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1.
World J Surg ; 48(5): 1252-1260, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38488859

RESUMEN

BACKGROUND: There is limited data to guide decision-making between performing a primary anastomosis and fashioning an end colostomy following emergency sigmoid colectomy for patients with sigmoid volvulus. The aim of this study was to compare the outcomes of these two approaches. METHODS: The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database from 2006 to 2021 was retrospectively analyzed. Missing data were multiply imputed, and coarsened exact matching was performed to generate matched cohorts. Rates of major complications and other postoperative outcomes were evaluated among patients who had a primary anastomosis as compared with matched controls who had an end colostomy following emergency sigmoid colectomy. RESULTS: Overall, 4041 patients who had a primary anastomosis and 1240 who had an end colostomy met the inclusion criteria. After multiple imputation and coarsened exact matching, 895 patients who had a primary anastomosis had a matched control. The rate of major complications was lower in patients who had an end colostomy (33.2% vs. 36.7%), but this difference was not statistically significant (OR 0.86, 95% CI 0.70-1.05). Results were similar in subgroup analyses of higher-risk patients. There were no significant differences in overall complication rate, mortality, length of hospital stay, or readmission rate. Patients with a colostomy were more likely to be discharged to a care facility (OR 1.35, 95% CI 1.09-1.67). CONCLUSION: Differences in rates of major complications and many other outcomes after primary anastomosis as compared with end colostomy were not statistically significant following emergency sigmoid colectomy for sigmoid volvulus.


Asunto(s)
Anastomosis Quirúrgica , Colectomía , Colostomía , Vólvulo Intestinal , Complicaciones Posoperatorias , Mejoramiento de la Calidad , Enfermedades del Sigmoide , Humanos , Colectomía/métodos , Colectomía/efectos adversos , Vólvulo Intestinal/cirugía , Femenino , Masculino , Estudios Retrospectivos , Persona de Mediana Edad , Anciano , Colostomía/métodos , Anastomosis Quirúrgica/métodos , Complicaciones Posoperatorias/epidemiología , Enfermedades del Sigmoide/cirugía , Colon Sigmoide/cirugía , Estados Unidos , Urgencias Médicas
2.
BMJ Case Rep ; 17(3)2024 Mar 19.
Artículo en Inglés | MEDLINE | ID: mdl-38508606

RESUMEN

Drainage of subdiaphragmatic abscesses is difficult due to its anatomical location and it can result in adverse events, including organ damage and the spread of infection. In recent years, endoscopic ultrasonography (EUS) guided drainage for upper abdominal abscesses has become available. We report a case of successful infection control using this procedure for a subdiaphragmatic cyst secondary to perforation of the sigmoid colon after cytoreductive surgery for advanced ovarian cancer. A Japanese woman in her 60s underwent laparotomy for ovarian cancer, and then developed sigmoid colon perforation 6 days after surgery. The emergency reoperation was performed, and a cyst suspected to be an antibiotic-resistant fungal abscess appeared under the left diaphragm in the postoperative period. We adopted an EUS-guided route for diagnostic and therapeutic drainage method, which enabled shrinkage of the cyst and did not concur further adverse events. This procedure was effective as a minimally invasive drainage route for subdiaphragmatic cysts.


Asunto(s)
Quistes , Neoplasias de los Genitales Masculinos , Neoplasias Ováricas , Absceso Subfrénico , Masculino , Femenino , Humanos , Colon Sigmoide/cirugía , Procedimientos Quirúrgicos de Citorreducción , Drenaje/métodos , Endosonografía/métodos , Neoplasias Ováricas/complicaciones , Neoplasias Ováricas/cirugía
3.
Surg Endosc ; 38(4): 2160-2168, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38448626

