Verbal memory network mapping in individual patients predicts postoperative functional impairments.

Verbal memory decline is a significant concern following temporal lobe surgeries in patients with epilepsy, emphasizing the need for precision presurgical verbal memory mapping to optimize functional outcomes. However, the inter-individual variability in functional networks and brain function-structural dissociations pose challenges when relying solely on group-level atlases or anatomical landmarks for surgical guidance. Here, we aimed to develop and validate a personalized functional mapping technique for verbal memory using precision resting-state functional MRI (rs-fMRI) and neurosurgery. A total of 38 patients with refractory epilepsy scheduled for surgical interventions were enrolled and 28 patients were analyzed in the study. Baseline 30-min rs-fMRI scanning, verbal memory and language assessments were collected for each patient before surgery. Personalized verbal memory networks (PVMN) were delineated based on preoperative rs-fMRI data for each patient. The accuracy of PVMN was assessed by comparing post-operative functional impairments and the overlapping extent between PVMN and surgical lesions. A total of 14 out of 28 patients experienced clinically meaningful declines in verbal memory after surgery. The personalized network and the group-level atlas exhibited 100% and 75.0% accuracy in predicting postoperative verbal memory declines, respectively. Moreover, six patients with extra-temporal lesions that overlapped with PVMN showed selective impairments in verbal memory. Furthermore, the lesioned ratio of the personalized network rather than the group-level atlas was significantly correlated with postoperative declines in verbal memory (personalized networks: r = -0.39, p = .038; group-level atlas: r = -0.19, p = .332). In conclusion, our personalized functional mapping technique, using precision rs-fMRI, offers valuable insights into individual variability in the verbal memory network and holds promise in precision verbal memory network mapping in individuals.

Older adults at greater risk for Alzheimer's disease show stronger associations between sleep apnea severity in REM sleep and verbal memory.

BACKGROUND: Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer's disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in cognitive impairment. OSA during rapid eye movement (REM) sleep is usually more severe than in non-rapid eye movement (NREM) sleep, but the relative effect of oxyhemoglobin desaturation during REM versus NREM sleep on memory is not completely characterized. Here, we examined the impact of OSA, as well as the moderating effects of AD risk factors, on verbal memory in a sample of middle-aged and older adults with heightened AD risk. METHODS: Eighty-one adults (mean age:61.7 ± 6.0 years, 62% females, 32% apolipoprotein E ε4 allele (APOE4) carriers, and 70% with parental history of AD) underwent clinical polysomnography including assessment of OSA. OSA features were derived in total, NREM, and REM sleep. REM-NREM ratios of OSA features were also calculated. Verbal memory was assessed with the Rey Auditory Verbal Learning Test (RAVLT). Multiple regression models evaluated the relationships between OSA features and RAVLT scores while adjusting for sex, age, time between assessments, education years, body mass index (BMI), and APOE4 status or parental history of AD. The significant main effects of OSA features on RAVLT performance and the moderating effects of AD risk factors (i.e., sex, age, APOE4 status, and parental history of AD) were examined. RESULTS: Apnea-hypopnea index (AHI), respiratory disturbance index (RDI), and oxyhemoglobin desaturation index (ODI) during REM sleep were negatively associated with RAVLT total learning and long-delay recall. Further, greater REM-NREM ratios of AHI, RDI, and ODI (i.e., more events in REM than NREM) were related to worse total learning and recall. We found specifically that the negative association between REM ODI and total learning was driven by adults 60 + years old. In addition, the negative relationships between REM-NREM ODI ratio and total learning, and REM-NREM RDI ratio and long-delay recall were driven by APOE4 carriers. CONCLUSION: Greater OSA severity, particularly during REM sleep, negatively affects verbal memory, especially for people with greater AD risk. These findings underscore the potential importance of proactive screening and treatment of REM OSA even if overall AHI appears low.

Retrieval Practice and Word Learning by Children With Developmental Language Disorder: Does Expanding Retrieval Provide Additional Benefit?

