Efficacy of ozone therapy for oral mucosa wound healing: a systematic review and meta-analysis.

OBJECTIVES: To conduct a systematic review and meta-analysis to assess the effectiveness of ozone therapy in oral ulcers healing when compared to placebo or active treatments. MATERIALS AND METHODS: The search was carried out using PubMed, EMBASE, Scopus, and Lilacs databases. Clinical trials involving human participants were included. The Risk Ratio (RR) and the standardized mean difference (SMD) with 95%CI (confidence interval) were calculated. The ROBINS-I (risk of bias in non-randomized studies of interventions) and RoB2 (risk of bias tool for randomized trials) assessment tool was used to detect bias. RESULTS: After the selection process, 12 studies were included. The meta-analysis showed that ozone therapy helps to reduce the size of the traumatic and autoimmune ulcers (RR=-0.44; 95% CI -0.71,-0.17; I2=0%) in comparison to placebo. Regarding pain reduction, ozone was superior to placebo (RR = 1.29, 95% CI -1.6 to -0.95); I2=0%), and equivalent to topical corticosteroid and laser photobiomodulation (RR = 0.26, 95% CI -0.27,0.78, p = 0.34). CONCLUSION: Ozone therapy is an alternative for accelerating healing and reducing pain for both traumatic and autoimmune ulcers. However, the quality of evidence is limited. CLINICAL RELEVANCE: Oral ulcerations are usually painful and impact quality of life requiring different approaches to boost wound healing and reduce symptoms. For this purpose, ozone therapy is a promising strategy.

The impact of craniofacial and dental osteogenesis imperfecta manifestations on oral health-related quality of life of children and adolescents.

OBJECTIVE: Craniofacial and oral manifestations of Osteogenesis Imperfecta (OI) can affect the functioning of the stomatognathic system and impact the patient's quality of life. The objective of the study was to evaluate the relationship between craniofacial and oral manifestations and the Oral Health-related Quality of Life (OHRQoL) of OI children and adolescents. MATERIAL AND METHODS: A total of 30 OI patients aged eight to fourteen years old followed up at the Oral Care Center for Inherited Diseases were enrolled in the research. OHRQoL was assessed using the short form of the Child Perceptions Questionnaire (CPQ) for eight to ten-year-olds (CPQ8-10) and 11 to 14-year-olds (CPQ11-14). The relationship between the OHRQoL index and its assessment domains, OI types, and the presence of dentinogenesis imperfecta (DI), class III malocclusion, and dental agenesis were evaluated. RESULTS: The median CPQ score of patients was 5, and there was no significant difference in OHRQoL between children and adolescents, nor associated with the disease severity or the presence of DI. The oral manifestations evaluated did not directly impact the patients' OHRQoL. CONCLUSIONS: The study demonstrated that the perception of OHRQoL is similar for both adolescents and children. The oral symptom was the most relevant domain for the index among patients aged eight to fourteen years while the emotional well-being was the most impacted. CLINICAL RELEVANCE: this study makes contributions by indicating that addressing dental care for children and adolescents with OI is important in clinical management and better OHRQoL for this population.

Secondary oral syphilis presenting as a tumor-like lesion on the lower lip

ABSTRACT This study presents a case of atypical manifestation of secondary syphilis. Diagnosis was initiated prompted by the patient's complaint of a lower lip lesion, present for three months, resembling a malignant neoplasm. The lesion, a 3 cm (diameter) ulcerated nodule, arising from conjunctive tissue, raised concern. However, further physical examination revealed additional clinical features, including cervical micropolyadenopathy and erythematous skin lesions, prompting a reevaluation of the diagnosis, most likely secondary syphilis. These findings led to a serological investigation, which, ultimately, confirmed the diagnosis of syphilis. The case underscores the importance of recognizing syphilis as a formidable imitator, posing challenges in establishing differential diagnoses of mucocutaneous diseases.

Oral manifestations in patients diagnosed with psoriasis: A systematic review.