RESUMEN

BACKGROUND: The landscape of robotic surgery is evolving with the emergence of new platforms. However, reports on their applicability in different surgical fields are still limited and come from teams with robotics experience. This study aims to describe the training process for colorectal surgery with the Hugo™ RAS system of a robotics-inexperienced surgical team and present the initial patient series. METHODS: The training process is depicted, and data from the first 10 consecutive patients operated on for colorectal conditions with the Hugo™ RAS system by a surgical team with no prior experience in robotic surgery were prospectively recorded and analysed. RESULTS: The team received intensive training in robotic surgery and specifically in the Hugo™ RAS system previously to the first case. Between May 2023 and December 2023, 10 patients underwent colorectal procedures: 5 right colectomies, 3 sigmoid resections, 1 high rectal resection and 1 ventral mesh rectopexy. The first case was proctored by an expert. Median docking time was 14 min and median total operative time was 185 min. The only technical difficulty during the procedures was occasional clashing of robotic arms. None had to be converted, and no intraoperative or postoperative morbidity was recorded. Hospital stays ranged from 2 to 4 days. A median of 21 lymph nodes were yielded in the operations for malignant conditions. CONCLUSIONS: Common colorectal procedures can be safely performed using the Hugo™ RAS platform. Prior experience in robotic surgery is not a necessary requirement, but following a structured training program is essential.


Asunto(s)
Neoplasias Colorrectales , Laparoscopía , Procedimientos Quirúrgicos Robotizados , Robótica , Humanos , Procedimientos Quirúrgicos Robotizados/métodos , Colectomía/métodos , Colon Sigmoide/cirugía , Neoplasias Colorrectales/cirugía
7.
Tech Coloproctol ; 28(1): 34, 2024 Feb 19.
Artículo en Inglés | MEDLINE | ID: mdl-38369674

RESUMEN

BACKGROUND: In the decision to perform elective surgery, it is of great interest to have data about the outcomes of surgery to individualize patients who could safely undergo sigmoid resection. The aim of this study was to provide information on the outcomes of elective sigmoid resection for sigmoid diverticular disease (SDD) at a national level. METHODS: All consecutive patients who had elective surgery for SDD (2010-2021) were included in this retrospective, multicenter, cohort study. Patients were identified from institutional review board-approved databases in French member centers of the French Surgical Association. The endpoints of the study were the early and the long-term postoperative outcomes and an evaluation of the risk factors for 90-day severe postoperative morbidity and a definitive stoma after an elective sigmoidectomy for SDD. RESULTS: In total, 4617 patients were included. The median [IQR] age was 61 [18.0;100] years, the mean ± SD body mass index (BMI) was 26.8 ± 4 kg/m2, and 2310 (50%) were men. The indications for surgery were complicated diverticulitis in 50% and smoldering diverticulitis in 47.4%. The procedures were performed laparoscopically for 88% and with an anastomosis for 83.8%. The severe complication rate on postoperative day 90 was 11.7%, with a risk of anastomotic leakage of 4.7%. The independent risk factors in multivariate analysis were an American Society of Anesthesiologists (ASA) score ≥ 3, an open approach, and perioperative blood transfusion. Age, perioperative blood transfusion, and Hartmann's procedure were the three independent risk factors for a permanent stoma. CONCLUSIONS: This series provides a real-life picture of elective sigmoidectomy for SDD at a national level. TRIAL REGISTRATION: Comité National Information et Liberté (CNIL) (n°920361).


Asunto(s)
Diverticulitis del Colon , Diverticulitis , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Estudios de Cohortes , Colon Sigmoide/cirugía , Diverticulitis/cirugía , Diverticulitis/complicaciones , Diverticulitis del Colon/cirugía , Diverticulitis del Colon/complicaciones , Complicaciones Posoperatorias/etiología , Estudios Retrospectivos , Factores de Riesgo , Resultado del Tratamiento , Adolescente , Adulto Joven , Adulto , Persona de Mediana Edad , Anciano
10.
Medicine (Baltimore) ; 103(3): e37001, 2024 Jan 19.
Artículo en Inglés | MEDLINE | ID: mdl-38241535

