Asunto(s)
Adenoma de los Conductos Biliares/veterinaria , Neoplasias de los Conductos Biliares/veterinaria , Conductos Biliares Intrahepáticos/patología , Enfermedades de los Peces/patología , Tilapia , Adenoma de los Conductos Biliares/diagnóstico , Adenoma de los Conductos Biliares/etiología , Adenoma de los Conductos Biliares/patología , Animales , Neoplasias de los Conductos Biliares/diagnóstico , Neoplasias de los Conductos Biliares/etiología , Neoplasias de los Conductos Biliares/patología , Femenino , Enfermedades de los Peces/diagnóstico , Enfermedades de los Peces/etiologíaAsunto(s)
Adenoma de los Conductos Biliares/veterinaria , Neoplasias de los Conductos Biliares/veterinaria , Conductos Biliares Intrahepáticos , Enfermedades de los Gatos/diagnóstico por imagen , Estómago/diagnóstico por imagen , Adenoma de los Conductos Biliares/diagnóstico por imagen , Adenoma de los Conductos Biliares/patología , Animales , Neoplasias de los Conductos Biliares/diagnóstico por imagen , Neoplasias de los Conductos Biliares/patología , Conductos Biliares Intrahepáticos/diagnóstico por imagen , Conductos Biliares Intrahepáticos/patología , Enfermedades de los Gatos/diagnóstico , Enfermedades de los Gatos/cirugía , Gatos , Diagnóstico Diferencial , Masculino , RadiografíaRESUMEN
Lake whitefish (Coregonus clupeaformis) were collected in 1996 from the St. Lawrence River, Quebec, Canada. Histologic examination was performed on major organs of 497 specimens and on the liver of 48 additional individuals. Preneoplastic and neoplastic hepatic changes consisted of vacuolated cell (n = 65), clear cell (n = 17), and acidophilic (n = 16) foci of altered hepatocyte, hepatocellular carcinoma (n = 12), cholangioma (n = 5), and cholangiocarcinoma (n = 28). Six fish were intersexes (1.2%), and 11.7% of the ovaries (26/223) had ducts containing spermatogonia or more differentiated cells of the male germ cell line. Asynchronous nodular maturation of the testes was present in 8.2% of the male fish (22/267). The mean hepatic concentrations of various contaminants, including polychlorinated biphenyls (PCBs), chlorobenzenes, pesticides, and trace metals, were 6 to 8 times higher in lake whitefish than in three other fish species (Ictalurus punctatus, Catostomus commersoni, and Stizostedion vitreum) collected at the same site. Condition factor of lake whitefish from this study was lower than that previously reported 40 to 50 years ago at this site and from contemporary pristine sites in the Great Lakes, USA. The presence of liver neoplasms, gonadal lesions, and a decreased condition factor in lake whitefish from the St. Lawrence River may be etiologically related to elevated tissue concentrations of toxic chemical contaminants.
Asunto(s)
Adenoma de los Conductos Biliares/veterinaria , Carcinógenos/efectos adversos , Carcinoma Hepatocelular/veterinaria , Colangiocarcinoma/veterinaria , Trastornos del Desarrollo Sexual/veterinaria , Contaminantes Ambientales/efectos adversos , Gónadas/anomalías , Neoplasias Hepáticas/veterinaria , Salmonidae , Adenoma de los Conductos Biliares/etiología , Animales , Carcinoma Hepatocelular/etiología , Colangiocarcinoma/etiología , Trastornos del Desarrollo Sexual/etiología , Monitoreo del Ambiente , Femenino , Estado de Salud , Neoplasias Hepáticas/etiología , Masculino , QuebecRESUMEN
The purpose of this study was to describe the ultrasonographic appearance of biliary cystadenomas in cats and compare the findings to a similar rare form of liver tumor in humans. Biliary cystadenomas are uncommon, benign liver tumors of older cats that may occur as focal or multifocal cystic lesions within the liver. The records of 10 cats which had abdominal ultrasonography and histologic diagnosis of biliary cystadenoma were reviewed. The average age of affected cats was 13.3 years (range 10-16 years). Eight cats were neutered males and two were neutered females. In three cats, the tumors were not seen ultrasonographically due to their small size or from being obscured by near-field reverberation echoes. The remaining seven cats had solitary (4 cats) or multifocal (3 cats) masses corresponding to variable ultrasonographic patterns: multilocular masses containing thin-walled cysts, hyperechoic masses with cystic components, or masses of mixed echogenicity with cystic components. The masses had variable ultrasonographic patterns when multifocal disease was present. Recognizable cysts were evident somewhere within the tumors seen ultrasonographically, although sometimes the cysts appeared very small. The biliary cystadenomas were thought to be clinically silent. Although liver enlargement or a cranial abdominal mass was palpable in 4 cats, no consistent trend of clinical signs, CBC or serum biochemical abnormalities could be directly attributed to biliary cystadenoma. The treatment of choice is surgical resection of the tumor, as continued growth may compress adjacent vital structures within the liver. The differential diagnosis of biliary cystadenomas from other cystic liver lesions such as hepatic cysts, hematomas, abscesses, parasitic cysts, or other liver tumors is discussed.
