Does the Use of Sanders Staging and Distal Radius and Ulna Classification Avoid Mismatches in Growth Assessment with Risser Staging Alone?

BACKGROUND: Although Risser stages are visible on the same radiograph of the spine, Risser staging is criticized for its insensitivity in estimating the remaining growth potential and its weak correlation with curve progression in patients with adolescent idiopathic scoliosis. Risser staging is frequently accompanied by other skeletal maturity indices to increase its precision for assessing pubertal growth. However, it remains unknown whether there is any discrepancy between various maturity parameters and the extent of this discrepancy when these indices are used concurrently to assess pubertal growth landmarks, which are important for the timing of brace initiation and weaning. QUESTIONS/PURPOSES: (1) What is the chronologic order of skeletal maturity grades based on the growth rate and curve progression rate in patients with adolescent idiopathic scoliosis? (2) What are the discrepancies among the grades of each maturity index for indicating the peak growth and start of the growth plateau, and how do these indices correspond to each other? (3) What is the effectiveness of Risser staging, Sanders staging, and the distal radius and ulna classification in assessing peak growth and the beginning of the growth plateau? METHODS: Between 2014 and 2017, a total of 13,536 patients diagnosed with adolescent idiopathic scoliosis were treated at our tertiary clinic. Of those, 3864 patients with a radiograph of the left hand and wrist and a posteroanterior radiograph of the spine at the same visits including initial presentation were considered potentially eligible for this study. Minimum follow-up was defined as 6 months from the first visit, and the follow-up duration was defined as 2 years since initial consultation. In all, 48% (1867 of 3864) of patients were eligible, of which 26% (485 of 1867) were excluded because they were prescribed bracing at the first consultation. These patients visited the subsequent clinics wearing the brace, which might have affected body height measurement. Six percent (117 of 1867) of eligible patients were also excluded as their major coronal Cobb angle reached the surgical threshold of 50° and had undergone surgery before skeletal maturity. Another 21% (387 of 1867) of patients were lost before minimum follow-up or had incomplete data, leaving 47% (878) for analysis. These 878 patients with 1139 skeletal maturity assessments were studied; 74% (648 of 878) were girls. Standing body height was measured in a standardized manner by a wall-mounted stadiometer. Several surgeons measured curve magnitude as per routine clinical consultation, skeletal maturity was measured according to the distal radius and ulna classification, and two raters measured Risser and Sanders stages. Reliability tests were performed with satisfaction. Data were collected for the included patients at multiple points when skeletal maturity was assessed, and only up to when brace wear started for those who eventually had bracing. The growth rate and curve progression rate were calculated by the change of body height and major coronal Cobb angle over the number of months elapsed between the initial visit and next follow-up. At each skeletal maturity grading, we examined the growth rate (in centimeters per month) and curve progression rate (in degrees per month) since the skeletal maturity assessment, as well as the mean age at which this maturity grading occurred. Each patient was then individually assessed for whether he or she was experiencing peak growth and the beginning of growth plateau at each timepoint by comparing the calculated growth rate with the previously defined peak growth rate of ≥ 0.7 cm per month and the beginning of growth plateau rate of ≤ 0.15 cm per month in this adolescent idiopathic scoliosis population. Among the timepoints at which the peak growth and the beginning of growth plateau occurred, the median maturity grade of each maturity index was identified as the benchmark grade for comparison between indices. We used the McNemar test to investigate whether pubertal growth landmarks were identified by specific maturity grades concurrently. We assessed the effectiveness of these skeletal maturity indices by the difference in proportions (%) between two benchmark grades in indicating peak growth and the growth plateau. RESULTS: For girls, the chronological order of maturity grades that indicated peak growth was the radius grade, ulna grade, Sanders stage, and Risser stage. Curve progression peaked between the age of 11.6 and 12.1 years at a similar timing by all maturity indices for girls but was inconsistent for boys. For both sexes, radius (R) grade 6, ulna (U) grade 5, Sanders stage (SS) 3, and Risser stage 0+ were the median grades for peak growth, whereas Risser stage 4, R8/9, U7/8, and SS6/7 indicated the beginning of the growth plateau. The largest discrepancy between maturity indices was represented by Risser stage 0+, which corresponded to six grades of the Sanders staging system (SS2 to SS7) and to R6 in only 41% (62 of 152) of girls in the whole cohort. Despite Risser stage 0+ corresponding to the wide range of Sanders and distal radius and ulna grades, none of the R6, U5, SS3, and Risser stage 0+ was found more effective than another grade in indicating the peak growth in girls. R6 most effectively indicated the peak growth in boys, and Risser stage 0+ was the least effective. For the beginning of the growth plateau in girls, SS6/7 was the most effective indicator, followed by U7/8. Risser stage 4 was the least effective because it indicated 29% (95% CI 21% to 36%; p < 0.001) fewer patients who reached the beginning of the growth plateau than did those with R8/9. Risser stage 4 also indicated 36% (95% CI 28% to 43%; p < 0.001) fewer patients who reached the beginning of the growth plateau than those indicated by U7/8, and it identified 39% fewer patients than SS6/7 (95% CI 32% to 47%; p < 0.001). For boys, similarly, R8/9, U7/8, and SS6/7 were all more effective than Risser stage 4 in identifying when the growth plateau began. CONCLUSION: Risser stage 0+ corresponds to a wide range of Sanders and distal radius and ulna grades. Risser stage 0+ is least effective in indicating the peak growth in boys, and Risser stage 4 is the least effective maturity grade for indicating when the growth plateau starts in both sexes. The concurrent use of R6 and SS3 can be useful for detecting the peak growth, and SS6/7 in conjunction with U7/8 is most effective in indicating the beginning of the growth plateau. Using a combination of specific grades of Sanders staging and the distal radius and ulna classification can indicate pubertal growth landmarks with reduced risk of underestimating or overestimating skeletal maturity. These findings may aid in refining clinical decision-making of brace initiation and weaning at a more precise timing. Among Risser stage 0, the appearance of R6, U5, and SS3 provide the most effective assessment of peak growth that can indicate the most effective bracing period within which curve progression occurs. For initiation of the growth plateau, Risser 4 is not useful, and SS6/7, R8/9 and U7/8 should be used instead. LEVEL OF EVIDENCE: Level III, diagnostic study.

