Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Adulto Joven , Enfermedad de Fabry/mortalidad , Enfermedad de Fabry/patología , Enfermedad de Fabry/diagnóstico por imagen , Disfunción Ventricular Izquierda/diagnóstico por imagen , Espectroscopía de Resonancia Magnética/métodos , Ecocardiografía Doppler/métodos , Terapia de Reemplazo Enzimático , Hipertensión/complicaciones , Hipertrofia/complicaciones , Angioqueratoma/complicacionesAsunto(s)
Angioqueratoma/complicaciones , Queratosis/etiología , Mancha Vino de Oporto/radioterapia , Radiodermatitis/complicaciones , Neoplasias Cutáneas/complicaciones , Anciano , Angioqueratoma/diagnóstico , Mejilla , Femenino , Humanos , Queratosis/diagnóstico , Piel/patología , Piel/efectos de la radiación , Neoplasias Cutáneas/diagnóstico , Factores de TiempoRESUMEN
RATIONALE: Angiokeratomas are the earliest manifestation of Fabry disease (FD), and the extent of their appearance is related to disease severity. Angiokeratomas are mostly found on cutaneous regions. PATIENT CONCERNS, DIAGNOSES, INTERVENTIONS, AND OUTCOMES: Here we report an FD patient with widespread gastrointestinal angiokeratomas who developed life-threatening bleeding following anticoagulation for atrial fibrillation. LESSONS: Careful observation for gastrointestinal bleeding is warranted for patients on anticoagulation with extensive cutaneous angiokeratomas. Furthermore, our experience suggests that surveillance is needed to assess the prevalence and extent of gastrointestinal angiokeratomas in patients with FD.
Asunto(s)
Angioqueratoma/complicaciones , Anticoagulantes/efectos adversos , Fibrilación Atrial/tratamiento farmacológico , Enfermedad de Fabry/complicaciones , Hemorragia Gastrointestinal/etiología , Anticoagulantes/uso terapéutico , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Fordyce angiokeratoma is a benign skin neoplasm, characterized by erythematous-violet keratotic papules with mamillated surface, which follows a chronic and minimally symptomatic course. However, symptoms can be related such as itching, burning, bleeding, dyspareunia; aesthetic and social concerns may prompt request for treatment. The condition mainly affects men and usually occurs in the scrotum, but rarely may occur in women. A 30-year-old woman with liver cirrhosis and portal hypertension is described. Over a period of two years she developed multiple angiokeratomas of the vulva, complicated by frequent bleeding. Histopathologic analysis of the lesion confirmed the diagnosis of angiokeratoma and all lesions were surgically removed. The results of the treatment were very satisfactory, with no relapses or complications.Angioqueratoma de Fordyce é uma dermatose incomum que compõe o grupo das neoplasias cutâneas benignas, caracterizando-se pelo aparecimento de lesões papuloceratósicas, eritemato-violáceas de superfície mamilonada, que apresentam curso crônico e oligossintomático. No entanto, outros sintomas podem estar associados, como prurido, ardência, sangramento e dispareunia, além de problemas estéticos e de ordem social. Afeta principalmente homens, acometendo a região escrotal, sendo raro seu surgimento em mulheres. Relata-se caso de uma paciente com 30 anos de idade, portadora de cirrose hepática e hipertensão portal evoluindo há 2 anos com múltiplos angioqueratomas na vulva de sangramento frequente. A análise histopatológica confirmou o diagnóstico de angioqueratoma e a paciente foi submetida à exérese cirúrgica das lesões. Os resultados terapêuticos foram satisfatórios, sem recidivas ou complicações.
Asunto(s)
Angioqueratoma/patología , Neoplasias Cutáneas/patología , Neoplasias de la Vulva/patología , Adulto , Angioqueratoma/complicaciones , Angioqueratoma/diagnóstico , Angioqueratoma/cirugía , Femenino , Humanos , Hipertensión Portal/complicaciones , Cirrosis Hepática/complicaciones , Piel/patología , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/cirugía , Neoplasias de la Vulva/complicaciones , Neoplasias de la Vulva/diagnóstico , Neoplasias de la Vulva/cirugíaAsunto(s)
Angioqueratoma/cirugía , Coagulación con Plasma de Argón , Cardias/cirugía , Enfermedad de Fabry/complicaciones , Neoplasias Primarias Múltiples/cirugía , Neoplasias Gástricas/cirugía , Angioqueratoma/complicaciones , Hemorragia Gastrointestinal , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Primarias Múltiples/complicaciones , Neoplasias Cutáneas , Neoplasias Gástricas/complicaciones , Resultado del TratamientoRESUMEN
Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare entity that typically occurs on the extremities of young females. Although linear arrangement of cutaneous lesions has been rarely reported, accompanying nail dystrophy has not been linked with this condition to our knowledge. We describe a case of linearly-oriented infiltrative papules and nodules on the index finger of a young female with associated onychodystrophy. Histology demonstrated a heavy lymphocytic infiltrate with plasma cells and proliferation of blood vessels consistent with APACHE. Our case is unique given the linear array of cutaneous lesions and associated nail dystrophy.
