RESUMEN
From September 2013 to July 2014, several gold miners working in the tropical forest consulted the Maripasoula Health Center in French Guiana for edema and findings consistent with right-sided cardiac failure. Of the 42 cases of beriberi that were diagnosed, one patient died. The laboratory and clinical investigation demonstrated vitamin B1 deficiency in most of the patients tested. Furthermore, 30 of 42 patients responded favorably to 500 mg of intravenous or intramuscular thiamine supplementation. In addition, dietary investigation showed insufficient thiamine intake in these patients. We concluded that patients had acquired beriberi because of diet restrictions, hard labor, and infectious diseases, notably malaria. In 2016, cases were still being reported. We recommend screening for compatible symptoms in gold miners, thiamine supplementation, and nutritional intervention.
Asunto(s)
Beriberi/dietoterapia , Beriberi/epidemiología , Brotes de Enfermedades , Malaria/epidemiología , Mineros , Tiamina/administración & dosificación , Adulto , Anciano , Beriberi/complicaciones , Beriberi/fisiopatología , Conducta Criminal , Femenino , Guyana Francesa/epidemiología , Oro , Humanos , Malaria/complicaciones , Malaria/tratamiento farmacológico , Malaria/parasitología , Masculino , Desnutrición/fisiopatología , Persona de Mediana Edad , Estudios RetrospectivosAsunto(s)
Suplementos Dietéticos , Estado Nutricional/efectos de los fármacos , Incertidumbre , Vitaminas/farmacología , Animales , Beriberi/dietoterapia , Beriberi/etiología , Beriberi/historia , Beriberi/prevención & control , Suplementos Dietéticos/estadística & datos numéricos , Historia del Siglo XX , Humanos , Escorbuto/dietoterapia , Escorbuto/etiología , Escorbuto/historia , Escorbuto/prevención & control , Vitaminas/historiaAsunto(s)
Deficiencia de Tiamina , Animales , Beriberi/dietoterapia , Beriberi/etiología , Beriberi/fisiopatología , Abastecimiento de Alimentos , Humanos , Lactante , Fórmulas Infantiles/química , Síndrome de Korsakoff/etiología , Enfermedad de Leigh/etiología , Tiamina/metabolismo , Tiamina/uso terapéutico , Deficiencia de Tiamina/complicaciones , Deficiencia de Tiamina/fisiopatologíaRESUMEN
Beriberi began to attract increasing attention in the second half of the 19th century, mostly due to the large numbers of victims among Dutch military personnel in the Netherlands East Indies. A study, carried out in Atjeh in 1886 by the Japanese Sugenoya and F. J. Cornelissen, led to the conclusion that there existed a beriberi bacillus which they could make visible in stained microscopical preparations. An extensive disinfection campaign in all barracks followed, but its benefits were a matter of debate. Inadequate nutrition in the investigators' eyes was only a predisposing factor. A.G. Vorderman (1844-1902) assumed a connection between rice feeding and beriberi in prisoners; he reported that the disease coincided with a diet of polished white rice. Beriberi could be prevented by providing the prisoners with 'red rice' (unpolished rice). However, red rice was regarded as inferior and status-lowering so that substitution of red for white rice in the rations was impossible. The concept of a 'lacking substance' (thiamine, vitamin B1) was hesitatingly accepted in the Netherlands. C. Winkler and C. Eijkman, for instance, refused until the early twenties of this century to exclude the possibility of a bacterial infection as the cause. As known, Eijkman in 1929 was awarded the Nobel prize for his contribution to vitamin research.
Asunto(s)
Beriberi/historia , Animales , Beriberi/diagnóstico , Beriberi/dietoterapia , Cricetinae , Historia del Siglo XIX , HumanosRESUMEN
The high incidence of Beri-beri in the 1890s and 1900s coupled with the ignorance of its causation led to many forms of treatment, culminating in the establishment of a "specialised hospital" in Singapore. However, the "anti-beri-beri" factor in unpolished rice soon made this hospital redundant.