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1.
Mycologia ; 112(3): 552-569, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32163338

RESUMEN

Species of Syncephalis (Zoopagomycotina, Piptocephalidaceae) are obligate mycoparasites that grow on common saprobic species of Mortierellomycotina and Mucoromycotina in soil and dung. Despite their ubiquitous occurrence across the globe, fungi in the genus Syncephalis are understudied, and there are few modern taxonomic treatments of these fungi. In order to clarify species concepts in the genus, we provide morphological data and discuss seven classical Syncephalis species: S. basibulbosa, S. cordata, S. depressa, S. hypogena, S. intermedia, S. nodosa, and S. sphaerica. Three of these species are only known as herbarium specimens (S. basibulbosa, S. cordata, S. intermedia). We have isolated co-cultures of the remaining parasites (S. depressa, S. nodosa, and S. sphaerica) on their host fungi both from nature and from culture collections. The remaining taxon (S. hypogena) was revived from a lyophilized culture. We provide photos and updated descriptions for all of these species as well as new geographic data and references to documented herbarium specimens for each taxon. In addition, we also describe the new species S. latigena.


Asunto(s)
Absidia/patogenicidad , Heces/microbiología , Hongos/clasificación , Hongos/citología , Hongos/patogenicidad , Parásitos/clasificación , Parásitos/citología , Microbiología del Suelo , Animales
3.
Schweiz Arch Tierheilkd ; 152(11): 523-7, 2010 Nov.
Artículo en Alemán | MEDLINE | ID: mdl-21043026

RESUMEN

A fattening pig with enlarged head and abdominal lymph nodes was examined. An aspirate of the abscesses did not produce a conclusive diagnosis. Only an excision with subsequent histological and bacteriological examination showed the mould Mycocladus corymbiferus (syn. Absidia corymbifera) to be present. Similar abscesses should be examined as actinomycosis and leucosis are the main differential diagnoses.


Asunto(s)
Mucormicosis/veterinaria , Enfermedades de los Porcinos/microbiología , Absceso/microbiología , Absceso/patología , Absceso/veterinaria , Absidia/aislamiento & purificación , Absidia/patogenicidad , Animales , Diagnóstico Diferencial , Masculino , Mucormicosis/diagnóstico por imagen , Mucormicosis/etiología , Mucormicosis/microbiología , Porcinos , Enfermedades de los Porcinos/diagnóstico por imagen , Enfermedades de los Porcinos/patología , Ultrasonografía
4.
Acta Biol Hung ; 61(3): 356-65, 2010 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-20724281

RESUMEN

The in vitro antifungal activity of different statins and the combinations of the two most effective ones (fluvastatin and rosuvastatin) with amphotericin B were investigated in this study on 6 fungal isolates representing 4 clinically important genera, namely Absidia, Rhizomucor, Rhizopus and Syncephalastrum . The antifungal effects of statins revealed substantial differences. The synthetic statins proved to be more effective than the fungal metabolites. All investigated strains proved to be sensitive to fluvastatin. Fluvastatin and rosuvastatin acted synergistically and additively with amphotericin B in inhibiting the fungal growth in clinically available concentration ranges. Results suggest that statins combined with amphotericin B have a therapeutic potential against fungal infections caused by Zygomycetes species.


Asunto(s)
Anfotericina B/farmacología , Antifúngicos/farmacología , Inhibidores de Hidroximetilglutaril-CoA Reductasas/farmacología , Mucorales/efectos de los fármacos , Absidia/efectos de los fármacos , Absidia/aislamiento & purificación , Absidia/patogenicidad , Anfotericina B/administración & dosificación , Antifúngicos/administración & dosificación , Interacciones Farmacológicas , Farmacorresistencia Fúngica , Humanos , Inhibidores de Hidroximetilglutaril-CoA Reductasas/administración & dosificación , Pruebas de Sensibilidad Microbiana , Mucorales/aislamiento & purificación , Mucorales/patogenicidad , Rhizomucor/efectos de los fármacos , Rhizomucor/aislamiento & purificación , Rhizomucor/patogenicidad , Rhizopus/efectos de los fármacos , Rhizopus/aislamiento & purificación , Rhizopus/patogenicidad , Cigomicosis/tratamiento farmacológico , Cigomicosis/microbiología
5.
BMC Infect Dis ; 7: 46, 2007 May 25.
Artículo en Inglés | MEDLINE | ID: mdl-17531089