Asunto(s)
Adenoma de los Conductos Biliares/veterinaria , Neoplasias de los Conductos Biliares/veterinaria , Conductos Biliares Intrahepáticos , Enfermedades de los Gatos/diagnóstico por imagen , Cistoadenoma/veterinaria , Adenoma de los Conductos Biliares/diagnóstico por imagen , Animales , Neoplasias de los Conductos Biliares/diagnóstico por imagen , Conductos Biliares Intrahepáticos/diagnóstico por imagen , Gatos , Cistoadenoma/diagnóstico por imagen , Femenino , Masculino , UltrasonografíaRESUMEN
As part of a survey of fish diseases, lake whitefish (Coregonus clupeaformis) were collected in fall 1995 from the St. Lawrence River 15 km upstream of Quebec City, Quebec, Canada, to assess the prevalence of liver lesions. A total of 141 fish were captured and necropsied, and three standard sections of liver were taken for histological examination. Prevalences of altered hepatocyte foci, hepatocellular carcinoma, cholangioma, and cholangiocarcinoma were 0.7%, 2.1%, 0.7%, and 2.1%, respectively. Thus, the overall prevalence of liver neoplasia was 4.9% (7/141). Hepatic tumors were only observed in fish 7 years old or older. Fish age was significantly and positively correlated with the index assessing the number and size of macrophage aggregates (p<0.001; rs = 0.16). Hepatocyte vacuolation, anisokaryosis, lymphocytic infiltration, and bile duct hyperplasia were also observed but were not related to the age, length, sex, or condition factor of the fish. These results represent the first report on a series of hepatic tumors in a wild salmonid species.
Asunto(s)
Enfermedad Hepática Inducida por Sustancias y Drogas/epidemiología , Enfermedad Hepática Inducida por Sustancias y Drogas/veterinaria , Neoplasias Hepáticas/epidemiología , Neoplasias Hepáticas/veterinaria , Salmonidae/fisiología , Adenoma de los Conductos Biliares/epidemiología , Adenoma de los Conductos Biliares/patología , Adenoma de los Conductos Biliares/veterinaria , Factores de Edad , Animales , Carcinoma Hepatocelular/epidemiología , Carcinoma Hepatocelular/patología , Carcinoma Hepatocelular/veterinaria , Enfermedad Hepática Inducida por Sustancias y Drogas/patología , Femenino , Hemangiosarcoma/epidemiología , Hemangiosarcoma/patología , Hemangiosarcoma/veterinaria , Neoplasias Hepáticas/patología , Masculino , Quebec/epidemiología , Factores SexualesAsunto(s)
Adenoma de los Conductos Biliares/veterinaria , Neoplasias de los Conductos Biliares/veterinaria , Conductos Biliares Intrahepáticos , Enfermedades de las Cabras , Mataderos , Adenoma de los Conductos Biliares/patología , Animales , Neoplasias de los Conductos Biliares/patología , Conductos Biliares Intrahepáticos/patología , Cabras , Hígado/patologíaRESUMEN
Published surveys of feline neoplasia have not specifically included biliary cystadenoma, and there is only one case report in the literature. This report is a compilation of 13 feline cases and provides a description of clinical, pathologic, immunohistochemical, and ultrastructural aspects of biliary cystadenoma as well as a discussion of comparative pathology of biliary cystadenoma in human beings and speculative histogenesis.
