RESUMEN
BACKGROUND: Human dichlorophen poisoning is rare. We aim to report a case of dichlorophen poisoning resulting in complete recovery despite life-threatening multiorgan failure and huge serum dichlorophen concentrations. METHODS: Description of features and management in one dichlorophen-poisoned patient. After liquid-liquid extraction, dichlorophen concentrations in the urine and the serum were measured using liquid chromatography-heated electrospray ionization-tandem mass spectrometry (LC-HESI-MS/MS). CASE REPORT: A 74-year-old female self-ingested an anti-moss dichlorophen solution (360 g/L) in a suicidal attempt. She rapidly developed caustic esophageal and gastric mucosal injuries, confusion, profuse diarrhea, and electrolyte disturbances. Initial elevation in serum aminotransferase and γ-glutamyltransferase concentrations resolved over 6 days. Serum dichlorophen concentration measured was 708.1 µg/L on admission, and its elimination was prolonged (serum apparent elimination half-life: 35.5 h), peaking in urine on day 2. Mild elevation in serum creatine phosphokinase concentration (peaking 48 h post-ingestion) and acute renal failure (requiring hemodialysis on day 8) occurred. The final outcome was favorable with supportive management. CONCLUSION: Dichlorophen ingestion results in life-threatening multiorgan dysfunction including rapid onset of caustic digestive lesions, diarrhea, liver enzyme disturbances, as well as acute kidney injury and rhabdomyolysis. Recovery can be complete if prompt supportive management is provided.
Asunto(s)
Diclorofeno/envenenamiento , Anciano , Cromatografía Liquida , Diclorofeno/sangre , Diclorofeno/farmacocinética , Diclorofeno/orina , Sobredosis de Droga/terapia , Femenino , Humanos , Espectrometría de Masa por Ionización de ElectrosprayRESUMEN
A case is presented involving an acute fatality resulting from self-administered dichlorophen, a chlorophenol fungicide. The compound was quantified using gas chromatography/mass spectrometry after extraction with methyl-tert-butyl ether, derivatization by methylation and separation on a HP5-MS capillary column. The blood concentration was 9.77 mg/l and other drugs, including ethanol, were not detected.