Influence of chronological age in the selection of players into the national basketball teams? / Influencia de la edad cronológica en la selección de jugadores y jugadoras en los equipos nacionales de baloncesto

The Relative Age Effect (RAE) is 'the difference in age and maturity, among people who have been grouped under the same age, for a specific purpose or function' (Lorenzo and Calleja, 2010). The aim of this study is to analyse the presence of the effect in the Spanish National Basketball Teams from U-16 category to the senior teams (n = 110), who competed over summer 2013. The study will address the possible relationship to gender and playing position. This analysis will show the variations in the percentage of births throughout the year calendar. A descriptive study set whose variables include month of birth, gender (male or female), category (U16, U18, U19, U20, Senior) and playing position (inside or outside player). Significant differences in the distribution of births grouped by periods (p = .46 χ2 (4) = 9.6) were found. In men’s youth teams there is a significant difference in the number of players who are selected from the first and second semester depending on whether they are inside or outside players (χ2 (1) = 5.42; p = .20, V = .34). Likewise, in women’s youth teams there is also a significant difference (χ2 (1) = 9.24; p = .002, V = .49). In conclusion, the effect is present through the Spanish basketball teams, especially at non-senior levels. It begins at the first competitive age and disappears into the senior teams. Furthermore, youth categories are specifically affected according to the position of play. It seems necessary to revise the models of organizing competitions trying to achieve other more balanced and less exclusive. Also rethinking selection and detection of talent methods of male and female players in the Spanish basketball

