[Specificity of cellular response to various occupational toxicants].

The article covers study concerning influence of coal rock dust and high fluorine concentrations on energy metabolism and oxidation-reduction reactions in blood WBC of experimental rats. The authors demonstrated that the cells vary in response to long action of coal rock dust and high fluorine concentrations.

[Clinical and experimental studies of metabolic response to chronic exposure to coal dust].

In miners anthracosilicosis is caused by chronic exposure to coal dust and is characterized by progressive development of the inflammatory process, the expressed disorders of lipid metabolism, and immunodeficiency. In the experiment we revealed the stages of anthracosilicosis development according to which adequate measures of prevention and correction of the disorders caused by long exposure of an organism to coal dust are recommended.

[Serum phospholipids in anthracosilicosis associated with vibration disease].

The authors studied serum phospholipid subunits in patients with anthracosilicosis associated with vibration disease. Findings are significantly higher detergent fraction of phospholipids--lysophosphatidylcholine, phosphatidylserine, sphingomyelin, lower phosphatidylcholine, phosphatidylethanolamine and phosphoinositides--that suggests increased transmissivity of biologic membranes and activated inosite mechanism of transmembrane signal transmission. Aeroionization appeared to have positive influence, normalizing serum phospholipids level.

[Cytochemical parameters in studying the body at peripheral hemopoiesis level].

The authors used cytochemical methods to study functions of neutrophils, RBC and lymphocytes of perpheral blood in miners suffering from anthracosilicosis stage I, revealed higher phospholipids content, lower catecholamines, increased activity of monoamine oxidase, esterase, decreased glycogen, RNA and lysosomal cationic proteins, in comparison with apparently healthy individuals. These tests are considered expedient in diagnosis of early anthracosilicosis manifestations in miners.

[The diagnostic value of the extreme inhibition of the processes of blood lipid peroxidation]. / O diagnosticheskoi tsennosti chrezmernogo ugneteniia protsessov perekisnogo okisleniia lipidov krovi.

The measuring of the blood serum content of lipid peroxidation LPO products permits giving a possible prognosis of the illness. A striking decline in LPO activity is indicative of an apparent inhibition of processes of vital activity and suggests to us a possibility of a fatal outcome.

[Cytochemical research on the peripheral blood erythrocytes and neutrophils of coal miners]. / Tsitokhimicheskie issledovaniia éritrotsitov i neitrofilov perifericheskoi krovi u shakhterov-ugol'shchikov.

A total of 140 miners, divided into 4 groups were studied. The first group consisted of 25 practically healthy people, newly employed, examined at a health center of the mine, the second of 21 patients with anthracosilicosis, the third of 36 with anthracosilicosis confirmed by X-ray, the fourth included 58 facing the first stage of anthracosilicosis. Erythrocyte histidine and catecholamine levels, myeloperoxidase and beta-glucuronidase activities, data of lysosomal cation (LC) and NBT tests in neutrophils were under study. The miners of groups 2, 3, 4 showed the increased beta-glucuronidase activity (by 47-73%) and NBT test values (37-96%), lowered levels of catecholamines (57-67%), histidine (48-60%), results of LC-test (29-32%) and myeloperoxidase activity (21-31%) in comparison with normal subjects. The findings will help diagnose the latent forms of anthracosilicosis comparatively early, when the structural changes cannot be detected by X-ray.