Asunto(s)
Adenoma de los Conductos Biliares/veterinaria , Neoplasias de los Conductos Biliares/veterinaria , Enfermedades de los Gatos/patología , Cistoadenoma/veterinaria , Adenoma de los Conductos Biliares/química , Adenoma de los Conductos Biliares/patología , Animales , Neoplasias de los Conductos Biliares/química , Neoplasias de los Conductos Biliares/patología , Enfermedades de los Gatos/diagnóstico , Enfermedades de los Gatos/metabolismo , Gatos , Cistoadenoma/química , Cistoadenoma/patología , Femenino , Inmunohistoquímica , Queratinas/análisis , Queratinas/metabolismo , Hígado/química , Hígado/patología , Hígado/ultraestructura , Masculino , Microscopía ElectrónicaRESUMEN
The medical and necropsy records of 41 cats diagnosed with nonlymphomatous hepatobiliary (NLHB) masses, including neoplasia and cysts, were reviewed. Overall, benign masses (n = 27) were more common than malignant ones (n = 14). The single most common malignancy was cholangiocellular carcinoma. The median age at diagnosis was significantly lower (P < .01) for cats with malignant rather than benign disease. Clinical signs associated with hepatobiliary neoplasia were usually vague and included lethargy, vomiting, and anorexia, often present for at least 2 weeks before presentation. Benign masses were an incidental finding in significantly more (P < .01) of the cases than were malignant masses. Median values for alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin were significantly higher (P < .05) in cats with malignant versus benign masses. The prognosis for malignant disease was poor, with 86% of the cats dying or being euthanatized during hospitalization. Cats with benign disease that underwent exploratory celiotomy were more likely to recover and warranted a more favorable prognosis than cats with malignant tumors. Factors associated with malignancy included age at presentation, presence of clinical signs at presentation, and specific serum chemistry changes.
Asunto(s)
Enfermedades de las Vías Biliares/veterinaria , Neoplasias del Sistema Biliar/veterinaria , Enfermedades de los Gatos/epidemiología , Hepatopatías/veterinaria , Neoplasias Hepáticas/veterinaria , Adenoma de los Conductos Biliares/epidemiología , Adenoma de los Conductos Biliares/cirugía , Adenoma de los Conductos Biliares/veterinaria , Adenoma de Células Hepáticas/epidemiología , Adenoma de Células Hepáticas/cirugía , Adenoma de Células Hepáticas/veterinaria , Alanina Transaminasa/sangre , Fosfatasa Alcalina/sangre , Animales , Aspartato Aminotransferasas/sangre , Enfermedades de las Vías Biliares/epidemiología , Enfermedades de las Vías Biliares/cirugía , Neoplasias del Sistema Biliar/epidemiología , Neoplasias del Sistema Biliar/cirugía , Bilirrubina/sangre , Carcinoma Hepatocelular/epidemiología , Carcinoma Hepatocelular/cirugía , Carcinoma Hepatocelular/veterinaria , Enfermedades de los Gatos/cirugía , Gatos , Colangiocarcinoma/epidemiología , Colangiocarcinoma/cirugía , Colangiocarcinoma/veterinaria , Colesterol/sangre , Quistes/epidemiología , Quistes/cirugía , Quistes/veterinaria , Femenino , Fibrosarcoma/epidemiología , Fibrosarcoma/cirugía , Fibrosarcoma/veterinaria , Hemangiosarcoma/epidemiología , Hemangiosarcoma/cirugía , Hemangiosarcoma/veterinaria , Hepatopatías/epidemiología , Hepatopatías/cirugía , Neoplasias Hepáticas/epidemiología , Neoplasias Hepáticas/cirugía , Masculino , New York/epidemiología , Pronóstico , Estudios Retrospectivos , Estadísticas no Paramétricas , Resultado del TratamientoAsunto(s)
Adenoma de los Conductos Biliares/veterinaria , Neoplasias de los Conductos Biliares/veterinaria , Neoplasias Hepáticas/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Reno , Adenoma de los Conductos Biliares/patología , Adenoma de los Conductos Biliares/secundario , Animales , Neoplasias de los Conductos Biliares/patología , Conductos Biliares Intrahepáticos , Femenino , Neoplasias Hepáticas/patología , Neoplasias Hepáticas/secundario , Embarazo , Complicaciones Neoplásicas del Embarazo/patologíaRESUMEN
Nonhematopoietic hepatic neoplasms (n = 25) were diagnosed in 21 cats during a 5.5-year period. Thirteen of the neoplasms were benign bile duct adenomas and 12 were malignant, 6 of which were bile duct adenocarcinomas. All cats were greater than or equal to 10 years old, and 14 were male. Main clinical signs were anorexia and lethargy, and 15 of 21 cats had hepatomegaly. All 21 cats were feline leukemia virus-test negative. Although there was a trend toward high activities of serum alanine transaminase and aspartate transaminase, neither clinical signs nor enzyme activity were specific for diagnosis of hepatic neoplasia in the cats of this study.