RESUMEN

RATIONALE: As the third most common cancer in women, cervical cancer usually spreads to adjacent organs. Distant metastasis from the cervix to the gastrointestinal tract is an extremely rare occurrence. PATIENT CONCERNS: Herein, we present a rare case of a 57-year-old woman who was treated by hysterectomy and bilateral salpingo-oophorectomy with pelvic lymphadenectomy for squamous cell carcinoma (SCC) of the uterine cervix. A metastatic location in the sigmoid colon was revealed after 8 years causing an acute intestinal obstruction in this patient. DIAGNOSES: Final surgical pathology showed an invasive lesion with squamous differentiation in full thickness of the colon wall from mucosa to serosa. Meanwhile, the results of immunohistochemistry (IHC) showed the cancer cells were positive for CK5/6, P63, P40, and P16 confirming the diagnosis of metastatic sigmoid colonic carcinoma originating from SCC of the uterine cervix. INTERVENTIONS: Sigmoid colon resection with lymph node dissection followed by adjuvant chemotherapy (paclitaxel, carboplatin, and paprillizumab) was performed on the patient. OUTCOMES: The patient was disease-free 16 months after surgery. LESSONS SUBSECTIONS: SCC is one of the rare malignant tumors of the gastrointestinal tract occurring as either a primary or secondary lesion. However, the secondary SCC of the colon has a poorer prognosis compared with the primary SCC. Therefore, colonic metastasis must be considered in the differential diagnosis of acute intestinal obstruction, especially in patients with the medical history of SCC in other organs.


Asunto(s)
Carcinoma de Células Escamosas , Obstrucción Intestinal , Neoplasias del Cuello Uterino , Humanos , Femenino , Persona de Mediana Edad , Cuello del Útero/patología , Neoplasias del Cuello Uterino/patología , Colon Sigmoide/cirugía , Colon Sigmoide/patología , Carcinoma de Células Escamosas/patología , Obstrucción Intestinal/etiología , Obstrucción Intestinal/cirugía
11.
BMJ Case Rep ; 17(1)2024 Jan 18.
Artículo en Inglés | MEDLINE | ID: mdl-38238160

RESUMEN

Compound volvulus, also known as ileosigmoid knot, is a rare cause of intestinal obstruction due to twisting of the small bowel around the large bowel or vice-versa. It poses a diagnostic dilemma due to the presence of features of closed-loop obstruction of both the small and large bowel. Being a surgical emergency due to the rapid progression to gangrene of involved segments leading to septicaemia, early suspicion of the disease entity, adequate resuscitation and prompt treatment are the need of the hour. Three cases encountered and managed in our setting are described here with a review of the literature.


Asunto(s)
Obstrucción Intestinal , Vólvulo Intestinal , Humanos , Colon Sigmoide/diagnóstico por imagen , Colon Sigmoide/cirugía , Gangrena/etiología , Obstrucción Intestinal/diagnóstico por imagen , Obstrucción Intestinal/etiología , Obstrucción Intestinal/cirugía , Vólvulo Intestinal/diagnóstico , Vólvulo Intestinal/diagnóstico por imagen , Intestino Delgado
12.
Am Surg ; 90(4): 866-874, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-37972411

RESUMEN

BACKGROUND: The role of neoadjuvant chemotherapy (NAC) in advanced sigmoid colon carcinoma remains to be further characterized. Rationale for NAC includes downstaging on final pathology and optimization of microscopically negative margins (R0 resection). We investigated rates of neoadjuvant chemotherapy use in advanced sigmoid colon cancer at academic cancer centers and assessed factors associated with likelihood of NAC administration. METHODS: The National Cancer Database was queried from 2004 to 2017 for patients with clinical T3 or T4, N0-2, M0 sigmoid colon cancer who underwent surgical resection. Those with neoadjuvant radiation or metastatic disease were excluded. The outcomes of patients who did and did not receive neoadjuvant chemotherapy were evaluated for this retrospective cohort study. RESULTS: There were 23,597 patients of whom 364 (1.5%) received NAC. More patients received NAC at academic (41%, P < .001) and high-volume centers (27%, P < .001). Patients with Medicare/Medicaid (39%) and private insurance (52%) were more likely to receive NAC (P < .001). There was a significantly higher rate of N2 to N1 downstaging in the NAC group. Propensity-score matching demonstrated comprehensive community cancer programs (CCCP) were less likely to provide NAC (OR 0.4; 95% CI 0.23, 0.70, P < .001). There was no difference in survival (P = .20), R0 resection (P = .090), or 30-day readmission rates (P = .30) in the NAC cohort compared to the non-NAC cohort. CONCLUSIONS: Access to centers offering multi-disciplinary care with NAC prior to surgical resection is important. This care was associated with academic and high-volume centers and private or government-sponsored insurance. There was no difference in survival between NAC and non-NAC cohort.