PURPOSE: The word learning of preschool-age children with developmental language disorder (DLD) is improved when spaced retrieval practice is incorporated into the learning sessions. In this preregistered study, we compared two types of spacing-an expanding retrieval practice schedule and an equally spaced schedule-to determine if one of these approaches yields better word learning outcomes for the children. METHOD: Fourteen children with DLD aged 4-5 years and 14 same-age children with typical language development (TD) learned eight novel nouns over two sessions. Spacing for half of the novel words was expanded gradually during learning; for the remaining novel words, greater spacing remained at the same level throughout learning. Immediately after the second session and 1 week later, the children's recall of the words was tested. RESULTS: The children with TD recalled more novel words than the children with DLD, although this difference could be accounted for by differences in the children's standardized receptive vocabulary test scores. The two groups were similar in their ability to retain the words over 1 week. Initially, the shorter spacing in the expanding schedule resulted in greater retrieval success than the corresponding (longer spaced) retrieval trials in the equally spaced schedule. These early shorter spaced trials also seemed to benefit retrieval of the trials with greater spacing that immediately followed. However, as the learning period progressed, the accuracy levels for the two conditions converged and were likewise similar during final testing. CONCLUSION: We need a greater understanding of how and when short spacing can be helpful to children's word learning, with the recognition that early gains might give a misleading picture of the benefits that short spacing can provide to longer term retention. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.25537696.

Can Infants Retain Statistically Segmented Words and Mappings Across a Delay?

Infants are sensitive to statistics in spoken language that aid word-form segmentation and immediate mapping to referents. However, it is not clear whether this sensitivity influences the formation and retention of word-referent mappings across a delay, two real-world challenges that learners must overcome. We tested how the timing of referent training, relative to familiarization with transitional probabilities (TPs) in speech, impacts English-learning 23-month-olds' ability to form and retain word-referent mappings. In Experiment 1, we tested infants' ability to retain TP information across a 10-min delay and use it in the service of word learning. Infants successfully mapped high-TP but not low-TP words to referents. In Experiment 2, infants readily mapped the same words even when they were unfamiliar. In Experiment 3, high- and low-TP word-referent mappings were trained immediately after familiarization, and infants readily remembered these associations 10 min later. In sum, although 23-month-old infants do not need strong statistics to map word forms to referents immediately, or to remember those mappings across a delay, infants are nevertheless sensitive to these statistics in the speech stream, and they influence mapping after a delay. These findings suggest that, by 23 months of age, sensitivity to statistics in speech may impact infants' language development by leading word forms with low coherence to be poorly mapped following even a short period of consolidation.

Cortical and Subcortical Mechanisms of Orthographic Word-form Learning.

We examined the initial stages of orthographic learning in real time as literate adults learned spellings for spoken pseudowords during fMRI scanning. Participants were required to learn and store orthographic word forms because the pseudoword spellings were not uniquely predictable from sound to letter mappings. With eight learning trials per word form, we observed changes in the brain's response as learning was taking place. Accuracy was evaluated during learning, immediately after scanning, and 1 week later. We found evidence of two distinct learning systems-hippocampal and neocortical-operating during orthographic learning, consistent with the predictions of dual systems theories of learning/memory such as the complementary learning systems framework [McClelland, J. L., McNaughton, B. L., & O'Reilly, R. C. Why there are complementary learning systems in the hippocampus and neocortex: Insights from the successes and failures of connectionist models of learning and memory. Psychological Review, 102, 419-457, 1995]. The bilateral hippocampus and the visual word form area (VWFA) showed significant BOLD response changes over learning, with the former exhibiting a rising pattern and the latter exhibiting a falling pattern. Moreover, greater BOLD signal increase in the hippocampus was associated with better postscan recall. In addition, we identified two distinct bilateral brain networks that mirrored the rising and falling patterns of the hippocampus and VWFA. Functional connectivity analysis revealed that regions within each network were internally synchronized. These novel findings highlight, for the first time, the relevance of multiple learning systems in orthographic learning and provide a paradigm that can be used to address critical gaps in our understanding of the neural bases of orthographic learning in general and orthographic word-form learning specifically.

Motor learning and performance in schizophrenia and aging: two different patterns of decline.

