Asunto(s)
Enfermedades de los Ganglios Basales/diagnóstico , Absceso Encefálico/diagnóstico , Mucormicosis/diagnóstico , Rhizopus/patogenicidad , Adulto , Enfermedades de los Ganglios Basales/etiología , Enfermedades de los Ganglios Basales/microbiología , Absceso Encefálico/etiología , Absceso Encefálico/microbiología , Resultado Fatal , Humanos , Masculino , Mucormicosis/complicaciones , Mucormicosis/microbiologíaRESUMEN
The disease of Lyme is a tick-borne infection. It involves skin, the nervous system, joints and the heart. Spirochaeta Borrelia burgdorferi is the etiologic agent of the disease. In the majority of cases, clinical symptoms, like migrating erythema, occur from 3 to 30 days, sometimes to 3 months after a bite from a tick. The early disseminated infection involves multiple migrating erythema, neuroborreliosis, arthritis, myocarditis and other organ-related symptoms. The late stage of chronic infection involves chronic atrophic leg dermatitis, neurological and rheumatological symptoms, and other organ-related symptoms which persist for above 12 months. The diagnosis of the disease of Lyme is based upon specific clinical symptoms confirmed by serologic tests. The two-step diagnostic protocol including the ELISA method, confirmed by the Western-blot test, is optimal. The present article describes a case of a 59-year-old man, a computer specialist, who often spends his free time walking in woods for recreation, and who was bitten by a tick 3 years before hospitalization. The bite resulted in migrating erythema that subsided without antimicrobial treatment. In spite of this, the man had not changed his hobby exposing himself to bites from ticks. One year later, multiple migrating erythema and extrapyramidalis symptoms appeared without any other organ malfunctions. In the current year, the patient was admitted to the Infectious Diseases Hospital, and received antibiotics (ceftriaxon) with following neurological improvement. Several months later, extrapyramidal symptoms increased. On the day of admission to the hospital, the neurologic examination showed abnormalities of upper and lower limbs movements (propulsive walking and the right lower leg traction), the right hand tremor, pouts of the face, and sleepiness.
Asunto(s)
Enfermedades de los Ganglios Basales/microbiología , Borrelia burgdorferi , Neuroborreliosis de Lyme , Antibacterianos/uso terapéutico , Enfermedades de los Ganglios Basales/tratamiento farmacológico , Humanos , Neuroborreliosis de Lyme/diagnóstico , Neuroborreliosis de Lyme/tratamiento farmacológico , Masculino , Persona de Mediana EdadRESUMEN
Cerebral phaeohyphomycosis is a rare diagnosis that designates a central nervous system (CNS) infection by dematiaceous fungi. These organisms most commonly cause cutaneous infections in humans, but much less commonly, they cause CNS disease with evidence of neurotropism. We describe here the clinical course and post-mortem findings in a fatal case of cerebral phaeohyphomycosis occurring in an 80-year-old man. He had a long and complex past medical history and approximately 7 weeks prior to his death, he presented to an outside institution with imaging findings reported to be consistent with a cerebrovascular accident. He was treated with thrombolytic therapy and sent to a rehabilitation program. Approximately 2 weeks prior to his death, he was transferred to our institution with worsening chronic heart failure symptoms. Imaging after admission showed a ring-enhancing lesion and the differential diagnosis shifted to include a primary neoplasm vs. an abscess. There was a downward clinical course and neurosurgical biopsy was declined secondary to predicted poor outcome. A full autopsy was performed and confirmed the pre-mortem imaging findings of a cerebral abscess with multiple satellite lesions. The histologic and microbiologic findings were characteristic of cerebral phaeohyphomycosis. Microbiological features and disease characteristics of these organisms as well as incidence and populations affected are also discussed.