Asunto(s)
Terapia Neoadyuvante , Neoplasias del Colon Sigmoide , Humanos , Anciano , Estados Unidos/epidemiología , Colon Sigmoide/cirugía , Puntaje de Propensión , Neoplasias del Colon Sigmoide/tratamiento farmacológico , Neoplasias del Colon Sigmoide/cirugía , Estudios Retrospectivos , Estadificación de Neoplasias , Medicare
13.
Fertil Steril ; 121(1): 126-127, 2024 01.
Artículo en Inglés | MEDLINE | ID: mdl-37813274

RESUMEN

OBJECTIVE: To present the use of robotic-integrated ultrasound for performing a double discoid excision of multifocal rectosigmoid endometriosis. DESIGN: Video article. STATEMENT OF CONSENT: The patient included in this video gave consent for publication of the video and posting of the video online, including social media, journal website, scientific literature websites (such as PubMed, ScienceDirect, Scopus), and other applicable sites. PATIENT: A 26-year-old G0 woman with chronic pelvic pain, dyschezia, and dysmenorrhea refractory to medical management desired future fertility. Imaging was suggestive of deep infiltrating endometriosis involving the rectosigmoid colon. INTERVENTION: Not applicable. MAIN OUTCOME MEASURES: Double discoid excision of multifocal rectosigmoid endometriosis using robotic-integrated ultrasound. RESULTS: Not applicable. CONCLUSIONS: Performing a complete preoperative evaluation in patients with suspected endometriosis is important for determining the extent of disease and necessity of a multidisciplinary approach. Robotic-integrated ultrasound can provide additional information, including the size and depth of bowel endometriosis lesions, which can play a role in surgical decision making. Performing a double discoid excision of multifocal rectosigmoid endometriosis using robotic-integrated ultrasound is a technique that can avoid the need for a segmental bowel resection.


Asunto(s)
Endometriosis , Procedimientos Quirúrgicos Robotizados , Adulto , Femenino , Humanos , Colon Sigmoide/cirugía , Endometriosis/diagnóstico por imagen , Endometriosis/cirugía , Endometriosis/patología , Recto/diagnóstico por imagen , Recto/cirugía , Recto/patología
14.
Urol Pract ; 11(2): 439-446, 2024 03.
Artículo en Inglés | MEDLINE | ID: mdl-38154038

RESUMEN

INTRODUCTION: The bowel remains the favored tissue for neo-vaginoplasty (NeoVP) in pediatric patients with vaginal agenesis. In 2001, the first description of NeoVP using the Yang-Monti technique with a sigmoid double tubular flap was published. We present our experience of NeoVP with a single Yang-Monti tube (SYMT) flap and report on the use of different segments of colon. METHODS: We conducted a retrospective review of patients who underwent NeoVP using a bowel SYMT between 2009 and 2021. The procedure was performed under open abdominal surgery by isolating 8 to 12 cm from the rectosigmoid, cecum, or ascending colon. Subsequently, this segment was detubularized near the mesenteric border, folded, and retubularized transversally, leaving the mesentery in a cephalic position. A channel was dissected in the pelvis to accommodate the NeoVP. RESULTS: Seventeen patients were identified. The median age was 16 years old. The principal diagnosis was Mayer-Rokitansky's syndrome (47.1%). The median follow-up was 50 months. The mean harvested bowel length was 9 cm, and the sigmoid was the preferred site (65%). The cecum-ascending colon was used in 3 (17.6%) patients. Complications were recorded in 6 patients (35%). Of these 6 patients, 4 had introital stenosis. There was 1 case of urethrovaginal fistula and another of left hematometrocolpos. Satisfactory sexual function has been reported in sexually active individuals. CONCLUSIONS: We described our experience in NeoVP using a large bowel SYMT as a safe and effective technique. It allows decreased tension on the vascular pedicle and the use of shorter colon segments.


