Comparative Analysis of Clinical, Treatment, and Survival Characteristics of Basaloid and Squamous Cell Carcinoma of the Esophagus.

BACKGROUND: Basaloid squamous cell carcinoma (BSC) is a rare variant of squamous cell carcinoma (SqCC) of the esophagus. Even though pathologically thought to be more aggressive than SqCC, there is discrepancy in the literature regarding the outcomes of BSC compared with those of SqCC. STUDY DESIGN: We conducted a retrospective cohort study using the Surveillance Epidemiology and End Results (SEER) database. All patients with a histologic diagnosis of BSC and SqCC between 2004 and 2013 were included. We compared treatment and survival characteristics of patients with BSC and SqCC. RESULTS: There were 16,158 patients included in this study; 173 patients (1.1%) had BSC. There were no significant differences between the 2 groups based on age, sex, marital status, insurance, or geographic region of diagnosis, but patients with BSC were more likely to be Caucasian (73.4% vs 64.7%; p = 0.017). Among staged patients, baseline tumor stage was similar in both groups. However, BSC tumors were more likely to be of high pathologic grade (56.8% vs 38.2%; p < 0.001). Patients with SqCC were more likely to receive radiation therapy (36.9% vs 53.9%; p < 0.001), while patients with BSC were more likely to undergo resection (32.4% vs 17.0%; p < 0.001). Median overall survival was similar in both groups (14 vs 9 months; log rank = 0.144), and this relationship persisted after stratification by treatment. CONCLUSIONS: Even though more likely to be poorly differentiated at presentation, BSC of the esophagus seems to have similar clinical features and survival outcomes when compared with SqCC. Patients with BSC and SqCC should undergo stage-specific treatment to achieve optimal outcomes.

Carcinoma de células basoescamosas em prepúcio de equino: relato de caso / Basosquamous cell carcinoma in equine prepuce - case report / Carcinoma de células basoescamosas en el prepucio equino - estudio de caso

Existem diversas causas para o aumento de volume em região de pênis e prepúcio em equinos, uma delas é o carcinoma basoescamoso, que é um tumor maligno raro e de comportamento agressivo. Existem algumas possibilidades para o tratamento dessa enfermidade. O objetivo deste trabalho é relatar o caso de um equino, macho, 17 anos que apresentava massa tumoral na região de prepúcio, diagnosticado por histopatológico como carcinoma basoescamoso, que foi tratado através de excisão cirúrgica. O animal não apresentou recidivas, tendo maior qualidade de vida e reestabelecimento de outros distúrbios gerados secundariamente a essa afecção.

There are various causes for the increase in the volume of penis and prepuce in horses, one of them is the basosquamous carcinoma, which is a rare malignant tumor with aggressive behavior. There are some possibilities for the treatment of this disease. The reason of this paper is to report the case of a horse, male, 17 years which featured tumor mass in the region of prepuce, diagnosed by histopathology as basosquamous carcinoma, which was treated by surgical excision. The animal showed no recurrences, having better quality of life and reestablishment of other disorders generated secondarily to that disease.

Hay varias causas para el aumento en el volumen del pene y prepucio en los caballos, uno de ellos es el carcinoma basoescamoso, que es un tumor malo raro con un comportamiento agresivo. Hay algunas posibilidades para el tratamiento de esta enfermedad. EI objetivo de este trabajo es reportar el caso de un caballo, hombre, 17 años, que contó con masa tumoral en la región del prepucio, diagnosticado por la histopatología como carcinoma basoescamoso, que fue tratado por la supresión quirúrgica. El animal no mostró recurrencias, tener mejor calidad de vida y establecimiento de otros trastornos que genera secundariamente a la enfermedad.

Carcinoma de células basoescamosas em prepúcio de equino: relato de caso / Basosquamous cell carcinoma in equine prepuce - case report / Carcinoma de células basoescamosas en el prepucio equino - estudio de caso

Existem diversas causas para o aumento de volume em região de pênis e prepúcio em equinos, uma delas é o carcinoma basoescamoso, que é um tumor maligno raro e de comportamento agressivo. Existem algumas possibilidades para o tratamento dessa enfermidade. O objetivo deste trabalho é relatar o caso de um equino, macho, 17 anos que apresentava massa tumoral na região de prepúcio, diagnosticado por histopatológico como carcinoma basoescamoso, que foi tratado através de excisão cirúrgica. O animal não apresentou recidivas, tendo maior qualidade de vida e reestabelecimento de outros distúrbios gerados secundariamente a essa afecção.(AU)