AIMS: To identify the main types of oral lesions associated with psoriasis. METHODS AND RESULTS: It was a systematic review, based on a search performed in the PubMed/Medline, and Scielo databases, and an associated manual search. Descriptors were selected from DeCs/MeSH and the PICOS strategy (population, intervention, comparison, outcomes, and study design) was applied. Randomized clinical trials and retrospective and prospective studies published from 2000 to 2022 were included, according to the PRISMA parameters (Preferred Reporting Items for Systematic Reviews and Meta-Analysis), registered in the PROSPERO platform. The STROBE quality scale (Strengthening the Reporting of Observational studies in Epidemiology) was also used. One hundred fourteen articles were identified using the search strategy, and nine articles were found in the manual search. Of the sixty-six preselected articles, seven were included in the study. Although it was not possible to identify a specific oral lesion associated with psoriasis, there was a greater occurrence of geographic tongue, fissured tongue, and Candida sp. infection CONCLUSION: Evidence shows that although patients with psoriasis may exhibit lesions in the oral mucosa, they are not specific to this condition. Further epidemiological studies are needed to address the association of psoriasis with possible changes in the oral mucosa.

[Oral pathologies in pediatric patients related to juvenile systemic lupus erythematosus and considerations in stomatological management. A review]. / Patologías orales en pacientes pediátricos relacionados con lupus eritematoso sistémico juvenil y consideraciones en el manejo estomatológico. Una revisión.

Introduction: Juvenile lupus erythematosus (jSLE) is a rheumatic disease that affects the functioning of internal organs and is multisystemic. It is a chronic condition and is usually associated with very significant morbidity, which is higher in children and adolescents than in adults. Objectives: Describe and identify the most current concepts of jSLE, etiology, epidemiology of the disease, semiology, oral manifestations, as well as treatment, consequences and differences with systemic lupus erythematosus in adults (aSLE). Materials and methods: A literature search was carried out in PubMed, Ebsco, SciELO, and ELSEVIER, using the key words, "Juvenile lupus erythematosus","dental caries", "oral manifestation", "children dentistry". Aimed at studies carried out in humans between 2010 to 2023 and the most relevant topics related to this disease were analyzed. Results: The information that was collected corresponds to the last 13 years, with the purpose of making an update on the topic of study, 750 articles were reviewed which were analyzed with the inclusion and exclusion criteria but only 50 met these criteria articles. Conclusion: Dental care in patients with SLEj is a challenge, since there are different considerations that we must take into account before carrying out any treatment, since they present alterations in the joints, salivary glands and failures of multiple organs. It is important to know the different differential diagnoses for unequivocal detection of the disease. In the presence of signs and symptoms based on the criteria of jSLE or early onset, a consultation with the immunology area is recommended to confirm or rule out this disease.

Photobiomodulation (PBMT) and antimicrobial photodynamic therapy (aPDT) in oral manifestations of patients infected by Sars-CoV-2: systematic review and meta-analysis.

Background: In 2019, a viral and respiratory pathology called COVID-19 emerged in Wuhan, China, and spread to other continents. Its main symptoms include fever, cough, dyspnea, myalgia, anorexia and respiratory distress in the most severe cases, which can lead to death. Furthermore, manifestations in the oral cavity such as ageusia and dysgeusia, as well as lesions in other regions of the oral cavity, can be observed. Main body: This systematic review and meta-analysis aimed to critically assess the clinical evidence on the use of photobiomodulation (PBMT) and antimicrobial photodynamic therapy (aPDT) for the treatment of oral lesions in patients infected with Sars-Cov-2. The literature extracted from electronic databases such as PubMed, Medline, CINAHL, and Google Scholar was screened for eligibility, and relevant articles were included. The review is limited to manuscripts published in English, Spanish and Portuguese language between December 2019 and October 2021. A total of 5 articles with 11 cases retracting PBMT and aPDT as therapeutic strategies for the regression of oral lesions and painful symptoms. The results show favoring the associated use of PBMT with aPDT (P = 0.004), and the isolated use of PBMT with the result of significant "P = 0.005" and good confidence interval (7.18, 39.20) in ulcerative lesions, herpetic, aphthous, erythematous, petechiae and necrotic areas. Conclusions: PBMT and aPDT could be effective in the treatment of oral lesions of patients infected with Sars-Cov-2 in a short period of time; however, more long-term randomized clinical trials studies are needed to define the therapeutic strategy.

Oral manifestations of graft-versus-host disease in patients submitted to allogeneic hematopoietic stem cell transplantation: the experience of a Brazilian Cancer Center.