Asunto(s)
Enfermedades de los Ganglios Basales , Micosis/complicaciones , Anciano de 80 o más Años , Autopsia , Enfermedades de los Ganglios Basales/etiología , Enfermedades de los Ganglios Basales/microbiología , Enfermedades de los Ganglios Basales/patología , Bronconeumonía/etiología , Bronconeumonía/patología , Calcinosis/etiología , Calcinosis/patología , Humanos , Imagen por Resonancia Magnética , MasculinoAsunto(s)
Enfermedades de los Ganglios Basales/microbiología , Enfermedades de los Ganglios Basales/patología , Ganglios Basales/microbiología , Ganglios Basales/patología , Meningitis Criptocócica/patología , Antifúngicos/uso terapéutico , Ganglios Basales/fisiopatología , Enfermedades de los Ganglios Basales/fisiopatología , Derivaciones del Líquido Cefalorraquídeo , Trastornos de la Conciencia/microbiología , Trastornos de la Conciencia/patología , Cryptococcus neoformans/aislamiento & purificación , Quimioterapia Combinada , Humanos , Hipocinesia/microbiología , Hipocinesia/patología , Hipocinesia/fisiopatología , Inmunocompetencia/inmunología , Hipertensión Intracraneal/etiología , Hipertensión Intracraneal/cirugía , Imagen por Resonancia Magnética , Masculino , Meningitis Criptocócica/líquido cefalorraquídeo , Meningitis Criptocócica/fisiopatología , Persona de Mediana Edad , Resultado del TratamientoAsunto(s)
Enfermedades de los Ganglios Basales/etiología , Enfermedades de los Ganglios Basales/microbiología , Ganglios Basales/microbiología , Mucormicosis/complicaciones , Rhizomucor/patogenicidad , Adulto , Ganglios Basales/patología , Humanos , Imagen por Resonancia Magnética/métodos , MasculinoAsunto(s)
Absceso Encefálico/microbiología , Absceso Encefálico/patología , Encéfalo/microbiología , Encéfalo/patología , Infecciones Estafilocócicas/microbiología , Infecciones Estafilocócicas/patología , Ganglios Basales/diagnóstico por imagen , Ganglios Basales/microbiología , Ganglios Basales/patología , Enfermedades de los Ganglios Basales/diagnóstico por imagen , Enfermedades de los Ganglios Basales/microbiología , Enfermedades de los Ganglios Basales/patología , Encéfalo/diagnóstico por imagen , Absceso Encefálico/diagnóstico por imagen , Edema Encefálico/microbiología , Edema Encefálico/patología , Preescolar , Farmacorresistencia Bacteriana/fisiología , Quimioterapia Combinada/farmacología , Quimioterapia Combinada/uso terapéutico , Humanos , Ventrículos Laterales/patología , Masculino , Paresia/microbiología , Paresia/patología , Especificidad de la Especie , Infecciones Estafilocócicas/diagnóstico por imagen , Staphylococcus/aislamiento & purificación , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Vancomicina/farmacología , Vancomicina/uso terapéutico , Zoonosis/microbiologíaAsunto(s)
Síndrome de Inmunodeficiencia Adquirida/complicaciones , Enfermedades de los Ganglios Basales/etiología , Meningitis Criptocócica/etiología , Adulto , Enfermedades de los Ganglios Basales/microbiología , Cryptococcus neoformans/aislamiento & purificación , Humanos , Imagen por Resonancia Magnética , Masculino , Meningitis Criptocócica/microbiologíaRESUMEN
INTRODUCTION: Necrosis of the basal ganglia (NBG) is an uncommon condition in childhood. Cases of NBG have been reported in connection with metabolic disorders, infections, degenerative conditions, intoxications, head injuries and hypoxic-ischemic encephalopathies. The commonest clinical features include alteration of consciousness, chorea-athetoic or dystonic movements, spasticity, contractures of the limbs and convulsions. CLINICAL CASE: We describe the case of an eight year old girl, who after having clinical gastroenteritis, developed acute neurological dysfunction, associated with images on cranial computerized axial tomography (CAT) showing a possible intracranial tumour and magnetic resonance (MR) studies showing bilateral hypodensity of the basal ganglia. Three months later magnetic resonance showed that these lesions had almost completely disappeared. This supports the diagnosis of post-infectious lesions. CONCLUSIONS: The clinical course is very variable. Cases with a previous history of infection have a better prognosis. In our patient treatment was started with corticosteroids. She made a good recovery and was sent home with no sequelae five days later. The new imaging techniques (CAT and MR) have led to more cases of selective involvement of the basal ganglia being diagnosed. MR is the most specific technique for diagnosis in these patients. Although there is no effective specific treatment, treatment with biperidine, thyrotropic hormone and corticosteroids have been used with no apparent effect on the course of the disorder.