El Efecto de la Edad Relativa (RAE) es 'la diferencia, en edad y maduración, entre personas que han sido agrupadas bajo la misma categoría de edad, para un propósito concreto o función' (Lorenzo y Calleja, 2010). Se pretende analizar la presencia de dicho efecto en las selecciones españolas de baloncesto, desde la U-16 hasta la selección absoluta (n = 110), que competirán a lo largo del verano de 2013. Se atenderá a las posibles relaciones con el género y la posición de juego. Dicho análisis mostrará las variaciones en el porcentaje del número de nacimientos a lo largo del año natural. Se planteó un estudio descriptivo cuyas variables son: mes de nacimiento, género (masculino o femenino),categoría (U16, U18, U19, U20, Sénior) y posición de juego (interior o exterior). Se encontraron diferencias significativas en la distribución de nacimientos agrupados por semestres (χ2 (4) = 9.6; p = .46) En categorías inferiores masculinas existe una diferencia significativa en el número de jugadores que son seleccionados del primer y segundo semestre en función de si son interiores o exteriores (χ2 (1) = 5.42; p = .20, V = .34). Así mismo, en las categorías inferiores femeninas también existe una diferencia significativa (χ2 (1) = 9.24; p = .002, V = .49). En conclusión, el efecto se encuentra presente en las selecciones españolas de baloncesto, principalmente en categorías inferiores. Se inicia en las primeras edades competitivas y desaparece en la selección absoluta. Además, en categorías de formación, incide de forma específica según la posición de juego. Parece necesario revisar los modelos de organización de las competiciones tratando de alcanzar otros más equilibrados y menos excluyentes. Replanteando también los métodos de selección y detección de jugadores y jugadoras dentro del baloncesto español

On the segmentation and classification of hand radiographs.

This research is part of a wider project to build predictive models of bone age using hand radiograph images. We examine ways of finding the outline of a hand from an X-ray as the first stage in segmenting the image into constituent bones. We assess a variety of algorithms including contouring, which has not previously been used in this context. We introduce a novel ensemble algorithm for combining outlines using two voting schemes, a likelihood ratio test and dynamic time warping (DTW). Our goal is to minimize the human intervention required, hence we investigate alternative ways of training a classifier to determine whether an outline is in fact correct or not. We evaluate outlining and classification on a set of 1370 images. We conclude that ensembling with DTW improves performance of all outlining algorithms, that the contouring algorithm used with the DTW ensemble performs the best of those assessed, and that the most effective classifier of hand outlines assessed is a random forest applied to outlines transformed into principal components.

Histomorphometric estimation of age in paraffin-embedded ribs: a feasibility study.

Estimation of age at death from human bones in legal medicine or in anthropology and archaeology is hampered by controversial results from the various macroscopic and histological techniques. This study attempted an estimation of age at death by histomorphometric analysis, from the fourth left rib adjacent to the costochondral joint in 80 forensic cases. Use of the picrosirius dye provided a reliable staining of the decalcified paraffin-embedded ribs. The total bone cortical area, the major and minor diameter as well as the area of the Haversian canals, the osteon areas of intact and remodelled secondary osteons, the area of non-Haversian canals were evaluated by means of image analysis, and derived parameters were calculated on both the internal and external sides of the rib. Most of the variables exhibited consistency between three different observers. Noteworthy, morphometric measurements in the internal cortex of the rib showed less variability than in the external cortex. Finally, discriminant statistical analysis from the 80 cases in this study indicated that the osteon population density was virtually sufficient to significantly discriminate between three groups of age: 20-39 (adulthood), 40-59 (middle age) and a group superior to 60. A subsequent blind evaluation of ten new subjects satisfactorily classified seven subjects out of ten within the three age groups. These results make feasible a larger study aimed at characterization of the practical relationships between bone tissue histomorphometry in ribs and chronological age in forensic cases.

The longitudinal sagittal growth changes of maxilla and mandible according to quantitative cervical vertebral maturation.

To investigate the longitudinal sagittal growth changes of maxilla and mandible according to the quantitative cervical vertebral maturation (QCVM) for adolescents with normal occlusion, mixed longitudinal data were used. The samples included 87 adolescents aged from 8 to 18 y old with normal occlusion (32 males, 55 females) selected from 901 candidates. Sequential lateral cephalograms and hand-wrist films were taken once a year, lasting for 6 y. The longitudinal sagittal growth changes of maxilla and mandible according to QCVM were measured. There were some significant differences between maxilla and mandible according to QCVM. The sagittal growth change of maxilla showed a trend towards high velocity-->decelerating velocity-->completing velocity from QCVM stage I to stage IV. The sagittal growth change of mandible showed a trend towards accelerating velocity-->high velocity-->decelerating velocity-->completing velocity from QCVM stage I to stage IV. With sagittal relationship, growth magnitude was almost the same between maxilla and mandible at QCVM stage I. At stage II the growth of mandible exceeded that of maxilla and growth in mandible continued at stages III and IV, while the maxilla ceased to grow. Growth magnitude was greater and the growth duration was longer with male mandible. It is concluded that the longitudinal sagittal growth changes of maxilla and mandible on the basis of QCVM is of value in the orthodontic practice.