PURPOSE: Graft-versus-host disease (GVHD) is an important complication of allogeneic hematopoietic stem cell transplantation (AHCT) that affects several organs, including the mouth. OBJECTIVES: The aim of the present study was to describe the prevalence and clinical manifestations of oral GVHD, to determine the time interval from AHCT to the onset of oral GVHD manifestations, to identify predictive factors of oral GVHD, and to evaluate the survival rates of patients diagnosed with oral GVHD. METHODS: Medical records of 147 patients who underwent AHCT between January 2010 and January 2015 were reviewed for clinical features and the statistical establishment of risk factors. RESULTS: Of the 147 patients in the study, 99 (67.3%) developed GVHD. The skin was the most affected site (45.6%), followed by the gastrointestinal tract (27.9%) and oral cavity (17.7%). The mean post-AHCT oral GVHD development time was 229 days. Among patients with oral GVHD, pain was the main complaint (96.2%) followed by xerostomia (65.4%). The most common oral manifestations were ulcers (53.8%) followed by striae-associated ulcers (19.2%), mostly affecting the buccal mucosa and tongue. Seventy-three patients (48.6%) died within 20 months of receiving AHCT. Cox regression analysis indicated that patients who received myeloablative conditioning regimen had higher survival rate than those who underwent a reduced-intensity conditioning regimen (RR = 0.541; 95% CI, 0.334-0.878; p = 0.03). CONCLUSION: The mouth was the third most common GVHD-affected site. Pain, xerostomia, and ulcers with or without striae were the main clinical manifestations of GVHD observed in our study cohort. Reduced-intensity conditioning regimen showed significant relationship with mortality risk.

Dental intervention prior to and subsequent to the diagnosis of acute myeloid leukemia: case report / Intervenção odontológica prévia e subsequente ao diagnóstico de leucemia mielóide aguda: relato de caso

ABSTRACT Leukemia's are characterized by the proliferation of immature white blood cells, called blasts, in the bone marrow and / or blood. Among them, we highlight the Monocytic Acute Myeloid Leukemia, which represents a malignant neoplasm whose unnatural monoblast proliferation results in suppression of myeloid series cells. Oral manifestations are common, arising at the onset of the disease and are also associated with chemotherapy during treatment leading to complications that compromise oncotherapy. The present study deals with a patient with this type of aggressive leukemia, with oral complications of the disease and later, oncological treatment. It also give prominence the performance of the dental surgeon in distinct phases of the treatment emphasizing the importance of maintaining oral health in cancer patients. The presence of the Dentist in the multi-professional team contributes to the reduction of manifestations that occur both due to the disease and the treatment, ensuring a better quality of life for cancer patients and avoiding higher expenses to the health system.

RESUMO As leucemias são caracterizadas pela proliferação de células imaturas da linhagem branca, denominadas blastos, na medula óssea e/ou sangue. Dentre elas destacamos a Leucemia Mielóide Aguda Monocítica, que representa uma neoplasia maligna, cuja proliferação anormal de monoblastos resulta na supressão das células da série mielóide. Manifestações orais são comuns, surgindo no início da doença e também associadas à quimioterapia durante o tratamento gerando complicações que comprometem a oncoterapia. O presente trabalho trata-se de um paciente portador deste tipo agressivo de leucemia, com complicações bucais da doença e posteriormente, do tratamento oncológico. Destaca ainda a atuação do cirurgião-dentista em fases distintas do tratamento realçando a importância da manutenção da saúde bucal em pacientes oncológicos. A presença do Cirurgião-Dentista na equipe multiprofissional contribui para diminuição das manifestações que ocorrem tanto devido à doença quanto ao tratamento, garantindo melhor qualidade de vida do paciente oncológico e evitando maiores gastos ao sistema de saúde.

Future Challenges of Covid-19 and Oral Manifestations in Daily Dental Practice: A Literature Review.

OBJECTIVE: Some patients reportedly present with oral manifestations of coronavirus disease 2019 (Covid-19). It is unknown if this is due to the virus itself or a side effect of treatment; however, severe acute respiratory syndrome coronavirus 2 has been shown to have a predilection for angiotensin-converting enzyme receptors that are present in the respiratory tract, oral mucosa, tongue, and salivary glands, causing alterations in taste and smell. Therefore, the objective of this review was to present the future challenges of Covid-19 and oral manifestations in daily dental practice through a literature review. MATERIALS AND METHODS: Scientific evidence in the databases Scopus and PubMed was searched using the Boolean operators. Articles published in Spanish and English between January and December 2020 were included. RESULTS: Of the 89 articles found in Scopus, 69 were of the open access type and 20 were in the "others" category; only 22 scientific articles were found in PubMed. CONCLUSION: It is important to take into account these clinical manifestations such as loss of taste and smell in order to detect the disease. Good oral hygiene is also recommended as a preventive measure to reduce viral load, which considerably reduces the probability of infecting other people who are in contact with the infected patient.