There are various causes for the increase in the volume of penis and prepuce in horses, one of them is the basosquamous carcinoma, which is a rare malignant tumor with aggressive behavior. There are some possibilities for the treatment of this disease. The reason of this paper is to report the case of a horse, male, 17 years which featured tumor mass in the region of prepuce, diagnosed by histopathology as basosquamous carcinoma, which was treated by surgical excision. The animal showed no recurrences, having better quality of life and reestablishment of other disorders generated secondarily to that disease.(AU)

Hay varias causas para el aumento en el volumen del pene y prepucio en los caballos, uno de ellos es el carcinoma basoescamoso, que es un tumor malo raro con un comportamiento agresivo. Hay algunas posibilidades para el tratamiento de esta enfermedad. EI objetivo de este trabajo es reportar el caso de un caballo, hombre, 17 años, que contó con masa tumoral en la región del prepucio, diagnosticado por la histopatología como carcinoma basoescamoso, que fue tratado por la supresión quirúrgica. El animal no mostró recurrencias, tener mejor calidad de vida y establecimiento de otros trastornos que genera secundariamente a la enfermedad.(AU)

Collision of malignant neoplasms of the skin: basosquamous cell carcinoma associated with melanoma.

Collision tumors are characterized by the coexistence of two cancers in the same anatomical site and its pathogenesis remains controversial. Although uncommon, the association of basal cell carcinoma and melanocytic nevus is the most common among combinations of skin tumors. Even rarer is the association of two malignant tumors. We report a case of tumor collision representing melanoma and basosquamous cell carcinoma, a combination not previously described in the literature, since there are no reported cases of melanoma with this type of basal cell carcinoma.

Collision of malignant neoplasms of the skin: basosquamous cell carcinoma associated with melanoma

Collision tumors are characterized by the coexistence of two cancers in the same anatomical site and its pathogenesis remains controversial. Although uncommon, the association of basal cell carcinoma and melanocytic nevus is the most common among combinations of skin tumors. Even rarer is the association of two malignant tumors. We report a case of tumor collision representing melanoma and basosquamous cell carcinoma, a combination not previously described in the literature, since there are no reported cases of melanoma with this type of basal cell carcinoma.

Carcinoma basoescamoso: reporte de un caso con exposición crónica a arsénico ambiental / Basosquamous carcinoma: a case report with chronic environmental arsenic exposition

Basosquamous carcinoma is a relatively rare cutaneous tumour that shares some characteristics of both basal cell and squamous cell carcinoma. Currently most dermatologists consider that it represents a subtype of basal cell carcinoma with a more aggressive behaviour. The clinical presentation is non-specific and in general the diagnosis is made after the histopathological studies. The prevalence is higher in male patients, during the seventh decade and it tends to appear on sun exposed areas. Many authors compare its behaviour with squamous cell carcinoma. We present the case of a 44 years old male patient with a history of chronic arsenic exposure that presented a firm tumor in the left inguinal region and the biopsy showed basosquamous carcinoma with lymphatic involvement. This case shows an atypical presentation because of its localization and the appearance 20 years before the mean age reported in the literature. This could be explained by chronic environmental arsenic exposure, a well known risk factor for the development of cutaneous tumours.

El carcinoma basoescamoso es una neoplasia cutánea relativamente rara que reúne características de carcinoma basocelular y espinocelular. Actualmente la mayoría de los dermatólogos reconocen que este es un subtipo del carcinoma basocelular con comportamiento muchísimo más agresivo. Su presentación clínica es inespecífica y en general su diagnóstico se realiza sólo después de la biopsia. Predomina en pacientes de sexo masculino durante la séptima década de la vida y tiende a aparecer en regiones fotoexpuestas. Muchos autores igualan su comportamiento al del carcinoma espinocelular. Se presenta el caso de un paciente, de sexo masculino, de 44 años de edad, con antecedente de exposición a arsénico medioambiental crónica, que presentó aumento de volumen, duro en la región inguinal izquierda, cuya biopsia fue compatible con carcinoma basoescamoso con compromiso linfático. El caso de nuestro paciente muestra una presentación atípica por su localización y por la aparición 20 años antes de la media de edad reportada en la literatura. Esto podría ser explicado por la exposición crónica a arsénico, conocido factor de riesgo para carcinogénesis cutánea.