RESUMEN
OBJECTIVE: To assess benzophenone-type ultraviolet (UV) filter concentrations, chemicals used in sunscreen and personal care products, and semen endpoints. DESIGN: Cohort. SETTING: Not applicable. PATIENT(S): A total of 413 men provided semen and urine samples, 2005-2009. Five UV filters were quantified (ng/mL) in urine using liquid chromatography-triple quadrupole mass spectrometry: BP-1 (2,4-dihydroxybenzophenone), BP-2 (2,2',4,4'-tetrahydroxybenzophenone), BP-3 (2-hydroxy-4-methoxybenzophenone), BP-8 (2,2'-dihydroxy-4-methoxybenzophenone), and 4-OH-BP (4-hydroxybenzophenone). Using linear regression, ß-coefficients (ß) and 95% confidence intervals (CIs) for each chemical dichotomized at the 75th percentile and Box-Cox transformed semen endpoint were estimated, after adjusting for age, body mass index, cotinine, season, and site. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Thirty-five semen endpoints. RESULT(S): BP-2 was associated with diminished sperm concentration (ß = -0.74; 95% CI -1.41, -0.08), straight (ß = -4.57; 95% CI -8.95, -0.18) and linear movement (ß = -3.15; 95% CI -6.01, -0.30), more immature sperm (ß = 0.38; 95% CI 0.15, 0.62), and a decreased percentage of other tail abnormalities (ß = -0.16; 95% CI -0.31, -0.01). BP-8 was associated with decreased hypo-osmotic swelling (ß = -2.57; 95% CI -4.86, -0.29) and higher acrosome area (ß = 1.14; 95% CI 0.01, 2.26). No associations were observed for BP-1, BP-3, or 4OH-BP. CONCLUSION(S): The findings suggest that specific UV filters may be associated with some aspects of semen endpoints, but await future corroboration.