Asunto(s)
Adenoma de los Conductos Biliares/veterinaria , Carcinoma Hepatocelular/veterinaria , Enfermedades de los Gatos , Hemangiosarcoma/veterinaria , Neoplasias Hepáticas/veterinaria , Adenoma de los Conductos Biliares/sangre , Alanina Transaminasa/sangre , Animales , Anorexia/veterinaria , Aspartato Aminotransferasas/sangre , Bilirrubina/sangre , Carcinoma Hepatocelular/sangre , Enfermedades de los Gatos/sangre , Gatos , Femenino , Hemangiosarcoma/sangre , Hepatomegalia , Recuento de Leucocitos/veterinaria , Neoplasias Hepáticas/sangre , Masculino , Estudios Retrospectivos , Fases del Sueño , Uremia/veterinariaRESUMEN
A study of 66 primary hepatic tumours was carried out on cattle. These consisted almost entirely of adult females. Fifty hepatocellular tumours (10 adenomas and 40 carcinomas), 10 cholangiocellular tumours (three adenomas and seven carcinomas), two cavernous haemangiomas, two haemangioendothelial sarcomas, one fibroma and one Schwannoma were diagnosed. The 50 hepatocellular tumours were classified into adenomas (20 per cent) and carcinomas (80 per cent), both prevalent in the solitary macronodular form. The hepatocellular carcinomas were divided into six groups based on their distinctive histological arrangement and the morphology of the neoplastic cells: trabecular (55 per cent), pseudoglandular (10 per cent), solid (12 per cent), scirrhous (12 per cent), pleomorphic (7 per cent) and fibrolamellar (2 per cent). Twenty-seven of 50 hepatocellular tumours (54 per cent) were associated with features of blood-filled lakes resembling telangiectasis within the neoplastic tissue. Metastasis was uncommon (10 per cent of hepatocellular carcinomas) and grading according to Edmondson's system (1958) showed a low level of anaplasia in most carcinomas (55 per cent). An association with cirrhosis was never found.
Asunto(s)
Enfermedades de los Bovinos/clasificación , Neoplasias Hepáticas/veterinaria , Adenoma de los Conductos Biliares/epidemiología , Adenoma de los Conductos Biliares/patología , Adenoma de los Conductos Biliares/veterinaria , Animales , Carcinoma Hepatocelular/epidemiología , Carcinoma Hepatocelular/patología , Carcinoma Hepatocelular/veterinaria , Bovinos , Enfermedades de los Bovinos/epidemiología , Enfermedades de los Bovinos/patología , Femenino , Incidencia , Neoplasias Hepáticas/clasificación , Neoplasias Hepáticas/epidemiología , Neoplasias Hepáticas/patología , Masculino , Metástasis de la Neoplasia , Estudios RetrospectivosRESUMEN
A Landrace sow had several neoplastic nodules in the liver. Histopathologically, the individual nodules consisted of two types of closely associated neoplastic cells; one was of hepatocellular type, the other of cholangiocellular type. Based on this finding, the term "hepatocholangioadenoma" is considered to be appropriate for this tumour. Previously reported in man, the dog and the duck, a mixed type of primary hepatic neoplasm has now been found in the pig.