Psychomotor slowing has consistently been observed in schizophrenia, however research on motor learning in schizophrenia is limited. Additionally, motor learning in schizophrenia has never been compared with the waning of motor learning abilities in the elderly. Therefore, in an extensive study, 30 individuals with schizophrenia, 30 healthy age-matched controls and 30 elderly participants were compared on sensorimotor learning tasks including sequence learning and adaptation (both explicit and implicit), as well as tracking and aiming. This paper presents new findings on an explicit motor sequence learning task, an explicit verbal learning task and a simple aiming task and summarizes all previously published findings of this large investigation. Individuals with schizophrenia and elderly had slower Movement Time (MT)s compared with controls in all tasks, however both groups improved over time. Elderly participants learned slower on tracking and explicit sequence learning while individuals with schizophrenia adapted slower and to a lesser extent to movement perturbations in adaptation tasks and performed less well on cognitive tests including the verbal learning task. Results suggest that motor slowing is present in schizophrenia and the elderly, however both groups show significant but different motor skill learning. Cognitive deficits seem to interfere with motor learning and performance in schizophrenia while task complexity and decreased movement precision interferes with motor learning in the elderly, reflecting different underlying patterns of decline in these conditions. In addition, evidence for motor slowing together with impaired implicit adaptation supports the influence of cerebellum and the cerebello-thalamo-cortical-cerebellar (CTCC) circuits in schizophrenia, important for further understanding the pathophysiology of the disorder.

Long-term memory consolidation of new words in children with self-limited epilepsy with centro-temporal spikes.

Accelerated long-term forgetting has been studied and demonstrated in adults with epilepsy. In contrast, the question of long-term consolidation (delays > 1 day) in children with epilepsy shows conflicting results. However, childhood is a period of life in which the encoding and long-term storage of new words is essential for the development of knowledge and learning. The aim of this study was therefore to investigate long-term memory consolidation skills in children with self-limited epilepsy with centro-temporal spikes (SeLECTS), using a paradigm exploring new words encoding skills and their long-term consolidation over one-week delay. As lexical knowledge, working memory skills and executive/attentional skills has been shown to contribute to long-term memory/new word learning, we added standardized measures of oral language and executive/attentional functions to explore the involvement of these cognitive skills in new word encoding and consolidation. The results showed that children with SeLECTS needed more repetitions to encode new words, struggled to encode the phonological forms of words, and when they finally reached the level of the typically developing children, they retained what they had learned, but didn't show improved recall skills after a one-week delay, unlike the control participants. Lexical knowledge, verbal working memory skills and phonological skills contributed to encoding and/or recall abilities, and interference sensitivity appeared to be associated with the number of phonological errors during the pseudoword encoding phase. These results are consistent with the functional model linking working memory, phonology and vocabulary in a fronto-temporo-parietal network. As SeLECTS involves perisylvian dysfunction, the associations between impaired sequence storage (phonological working memory), phonological representation storage and new word learning are not surprising. This dual impairment in both encoding and long-term consolidation may result in large learning gap between children with and without epilepsy. Whether these results indicate differences in the sleep-induced benefits required for long-term consolidation or differences in the benefits of retrieval practice between the epilepsy group and healthy children remains open. As lexical development is associated with academic achievement and comprehension, the impact of such deficits in learning new words is certainly detrimental.

Spoken verb learning in children with language disorder.

The current study examined spoken verb learning in elementary school children with language disorder (LD). We aimed to replicate verb learning deficits reported in younger children with LD and to examine whether verb instrumentality, a semantic factor reflecting whether an action requires an instrument (e.g., "to chop" is an instrumental verb), influenced verb learning. The possible facilitating effect of orthographic cues presented during training was also evaluated. In an exploratory analysis, we investigated whether language and reading skills mediated verb learning performance. General language skills and verb learning were assessed in Dutch children with LD and age-matched typically developing controls (n = 25 per group) aged 8 to 12 years (M = 9;9 [years;months], SD = 1;3). Using video animations, children learned 20 nonwords depicting actions comprising 10 instrumental and 10 noninstrumental verbs. Half of the items were trained with orthographic information present. Verb learning was assessed using an animation-word matching and animation naming task. Linear mixed-effects models showed a main effect of group for all verb learning measures, demonstrating that children with LD learned fewer words and at a slower rate than the control group. No effect of verb instrumentality, presence of orthographic information, or the included mediators was found. Our results emphasize the importance of continued vocabulary instruction in elementary school to strengthen verb encoding. Given that our findings are inconsistent with the overall literature showing an orthographic facilitation effect, future studies should investigate whether participants pay attention to the written word form in learning contexts with moving stimuli.