Asunto(s)
Procedimientos de Cirugía Plástica , Adolescente , Niño , Femenino , Humanos , Colon/cirugía , Colon Sigmoide/cirugía , Colgajos Quirúrgicos/cirugía , Vagina/cirugía , Estudios Retrospectivos
16.
Int J Colorectal Dis ; 38(1): 276, 2023 Dec 02.
Artículo en Inglés | MEDLINE | ID: mdl-38040936

RESUMEN

OBJECTIVE: To analyze the surgical management of sigmoid diverticular disease (SDD) before, during, and after the first containment rules (CR) for the first wave of COVID-19. METHODS: From the French Surgical Association multicenter series, this study included all patients operated on between January 2018 and September 2021. Three groups were compared: A (before CR period: 01/01/18-03/16/20), B (CR period: 03/17/20-05/03/20), and C (post CR period: 05/04/20-09/30/21). RESULTS: A total of 1965 patients (A n = 1517, B n = 52, C n = 396) were included. The A group had significantly more previous SDD compared to the two other groups (p = 0.007), especially complicated (p = 0.0004). The rate of peritonitis was significantly higher in the B (46.1%) and C (38.4%) groups compared to the A group (31.7%) (p = 0.034 and p = 0.014). As regards surgical treatment, Hartmann's procedure was more often performed in the B group (44.2%, vs A 25.5% and C 26.8%, p = 0.01). Mortality at 90 days was significantly higher in the B group (9.6%, vs A 4% and C 6.3%, p = 0.034). This difference was also significant between the A and B groups (p = 0.048), as well as between the A and C groups (p = 0.05). There was no significant difference between the three groups in terms of postoperative morbidity. CONCLUSION: This study shows that the management of SDD was impacted by COVID-19 at CR, but also after and until September 2021, both on the initial clinical presentation and on postoperative mortality.


Asunto(s)
COVID-19 , Diverticulitis del Colon , Divertículo , Humanos , Anastomosis Quirúrgica/métodos , Colon Sigmoide/cirugía , Colostomía/métodos , Diverticulitis del Colon/cirugía , Diverticulitis del Colon/complicaciones , Divertículo/complicaciones , Complicaciones Posoperatorias , Recto/cirugía , Estudios Retrospectivos
17.
Cir Cir ; 91(6): 839-843, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-38096878

RESUMEN

Large bowel obstruction is caused by colorectal cancer, diverticular disease or volvulus. The latter is caused by rotation of the intestinal loop on its own mesenteric axis, and occurs in the sigmoid colon (80%) and in the cecum (15-20%) Its management includes devolution by colonoscopy or surgery. Malignant bowel obstruction is the initial presentation in 7-29% of colorectal cancer, and its optimal treatment is controversial. We describe a clinical case of a double obstructive lesion and its surgical approach, an unusual presentation that poses a diagnostic and medical-surgical management challenge.


La obstrucción del intestino grueso es causada por cáncer colorrectal, enfermedad diverticular o vólvulo. Este último, por la rotación del asa intestinal sobre su propio eje mesentérico, y se da en el colon sigmoide (80%) y en el ciego (15-20%). Su manejo incluye devolvulación por colonoscopia o quirúrgica. La obstrucción intestinal maligna es la presentación inicial en el 7-29% del cáncer colorrectal, y su tratamiento óptimo es controvertido. Describimos un caso clínico de una doble lesión obstructiva y su abordaje quirúrgico; una presentación inusual que conlleva un reto diagnóstico y de manejo médico quirúrgico.


Asunto(s)
Adenocarcinoma , Neoplasias del Colon , Obstrucción Intestinal , Vólvulo Intestinal , Humanos , Vólvulo Intestinal/complicaciones , Vólvulo Intestinal/cirugía , Adenocarcinoma/complicaciones , Adenocarcinoma/cirugía , Neoplasias del Colon/complicaciones , Neoplasias del Colon/cirugía , Obstrucción Intestinal/etiología , Obstrucción Intestinal/cirugía , Colon Sigmoide/cirugía
18.
BMJ Case Rep ; 16(12)2023 Dec 20.
Artículo en Inglés | MEDLINE | ID: mdl-38123322

RESUMEN

Adult ileocecal intussusception due to non-specific inflammation is a rare condition. Intussusception is the intestinal segment telescoping into the adjacent intestinal lumen. Typically, a pathological lesion is discovered with a high percentage of malignancy. Intussusception of the most common ileocolic kind includes the appendix, but it is uncommon for an appendix to serve as the lead point. The patient was admitted to the emergency department with a complaint of acute intestinal obstruction. After getting a diagnostic workup, an exploratory laparotomy was done, and the ileocecal and ascending colon segment was intussuscepted directly into the sigmoid colon. Transverse and descending colon were normal, and resection of necrosed intussuscepted bowel, primary repair of sigmoid colon with ileostomy with transverse colon as distal mucus fistula done, after the 3-month restoration of bowel continuity done, patient discharged and doing well. After the diagnosis of intussusception, the best surgical choice is in the hands of an experienced surgeon.