Asunto(s)
Adenoma de los Conductos Biliares/veterinaria , Adenoma/veterinaria , Carcinoma Hepatocelular/veterinaria , Neoplasias Hepáticas/veterinaria , Adenoma/diagnóstico , Adenoma/patología , Adenoma de los Conductos Biliares/diagnóstico , Adenoma de los Conductos Biliares/patología , Animales , Carcinoma Hepatocelular/diagnóstico , Carcinoma Hepatocelular/patología , Femenino , Histocitoquímica/métodos , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/patología , Coloración y Etiquetado/métodos , PorcinosRESUMEN
Duck hepatitis B virus (DHBV) DNA was detected in both multiple primary cancers and intrahepatic metastatic tumors in duck liver by Southern blot technique. Among 7 ducks with multiple primary tumors in the liver, the banding pattern of integrated DHBV DNA in different tumors was identical in 3 animals but different in 2. One duck showed a similar hybridization pattern in different tumor nodules and the remaining one was negative for DHBV DNA. Integrated DHBV DNA was also identified in one duck with metastatic tumor in the lung, in which the hybridization pattern was the same as that of the primary hepatocellular carcinoma. The presence of the same distinct hybridization bands in various tumor nodules indicated that they may arise from the same clone of neoplastically transformed cell. Different hybridization bands showed that tumors may arise from different clones. The results suggest that hybridization pattern of hepatic carcinoma with viral DNA probe could be used as a clone marker of transformed cells to distinguish multiple primary hepatic cancers from intrahepatic metastasis.
Asunto(s)
Carcinoma Hepatocelular/veterinaria , ADN Viral/análisis , Patos , Virus de la Hepatitis B del Pato/genética , Neoplasias Hepáticas/veterinaria , Neoplasias Primarias Múltiples/veterinaria , Enfermedades de las Aves de Corral/genética , Adenoma de los Conductos Biliares/genética , Adenoma de los Conductos Biliares/patología , Adenoma de los Conductos Biliares/veterinaria , Animales , Carcinoma Hepatocelular/genética , Carcinoma Hepatocelular/patología , Carcinoma Hepatocelular/secundario , Femenino , Neoplasias Hepáticas/genética , Neoplasias Hepáticas/patología , Neoplasias Pulmonares/secundario , Neoplasias Pulmonares/veterinaria , Neoplasias Primarias Múltiples/genética , Hibridación de Ácido Nucleico , Enfermedades de las Aves de Corral/patologíaRESUMEN
Acquired myasthenia gravis and cholangiocellular carcinoma were diagnosed in a 7-year-old English Setter referred because of forelimb lameness, exercise-induced weakness, and fever. Three months earlier, the dog had had a pleuropulmonary infection caused by a Fusobacterium sp. The concurrent development of myasthenia gravis and cholangiocellular carcinoma in this dog may be explained by a paraneoplastic syndrome, although it is unproven. The cholangiocellular carcinoma may have possessed an acetylcholine receptor-like antigen on the tumor surface, which induced autoantibodies to cross-react with acetylcholine receptors at the neuromuscular junction.
Asunto(s)
Adenoma de los Conductos Biliares/veterinaria , Neoplasias de los Conductos Biliares/veterinaria , Enfermedades de los Perros , Miastenia Gravis/veterinaria , Adenoma de los Conductos Biliares/complicaciones , Adenoma de los Conductos Biliares/secundario , Animales , Neoplasias de los Conductos Biliares/complicaciones , Perros , Femenino , Infecciones por Fusobacterium/complicaciones , Infecciones por Fusobacterium/veterinaria , Cojera Animal/etiología , Neoplasias Pulmonares/secundario , Neoplasias Pulmonares/veterinaria , Miastenia Gravis/complicaciones , Infecciones del Sistema Respiratorio/complicaciones , Infecciones del Sistema Respiratorio/veterinariaRESUMEN
A cholangiocarcinoma was diagnosed in a 4-month-old double yellow-cheeked Amazon parrot (Amazona autumnalis). Histologically, neoplastic cells effaced hepatocellular architecture. Ultrastructurally, variably dilated bile ductules were lined by simple cuboidal to low columnar ciliated epithelial cells with sparse cellular organelles and prominent junctional complexes. Elongated single cilia arising from basal bodies in the apical cytoplasm were occasionally evident. The presence of such a neoplasm in a 4-month-old parrot is extremely unusual.