RESUMEN

BACKGROUND: We report a case of mucormycosis in a healthy 17-year-old accident victim with multiple abdominal injuries which was caused by infection with Absidia Corymbifera, a ubiquitous saphrophyte in the ground. CASE PRESENTATION: The patient was admitted to hospital with massive abdominal trauma. During an 8-hour emergency operation he received transfusions of compacted red blood cells, plasma, platelets and hemagel. He developed a crush syndrome with acute renal failure, resolved with extra-corporeal dialysis and had to undergo splenectomy because of spleen hematoma. As wound secretion and central venous catheter (CVC) blood cultures and drainage fluid were positive for Enterococcus Faecium, Providentia Rettgeri, Hafnia Alvei and Candida Albicans, tecoplanin, metronidazole, imipenem, and flucanozole were administered. Although the CVC was changed high fever persisted and discharge continued from the large abdominal wound. Repeated tampons in different sections and wound secretion smears were positive for A. corymbifera. Flucanozole was stopped and liposomal amphotericin (Ambisome; 5 mg/Kg i.v.) given for over 3 months. The patient improved; fever gradually disappeared. After 8 days, tampons and wound secretion smears were negative for A. corymbifera. No other fungal infections developed. Drainage fluid was later positive for tecoplanin-resistant E. faecium and Pseudomonas Aeroginosa responding only to meropenem and ciprofloxacin. Abdominal computerized tomography visualized fluid accumulation around the iliac-femoral bypass. Abcess was ruled out when scintigraphy showed no tracer uptake. The lesion was drained. Drainage fluid cultures were negative for bacteria and fungi. Fluid accumulation gradually disappeared with prolonged antibiotic and antifungal therapy. One year after the accident the patient is in good health, with normal quality of life. CONCLUSION: Successful outcome was due to early, specific antifungal therapy, at sufficiently high dosage which was prolonged for an adequate period of time. Early diagnosis of mucormycosis is essential for efficacious anti-fungal treatment and prevention of irreversible spread of mucormycosis to vital organs. It presupposes awareness that A. corymbifera infection can develop in healthy individuals who are stressed and traumatized through skin-ground contact in accidents.


Asunto(s)
Traumatismos Abdominales/complicaciones , Absidia/patogenicidad , Catéteres de Permanencia/microbiología , Síndrome de Aplastamiento/complicaciones , Mucormicosis/tratamiento farmacológico , Absidia/efectos de los fármacos , Absidia/aislamiento & purificación , Accidentes de Trabajo , Adolescente , Anfotericina B/uso terapéutico , Antifúngicos/uso terapéutico , Cateterismo Venoso Central/efectos adversos , Síndrome de Aplastamiento/etiología , Humanos , Masculino , Mucormicosis/etiología
6.
J Chem Ecol ; 31(10): 2373-90, 2005 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-16195849

RESUMEN

Three strains of each of the seven taxa comprising the Penicillium series Corymbifera were surveyed by direct injection mass spectrometry (MS) and liquid chromatography-MS for the production of terrestric acid and roquefortine/oxaline biosynthesis pathway metabolites when cultured upon macerated tissue agars prepared from Allium cepa, Zingiber officinale, and Tulipa gesneriana, and on the defined medium Czapek yeast autolysate agar (CYA). A novel solid-phase extraction methodology was applied for the rapid purification of roquefortine metabolites from a complex matrix. Penicillium hordei and P. venetum produced roquefortine D and C, whereas P. hirsutum produced roquefortine D and C and glandicolines A and B. P. albocoremium, P. allii, and P. radicicola carried the pathway through to meleagrin, producing roquefortine D and C, glandicolines A and B, and meleagrin. P. tulipae produced all previously mentioned metabolites yet carried the pathway through to an end product recognized as epi-neoxaline, prompting the proposal of a roquefortine/epi-neoxaline biogenesis pathway. Terrestric acid production was stimulated by all Corymbifera strains on plant-derived media compared to CYA controls. In planta, production of terrestric acid, roquefortine C, glandicolines A and B, meleagrin, epi-neoxaline, and several other species-related secondary metabolites were confirmed from A. cepa bulbs infected with Corymbifera strains. The deposition of roquefortine/oxaline pathway metabolites as an extracellular nitrogen reserve for uptake and metabolism into growing mycelia and the synergistic role of terrestric acid and other Corymbifera secondary metabolites in enhancing the competitive fitness of Corymbifera species in planta are proposed.


Asunto(s)
Imidazoles/metabolismo , Indoles/metabolismo , Penicillium/metabolismo , Absidia/patogenicidad , Alcaloides/metabolismo , Canadá , Cromatografía de Gases y Espectrometría de Masas , Compuestos Heterocíclicos de 4 o más Anillos/metabolismo , Ovomucina/metabolismo , Penicillium/clasificación , Piperazinas/metabolismo , Raíces de Plantas/microbiología , Raíces de Plantas/ultraestructura , Especificidad de la Especie
7.
Eur J Pediatr ; 164(4): 231-5, 2005 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-15633048

RESUMEN

UNLABELLED: Voriconazole is increasingly used as a first-line agent for empirical antifungal therapy of prolonged febrile neutropenia in paediatric cancer patients. We describe the case of a 9-year-old patient with stage IV Burkitt lymphoma, who developed pulmonary and splenic zygomycosis while receiving voriconazole for persistent febrile neutropenia. The causative agent, Absidia corymbifera, was identified by broad-range fungal PCR in a lung biopsy sample. The patient was successfully treated with a combination of partial resection of the left upper lobe and antifungal therapy with high-dose liposomal amphotericin B followed by oral itraconazole as demonstrated by resolving pulmonary infiltrates on serial high resolution CT scans. CONCLUSION: This case emphasises that the lack of in vitro activity of voriconazole against zygomycetes is clinically relevant. Failure of voriconazole in suspected fungal infection should be investigated for the possibility of zygomycosis. Broad-range polymerase chain reaction may be able to identify the causative organism when cultures remain sterile.