Quantitative cervical vertebral maturation assessment in adolescents with normal occlusion: a mixed longitudinal study.

INTRODUCTION: The purpose of this study was to establish a quantitative cervical vertebral maturation (CVM) system for adolescents with normal occlusion. METHODS: Mixed longitudinal data were used. The subjects included 87 children and adolescents from 8 to 18 years old with normal occlusion (32 boys, 55 girls) selected from 901 candidates. Sequential lateral cephalograms and hand-wrist films were taken once a year for 6 years. The lateral cephalograms of all subjects were divided into 11 maturation groups according to the Fishman skeletal maturity indicators. The morphologic characteristics of the second, third, and fourth cervical vertebrae at 11 developmental stages were measured and analyzed. RESULTS: Three characteristic parameters (H4/W4, AH3/PH3, @2) were selected to determine the classification of CVM. With 3 morphologic variables, the quantitative CVM system including 4 maturational stages was established. An equation that can accurately estimate the maturation of the cervical vertebrae was established: CVM stage=-4.13+3.57xH4/W4+4.07xAH3/PH3+0.03x@2. CONCLUSIONS: The quantitative CVM method is an efficient, objective, and relatively simple approach to assess the level of skeletal maturation during adolescence.

Índice de la cavidad coronal pulpar: una herramienta forense para la determinación de la edad en humanos adultos / The Coronal Pulp Cavity Index: A Forensic Tool for Age Determination in Human Adults

La correlación entre la reducción de la cavidadcoronal pulpar y la edad cronológica ha sido estudiada enuna muestra de 846 dientes intactos procedentes de 433individuos de sexo y edad conocidos. La radiografía panorámicaha sido utilizada para medir el largo (mm) de lacorona (CL=coronal length) y el largo (mm) de la cavidadcoronal pulpar. El índice dentario “Tooth coronal index”(TCI) según Ikeda et al. (1985) ha sido calculado por cadadiente para determinar la edad real del individuo con elmétodo de la regresión. Los coeficientes de regresiónvarían de -0.92 (molares, muestra total, lado derecho) a-0.87 (molares femeninos) con un S. E. de estimación de5.88 a 6.66 años. Las correlaciones son más altas en losvarones respecto a las mujeres. Las ecuaciones obtenidaslograron estimar la edad en una muestra de 100 dientes(no utilizados en la regresión) con un error de ± 5 añosen el 81.4% de los casos por los molares masculinos. Elestudio ilustra el valor potencial de un método que puedeser utilizado para estimar la edad en individuos vivos ymaterial esquelético de edad desconocida(AU)

The correlation between the reduction of thecoronal pulp cavity and the chronological age wasexamined in a sample of 846 intact teeth from 433individuals of known age and sex. Panoramic (rotational)radiography was used to measure the length (mm) of thetooth crown (CL=coronal length) and the length (mm) ofthe coronal pulp cavity (CPCL=coronal pulp cavity length).The tooth-coronal index (TCI) after Ikeda et al. (1985) wascomputed for each tooth and regressed on the real age ofthe sample. The correlation coefficients ranged from -0.92(molars, combined sample, right side) to -0.87 (femalemolars), with a S.E. of the estimate ranging from 5.88 to6.66 years. Correlations were slightly higher in males thanfemales. The obtained equations allowed estimation of agein a sample of 100 teeth of both sexes (not used for theregression) with an error of ± 5 years in 81.4% of casesfor the male molars. This study shows the potential valueof a little-known aging method, which can be easily used toestimate age both in living individuals and skeletal materialof unknown age in a forensic context(AU)