Manifestaciones orales asociadas a SARS-COV-2: Revisión de la literatura / Manifestações orais associadas ao SARS-COV-2: Revisão da literatura / Oral manifestations associated with SARS-COV-2: A literature review

Resumen Objetivo: Identificar las principales manifestaciones y describir su ubicación en la cavidad oral en pacientes COVID-19. Métodos: Se utilizaron las bases de datos PubMed, Medline, LILACS, LIVIVO, Web of Science y SciELO; utilizando los términos de búsqueda oral mucosa, oral mucosa lesion, oral manifestations, COVID-19 y SARS-CoV-2. Se eliminaron duplicados, luego se realizó preselección de artículos, y finalmente se aplicaron los criterios de inclusión y exclusión. Resultados: Se seleccionaron 47 publicaciones, encontrando manifestaciones orales en pacientes COVID-19 tales como alteración en gusto, xerostomía, úlceras, vesículas, entre otras; ubicándose en diferentes áreas de la mucosa oral. Conclusiones: Se necesitan más estudios para vislumbrar la posible etiopatogenia a nivel oral del SARS-CoV-2. Además, se destaca el rol del odontólogo en el equipo multidisciplinario y en la teleconsulta.

Resumo Objetivo: Identificar as principais manifestações e descobrir sua ubiquação na cavidade oral em pacientes com COVID-19. Método: Foram utilizadas as bases de dados PubMed, Medline, LILACS, LIVIVO, Web of Science e SciELO; utilizando os termos de pesquisa oral mucosa, oral mucosa lesion, oral manifestations, COVID-19 e SARS-CoV-2. Duplicadas foram removidas, depois uma pré-seleção de artigos foi feita, e finalmente os critérios de inclusão e exclusão foram aplicados. Resultados: Foram selecionadas 47 publicações, encontrando manifestações orais em pacientes com COVID-19, tais como alterações no paladar, xerostomia, ulcerações, vesículas, entre outros; localizando-as em diferentes áreas da mucosa oral. Conclusão: São precisos mais estudos pra vislumbrar a possível etiopatogenia a nível oral do SARS-CoV-2. Ademais, destaca-se o role do odontólogo na equipe multidisciplinar e na tele consulta.

Abstract Objective: Identify the main oral manifestations associated with COVID19 and describe their location in the oral cavity. Methods: The literature search was conducted in PubMed, Medline, LILACS, LIVIVO, Web of Science, and SciELO. The following words were searched for: oral mucosa, oral mucosa lesion, oral manifestations, COVID-19, and SARS-CoV-2. Duplicate articles were eliminated, and the pieces were shortlisted. Finally, inclusion and exclusion criteria were applied. Results: This study included 47 articles. The main oral manifestations in patients with COVID-19 are taste disorders, xerostomia, ulcers, vesicles, and others located in different areas of the oral mucosa. Conclusions More studies are needed to determine the potential oral etiopathogenesis of SARS-CoV-2. Moreover, dentists play a significant role in the multidisciplinary and telemedicine team.

Periodontal tissues are targets for Sars-Cov-2: a post-mortem study.

Background: The ability of coronavirus SARS-CoV-2 to spread is one of the determinants of the COVID-19 pandemic status. Until June 2020, global COVID-19 cases surpassed 10 million. Asymptomatic patients, with no respiratory impairment, are believed to be responsible for more than 80% of the transmission. Other viruses have been consistently detected in periodontal tissues. Objective: The aim of this study was to investigate the presence of SARS-CoV-2 in periodontal tissue. Methods: We conducted video-endoscope minimally invasive post-mortem biopsy in seven fatal cases of COVID-19, using a regular endoscope video system associated with a smartphone to locate periodontal tissue. We analyzed the samples using RT-PCR, to identify the SARS-CoV-2 RNA and histopathological analysis. Results: The seven studied autopsies with positive laboratory tests for COVID-19 included 57.14% of female patients at the average age of 47.4 (range 8 to 74). In five cases, periodontal tissue was positive for SARS-CoV-2 (RT-PCR). Histopathologic analyses showed morphologic alterations in the keratinocytes of the junctional epithelium, a vacuolization of the cytoplasm and nucleus and nuclear pleomorphism. Conclusion: We presented a biomolecular analysis obtained from minimally invasive autopsies. This is the first study to demonstrate the presence of SARS-CoV-2 in periodontal tissue in COVID-19 positive patients.