Asunto(s)
Absidia/aislamiento & purificación , Antifúngicos/uso terapéutico , Neutropenia/tratamiento farmacológico , Pirimidinas/uso terapéutico , Triazoles/uso terapéutico , Cigomicosis/etiología , Absidia/efectos de los fármacos , Absidia/patogenicidad , Niño , Farmacorresistencia Fúngica , Femenino , Humanos , Neutropenia/complicaciones , Tomografía de Emisión de Positrones , Voriconazol , Cigomicosis/tratamiento farmacológico
9.
Trop Anim Health Prod ; 31(3): 143-60, 1999 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-10445250

RESUMEN

Absidiosis was produced experimentally in 18 buffalo calves by intravenous inoculation of spores of Absidia corymbifera. Infected animals exhibited dullness, depression, partial anorexia and an initial pyrexia and coughing during the first week and two animals died on each of 9, 13 and 16 days post infection (DPI). The haemoglobin concentration and total erythrocyte count showed no appreciable change from their basal values at any stage of the experiment. However, the erythrocyte sedimentation rate and total leukocyte count increased significantly in the infected animals. The differential leukocyte count revealed a relative neutrophilia from 5 to 20 DPI. There was a significant increase in the serum total proteins, blood urea nitrogen, creatinine, alanine aminotransferase, aspartate aminotransferase, serum alkaline phosphatase, total immunoglobulins and circulating immune complexes in the infected animals as compared to the controls. In the sera of the infected animals, specific Absidia corymbifera IgM and IgG antibodies were detected from 3 DPI to 6 DPI respectively by Dot-EIA. Type I and type III skin hypersensitivity were detected from 10 DPI and type IV hypersensitivity from 15 DPI onwards. The gross and microscopic pathological lesions were seen mainly in the lungs, in all except one of the affected animals. This animal died 9 DPI and mycotic granulomas were also seen in its heart and kidneys. The microscopic lesions in the lung took the form of well-developed granulomas.


Asunto(s)
Absidia/patogenicidad , Búfalos , Mucormicosis/veterinaria , Alanina Transaminasa/sangre , Fosfatasa Alcalina/sangre , Animales , Anticuerpos Antifúngicos/sangre , Complejo Antígeno-Anticuerpo/sangre , Aspartato Aminotransferasas/sangre , Proteínas Sanguíneas/análisis , Sedimentación Sanguínea , Nitrógeno de la Urea Sanguínea , Creatinina/sangre , Recuento de Eritrocitos/veterinaria , Hemoglobinas/análisis , Hipersensibilidad/veterinaria , Técnicas para Inmunoenzimas/veterinaria , Riñón/microbiología , Riñón/patología , Recuento de Leucocitos/veterinaria , Pulmón/microbiología , Pulmón/patología , Masculino , Mucormicosis/sangre , Mucormicosis/inmunología , Mucormicosis/patología , Distribución Aleatoria , Albúmina Sérica/análisis
10.
Mycopathologia ; 144(1): 29-37, 1998.
Artículo en Inglés | MEDLINE | ID: mdl-10422271

RESUMEN

Zygomycosis was produced experimentally in 20 New Zealand white rabbits (Oryctolagus cuniculus) by intra-nasal administration of spores of Absidia corymbifera. Infected animals showed dullness, depression, coughing and mucopurulent nasal discharge, but no mortality. Haematology revealed no significant change in Hb and PCV, but leukocytosis due to neutrophilia in the initial stages of the experiment. There was a significant increase in serum total proteins, creatinine, AST, ALT, total Igs and CICs. A. corymbifera specific IgM and IgG antibodies were detected in the sera of the infected animals. Gross lesions consisted of pneumonic consolidations of the anteroventral lobes of the lungs. Microscopically, histology showed formation of pyogranulommas in the lungs. Fungal elements typical of A. corymbifera were demonstrated in the tissues upto 15 days after infection by special stains and confirmed by indirect immunoperoxidase. Re-isolation of the fungus from lungs was also achieved consistently upto 15 days only. It was concluded that intra-nasal instillation of A. corymbifera in rabbits produced significant clinico-pathological alterations with the lesions confined mainly to the lungs. In the present study, neither systemic dissemination of the disease occurred nor were kidneys site of predilection as reported earlier.


Asunto(s)
Absidia , Enfermedades Pulmonares Fúngicas , Mucormicosis , Absidia/inmunología , Absidia/aislamiento & purificación , Absidia/patogenicidad , Animales , Anticuerpos Antifúngicos/sangre , Pulmón/microbiología , Pulmón/patología , Enfermedades Pulmonares Fúngicas/sangre , Enfermedades Pulmonares Fúngicas/inmunología , Enfermedades Pulmonares Fúngicas/microbiología , Enfermedades Pulmonares Fúngicas/patología , Masculino , Mucormicosis/sangre , Mucormicosis/inmunología , Mucormicosis/microbiología , Mucormicosis/patología , Conejos
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