Asunto(s)
Cuerpo Estriado/diagnóstico por imagen , Cuerpo Estriado/patología , Enfermedades de los Ganglios Basales/complicaciones , Enfermedades de los Ganglios Basales/microbiología , Enfermedades de los Ganglios Basales/patología , Niño , Cuerpo Estriado/microbiología , Electroencefalografía , Infecciones por Virus de Epstein-Barr/complicaciones , Infecciones por Virus de Epstein-Barr/inmunología , Potenciales Evocados Somatosensoriales , Femenino , Humanos , Inmunoglobulina G/inmunología , Imagen por Resonancia Magnética , Necrosis , Trastornos Respiratorios/etiología , Trastornos Respiratorios/rehabilitación , Respiración Artificial , Tomografía Computarizada por Rayos XAsunto(s)
Absceso Encefálico/diagnóstico por imagen , Criptococosis/diagnóstico por imagen , Enfermedades Pulmonares Fúngicas/diagnóstico por imagen , Adulto , Enfermedades de los Ganglios Basales/diagnóstico por imagen , Enfermedades de los Ganglios Basales/microbiología , Edema Encefálico/diagnóstico por imagen , Edema Encefálico/microbiología , Ventrículos Cerebrales/microbiología , Ventriculografía Cerebral , Cuerpo Estriado/diagnóstico por imagen , Cuerpo Estriado/microbiología , Femenino , Humanos , Hidrocefalia/diagnóstico por imagen , Hidrocefalia/microbiología , Tomografía Computarizada por Rayos XRESUMEN
We describe three cases of cerebral mucormycosis in intravenous drug users and review 22 previously reported cases. Involvement of the basal ganglia was demonstrated in all but two cases. Seven of the 10 patients tested for antibodies to the human immunodeficiency virus (HIV) were seronegative. Eight of the 25 patients survived and were discharged from the hospital; for 7 of 10 patients, cultures of brain lesions yielded Rhizopus arrhizus. The radiographic findings varied, and in most cases, no or minimal contrast enhancement was seen in the initial computed tomography scans. Although uncommon, the diagnosis of cerebral mucormycosis should be considered when basal ganglia lesions are present in an intravenous drug user, regardless of previous exposure to HIV.
Asunto(s)
Enfermedades de los Ganglios Basales/etiología , Mucormicosis/etiología , Abuso de Sustancias por Vía Intravenosa/complicaciones , Infecciones Oportunistas Relacionadas con el SIDA/diagnóstico , Infecciones Oportunistas Relacionadas con el SIDA/terapia , Adulto , Ganglios Basales/microbiología , Ganglios Basales/patología , Enfermedades de los Ganglios Basales/diagnóstico , Enfermedades de los Ganglios Basales/microbiología , Resultado Fatal , Femenino , Humanos , Masculino , Mucormicosis/diagnóstico , Rhizopus/aislamiento & purificaciónAsunto(s)
Enfermedades de los Ganglios Basales/patología , Mucormicosis/patología , Adulto , Enfermedades de los Ganglios Basales/diagnóstico , Enfermedades de los Ganglios Basales/microbiología , Diagnóstico Diferencial , Femenino , Hongos/aislamiento & purificación , Seropositividad para VIH/complicaciones , Humanos , Mucormicosis/diagnóstico , Mucormicosis/microbiología , Abuso de Sustancias por Vía Intravenosa/complicacionesRESUMEN
A case of a patient with haematogeneous infection by listeria monocytogenes, involving the basal and brainstem is reported. Clinically the disease manifested by fever and brainstem syndrome of acute onset. The microscopic examination revealed foci of suppurative encephalitis in the brainstem and basal ganglia. The possible pathogenic mechanisms are discussed. It is emphasized that the association of a febrile syndrome with brainstem dysfunction should raise the possibility of infection of the nervous system by listeria monocytogenes.