Asunto(s)
Obstrucción Intestinal , Intususcepción , Adulto , Humanos , Intususcepción/diagnóstico por imagen , Intususcepción/etiología , Colon Sigmoide/diagnóstico por imagen , Colon Sigmoide/cirugía , Obstrucción Intestinal/cirugía , Inflamación
19.
Updates Surg ; 75(8): 2395-2401, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37840105

RESUMEN

Increasing evidence based on the safety and benefits of robot-assisted surgery indicates the disadvantage of the lack of tactile feedback. A lack of tactile feedback increases the risk of intraoperative complications, prolongs operative times, and delays the learning curve. A 40-year-old female patient presented to our hospital with a positive fecal occult blood test. A colonoscopy revealed type 2 advanced cancer of the sigmoid colon, and histological examination showed a well-differentiated adenocarcinoma. Furthermore, abdominal contrast-enhanced computed tomography revealed a tumor in the sigmoid colon and several swollen lymph nodes in the colonic mesentery without distant metastases. The patient was diagnosed with cStage IIIb (cT3N1bM0) sigmoid cancer and underwent sigmoidectomy using the Saroa Surgical System, which was developed by RIVERFIELD, a venture company at the Tokyo Medical and Dental University, and the Tokyo Institute of Technology. Based on adequate simulation, surgery was safely performed with appropriate port placement and arm base-angle adjustment. The operating time was 176 min, with a console time of 116 min and 0 ml blood loss. The patient was discharged 6 days postoperatively without complications. The pathological diagnosis was adenocarcinoma, tub1, tub2, pT2N1bM0, and pStage IIIa. Herein, we report the world's first surgery for sigmoid cancer using the Saroa Surgical System with tactile feedback in which a safe and appropriate oncological surgery was performed.


Asunto(s)
Adenocarcinoma , Neoplasias del Colon Sigmoide , Femenino , Humanos , Adulto , Neoplasias del Colon Sigmoide/cirugía , Neoplasias del Colon Sigmoide/complicaciones , Neoplasias del Colon Sigmoide/patología , Colon Sigmoide/cirugía , Retroalimentación , Colonoscopía , Adenocarcinoma/patología
20.
Asian J Surg ; 46(10): 4330-4336, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37803809

RESUMEN

INTRODUCTION: There is no standard treatment strategy for rectosigmoid cancer because of the diverse definitions of the proximal rectal origin. This study aimed to evaluate sigmoid take-off compared with other landmarks of the rectosigmoid junction in guiding oncological therapy and outcomes. MATERIALS AND METHODS: This retrospective, comparative cohort study included patients diagnosed with rectosigmoid carcinoma at our centre between January 2010 and December 2018. The patients were classified into the neoadjuvant treatment group and upfront surgery group. The oncological outcomes were compared between the two groups in relation to the tumor position. RESULTS: A total of 656 patients (median age 64 years) were included. After propensity score matching, the 3- and 5-year overall survival and disease-free survival in patients in both the groups were comparable. However, when only patients with rectal cancer as defined by the sigmoid take-off point were included, the disease-free survival rate in the upfront surgery group was significantly lower than that in the neoadjuvant treatment group (p = 0.03 in patients who underwent computed tomography, p = 0.03 in patients who underwent magnetic resonance imaging). The turning point of the beneficial hazard ratio of neoadjuvant therapy was compared according to the different definitions of the rectosigmoid junction and the sigmoid take-off was found to be the most effective. CONCLUSION: The sigmoid take-off point is a suitable landmark for identifying the rectosigmoid junction and is an important defining criterion for assessing the benefit of neoadjuvant therapy. The application of this definition in clinical practice and future trials is warranted.


Asunto(s)
Neoplasias del Recto , Neoplasias del Colon Sigmoide , Humanos , Persona de Mediana Edad , Terapia Neoadyuvante/métodos , Estudios Retrospectivos , Estudios de Cohortes , Colon Sigmoide/cirugía , Neoplasias del Recto/cirugía , Neoplasias del Colon Sigmoide/patología , Estadificación de Neoplasias
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