Asunto(s)
Andrología/normas , Suplementos Dietéticos , Enfermedades de los Genitales Masculinos/dietoterapia , Infertilidad Masculina/dietoterapia , Medicina Reproductiva/normas , Disfunciones Sexuales Fisiológicas/dietoterapia , Andrología/organización & administración , Suplementos Dietéticos/normas , Práctica Clínica Basada en la Evidencia/normas , Humanos , Italia , Masculino , Enfermedades de la Próstata/dietoterapia , Medicina Reproductiva/organización & administración , Conducta Sexual/fisiología , Sociedades Médicas/organización & administración , Sociedades Médicas/normas , Vitaminas/uso terapéuticoRESUMEN
BACKGROUND: Lower urinary tract symptoms (LUTS) in men are associated with obesity, particularly central obesity as measured by waist circumference (WC), and may improve with weight loss. We aimed to compare effects of a meal-replacement based diet with isocaloric reduced-fat plan on LUTS and nutrient intake in obese Asian men. METHODS: Obese Asian [mean (range) body mass index of 32.9 (30.5-42.3) kg m(-2) ] men [mean (range) age 40.2 (30-61) years] were randomised to a reduced-fat (< 30% of energy) diet [conventional reduced-fat diet (CD) group; n = 23] or meal-replacement-based plan [meal replacement (MR) group; n = 23], to reduce daily intake by 2000 kJ for 12 weeks. RESULTS: CD and MR groups had statistically significant and similar reductions in weight (-2.6 ± 1.9 kg versus -4.2 ± 3.8 kg), overall LUTS severity measured with International Prostate Symptom Scale (IPSS) scores (-1.71 ± 1.93 points versus -2.42 ± 2.12 points) and insulin resistance [homeostasis model assessment (HOMA) calculated from plasma glucose and insulin]. The MR group had significantly greater decreases in WC (-4.8 ± 3.3 cm versus -2.5 ± 2.3 cm), fat mass (-2.47 ± 3.63 kg versus -1.59 ± 2.32 kg), fat intake, plasma C-reactive protein, and in storage LUTS score (-1.59 ± 1.33 points versus -1.00 ± 0.87 points), which was associated with a decreased fat intake (r = 0.48, P = 0.03). A decrease in overall IPSS score was associated with reductions in weight, WC and HOMA. CONCLUSIONS: Weight loss as a result of CD or MR had similar efficacy in relieving LUTS. MR produced greater reductions in fat intake, adiposity and storage LUTS.
Asunto(s)
Dieta con Restricción de Grasas , Ingestión de Energía , Obesidad/complicaciones , Enfermedades Urológicas/dietoterapia , Enfermedades Urológicas/etiología , Adiposidad , Adulto , Glucemia/análisis , Dieta , Metabolismo Energético , Humanos , Insulina/sangre , Resistencia a la Insulina , Masculino , Comidas , Persona de Mediana Edad , Enfermedades de la Próstata/dietoterapia , Circunferencia de la Cintura , Pérdida de PesoRESUMEN
Dietary supplements and nutraceuticals are commonly used by men with erectile dysfunction, decreased libido, BPH, and concerns about developing prostate cancer. Many preparations do not contain the advertised dosages of the active ingredient or are contaminated. Dietary supplements and nutraceuticals, particularly those addressing erectile dysfunction and libido, need to undergo rigorous testing before they can be wholeheartedly recommended.