Absence of influence of polymorphisms of the MBL2 gene in oral infections by HSV-1 in individuals with HIV.

Polymorphisms in the structural gene MBL-2 (mannose-binding lectin-2) may result in low MBL serum concentration, associated with greater susceptibility to infection. The study evaluated the effects of MBL-2 polymorphisms with the oral manifestations of the HSV in human immunodeficiency virus (HIV)-infected patients. An observational case-control study was carried out, with the sample comprising 64 HIV+ and 65 healthy individuals. The signs and symptoms of HSV oral infection were evaluated, and oral mucosa buccal smears were collected. Polymorphisms of the MBL-2 gene and HSV-1 DNA were amplified through real-time PCR. The data revealed that of 64 HIV+, 29.6% presented signs and symptoms of HSV oral infection. Of these, the HSV-1 DNA was detected through real-time PCR in 21% of cases, and in 13.3% of asymptomatic individuals. There was no statistically significant difference between the symptomatic (p = 1) and the asymptomatic (p = 0.52) individuals, HIV+ and HIV-. Different genotypes (AA, A0, or 00) did not contribute to the oral manifestation of HSV in the HIV+ patients (p = 0.81) or HIV- (p = 0.45). There was no statistically significant difference in either group (p = 0.52). No significant association was identified between the MBL-2 gene polymorphisms in the oral manifestation of HSV infection. However, further studies are recommended with larger population groups before discarding this interrelationship.

Manifestaciones bucales de la sífilis secundaria en una paciente adulta / Oral manifestations of secondary syphilis in an adult female patient

Se describe el caso clínico de una paciente de 38 años de edad, quien fue atendida en la consulta estomatológica del Policlínico Cuatro Caminos, por presentar múltiples lesiones indoloras en casi toda la mucosa bucal. Teniendo en cuenta estos síntomas se le diagnosticó una estomatitis aftosa recurrente, pero el tratamiento indicado no resultó satisfactorio. Luego se interconsultó con el especialista en Medicina Interna, quien le indicó exámenes complementarios y, según los criterios clínicos y de laboratorio, se confirmó la presencia de sífilis secundaria. Se efectuó el control de foco y se logró la remisión de la enfermedad.

The case report of a 38 year-old patient who was assisted in the stomatological department of Cuatro caminos polyclinic is described due to multiple painless lesions in almost all the oral mucous. Keeping in mind these symptoms a recurrent aphthous stomatitis was diagnosed, but the prescribed treatment was not satisfactory. Then a consultation with the specialist in Internal Medicine was carried out, who indicated her complementary exams and, according to the clinical and laboratory criteria, the presence of secondary syphilis was confirmed. The focus control was carried out and the remission of the disease was achieved.

Consideraciones bucales en el tratamiento de pacientes con esclerodermia: reporte de dos casos / Bucal considerations in the treatment of patients with scleroderma: Report of two cases

La esclerodermia pertenece a un grupo de enfermedades autoinmunes del tejido conectivo, que produce: inflamación, disfunción vascular y fibrosis excesiva del tejido conectivo de soporte de la piel y los órganos viscerales. A nivel bucal se evidencian afecciones como xerostomía, microstomía, caries y enfermedad periodontal. El tratamiento odontológico requiere un manejo integral por parte de los profesionales, que comprenda las patologías orales presentes y los síntomas permanentes característicos de la enfermedad sistémica de base. El objetivo de este artículo es presentar dos casos de esclerodermia resaltando sus manifestaciones orales presentes.

Scleroderma belongs to a group of autoimmune connective tissue diseases that causes inflammation, vascular dysfunction and excessive fibrosis of the connective tissue supporting the skin and visceral organs. A level oral conditions such as xerostomia, microstomia, caries and periodontal disease are evident. Dental treatment requires a comprehensive management by professionals who understand oral pathologies and permanent characteristic symptoms of systemic disease. The aim of this paper is to present two cases of scleroderma highlighting present oral manifestations.

A Rare Case of Labial Myiasis caused by Dermatobia hominis.