Asunto(s)
Angioqueratoma/patología , Enfermedades de la Uña/patología , Seudolinfoma/patología , Neoplasias Cutáneas/patología , Angioqueratoma/complicaciones , Angioqueratoma/diagnóstico , Biopsia con Aguja , Niño , Femenino , Dedos/patología , Humanos , Inmunohistoquímica , Enfermedades de la Uña/complicaciones , Enfermedades de la Uña/diagnóstico , Pronóstico , Seudolinfoma/complicaciones , Seudolinfoma/diagnóstico , Enfermedades Raras , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/diagnósticoAsunto(s)
Angioqueratoma/patología , Enfermedades del Pie/patología , Neoplasias Cutáneas/patología , Angioqueratoma/irrigación sanguínea , Angioqueratoma/complicaciones , Dermoscopía , Diagnóstico Diferencial , Enfermedades del Pie/complicaciones , Hemorragia/etiología , Humanos , Masculino , Melanoma/diagnóstico , Microscopía Confocal , Persona de Mediana Edad , Neoplasias Cutáneas/irrigación sanguínea , Neoplasias Cutáneas/complicaciones , Dedos del Pie/patología , Tomografía de Coherencia ÓpticaRESUMEN
Angiokeratomas are benign mucocutaneous lesions which are composed of enlarged veins in the dermis of the skin. Although angiokeratomas may be part of a systemic disease, it is important to distinguish them from other vascular lesions. In this report, we present a rare case of angiokeratoma of the nasal vestibule. To our knowledge, this is the first nasal angiokeratoma case in the literature. The diagnostic and treatment features of this case and the association of angiokeratoma with systemic diseases like Fabry disease were discussed.
Asunto(s)
Angioqueratoma/diagnóstico , Enfermedad de Fabry/diagnóstico , Cavidad Nasal , Neoplasias Cutáneas/diagnóstico , Angioqueratoma/complicaciones , Angioqueratoma/cirugía , Diagnóstico Diferencial , Epistaxis/etiología , Enfermedad de Fabry/complicaciones , Humanos , Masculino , Obstrucción Nasal/etiología , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/cirugía , Adulto JovenRESUMEN
Los angioqueratomas son malformaciones vasculares, caracterizadas por ectasias vasculares en la dermis papilar con hiperplasia epitelial e hiperqueratosis reactiva, que pueden aparecer de manera aislada o como forma sistémica generalizada asociados a enfermedades metabólicas. El angioqueratoma solitario de mucosa oral es una lesión poco frecuente, que hasta la comunicación de Sipponen, en 2006, se creía siempre típica de las formas sistémicas y muy rara en las localizadas. Su aparición en la infancia es, asimismo, poco frecuente, habiéndose descrito hasta la fecha sólo 5 casos en menores de 18 años, aunque algunos autores señalan que puede tratarse de una enfermedad infradiagnosticada de ahí la importancia de su adecuado estudio y diagnóstico. Presentamos el caso de una paciente de 7 años de edad, con una lesión rojiza en el dorso de la lengua, no dolorosa, sin antecedente traumático, en cuyo examen físico se observó una lesión de 14 mm de diámetro en el borde derecho de la lengua, con múltiples pápulas eritematosas, sin apreciarse otros cambios en la mucosa oral. Se realizó una extirpación bajo anestesia general, y el diagnóstico se verificó por examen histopatológico de la pieza extirpada (AU)
Angiokeratomas are vascular malformations characterized by vascular ectasia in the papillary dermis with reactive epithelial hyperplasia and hyperkeratosis, which can occur in isolation or as widespread systemic form associated with metabolic diseases. The solitary angiokeratoma of the oral mucosa is a rare injury, which to Sipponen communication in 2006, always believed typical of systemic forms and very rare in localized. Its occurrence in childhood is likewise rare, having been described to date only 5 cases in children under 18, although some authors suggest that this may be an underdiagnosed disease, hence the importance of adequate study and diagnosis. We report a 7 years with a reddish lesion on the dorsum of the tongue, no pain, no history of trauma, in which physical examination showed a lesion of 14 mm in diameter in right right edge of the tongue with multiple erythematous papules, showing no other changes in the oral mucosa. Excision was performed under general anesthesia and the diagnosis was verified by histopathological examination of the resected specimen (AU)
Asunto(s)
Humanos , Femenino , Niño , Angioqueratoma/complicaciones , Angioqueratoma/diagnóstico , Angioqueratoma/cirugía , Neoplasias de la Lengua/diagnóstico , Neoplasias de la Lengua/cirugía , Angioqueratoma/fisiopatología , Enfermedades Metabólicas/complicaciones , Hiperqueratosis Epidermolítica/complicaciones , Lengua/patología , Lengua/cirugía , Acantosis Nigricans/complicacionesRESUMEN