Asunto(s)
Adenoma de los Conductos Biliares/veterinaria , Neoplasias de los Conductos Biliares/veterinaria , Enfermedades de las Aves/patología , Neoplasias Hepáticas/veterinaria , Loros , Psittaciformes , Adenoma de los Conductos Biliares/patología , Factores de Edad , Animales , Neoplasias de los Conductos Biliares/ultraestructura , Neoplasias Hepáticas/ultraestructura , Microscopía ElectrónicaRESUMEN
Ulex europaeus agglutinin 1 (UEA-1) lectin-binding is a feature of canine intrahepatic bile duct epithelial cells but not of canine hepatocytes. In tumours diagnosed histologically as cholangiocarcinomas or hepatocellular carcinomas, UEA-1 staining occurred in tumour cells regardless of histological appearance. The division of primary liver carcinomas into different presumed cell types of origin is not reflected by equivalent differentiation of the tumour cells and is not of diagnostic value.
Asunto(s)
Adenoma de los Conductos Biliares/veterinaria , Carcinoma Hepatocelular/veterinaria , Enfermedades de los Perros/diagnóstico , Lectinas , Neoplasias Hepáticas/veterinaria , Lectinas de Plantas , Adenoma de los Conductos Biliares/diagnóstico , Adenoma de los Conductos Biliares/patología , Animales , Carcinoma Hepatocelular/diagnóstico , Carcinoma Hepatocelular/patología , Diagnóstico Diferencial , Enfermedades de los Perros/patología , Perros , Histocitoquímica , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/patologíaAsunto(s)
Adenoma de los Conductos Biliares/veterinaria , Ácidos y Sales Biliares/análisis , Neoplasias de los Conductos Biliares/veterinaria , Enfermedades de los Perros/diagnóstico , Neoplasias Hepáticas/veterinaria , Adenoma de los Conductos Biliares/diagnóstico , Adenoma de los Conductos Biliares/secundario , Animales , Neoplasias de los Conductos Biliares/diagnóstico , Perros , Hígado/patología , Neoplasias Hepáticas/secundario , MasculinoRESUMEN
A case of cholangiocarcinoma in a 3-year-old blue-fronted Amazon parrot (Amazona estiva) is reported. Neoplastic tissue was limited to the liver, where it infiltrated and replaced much of the hepatic parenchyma. The only other reported cases of cholangiocarcinoma in an Amazon parrot (Amazona xanthops) also occurred in a bird in its fourth year of age.
Asunto(s)
Adenoma de los Conductos Biliares/veterinaria , Enfermedades de las Aves/patología , Neoplasias Hepáticas/veterinaria , Loros , Psittaciformes , Adenoma de los Conductos Biliares/patología , Animales , Hígado/patología , Neoplasias Hepáticas/patologíaRESUMEN
Cholangiomas found in two of 21 wild-caught white perch (Morone americana) from the Chesapeake Bay are described. The two fish were part of a study investigating a condition of abnormal hepatic copper storage in this species. The tumors were superficial, solitary masses consisting of cuboidal to columnar cells in tubuloglandular arrangement. Mild to marked peribiliary inflammation and fibrosis was seen also. Environmental pollution, the condition of abnormal copper storage, peribiliary fibrosis, and/or parasites may have contributed to the development of these tumors.
Asunto(s)
Adenoma de los Conductos Biliares/veterinaria , Enfermedades de los Peces/patología , Neoplasias Hepáticas/veterinaria , Percas , Perciformes , Adenoma de los Conductos Biliares/patología , Animales , Neoplasias Hepáticas/patologíaRESUMEN
White perch (Morone americana) sampled from 15 estuaries of the Chesapeake Bay contained a variety of hyperplastic and neoplastic alterations in their livers. The lesions were derived from bile ductular epithelium and/or hepatocytes. The biliary lesions consisted of hyperplasias and adenomas. The hepatocellular lesions consisted of focal populations of altered cells and neoplasms, of clear-cell and basophilic morphologic appearance. The hepatocellular lesions were conspicuous in the absence of the decreased amount of copper accumulation. In this respect, the cells comprising these lesions are reminiscent of cells from hepatocellular neoplasia in mice and rats resistant to accumulation of iron.