Keratoacanthoma centrifugum marginatum: a rare atypical variant of keratoacanthoma.

Keratoacanthoma centrifugum marginatum (KCM) is an extremely rare variant of keratoacanthoma (KA), with about 30 cases reported since it was first described in 1962. Clinically, KA is an exoendophytic lesion of 10-25 mm with a horn-filled crater that resolves spontaneously within 6 months. In contrast, KCM is characterized by a larger diameter continuous centrifugal spread, concurrent central atrophy and lack of spontaneous remission. Histologically, KCM is similar to KA, with a central keratin-filled crater, overhanging lips of epithelium, a sharp outline between the tumour nests and stroma, and lack of anaplasia and stroma desmoplasia. We describe a 63-year-old agricultural worker with a 9-month history of a multinodular tumour, 70-75 mm in size, on his right hand. The clinical diagnosis of KCM was confirmed by histological examination. Local radiotherapy proved effective, with no recurrence during a 4-year follow-up.

Invading basal cell carcinoma of the jaw: an under-evaluated complex entity.

Basal cell carcinoma (BCC) is a locally invasive neoplasm, rarely metastatic, yet capable of significant local destruction and disfigurement. Invasion into the bone is uncommon and only a few cases of invasion into facial bones, but never to the mandible or maxilla, have been described. We report three patients with BCC lesions invading their jaws, as a consequence of which either their mandible or maxilla had to be partially resected. This resulted in facial mutilation which required comprehensive multi-disciplinary therapy to restore function and esthetics. Such therapy requires a combination of modalities offered by both plastic and maxillofacial surgeons, as well as oral and dental rehabilitators.

[The correction of hemodynamic disorders with low-intensity infrared laser radiation in agricultural machinery operators with borderline arterial hypertension]. / Korrektsiia narushenii gemodinamiki nizkointensivnym lazernym izlucheniem infrakrasnogo diapazona u mekhanizatorov sel'skogo khoziaistva s pogranichnoi arterial'noi gipertenziei.

Data on the influence of low-intensity infrared laser on the central and peripheral hemodynamics in 76 agricultural machine operators facing transitory arterial hypertension are presented. Analysis revealed that low-intensity laser is more effective at the early stages of cardiovascular diseases. Low-intensity infrared laser exposure of reflexogenic zones can be effectively used to correct hemodynamic disorders in subjects facing transitory arterial hypertension.