INTRODUCTION: The aim of this article is to present a rare case of myiasis caused by Dermatobia hominis. Myiasis is a disease caused by invasion of tissues of animals and humans by larval stages of dipterous (2-winged) flies. There are few reports of oral myiasis in the literature, mostly related to Cochliomyia hominivorax larvae. We present a case of a 53-year-old man with painful swelling of the left lower lip that was confirmed to be myiasis caused by D. hominis. Though more common in tropical and subtropical regions of North and South America, myiasis should be considered in the differential diagnosis of subcutaneous masses among residents or travelers in endemic areas.

Tuberous Sclerosis: A Case Report with Oral Manifestation / Esclerosis Tuberosa: Caso Clínico con Manifestaciones Orales

Tuberous sclerosis is an autosomal dominant neurocutaneous syndrome, which may involve multiple organ systems and shows highly variable clinical manifestations. Oral manifestations, including lesions on hard tissues, enamel hypoplasia and gingival hyperplasia have been previously described. We report a case of 25-year-old woman with this syndrome presenting multiple fibrous nodules on the buccal mucosa and lips. Awareness of the different oral manifestations of tuberous sclerosis is important to ensure appropriate diagnosis and treatment.

La esclerosis tuberosa es un síndrome autosómico dominante neurocutáneo, que puede afectar varias partes del cuerpo y las manifestaciones clínicas son variables. Manifestaciones orales que incluyen lesiones en tejidos duros, hipoplasia del esmalte e hiperplasia gingival se han descrito previamente. Este artículo presenta un caso de una mujer de 25 años con esclerosis tuberosa presentando múltiples nódulos fibrosos en la mucosa bucal y los labios. El conocimiento de las diferentes manifestaciones orales de la esclerosis tuberosa es importante para asegurar el diagnóstico y tratamiento adecuados.

Avaliação das condições bucais e antropométricas em adolescentes soropositivos entre 12 a 19 anos de idade, atendidos no Hospital Central de Maputo-Moçambique / Evalute the antropometric measurements and oral health in adolescents seropositive 12-19 years in Hospital Central Maputo- Mozambique

O objetivo deste trabalho foi avaliar e comparar as condições de saúde bucal e antropométricas em adolescentes portadores da AIDS (Síndrome de imunodeficiência adquirida) em Maputo-Moçambique e correlacioná-las com o número de linfócitos T CD4+. A amostra foi constituída por 143 adolescentes, entre 12 e19 anos de ambos os gêneros, dividida em 2 grupos: GA - grupo com AIDS (n=68) e GC-grupo controle (n=75) sem a doença. As condições bucais analisadas foram: doença periodontal (IPC) alterações do tecido mole e cárie dentária (CPOD). A avaliação antropométrica foi realizada por meio do índice de massa corpórea (IMC) e a contagem de linfócitos TCD4 foi obtida dos prontuários. As variáveis foram analisadas por meio de odds ratio e correlação de Sperman (p<0,05). A maioria dos indivíduos avaliados em ambos os grupos apresentou IMC normal. A maioria dos pacientes não apresentou doença periodontal, sendo 67,6% do GA e 61,3% do GC (p>0,05). As alterações de tecido mole foram encontradas em 11,8% (GA=14 e GC=3), sendo que no GC foram encontradas apenas ulcerações aftosas. Não houve diferença estatística, entre os grupos (p>0,05). O CPOD médio na amostra estudada foi 2,90±2,78, no GA foi de 3,06±2,63 e no GC foi de 2,76±2,91, (p>0,05). O Significant Index Caries (SIC ) encontrado no estudo foi de 6,12± 2,04, (GA: 6,17±3,05 e GC: 6,08±2,76). Nas condições bucais e no número de linfócitos T CD4 houve correlação negativa no CPOD e IPC (r= - 0,185) e na alteração de tecido mole houve correlação negativa (r=-0,0136) entretanto não foram significativas (p>0,05), Encontrou-se correlação positiva entre o IMC e o número de linfócitos T CD4 (r=-0,012 p=0>0,05). O CPOD e IPC mostram-se baixos e as condições antropométricas dentro da normalidade nos adolescentes HIV soropositivos submetidos à terapia antirretroviral.

