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2.
Tierarztl Prax Ausg K Kleintiere Heimtiere ; 45(5): 337-343, 2017 Oct 17.
Artículo en Inglés | MEDLINE | ID: mdl-28905976

RESUMEN

A cutaneous infection with Alternaria spp. was diagnosed in a 2-year-old male intact Irish setter dog, presenting with multifocal papules, plaques and ulcerations involving all four distal limbs, shoulder blades, scrotum, pinnae and nasal mucous membranes. The dog had been treated for inflammatory bowel disease and lymphangiectasia with immunosuppressive doses of cyclosporine and prednisolone for approximately 3 months. The diagnosis was based on clinical signs, the demonstration of fungal elements within skin biopsies, deep fungal culture and fungal PCR from a formalin-fixed tissue specimen. Complete clinical remission was achieved by tapering and cessation of the immunosuppressive medication, treatment with cold atmospheric-pressure plasma (CAPP) and topical enilconazole within 8 weeks.


Asunto(s)
Alternariosis/veterinaria , Enfermedades de los Perros/terapia , Huésped Inmunocomprometido , Inmunosupresores/efectos adversos , Gases em Plasma/uso terapéutico , Alternariosis/inmunología , Alternariosis/terapia , Animales , Antiinflamatorios/efectos adversos , Antifúngicos/efectos adversos , Ciclosporina/efectos adversos , Enfermedades de los Perros/microbiología , Perros , Fungicidas Industriales/uso terapéutico , Imidazoles/uso terapéutico , Enfermedades Inflamatorias del Intestino/tratamiento farmacológico , Enfermedades Inflamatorias del Intestino/veterinaria , Linfangiectasia/tratamiento farmacológico , Linfangiectasia/veterinaria , Masculino , Prednisolona/efectos adversos
5.
Ann Pathol ; 36(4): 245-51, 2016 Aug.
Artículo en Francés | MEDLINE | ID: mdl-27475007

RESUMEN

Rhino-sinusal infections are serious diseases and possibly lethal. When they are invasive, we easily discuss apergilloses and mucormycoses. The confirmation of the diagnosis of mucormycosis need an extensive surgery for precise histopathological and mycological evaluation. The pathologist may be faced to other rare mycoses such as phaeohyphomycoses, which present different morphological features than mucormycoses and Aspergillus. Once the diagnosis is established, an appropriate antifungal treatment is quickly started. The aim of our work is to report two observations of phaeohyphomycoses, to describe their histopathological features, to discuss complementary diagnostic methods and to present the main differential diagnoses.


Asunto(s)
Alternaria/aislamiento & purificación , Alternariosis/microbiología , Feohifomicosis/microbiología , Rinitis/microbiología , Sinusitis/microbiología , Adulto , Alternaria/ultraestructura , Alternariosis/diagnóstico , Alternariosis/patología , Alternariosis/terapia , Anfotericina B/administración & dosificación , Anfotericina B/uso terapéutico , Antifúngicos/uso terapéutico , Terapia Combinada , Desbridamiento , Diagnóstico Diferencial , Diagnóstico Precoz , Resultado Fatal , Femenino , Humanos , Liposomas , Mastoiditis/tratamiento farmacológico , Mastoiditis/microbiología , Mastoiditis/cirugía , Feohifomicosis/diagnóstico , Feohifomicosis/patología , Feohifomicosis/terapia , Complicaciones Posoperatorias/etiología , Estudios Retrospectivos , Rinitis/diagnóstico , Rinitis/patología , Rinitis/terapia , Choque Séptico/etiología , Sinusitis/diagnóstico , Sinusitis/patología , Sinusitis/terapia
7.
Clin Lab ; 60(9): 1569-72, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-25291955

RESUMEN

Organ transplant recipients under immunosuppressive therapy have a highly increased risk of opportunistic fungal infections. Cutaneous infection caused by Alternaria species are relatively rare in humans and most cases reported in the literature are in immunocompromised individuals. We report here on a 33-year old male renal transplant patient with diabetes mellitus who presented with cutaneous alternariosis caused by Alternaria infectoria, two years after the transplant. The diagnosis was performed by real-time polymerase chain reaction assay and histopathologic examination. The extension of the lesion under itraconazole treatment required treatment consisting of a combination of surgical excision and liposomal amphotericin B.