A processing advantage in favor of animate entities in incidental word learning in young children.

Because of their evolutionary importance, it has been proposed that animate entities would be better remembered than inanimate entities. Although a growing body of evidence supports this hypothesis, it is still unclear whether the animacy effect persists under incidental learning conditions. Furthermore, few studies have tested the robustness of this effect in young children, with conflicting results. Using an incidental learning paradigm, we investigated whether young children (4- and 5-year-olds) would be better at learning words that refer to either human or animal entities rather than vehicle entities using pictures as stimuli. A sample of 79 children were asked to play digital Memory games while associations between pictures and words were presented incidentally. Consistent with the adaptive view of memory, the results showed that words associated with human and animal entities were better learned incidentally than words associated with vehicle entities. The visual complexity of the pictures did not influence this animacy effect. In addition, the more exposure to the pictures, the more incidental learning occurred. Overall, the results confirm the robustness of the animacy effect and show that this processing advantage can be found in an incidental learning task in children as young as 4 or 5 years. Furthermore, it is the first study to show that this effect can be obtained with pictures in children. The demonstration of the animacy effect with pictures, and not just words, is a prerequisite for an ultimate explanation of this effect in terms of survival.

Tonal interference in word learning? A comparison of Cantonese and French.

Most languages of the world use lexical tones to contrast words. Thus, understanding how individuals process tones when learning new words is fundamental for a better understanding of the mechanisms underlying word learning. The current study asked how tonal information is integrated during word learning. We investigated whether variability in tonal information during learning can interfere with the learning of new words and whether this is language and age dependent. Cantonese- and French-learning 30-month-olds (N = 97) and Cantonese- and French-speaking adults (N = 50) were tested with an eye-tracking task on their ability to learn phonetically different pairs of novel words in two learning conditions: a 1-tone condition in which each object was named with a single label and a 3-tone condition in which each object was named with three different labels varying in tone. We predicted learning in all groups in the 1-tone condition. For the 3-tone condition, because tones are part of the phonological system of Cantonese but not of French, we expected the Cantonese groups to either fail (toddlers) or show lower performance than in the 1-tone condition (adults), whereas the French groups might show less sensitivity to this manipulation. The results show that all participants learned in the 1-tone condition and were sensitive to tone variation to some extent. Learning in the 3-tone condition was impeded in both groups of toddlers. We argue that tonal interference in word learning likely comes from the phonological level in the Cantonese groups and from the acoustic level in the French groups.

Touch-and-feel features in "first words" picture books hinder infants' word learning.

Little is known about the role of book features in infant word learning from picture books. We conducted a preregistered study to assess the role of touch-and-feel features in infants' ability to learn new words from picture books. A total of 48 infants (Mage = 16.75 months, SD = 1.85) were assigned to a touch-and-feel picture-book condition or a standard picture-book condition (no touch-and-feel features) and were taught a novel label for an unfamiliar animal by the researcher during a book-reading session. Infants were then tested on their ability to recognize the label (i.e., choose the target from a choice of two pictures on hearing it named) and to generalize this knowledge to other types of pictures and real-world objects (scale model animals and stuffed animals). Infants in the no touch-and-feel condition performed above chance when choosing the target picture, whereas infants in the touch-and-feel condition did not. Infants in both conditions failed to generalize this knowledge to other pictures and objects. This study extends our knowledge about the role of tactile features in infant word learning from picture books. Although manipulative features like touch-and-feel patches might be engaging for infants, they may detract from learning. Depending on the purpose of the activity, parents and practitioners might find it useful to consider such book features when selecting books to read with their infants.

