Allopurinol in the treatment of acquired reactive perforating collagenosis.

Acquired reactive perforating collagenosis is a perforating dermatosis usually associated with different systemic diseases, mainly diabetes mellitus and/or chronic renal insufficiency. Different therapies have been tried but treatment is not standardized yet and remains a challenge. In the last few years, allopurinol has been reported as a good therapeutic option for acquired reactive perforating collagenosis. We describe the case of a 73-year-old man affected by acquired reactive perforating collagenosis associated with diabetes type 1 and chronic renal failure with secondary hyperparathyroidism. The patient was successfully treated with allopurinol 100mg once/day p.o..

Colagenosis perforante reactiva adquirida: Caso clínico / Acquired reactive perforating collagenosis: Report of two cases

Acquired reactive perforating collagenosis is a perforating dermatosis characterized by transepidermal elimination of collagen. It is frequently associated to diabetes mellitus and chronic renal insuffciency, but it is also related to other systemic diseases. The lesions tend to resolve once the underlying condition is treated. We report two patients with the condition. A 65 year-old diabetic female on hemodialysis consulted for multiple itching cutaneous ulcers lasting one year. On physical examination, hyperpigmented papules and nodules were observed. A 65 year-old female with chronic renal failure in hemodialysis consulted for itching lesions in hands, forearms and arms. On physical examination, hyperpigmented lesions with ulcers, erosions and crusts were observed. In both cases, the pathological study of the lesions disclosed a reactive perforating collagenosis.

[Acquired reactive perforating collagenosis: report of two cases]. / Colagenosis perforante reactiva adquirida: Caso clínico.

Acquired reactive perforating collagenosis is a perforating dermatosis characterized by transepidermal elimination of collagen. It is frequently associated to diabetes mellitus and chronic renal insufficiency, but it is also related to other systemic diseases. The lesions tend to resolve once the underlying condition is treated. We report two patients with the condition. A 65 year-old diabetic female on hemodialysis consulted for multiple itching cutaneous ulcers lasting one year. On physical examination, hyperpigmented papules and nodules were observed. A 65 year-old female with chronic renal failure in hemodialysis consulted for itching lesions in hands, forearms and arms. On physical examination, hyperpigmented lesions with ulcers, erosions and crusts were observed. In both cases, the pathological study of the lesions disclosed a reactive perforating collagenosis.

Enteropathic arthritis in association with collagenous colitis.

A 46-year-old man simultaneously developed chronic seronegative non destructive oligoarthritis and chronic watery diarrhoea. Biopsies from the colorectal mucosa showed a thickened subepithelial collagen layer consistent with collagenous colitis. Collagenous colitis should be added to the list of causes of enteropathic arthritis.

Subsídios conceituais sobre hanseníase e estados reacionais / Conceptual subsidies about hanseniasis and reactional status

Os autores fazem uma revisäo histórica da hanseníase e sua magnitude no Brasil. Apresentam revisäo atualizada da imunopatia, genética e suas expressöes clínicas na classificaçäo, dando especial enfoque a seus conceitos sobre hanseníase virchowiana e os estados reacionais qeu nela incidem

[Reactive perforating collagenosis associated with chronic renal insufficiency and diabetes mellitus]. / Colagenose reativa perfurante associada à insuficiência renal crônica e diabetes mellitus.

Reactive perforating collagenosis is an uncommon skin disorder characterized by extrusion of collagen fibers through the epidermis. The lesions may appear in infancy, from genetic inheritance, or in adulthood in association with diabetes mellitus and/or chronic renal insufficiency. One case of reactive perforating collagenosis is reported, in a 42 year old man, with chronic renal failure diabetes mellitus and undergoing hemodialysis. The literature was reviewed on perforating dermatoses in adults associated with diabetes and chronic renal insufficiency.