BACKGROUND: Port-wine stains or capillary malformations are generally congenital. Very few cases of acquired port-wine stains in adults have been described, and these occur particularly after trauma. PATIENTS AND METHOD: We report three cases of acquired port-wine stains and we performed a review of the literature using the keywords "port-wine stain", "capillary malformation", "angioma" and "acquired" in the Medline database PubMed. All relevant articles were included. RESULTS: Two male patients and one female patient consulted for one or more angiomatous lesions, located respectively on the upper rear part of the right thigh (case 1), the left leg (case 2) and the right side of the face, skull and chest (case 3). Each patient's skin biopsy was consistent with port-wine stain. The three patients asserted the acquired nature of the lesions: the male patients were respectively 17 and 38 years old, and the female patient was 11 years old. No causative factors were evident preceding the lesion, and there was no family history of port-wine stain. The topography was systematic in patients 2 and 3. The lesions were light red in patient 1, dark red in patient 2 and pale pink in patient 3. The remainder of the physical examination was unremarkable, except for benign angiokeratoma of the scrotum in case 1 and pigmented leucoderma-type macules in case 3. LITERATURE RESULTS: Sixty-six cases of acquired port-wine stains were reported in the literature. The average age was 25 years (3-69) with a sex-ratio of 0.88. Generally, no causative factor was given. However, trauma (30.5%), estrogenic impregnation (16.5%), and more rarely, medication, solar damage, frostbite, cluster headache, herpes zoster and acoustic neuroma were reported as causatives factors. DISCUSSION: Acquired port-wine stain is rare. Although often idiopathic, it can result from spinal trauma, which must be explored if suggested by the history. In our series, the clinical presentation suggested a latent congenital vascular malformation of late onset, in particular in patients 2 and 3, because of the segmental distribution.
Asunto(s)
Mancha Vino de Oporto/diagnóstico , Adolescente , Adulto , Edad de Inicio , Angioqueratoma/complicaciones , Biopsia , Diagnóstico Diferencial , Dermatosis Facial/diagnóstico , Dermatosis Facial/patología , Femenino , Hemangioma Capilar/diagnóstico , Hemangioma Capilar/patología , Humanos , Masculino , Mancha Vino de Oporto/embriología , Mancha Vino de Oporto/genética , Mancha Vino de Oporto/patología , Escroto , Neoplasias Cutáneas/complicaciones , Pigmentación de la Piel , Terminología como Asunto , Proteína Activadora de GTPasa p120/genéticaAsunto(s)
Angioqueratoma/complicaciones , Enfermedades del Yeyuno/complicaciones , Suelo de la Boca/irrigación sanguínea , Escroto , Neoplasias Cutáneas/complicaciones , Várices/complicaciones , Malformaciones Vasculares/complicaciones , Enteroscopía de Doble Balón , Humanos , Enfermedades del Yeyuno/diagnóstico , Enfermedades del Yeyuno/cirugía , Yeyuno/irrigación sanguínea , Masculino , Persona de Mediana Edad , Malformaciones Vasculares/diagnóstico , Malformaciones Vasculares/cirugíaAsunto(s)
Angioqueratoma/diagnóstico , Neoplasias Cutáneas/diagnóstico , Adulto , Angioqueratoma/complicaciones , Angioqueratoma/patología , Humanos , Queratosis/complicaciones , Queratosis/diagnóstico , Queratosis/patología , Pierna , Masculino , Psoriasis/complicaciones , Psoriasis/diagnóstico , Psoriasis/patología , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/patologíaRESUMEN
Angiokeratoma is a very rare vascular lesion of the papillary dermis. It is characterized by vascular ectasia with overlying epidermal hyperkeratosis. The systemic form of angiokeratoma is associated with Fabry disease and fucosidosis. There are several localized forms. Tongue involvement is uncommon. Hemangiomas are tumors made up of capillaries; they grow by active endothelial proliferation as opposed to expansion of vascular spaces in vascular malformations. Lingual hemangiomas are usually indolent, but they can cause cosmetic deformities, recurrent hemorrhage, and functional problems with speaking, mastication, and deglutition. We report a case of angiokeratoma of the tongue with an underlying hemangioma in a 30-year-old woman. Angiokeratomas have been reported to develop over arteriovenous malformations and in the area of lymphangioma circumscriptum following repeated local trauma. To the best of our knowledge, the development of a lingual hemangioma in a patient with long-standing angiokeratomatous lesions has not been previously reported in the literature.
