ABC de la diálisis peritoneal en pediatría / ABC of the peritoneal dialysis in pediatrics

Resumen: La enfermedad renal crónica terminal (ERCT) tiene una incidencia de 5,5 a 9 ppm, y una prevalencia de 23 a 65 ppm en menores de 15 años. La diálisis peritoneal (DP) crónica representa en pediatría la terapia de reemplazo renal más usada, previo al trasplante renal. Existen 2 tipos de DP crónicas, manual (DPCA) y automatizada (DPA), cuya elección se basa en las características del peritoneo eva luado mediante el test de equilibrio peritoneal (PET), que divide a los pacientes en transportadores altos (intercambio rápido), promedio alto, promedio bajo, y bajos (intercambio lento). Este test eva lúa básicamente el transporte de solutos, al cual se ha sumado el MiniPET, que evalúa el transporte peritoneal de agua libre. Se debe igualmente determinar la cuantía de diálisis (Kt/V), que representa la dosis de diálisis aplicada, con un valor mínimo sugerido de 1,7, relacionado a la morbimortalidad. Estos parámetros deben ser evaluados periódicamente para ajustar la DP, y cada vez que se sospeche una depuración o ultrafiltración inadecuadas. El objetivo de esta revisión es entregar conceptos bási cos sobre fisiología del transporte peritoneal, modalidades de DP, evaluación del transporte de agua y solutos peritoneal, y el cálculo de la dosis de diálisis para una diálisis ajustada a las necesidades de cada paciente, como también revisar los mecanismos de corrección y ajuste del procedimiento cada vez que se requiera.

Abstract: End-stage renal disease (ESRD) has an incidence of 5.5 to 9 pmp, and a prevalence of 23 to 65 pmp in children under 15 years of age. Chronic peritoneal dialysis (PD) represents the most widely used renal replacement therapy in children before kidney transplantation. There are two PD modalities, the manual one (CAPD) and the automated one (APD). The choice is based on the peritoneum characteristics, evaluated through the peritoneal equilibrium test (PET), which divides patients into high transporters (rapid exchange membrane), high average, low average, and low transporters (slow exchange membrane). This test basically evaluates the solutes transport rate, and the MiniPET has been added which evaluates peritoneal free water transport. The amount of dialysis (Kt/V), which represents the dose of dialysis administered also must be evaluated to assure a minimal value of 1.7 related to morbidity and mortality. These parameters should be evaluated periodically to ad just the PD and whenever suspected an inadequate clearance or ultrafiltration. The objective of this review is to provide basic concepts on peritoneal transport physiology, PD modalities, free water transport and peritoneal solute transport evaluation, and the dialysis dose to be applied according to the patient's needs, as well as reviewing the correction mechanisms and procedure adjustment whenever required.

The Behavior of the Type of Peritoneal Transport in the Inflammatory and Oxidative Status in Adults Under Peritoneal Dialysis.

Peritoneal dialysis (PD) is an alternative for managing the end-stage renal disease (ESRD). The peritoneal membrane (PM) is not just a membrane that passively responds to diffusion and convection. The characteristics of PM result in the peritoneal equilibrium test (PET) and with this test is possible to obtain the type of peritoneal transport (PT). The patient on PD can be classified in different types of PT as; Low, Low Average, High Average, and High. The aim of the study was to compare the inflammatory cytokines, oxidants, antioxidants, and oxidative DNA damage markers in the different types of PT. A cross-sectional analytical study of 77 adult PD patients was performed. Levels of lipoperoxides (LPO) were higher in all types of PT vs. healthy volunteer controls (HC) (p < 0.0001). Nitric oxide (NO) levels were found significantly down-regulated in all types of PT (p < 0.0001). The activity of the superoxide dismutase enzyme (SOD) was found to be significantly increased in all types of PT vs. the HC (p < 0.0001). The levels of the DNA repair enzyme were found to be decreased in all types of PT. The levels of the pro-inflammatory cytokines TNF-α, IL-6, the marker of oxidative DNA damage, 8-IP and the total antioxidant capacity (TAC) were all significantly decreased, contrary to the levels in HC, possibly by the clearance in the dialysis fluid in all types of PT or due to down-regulation of their expression. In conclusion, we found significant changes in markers of inflammation, oxidative stress, and oxidative damage to DNA in all types of PT; Low, low average, high average, and high PT in the values of D/P creatinine at 4 h compared to HC.