Infants' attention during cross-situational word learning: Environmental variability promotes novelty preference.

Infants as young as 14 months can track cross-situational statistics between sets of words and objects to acquire word-referent mappings. However, in naturalistic word learning situations, words and objects occur with a host of additional information, sometimes noisy, present in the environment. In this study, we tested the effect of this environmental variability on infants' word learning. Fourteen-month-old infants (N = 32) were given a cross-situational word learning task with additional gestural, prosodic, and distributional cues that occurred reliably or variably. In the reliable cue condition, infants were able to process this additional environmental information to learn the words, attending to the target object during test trials. But when the presence of these cues was variable, infants paid greater attention to the gestural cue during training and subsequently switched preference to attend more to novel word-object mappings rather than familiar ones at test. Environmental variation may be key to enhancing infants' exploration of new information.

The effect of target detection on memory retrieval.

Attention and memory are fundamental cognitive processes that closely interact. In the attentional boost effect (ABE), the stimuli that co-occur with targets are remembered better than those that co-occur with distractors in target detection tasks performed during memory encoding. In target detection tasks performed during retrieval, the stimuli that co-occur with targets are recognized as 'old' more easily than the stimuli that co-occur with distractors. This study mainly explored the internal mechanism of the effect of target detection on recognition. In Experiment 1, the full attention (FA; where participants performed only the memory task) condition was used to compare with divided attention (DA; where participants performed target detection while performing memory retrieval) condition to explore the impact of target detection and distraction inhibition on recognition. In Experiment 2, the proportion of old and new words in the retrieval stage was adjusted to 1:1 to eliminate the possible reaction tendency caused by the high proportion of old words. In Experiment 3, the presentation time of words was extended to 1.5 s and 3 s to eliminate the possible impact of rapid processing. The results indicated that the effect of target detection on recognition was attributed to both target detection and distraction rejection and is not affected by the ratio of old and new words and the word presentation time. The effect of target detection on recognition may be owing to temporal yoking of the dual tasks, which is different from the effect of target detection on memory encoding.

Wordform variability in infants' language environment and its effects on early word learning.

Most research regarding early word learning in English tends to make the simplifying assumption that there exists a one-to-one mapping between concrete objects and their labels. In the current work, we provide evidence that runs counter to this assumption, aligning English with more morphologically-rich languages. We suggest that even in a morphologically-poor language like English, real world language input to infants does not provide tidy 1-to-1 mappings. Instead, infants encounter many variant wordforms for familiar nouns (e.g. dog∼doggy∼dogs). We explore this wordform variability in 44 English-learning infants' naturalistic environments using a longitudinal corpus of infant-available speech. We look at both the frequency and composition of wordform variability. We find two broad categories of variability: referent-changing alterations, where words were pluralized or compounded (e.g. coat∼raincoats); and wordplay, where words changed form without a notable change in referent (e.g. bird∼birdie). We further find that wordplay occurs with a limited number of lemmas that are usually early-learned, high-frequency, and shorter. When looking at all wordform variability, we find that individual words with higher levels of wordform variability are learned earlier than words with fewer wordforms, over and above the effect of frequency.

Examining Gesture Production in the Presence of Communication Challenges.

Understanding why speakers modify their co-speech hand gestures when speaking to interlocutors provides valuable insight into how these gestures contribute to interpersonal communication in face-to-face and virtual contexts. The current protocols manipulate the visibility of speakers and their interlocutors in tandem in a face-to-face context to examine the impact of visibility on gesture production when communication is challenging. In these protocols, speakers complete tasks such as teaching words from an unfamiliar second language or recounting the events of cartoon vignettes to an interlocutor who is either another participant or a confederate. When performing these tasks, speakers are visible or non-visible to their interlocutor, and the speaker is visible or non-visible to the participant. In the word learning task, speakers and interlocutors visible to one another produce more representational gestures, which convey meaning via handshape and motion, and deictic (pointing) gestures than speakers and interlocutors who are not visible to one another. In the narrative retelling protocol, adolescents with autism spectrum disorder (ASD) produced more gestures when speaking to visible interlocutors than non-visible interlocutors. A major strength of the current protocol is its flexibility in terms of the tasks, populations, and gestures examined, and the current protocol can be implemented in videoconferencing as well as face-to-face contexts. Thus, the current protocol has the potential to advance the understanding of gesture production by elucidating its role in interpersonal communication in populations with communication challenges.