Asunto(s)
Angioqueratoma/complicaciones , Hemangioma/complicaciones , Neoplasias de la Lengua/complicaciones , Adulto , Angioqueratoma/patología , Femenino , Hemangioma/patología , Humanos , Neoplasias de la Lengua/patologíaRESUMEN
Angiokeratomas of the vulva are uncommon, benign vascular lesions that are generally located on the labia. However, the clitoris is an extremely rare location, with only three published cases. We report a case of clitoral angiokeratoma in a 22-year-old nulligravida with a history of surgery to remove a clitoral mass at 6 years of age. The case described herein is distinguished from the other case reports by an accompanying varicose structure involving the vulva.
Asunto(s)
Angioqueratoma/patología , Clítoris/patología , Neoplasias Cutáneas/patología , Angioqueratoma/complicaciones , Femenino , Humanos , Neoplasias Cutáneas/complicaciones , Várices/complicaciones , Vulva/irrigación sanguínea , Adulto JovenRESUMEN
Several types of vascular anomalies have been described in patients with Turner syndrome, including cutaneous lymphatic malformations, vascular anomalies of the heart and aorta, acral venous malformations, and intestinal vascular anomalies. Angiokeratomas have rarely been reported in patients with Turner syndrome. Here, we describe a 14-year-old girl with Turner syndrome who presented with a 2-year history of tender bluish-black keratotic acral papules. Biopsy showed acral skin with focal epidermal acanthosis that was centered on a dilated superficial vessel, consistent with an angiokeratoma. Lysosomal enzyme assays were normal, and she did not demonstrate any other features of a lysosomal storage disorder.
Asunto(s)
Angioqueratoma/complicaciones , Angioqueratoma/patología , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/patología , Síndrome de Turner/complicaciones , Adolescente , Biopsia , Femenino , HumanosRESUMEN
Los angioqueratomas son lesiones vasculares benignas que histopatológicamente están formadas por vasos capilares dilatados subepidérmicos, asociados a una reacción epidérmica con acantosis e hiperqueratosis. Clínicamente podemos encontrar lesiones solitarias o múltiples, en forma de pápulas o placas de pequeño tamaño de color rojo a negro, en variadas localizaciones y con una superficie hiperqueratósica. Presentamos el caso de un niño de 5 años con un angioqueratoma solitario localizado en el tronco que presenta una dermatoscopia característica (AU)
Angiokeratomas are benign vascular lesions that histopathologically consist of subepidermal dilated capillary vessels, associated to an epidermal reaction with acanthosis or hyperkeratosis. Clinically we can find solitary or multiple lesions, as small size red to black papules or plaques, in several locations with an hyperkeratosis surface. We present the case of a solitary angiokeratoma in a 5-years-old child, located on the trunk, with a characteristic dermatoscopy (AU)
Asunto(s)
Humanos , Masculino , Niño , Angioqueratoma , Angioqueratoma/complicaciones , Angioqueratoma/diagnóstico , Angioqueratoma/epidemiología , Angioqueratoma/etiología , Angioqueratoma/cirugía , Angioqueratoma/terapia , Traumatismos Cerebrovasculares , Traumatismos Cerebrovasculares/complicaciones , Neoplasias VascularesRESUMEN
A 44-year-old woman developed punctate erythematous maculae on the backs of her hands, arms and shoulders following a pregnancy. Laboratory evaluation was unremarkable. Our differential diagnosis includes idiopathic teleangiectases, teleangiectasia eruptiva perstans, angioma serpiginosum and angiokeratoma corporis diffusum Fabry. Microscopic examination showed increased numbers of the small vessels of the upper vascular plexus with dilated capillaries. This coupled with the clinical findings led us to the diagnosis of angioma serpiginosum with symmetrical distribution involving the shoulder girdle, upper aspects of the arms, and the backs of the hands. We treated with a pulsed dye laser and noted some regression after two sessions.