RESUMEN
BACKGROUND: Prenatal exposure to cocaine has been associated with a wide spectrum of structural abnormalities in infant brains. The growing use of crack, a smokable and extremely addictive form of cocaine, could exacerbate the situation. OBJECTIVE: The purpose of this study was to determine the frequency, type and severity of cerebral lesions detected by transfontanellar US in newborns exposed to crack during gestation. MATERIALS AND METHODS: This was a retrospective study, involving a review of the medical records of children who were born to crack-using women and who were subjected to transfontanellar US imaging during their first days of life. RESULTS: Transfontanellar US revealed abnormalities in 45/129 newborns examined (34.9%). The changes detected were subependymal cysts in 24 infants (18.6%), lenticulostriate vasculopathy in 18 infants (14%), subependymal hemorrhage in 9 infants (7%), and choroid plexus cysts in 9 infants (7%). CONCLUSION: All of the abnormalities found by US examination were discrete and likely without clinical significance for the babies. However, prospective studies with a long period of tracking are needed to determine whether there are later consequences on the neurodevelopment of children with prenatal exposure to crack.
Asunto(s)
Encefalopatías/inducido químicamente , Encefalopatías/diagnóstico por imagen , Cocaína Crack/envenenamiento , Intercambio Materno-Fetal , Efectos Tardíos de la Exposición Prenatal/inducido químicamente , Efectos Tardíos de la Exposición Prenatal/diagnóstico , Ultrasonografía Prenatal/métodos , Encefalopatías/embriología , Femenino , Humanos , Masculino , Embarazo , Estudios RetrospectivosAsunto(s)
Humanos , Cerebro/anomalías , Líquido Cefalorraquídeo , Plexo Coroideo , Encefalopatías/clasificación , Encefalopatías/congénito , Encefalopatías/diagnóstico , Encefalopatías/embriología , Encefalopatías/genética , Encefalopatías , Holoprosencefalia , Hidranencefalia , Hidrocefalia , Síndrome de Dandy-Walker/diagnóstico , Cuerpo Calloso , Diagnóstico Diferencial , Malformación de Arnold-Chiari/diagnóstico , UltrasonografíaRESUMEN
Xanthomas of the choroid plexus are rare lesions of the central nervous system. The scarcity of reported cases probably accounts for the little information available about their origin, growth and spread. In the present article, we report the case of a 17 week old fetus with a xanthoma of the choroid plexus. The tumor extended from the trigone of the right lateral ventricle into the inter-hemispheric fissure, a defect at the junction of the splenium with the cerebral hemisphere. The size of the xanthoma suggested a time to double-size of a few days and an inception in the second month of gestation. The case illustrates the potential rapid growth of these tumors during gestation and a route for their spread outside of the ventricles.
Asunto(s)
Plexo Coroideo , Enfermedades Fetales/patología , Xantomatosis/patología , Encefalopatías/embriología , Encefalopatías/patología , Femenino , Humanos , Embarazo , Xantomatosis/embriologíaRESUMEN
Los xantomas del plexo coroideo son lesiones de escasa incidencia dentro del sistema nervioso central. La escasez de casos reportados es posiblemente responsable de la poca información que existe al presente sobre el origen y crescimiento de estos tumores. En este artículo reportamos el caso de un feto (17 semanas de gestación con un xantomas del plexo coroideo. El tumor se extendía desde el trigono del ventículo en la unión del splenio con el hemisferio del cerebro. El tamaño del xantoma sugería un tiempo de replicación de varios días y un origen durante el segundo mes de gestación. El caso ilustra que durante el períod de gestación estos tumores pueden aduqirir un crecimiento rápido y además sugiere una ruta para la extensión de tumores intraventriculares hacia la fisura interhemisférica