RESUMEN
Schizophrenia is a chronic debilitating condition associated with impaired social functioning, memory, and executive functioning. To date, we are still unsure about the exact etiology of schizophrenia, but there are many factors, such as genetics, diminished hippocampal volume, and imbalance of neurotransmitters, that lead to the pathogenies of the disease. Antipsychotics are the most effective treatment option for schizophrenia so far, yet they are associated with a wide array of side effects, ranging from extrapyramidal side effects to conditions, such as metabolic syndrome. Exercise has been shown to increase neural connections in the brain, which can improve cognition and memory. This literature review focuses on the signs and symptoms of schizophrenia, its treatment options, and how exercise can help with some of the symptoms of schizophrenia, especially the negative symptoms that are least effectively treated by antipsychotics.
RESUMEN
The effects of exercise on the cardiovascular system are multifaceted and complex. It is well-documented that exercise can reduce mortality related to cardiovascular pathology. One anatomical structure that has been implicated in this process is the coronary collateral circulation. The goal of this review is to evaluate the current literature on the effects of exercise on human coronary collateral circulation. A search for literature was conducted on the databases Science Direct and PubMed using the terms: coronary collateral, collateral, exercise, physical activity, resistance training, endurance training, and collateral artery. Research that had the primary outcome of assessing human coronary collateralization secondary to exercise was included. Research in which the effect of exercise was not the primary outcome was excluded. As a result, a total of 13 research papers on the effects of exercise on coronary collateral circulation were included. Thirteen original research papers were reviewed. The mean age range in all studies was between 48 and 64 years old. There was a predominance of male participants, with a total of 597 male patients and 108 female patients across all studies. It was found that initial research underestimated the effect of exercise on coronary collateral circulation due to a lack of sensitive assessment methods. With the introduction of sensitive measures like the collateral flow index (CFI) and Rentrop scoring, results have shown that coronary collateral function can be increased with exercise. Exercise has been shown to enhance coronary collateral function. There is limited evidence as to which type, duration, or intensity of exercise is most favourable to enhance coronary collateral function. There is also relatively little data on the effects of exercise in the female population and those over the age of 65 years. More research is required to determine the specific effects of exercise on coronary collateral circulation in various age groups, genders, co-morbidities, specific exercise modalities, durations, intensities, and the effect of pharmacotherapy.
RESUMEN
Cervical artery dissection (CeAD) occurring in the context of sports is a matter of concern for CeAD patients. They seek advice on the role of sports in CeAD and on the safety of resuming sports after CeAD. The scarcity of studies and guidelines addressing these issues poses a challenge. We aimed at summarizing the current knowledge about CeAD and sports in order to provide an informed, comprehensive opinion for counseling CeAD patients. We took into account pathophysiological considerations, observations of cases reports, series, and registries, and conclusions by analogy from aortic dissection or inherited connective tissue syndromes. In summary, practicing active sports as the cause of CeAD seems uncommon. It seems recommendable to refrain from any kind of sports activities for at least 1 month, which can be extended in case of an unfavorable clinical or neurovascular course. We recommend starting with sport activities at low intensity-preferably with types of endurance sports-and to gradually increase the pace in an individually tailored manner, taking into circumstances of the occurrences of the CeAD in the individual patient (particularly in relation to sports), the meaning of sports activities for the individual well-being, the presence or absence of comorbidities and of neurological sequela, neurovascular findings, and whether there are signs of an underlying connective tissue alteration. Major limitations and several forms of bias are acknowledged. Still, in the absence of any better data, the summarized observations and considerations might help clinicians in advising and counseling patients with CeAD in clinical practice.