The effect of masks on infants' ability to fast-map and generalize new words.

Young children today are exposed to masks on a regular basis. However, there is limited empirical evidence on how masks may affect word learning. The study explored the effect of masks on infants' abilities to fast-map and generalize new words. Seventy-two Chinese infants (43 males, Mage = 18.26 months) were taught two novel word-object pairs by a speaker with or without a mask. They then heard the words and had to visually identify the correct objects and also generalize words to a different speaker and objects from the same category. Eye-tracking results indicate that infants looked longer at the target regardless of whether a speaker wore a mask. They also looked longer at the speaker's eyes than at the mouth only when words were taught through a mask. Thus, fast-mapping and generalization occur in both masked and not masked conditions as infants can flexibly access different visual cues during word-learning.

Chatbot dialogic reading boosts comprehension for Chinese kindergarteners with higher language skills.

Dialogic reading promotes early language and literacy development, but high-quality interactions may be inaccessible to disadvantaged children. This study examined whether a chatbot could deliver dialogic reading support comparable to a human partner for Chinese kindergarteners. Using a 2 × 2 factorial design, 148 children (83 girls; Mage = 70.07 months, SD = 7.64) from less resourced families in Beijing, China, were randomly assigned to one of four conditions: dialogic or non-dialogic reading techniques with either a chatbot or human partner. The chatbot provided comparable dialogic support to the human partner, enhancing story comprehension and word learning. Critically, the chatbot's effect on story comprehension was moderated by children's language proficiency rather than age or reading ability. This demonstrates that chatbots can facilitate dialogic reading and highlights the importance of considering children's language skills when implementing chatbot dialogic interventions.

A changing role for transitional probabilities in word learning during the transition to toddlerhood?

Infants' sensitivity to transitional probabilities (TPs) supports language development by facilitating mapping high-TP (HTP) words to meaning, at least up to 18 months of age. Here we tested whether this HTP advantage holds as lexical development progresses, and infants become better at forming word-referent mappings. Two groups of 24-month-olds (N = 64 and all White, tested in the United States) first listened to Italian sentences containing HTP and low-TP (LTP) words. We then used HTP and LTP words, and sequences that violated these statistics, in a mapping task. Infants learned HTP and LTP words equally well. They also learned LTP violations as well as LTP words, but learned HTP words better than HTP violations. Thus, by 2 years of age sensitivity to TPs does not lead to an HTP advantage but rather to poor mapping of violations of HTP word forms. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Fostering retention of word learning: The number of training sessions children retrieve words positively relates to post-training retention.

During vocabulary instruction, it is important to teach words until their representations are robust enough to be retained. For adults, the number of training sessions a target item is successfully retrieved during training predicts the likelihood of post-training retention. To assess this relationship in children, we reanalyzed data from Gordon et al. (2021b, 2022). Four- to six-year-old children completed six training days with word form-object pairs and were tested one month later. Results indicate that the number of training sessions that a word form was retrieved was positively related to post-training retention. We discuss implications for vocabulary instruction and interventions.

Word meaning is complex: Language-related generalization differences in autistic adults.

The current study marries two important observations. First, there is a growing recognition that word meanings need to be flexibly extended in new ways as new contexts arise. Second, as evidenced primarily within the perceptual domain, autistic individuals tend to find generalization more challenging while showing stronger veridical memory in comparison to their neurotypical peers. Here we report that a group of 80 autistic adults finds it more challenging to flexibly extend the meanings of familiar words in new ways than a group of 80 neurotypical peers, while the autistic individuals outperform the neurotypicals on a novel word-learning task that does not require flexible extension. Results indicate that recognized differences in generalization present an ongoing challenge for autistic adults in the domain of language, separate from social cognition, executive function, or the ability to assign single fixed meanings to new words.