Spontaneous testicular tumor regression: case report and historical review.

Spontaneous regression of a primary testicular germ-cell tumour (GCT), over time known as 'Burned out', 'Shrinking Seminoma', 'pT0', 'Burnout' or 'Spontaneous Regression', is an uncommon, generally metastatic phenomenon, which may present elevated tumour markers and a suspicious testicular ultrasound image. The histological study of the testicle demonstrated morphological changes of complete or partial tumour regression and found fibrous scarring and other characteristic changes of this phenomenon, which in some cases include vestiges of GCT. There are few publications on testicular GCT tumour regression and those that exist present limited data on the biology of the disease and its etiopathogenesis. This entity was recently recognised in the latest edition of the World Health Organization's (WHO) Classification of Tumours. We present our clinical, imaging, laboratory, cytohistological and management experience, as well as a historical review of the literature.

Extruded Lumbar Disc Herniation with Spontaneous Reabsorption: Case Report and Review / Reabsorção espontânea de hérnia discal lombar extrusa: relato de caso

Disc herniation is a common condition in the population and has a direct impact on the quality of life in patients, also causing functional limitations in the work place. Treatment protocols include conservative management and/or various surgical interventions. This paper reports on a case of symptomatic large extruded disc herniation, together with spontaneous clinical regression and total re-absorption. We show here conservative management, and a literature review of the main pathophysiological hypotheses for such an unusual evolution.

Hérnia discal é condição comum na população e tem impacto direto na qualidade de vida dos pacientes, assim como causa limitações funcionais em seu ambiente de trabalho. Protocolos de tratamento incluem manejo conservador e/ou diversos tipos de intervenção cirúrgica. Este artigo relata o caso de uma extensa hérnia extrusa sintomática, juntamente a sua regressão clínica espontânea e sua total reabsorção. Descrevemos também seu manejo conservador e uma revisão da literatura para a principal hipótese diagnóstica nesta evolução incomum.

Spontaneous regression of intralobar pulmonary sequestration during the pregnancy: report of two cases through relationships between mass and fetal biometry and review of the literature.

Intralobar pulmonary sequestration is a rare bronchopulmonary malformation consisting of a non-functioning lung mass that receives its arterial blood supply from systemic circulation and that does not adequately communicate with the tracheobronchial tree through a normal bronchus. These sequestrations account for 1.1-1.8% of all lung resections. Herein we present two clinical cases with a prenatal diagnosis of pulmonary sequestration using ultrasound and magnetic resonance imaging. Pulmonary images indicated a progressive decrease in the size and echogenicity of the lung mass with fetal growth, resulting in asymptomatic neonates with normal chest radiographs. We emphasize the importance of combining imaging examinations with follow-up by a multidisciplinary team working in a center specialized in maternal-fetal medicine. For the successive monitoring of the size of the lung tissue mass, we propose the calculation of the following two biometric ratios that are not yet described in the literature: mass area/head circumference and mass volume/estimated fetal weight. The second ratio was similar in both cases, a result which suggests its potential for use in estimating the probability of the spontaneous regression of intralobar pulmonary sequestration.

Fibromatosis agresiva en edad pediátrica / Aggressive Fibromatosis in Pediatric Age

Introducción: la fibromatosis agresiva es rara, benigna, con alto grado de agresividad y recidivante. Objetivo: caracterizar la fibromatosis en pacientes atendidos en el Hospital Pediátrico Provincial de Holguín. Método: se realizó un estudio, transversal y retrospectivo de los pacientes, en edad pediátrica, con diagnósticos de fibromatosis profunda que incluyó los años 2002-2012. Resultados: la prevalencia de la fibromatosis fue de 2,1 por cada 100 000 habitantes. Predominó el sexo femenino. La localización glútea fue más frecuente seguida del cuello y la pared abdominal. La etiología fue desconocida en el 75 %. La biopsia por aspiración con aguja fina no fue útil para el diagnóstico. El tratamiento inicial fue quirúrgico e incompleto. La regresión espontánea ocurrió en el 50 % de la recidiva. La quimioterapia y la radioterapia se emplearon sin resultados satisfactorios. Conclusiones: debe considerarse el tratamiento inicial expectante, pues la regresión espontánea se ve en muchos casos y la cirugía no previene la recidiva independientemente del grado de resección tumoral.

Introduction: aggressive fibromatosis is an uncommon, benign and recurrent disease. Objective: to characterize fibromatosis in patients attended al Provincial Pediatric Hospital of Holguín. Method: a retrospective cross-sectional study on aggressive fibromatosis in children younger than 19 years old was done during 2002 to 2012. Results: fibromatosis prevalence was 2.1 per 100 000 inhabitants. Females prevailed over males. The tumor was mainly localized in the gluteal region followed by the neck and the abdominal wall. The etiology was unknown in 75 % of cases. Fine needle aspiration biopsy was not useful for diagnosis. The initial treatment was 100 % surgical but incomplete; nevertheless, spontaneous regression of recurrence was seen in 50 % of cases. Chemotherapy and radiotherapy were applied to recurrence without successful results. Conclusions: the procedure, as the first line of treatment, should be considered because of tumor spontaneous regression. Surgical resection degree of the tumor does not prevent recurrence.

Spontaneous remission of a squamous cell carcinoma of the floor of the mouth.

Spontaneous remission is a rare, but well recognized event in oncology. Certain tumours, such as melanomas, hypernephromas and neuroblastomas, are known for showing spontaneous regression. Similarly, spontaneous regression of oral lymphomas, as well as oropharyngeal and recurrent tongue carcinomas, has been reported. Here, we present a novel case of a patient with a primary squamous cell carcinoma on the floor of the mouth whose tumour regressed spontaneously in three months, without any treatment. We also review of the literature on the spontaneous remission of oral cancer and discuss possible mechanisms for this phenomenon.