Análisis de pacientes en diálisis peritoneal: factores clínico-epidemiológicos y tipo de transporte peritoneal con recambio hipertónico / Analysis of patients in peritoneal dialysis: clinical-epidemiologic factors and peritoneal transport type with

Resumen Introducción: la diálisis peritoneal ha sido una terapia efectiva para los pacientes con falla renal terminal. Objetivo: determinar las características de la población y el tipo de transporte peritoneal (utilizando una solución dializante hipertónica). Materiales y métodos: estudio descriptivo transversal en pacientes del Servicio de Nefrología del Hospital Escuela Universitario de Tegucigalpa, durante el período comprendido entre el 1 de octubre al 15 de noviembre de 2016. Resultados: la nefropatía diabética fue identificada como la causa de nefropatía crónica en 18 (42.9 %) pacientes; seguida de la nefropatía hipertensiva, con 14 (33.3 %), y la nefropatía mesoamericana, con 8 (19.0 %). El tipo de transporte peritoneal más frecuente fue el promedio alto, en 21 (50.0 %) de los pacientes; seguido del promedio bajo, con 12 (28.6 %); el transporte bajo, con 7 (16.7 %); y el transporte alto, con 2 (4.8 %). Discusión: en Centroamérica, durante los últimos años, ha habido un aumento de incidencia de la enfermedad renal en trabajadores provenientes de la costa pacífica, especialmente varones agricultores sin factores de riesgo. Esto constituye una epidemia de la nefropatía mesoamericana. Existe una relación entre el aumento de la transferencia de solutos y la disminución de la ultrafiltración con el paso del tiempo. Conclusiones: la nefropatía mesoamericana es una causa emergente de enfermedad en la región. No se encontró relación entre el tiempo prolongado de diálisis peritoneal, o el antecedente de peritonitis, y un transporte peritoneal bajo.

Abstract Introduction: Peritoneal dialysis has been an effective therapy in the management of patients with end-stage renal failure. Objective: To determine the characteristics of the population and the type of peritoneal transport using hypertonic dialyzing solution. Methods and Materials: Prospective and cross-sectional study in patients of the Nephrology Service of the Hospital Escuela Universitario of Tegucigalpa during the period from October 1 to November 15, 2016. Results: Diabetic nephropathy was associated as the cause of chronic kidney disease in 18 (42.9%) patients, followed by nephropathy hypertensive disease with 14 (33.3%) and Mesoamerican nephropathy with 8 (19.0%). The most frequent type of peritoneal transport was the high average in 21 (50.0%) of the patients, followed by the low average with 12 (28.6%), low transport with 7 (16.7%) and high transport with 2 (4.8%). Discussion: In Central America during the last years there has been an increase in the incidence of kidney disease in workers from the Pacific coast, especially male farmers with no risk factors, thus constituting the epidemic of Mesoamerican nephropathy. There is a relationship between the increase in solutes transfer and the decrease of the ultrafiltration with the passage of time. Conclusions: Mesoamerican nephropathy is an emerging cause of disease in the region. No relationship was found between prolonged peritoneal dialysis time or the history of peritonitis with low peritoneal transport.

The effects of angiotensin-converting enzyme inhibitors on peritoneal protein loss and solute transport in peritoneal dialysis patients

OBJECTIVE: The objective of this study was to examine the effects of angiotensin-converting enzyme inhibitors on peritoneal membrane transport, peritoneal protein loss, and proteinuria in peritoneal dialysis patients. METHODS: Fifty-four peritoneal dialysis patients were included in the study. The patients were divided into two groups. Group 1 (n = 34) was treated with angiotensin-converting enzyme inhibitors. Group 2 (n = 20) did not receive any antihypertensive drugs during the entire follow-up. Eleven patients were excluded from the study thereafter. Thus, a total of 30 patients in Group 1 and 13 patients in Group 2 completed the study. We observed the patients for six months. Group 1 patients received maximal doses of angiotensin-converting enzyme inhibitors for six months. Parameters at the beginning of study and at the end of six months were evaluated. RESULTS: At the end of six months, total peritoneal protein loss in 24-hour dialysate effluent was significantly decreased in Group 1, whereas it was increased in Group 2. Compared to the baseline level, peritoneal albumin loss in 24-hour dialysate effluent and 4-hour D/P creatinine were significantly increased in Group 2 but were not significantly changed in Group 1. A covariance analysis between the groups revealed a significant difference only in the decreased amount of total protein loss in 24-hour dialysate. Proteinuria was decreased significantly in Group 1. CONCLUSION: This study suggests that angiotensin-converting enzyme inhibitors reduce peritoneal protein loss and small-solute transport and effectively protect peritoneal membrane transport in peritoneal dialysis patients.