bridging the Gap between Endodontic Failure and Success: A Case Report on Intentional Replantation.

This case report describes a case of intention replantation in a 15-year-old patient with a mandibular permanent right second molar that had undergone root canal treatment previously. The tooth was tender on percussion. Radiographic evaluation showed the presence of a separated instrument and periapical radiolucency. The surgical procedure was performed under local anesthesia, and the tooth was extracted. After cleaning and disinfecting the root canal system, the tooth was reimplanted, and the socket was filled with a mixture of bone graft material and a growth factor. A stainless steel crown was then placed to protect the tooth. A follow-up examination was performed after 12 months. The clinical and radiographic examinations revealed a well-healing periapical lesion with no signs of infection. The patient was asymptomatic, and the tooth was functional. The results of this case indicate that intentional replantation can lead to a favorable outcome.

Food adulteration: Causes, risks, and detection techniques-review.

Food adulteration is the intentional addition of foreign or inferior substances to original food products for a variety of reasons. It takes place in a variety of forms, like mixing, substitution, hiding poor quality in packaging material, putting decomposed food for sale, misbranding or giving false labels, and adding toxicants. Several analytical methods (such as chromatography, spectroscopy, electronic sensors) are used to detect the quality of foodstuffs. This review provides concise but detailed information to understand the scope and scale of food adulteration as a way to further detect, combat, and prevent future adulterations. The objective of this review was to provide a comprehensive overview of the causes, risks, and detection techniques associated with food adulteration. It also aimed to highlight the potential health risks posed by consuming adulterated food products and the importance of detecting and preventing such practices. During the review, books, regulatory guidelines, articles, and reports on food adulteration were analyzed critically. Furthermore, the review assessed key findings to present a well-rounded analysis of the challenges and opportunities associated with combating food adulteration. This review included different causes and health impacts of food adulteration. The analytical techniques for food adulteration detection have also been documented in brief. In addition, the review emphasized the urgency of addressing food adulteration through a combination of regulatory measures, technological advancements, and consumer awareness. In conclusion, food adulteration causes many diseases such as cancer, liver disease, cardiovascular disease, kidney disease, and nervous system-related diseases. So, ensuring food safety is the backbone of health and customer satisfaction. Strengthening regulations, taking legal enforcement action, enhancing testing, and quality control can prevent and mitigate the adulteration of food products. Moreover, proper law enforcement and regular inspection of food quality can bring about drastic changes.

Evaluation methods of BDS-3 ground-segment defensive capability oriented to satellite navigation countermeasures.

Owing to intentional interference and destructions during satellite navigation countermeasures, the security application of global navigation satellite systems (GNSS) faces immense challenges. To ensure the safe application of the GNSS in complex electromagnetic environment, the system-level defensive capability need be assessed, which can make for maintaining GNSS normal service during countering and further realizing the optimal decision. Therefore, this study used the ground control segment in the GNSS as the evaluation object, the bottom indices related to the criterion layers including service performance and station function as the key evaluation indices, and the technical requirement of each index under a secure situation as the standard, to propose the evaluation system including index system and evaluation methods for the ground-segment defensive capability. As BeiDou navigation satellite system III (BDS-3) is a global navigation satellite system independently built and operated by China, it was taken as a case for method verification. Then, BDS-3 two-way observation data between the satellite and the ground and between stations, which was collected from Beijing flight Control Center, from March 5 to 12 (2022) were selected during tests, and the results were compared with the existing standards contained in BDS open service performance standard to evaluate the system-level defensive capability. Evaluation Results of positioning accuracy and error correction ability for the BDS-3's ground stations determined through seven damage experiments with different interference strength show that: Corresponding horizontal and vertical positioning accuracy of stations under test did not exceed 1 m in the statistical period and their convergence time did not exceed the limit (30 min); thus, the ground segment of the BDS-3 has a good defensive capability. Compared to comprehensive evaluation results of the BDS-3, based on the theoretical threshold (the ground-segment threshold ≤48.40 % and the space-segment threshold ≤51.60 %), we know that its ground-segment defense (14.06 %) was worse than GPS ground-segment defense (14.43 %), whereas the ground-segment defense of the BDS/GPS integrated system (15.29 %) was best and its capability evaluation grade was strong. They indicate system's future improvements should focus more on enhancing the development scale and service efficiency of the BDS-3's ground stations in the Western Hemisphere, and reasonably promote system compatibility and interoperability while considering facility cost and operating efficiency.