RESUMEN
N,N-Dimethylformamide (DMF) is a well-documented occupational hazardous material, which can induce occupational liver injury. The current study was designed to investigate whether ethanol consumption can affect DMF-induced hepatotoxicity and the potential underlying mechanisms involved. We found that a single dose of ethanol (1.25, 2.5, or 5â¯g/kg bw by gavage) significantly repressed the increase in serum alanine transaminase (ALT) and aspartate transaminase (AST) activities and alleviated the liver histopathological changes in mice challenged with 3â¯g/kg DMF. In contrast, long-term moderate drinking (2.5â¯g/kg bw) significantly aggravated the repeated DMF (0.7â¯g/kg bw) exposure-induced increase in the serum ALT and AST activities. Mechanistically, acute ethanol consumption suppressed DMF-induced activation of the NLR family pyrin domain-containing protein 3 (NLRP3) inflammasome, while long-term moderate ethanol consumption promoted hepatocyte apoptosis in the mouse liver. Notably, cytochrome P4502E1 (CYP2E1) protein level and activity in mouse livers were not significantly affected by ethanol per se in the two models. These results confirm that regular drinking can increase the risk of DMF-induced hepatotoxicity, and suggest that DMF-handling workers should avoid consuming ethanol to reduce the risk of DMF-indued liver injury.
Asunto(s)
Consumo de Bebidas Alcohólicas , Enfermedad Hepática Inducida por Sustancias y Drogas , Citocromo P-450 CYP2E1 , Dimetilformamida , Etanol , Hígado , Animales , Dimetilformamida/toxicidad , Etanol/toxicidad , Enfermedad Hepática Inducida por Sustancias y Drogas/patología , Enfermedad Hepática Inducida por Sustancias y Drogas/etiología , Enfermedad Hepática Inducida por Sustancias y Drogas/metabolismo , Ratones , Masculino , Citocromo P-450 CYP2E1/metabolismo , Hígado/efectos de los fármacos , Hígado/patología , Hígado/metabolismo , Consumo de Bebidas Alcohólicas/efectos adversos , Apoptosis/efectos de los fármacos , Alanina Transaminasa/sangre , Aspartato Aminotransferasas/sangre , Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo , Hepatocitos/efectos de los fármacos , Hepatocitos/patología , Relación Dosis-Respuesta a Droga , Inflamasomas/metabolismo , Inflamasomas/efectos de los fármacos , Ratones Endogámicos C57BLRESUMEN
Occupational diseases may be defined only medically or scientifically, and even then, their definition is not simple. However, compensable occupational diseases involve the additional layer of legal systems and social welfare policies as well. Their multifaceted nature makes determining the work-relatedness of these diseases more complex. Korea has established standards for the recognition of occupational diseases in Schedule 5 of the Enforcement Decree of the Labor Standards Act, and specific criteria for the recognition of occupational diseases are listed in Schedule 3 of the Enforcement Decree of the Industrial Accident Compensation Insurance Act. The new list of compensable occupational diseases comprises 13 articles as an open-ended system. The newly added articles pertain to lymphohematopoietic (Article 5) and infectious diseases (Article 9), as well as diseases of other target organs. Furthermore, the article on liver diseases (Article 8) has been partially revised. The new act has been changed to clarify the meaning as it has been presented in recent research. It is necessary to achieve agreement among concerned parties, including experts from the legal, medical, and social domains to resolve the issues of work-relatedness, causation, notion of aggravation, and so on for preparing a list and a process that are more reasonable.
Asunto(s)
Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Benceno/toxicidad , Enfermedades Transmisibles/economía , Dimetilformamida/toxicidad , Enfermedad Hepática Inducida por Sustancias y Drogas/economía , Enfermedades Hematológicas/inducido químicamente , Plomo/toxicidad , Hepatopatías/economía , Enfermedades Profesionales/economía , República de Corea , Tricloroetileno/toxicidad , Cloruro de Vinilo/toxicidad , Indemnización para Trabajadores/economíaRESUMEN
A dimetilformamida é uma substância amplamente utilizada nos dias atuais, apresentando um amplo espectro de aplicações na indústria moderna. Este estudo busca abordar seus efeitos toxicofarmacológicos especificamente sobre o fígado, sua relação com os riscos ocupacionais, as medidas de proteção à saude do trabalhador e as opções terapêuticas atuais.
Asunto(s)
Humanos , Dimetilformamida/farmacología , Dimetilformamida/toxicidad , Hígado/patología , Hepatopatías , Enfermedades Profesionales , Salud Laboral , Medicina del TrabajoRESUMEN
Aborda as características toxicológicas da N,N-dimetilformamida na avaliaçäo da exposiçäo ocupacional