RESUMEN
Proline-rich peptides from Bothrops jararaca venom (Bj-PRO) were characterized based on the capability to inhibit the somatic angiotensin-converting enzyme. The pharmacologicalaction of these peptides resulted in the development of Captopril, one of thebest examples of a target-driven drug discovery for treatment of hypertension. However, biochemical and biological properties of Bj-PROs were not completely elucidated yet, and many recent studies have suggested that their activity relies on angiotensinconvertingenzyme-independent mechanisms. Here, we show that Bj-PRO-7a (Asunto(s)
Bothrops/fisiología
, Hipertensión/terapia
, Inhibidores de la Enzima Convertidora de Angiotensina/análisis
, Agonistas Muscarínicos/análisis
, Agonistas Muscarínicos/uso terapéutico
, Células CHO/ultraestructura
, Microscopía Confocal/métodos
, Prolina/análogos & derivados