Asunto(s)
Alternaria/genética , Alternariosis/microbiología , Técnicas Bacteriológicas , ADN de Hongos/aislamiento & purificación , Trasplante de Riñón/efectos adversos , Infecciones Oportunistas/microbiología , Reacción en Cadena en Tiempo Real de la Polimerasa , Adulto , Alternaria/clasificación , Alternaria/inmunología , Alternaria/aislamiento & purificación , Alternariosis/diagnóstico , Alternariosis/inmunología , Alternariosis/terapia , Humanos , Huésped Inmunocomprometido , Inmunosupresores/efectos adversos , Masculino , Infecciones Oportunistas/diagnóstico , Infecciones Oportunistas/inmunología , Infecciones Oportunistas/terapia , Valor Predictivo de las Pruebas , Factores de Tiempo , Resultado del Tratamiento
8.
Dermatol Online J ; 20(7)2014 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-25046464

RESUMEN

Alternaria species are a group of dematiaceous fungi that are ubiquitous in nature and are becoming an increasingly important cause of disease in immunocompromised patients. We present a case of a 70 year old renal transplant recipient with multiple areas of cutaneous Alternaria infections likely introduced during local trauma. Treatment has required a combination of systemic therapy and surgical excision. This case illustrates the importance of recognizing fungal infections with cutaneous manifestations, such as alternariosis, in immunosuppressed patients.


Asunto(s)
Alternariosis/terapia , Antifúngicos/uso terapéutico , Huésped Inmunocomprometido , Trasplante de Riñón , Anciano , Alternariosis/diagnóstico , Alternariosis/inmunología , Biopsia , Procedimientos Quirúrgicos Dermatologicos/métodos , Diagnóstico Diferencial , Humanos , Masculino , Piel/patología
10.
Am J Otolaryngol ; 34(6): 743-5, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-24018172

RESUMEN

During the past three decades intranasal corticosteroid sprays have been proven to be efficient and reasonably safe for the treatment of rhinitis, sinusitis and nasal polyposis. The adverse effects are generally localized and self-limited and rarely systemic or significant. We report an immunocompetent female treated with triamcinolone acetonide nasal spray for chronic rhinitis in whom an intranasal fungal infection with Alternaria species developed three months later. The infection was refractory to topical therapies alone, and was resolved with a combination of systemic and topical antifungal therapy. We also described the clinical manifestations of this rare infection and our therapeutic experience. In addition, we reviewed previous literature of fungal infections related to nasal corticosteroid sprays and compared them with our report.


Asunto(s)
Alternariosis/inducido químicamente , Glucocorticoides/efectos adversos , Rociadores Nasales , Triamcinolona Acetonida/efectos adversos , Alternariosis/diagnóstico , Alternariosis/terapia , Antifúngicos/uso terapéutico , Femenino , Fluconazol/uso terapéutico , Glucocorticoides/administración & dosificación , Humanos , Persona de Mediana Edad , Lavado Nasal (Proceso) , Tabique Nasal/microbiología , Rinitis/tratamiento farmacológico , Triamcinolona Acetonida/administración & dosificación , Cornetes Nasales/microbiología
11.
Acta Clin Belg ; 67(3): 219-21, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22897073

RESUMEN

Both Paecilomyces spp. and Alternaria spp. are hyphomycetes with a worldwide distribution, and with many species being common saprophytes in soil and air. Both species mainly cause infections in immunocompromised patients, but also in an increasing number of immunocompetent hosts. We describe a double-lung transplant patient suffering successively from two rare cutaneous fungal infections caused by Paecilomyces lilacinus and Alternaria infectoria. Antifungal treatment and surgery of residual skin lesions was necessary to cure the infections. With this report, we aim at highlighting the importance of dermatological control of patients post lung transplantation.


Asunto(s)
Alternariosis/diagnóstico , Dermatomicosis/diagnóstico , Trasplante de Pulmón , Infecciones Oportunistas/microbiología , Paecilomyces , Alternariosis/terapia , Antifúngicos/uso terapéutico , Dermatomicosis/terapia , Femenino , Humanos , Huésped Inmunocomprometido , Persona de Mediana Edad , Infecciones Oportunistas/diagnóstico , Infecciones Oportunistas/terapia , Pirimidinas/uso terapéutico , Triazoles/uso terapéutico , Voriconazol
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