The aim of this study was to evaluate the oral health conditions and anthropometric measurements in adolescents with AIDS in Maputo Mozambique and correlate them to the level of TCD4 count . The sample was comprised of 143 adolescents aged 12-19 years of both genders divided into 2 groups : GA - AIDS group (n = 68) and CG - control group (n =75) without disease ,The oral conditions were analyzed: periodontal disease (CPI), soft tissue changes and Dental caries (DMFT). Anthropometric evaluation was performed using the body mass index (BMI) and TCD4 cell count was obtained from medical records, The variables were analyzed using the Student t test and Spearman correlation (p < 0,05) , The mean DMFT in the sample was 2,90 ± 2,78; in the GA 3,06 ± 2,63 and GC 2,76 ± 2,91 ( p > 0,05) , The Significant Index Caries (SIC) found was 6,12 ± 2,04 (GA : 6,17 ± 3,05 and CG: 6,08 ± 2,76),The most patients did not show periodontal disease, The GA was 67,6% and GC was 61,3 % of adolescents groups (p > 0,05), Most of the subjects in both groups had normal BMI. The soft tissue changes were found in 17 adolescents ( GA = 14 and CG = 3) and the GC only aphthous ulcerations were found, There was no statistical difference between groups ( p > 0,05), There was a positive correlation between DMFT and CPI (r = 0,185 p < 0,05). In dental conditions and TCD4 counts correlated negatively in DMFT (r = -0,0037) in the CPI (r = -0,07) and soft-tissue abnormalities correlated negatively (r = -0,098) however they were not significant (p> 0,05). A positive correlation was found between BMI and CD4 lymphocyte count (r = 0,012 p =0> 0,05). In adolescents seropositive undergoing antiretroviral therapy the oral conditions showed to be of low prevalence and anthropometric measurement was normal.

Manifestações orais decorrentes da quimioterapia em crianças de um centro de tratamento oncológico / Oral manifestations of chemotherapy in children from a cancer treatment center

Objetivo: Identificar as manifestações orais em pacientes pediátricos em tratamento quimioterápico de um Centro de Tratamento Oncológico de Teresina-PI e correlacioná-las com a qualidade da sua saúde oral. Métodos: A amostra desta pesquisa consistiu de 24 crianças entre seis e 12 anos de idade. Durante os meses de junho a julho de 2010, foi aplicado um questionário com perguntas objetivas e subjetivas, direcionado ao paciente e seu responsável, para a coleta dos seguintes dados: idade, gênero, tipo de câncer, sinais e sintomas das manifestações bucais apresentadas após a quimioterapia e hábitos de higiene bucal. Realizou-se, também, um exame clínico intrabucal nos pacientes, pelo pesquisador, para visualização das alterações na mucosa oral e classificar a sua saúde bucal em favorável ou desfavorável. Foram utilizados os testes estatísticos de correlação de Kendall´s, Spearman´s e para relacionar a saúde oral dos pacientes da amostra com as manifestações orais encontradas. Resultados: Os resultados encontrados mostraram que a idade média dos pacientes pesquisados foi de 8,5 anos; o gênero masculino (75,0%) foi predominante na amostra; a neoplasia maligna mais incidente foi a leucemia (50,0%); 83,3% dos pacientes apresentaram pelo menos uma manifestação oral, sendo a mucosite de maior prevalência (62,5%), seguida da xerostomia (54,1%), disfagia (50,0%), disgeusia (45,8%), candidíase (41,6%), sangramento gengival (25,0%), herpes labial (25,0%) e odontoalgia (12,5%). Encontraram-se 28,6% dos pacientes com saúde bucal favorável e 71,4% deles com saúde bucal desfavorável, os quais todos estes apresentaram complicações orais da quimioterapia. Conclusão: As manifestações orais dos pacientes submetidos à quimioterapia do Centro de Tratamento de Teresina no período estudado foram diversas: mucosite, xerostomia, disfagia, disgeusia, sangramento gengival, candidíase, herpes labial e odontoalgia. Os efeitos colaterais na cavidade oral do pacientes foram associados à presença de uma saúde bucal desfavorável.

Objective: identify the oral manifestations in pediatric patients caused by chemotherapy at a Cancer Treatment Center in Teresina, PI, Brazil and correlate them with the quality of oral health. Methods: The sample of this research consisted of 24 children between 6 and 12 years. From June to July, 2010, a questionnaire directed to the patients and their parents/caregivers, with subjective and objective questions, was applied for collecting the following data: age, gender, type of cancer, signs and symptoms of oral manifestations presented after chemotherapy, and oral hygiene habits. Intraoral clinical examination of patients was performed by the researcher, to detect the changes in the oral mucosa caused by chemotherapy and classify their oral health as favorable or unfavorable. Kendall's, Spearman's and Pearson's statistical tests were used to correlate the oral health of the patients with the found oral manifestations. Results: The results showed that the mean age of the patients was 8.5 years; the male gender (75.0%) was prevalent in the sample; the most frequent malignancy was leukemia (50.0%); 83. 3% of patients had at least one oral manifestation, mucositis being the most prevalent (62,5%), followed by xerostomia (54.1%), dysphagia (50.0%), dysgeusia (45.85), candidiasis (41.6%), gingival bleeding (25.0%), herpes labialis (25.0%) and toothache (12.5%). Favorable and unfavorable oral health was found for 28.6% and 71.4% of the patients, respectively, and all of them presented oral complications due to chemotherapy. Conclusion: The oral manifestations of the patients at Teresina' cancer treatment center within the studied period were diverse: mucositis, xerostomia, dysphagia, dysgeusia, gingival bleeding, candidiasis, herpes labialis and toothache. Side effects in the oral cavity of these patients were associated with the presence of an unfavorable oral health.

Manifestaciones orales y caries dental en niños expuestos al virus de inmunodeficiencia humana / Oral manifestations and dental caries in children exposed to human immunodeficiency virus

Objetivo Determinar las manifestaciones orales y caries dental en niños expuestos al virus de inmunodeficiencia humana (VIH). Métodos Se estudiaron 37 niños que acuden a la consulta pediátrica del programa nacional de control de SIDA (PRONASIDA-Lara). Se informó a padres y representantes sobre los objetivos del estudio y su carácter confidencial. El examen de la cavidad oral lo realizó un odontólogo, quien además indagó sobre historia de manifestaciones bucales y corroboró la información con la historia clínica. Resultado La edad promedio fue 5,15±3,79 años, 62,2 % era del género masculino. Se infectaron por trasmisión vertical 91,8 %. La mayoría de los niños pertenecían a la categoría clínica A (35,1 %). El mayor porcentaje (37,8 %) de niños se encontró en la categoría 15-24 % de linfocitos CD4. Entre las manifestaciones orales más prevalentes se encontró la candidiasis oral, queilitis angular, eritema gingival lineal y parotiditis. Se observó diferencia estadísticamente significativa entre el porcentaje de linfocitos CD4 y queilitis angular (p<0,05). Cuarenta y cinco coma nueve (45,9 %) presentó caries dental y 29,7 % tenían necesidad de tratamiento dental "urgente". Por otra parte, el índice de necesidad de tratamiento calculado (INT) muestra que tres cuartos de los niños tenían necesidad de tratamiento dental. Conclusiones Los resultados del estudio permiten concluir que existe la necesidad de una estrategia basada en el manejo de las manifestaciones orales, frecuentes en la infección por VIH en niños, que permita un tratamiento desde un punto de vista integral, con un enfoque clínico y preventivo.

Objective Determining oral manifestations and dental caries amongst children exposed to the immunodeficiency virus (HIV). Methods Thirty-seven (n=37) children attending the Colombian AIDS Control Program (PRONASIDA-Lara) pediatric service were studied. Parents and guardians were informed about the purpose of the study and its confidentiality. An oral examination was conducted by a dentist; parents/guardians were asked about their children's history of oral manifestations and this was corroborated with their clinical charts. Results The mean age was 5.15±3.79; 62.2 % were males. Ninety-eight point eight percent had become vertically infected. Most of the children were classified in the A immune suppression category (35.1 %). The highest percentage (37.8 %) of children were in the 15 %-24 % total CD4+ lymphocyte category. The most prevalent oral manifestations were oral candidiasis, angular cheilitis, linear gingival erythema and parotid enlargement. There was a significant statistical difference between percentages of CD4 lymphocytes and angular qualities (p<0.05). Forty-five point nine percent had dental caries and 54.1 % were in "urgent" need of dental treatment. The Index of Orthodontic Treatment Need (IOTN) showed that ¾ of the children needed dental treatment. Conclusions The results of the study led to concluding that there was a need for an oral manifestation management-based strategy focusing on clinical and preventative treatment, as oral manifestations are frequent in children suffering from HIV infection.