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4.
J Bone Joint Surg Am ; 101(17): e85, 2019 Sep 04.
Artículo en Inglés | MEDLINE | ID: mdl-31483404

RESUMEN

BACKGROUND: Structural bone allografts are an established treatment method for long-bone structural defects resulting from such conditions as traumatic injury and sarcoma. The functional lifetime of structural allografts depends on resistance to cyclic loading (cyclic fatigue life), which can lead to fracture at stress levels well below the yield strength. Raman spectroscopy biomarkers can be used to non-destructively assess the 3 primary components of bone (collagen, mineral, and water), and may aid in optimizing allograft selection to decrease fatigue fracture risk. We studied the association of Raman biomarkers with the cyclic fatigue life of human allograft cortical bone. METHODS: Twenty-one cortical bone specimens were machined from the femoral diaphyses of 4 human donors (a 63-year old man, a 61-year-old man, a 51-year-old woman, and a 48-year-old woman) obtained from the Musculoskeletal Transplant Foundation. Six Raman biomarkers were analyzed: collagen disorganization, mineral maturation, matrix mineralization, and 3 water compartments. The specimens underwent cyclic fatigue testing under fully reversed conditions (35 and 45 MPa), during which they were tested to fracture or to 30 million cycles ("runout"), simulating 15 years of moderate activity. A tobit censored linear regression model for cyclic fatigue life was created. RESULTS: The multivariate model explained 60% of the variance in the cyclic fatigue life (R = 0.604, p < 0.001). Increases in Raman biomarkers for disordered collagen (coefficient: -2.74×10, p < 0.001) and for loosely collagen-bound water compartments (coefficient: -2.11×10, p < 0.001) were associated with a decreased cyclic fatigue life. Increases in Raman biomarkers for mineral maturation (coefficient: 3.50×10, p < 0.001), matrix mineralization (coefficient: 2.32×10, p < 0.001), tightly collagen-bound water (coefficient: 1.19×10, p < 0.001), and mineral-bound water (coefficient: 3.27×10, p < 0.001) were associated with an increased cyclic fatigue life. Collagen disorder accounted for 44% of the variance in the cyclic fatigue life, mineral maturation accounted for 6%, and all bound water compartments accounted for 3%. CONCLUSIONS: Increasing baseline collagen disorder was associated with a decreased cyclic fatigue life and had the strongest correlation with the cyclic fatigue life of human cortical donor bone. This model should be prospectively validated. CLINICAL RELEVANCE: Raman analysis is a promising tool for the non-destructive evaluation of structural bone allograft quality for load-bearing applications.


Asunto(s)
Enfermedades del Colágeno/fisiopatología , Hueso Cortical/fisiología , Supervivencia de Injerto/fisiología , Adulto , Aloinjertos/fisiología , Biomarcadores/metabolismo , Fenómenos Biomecánicos/fisiología , Agua Corporal/química , Densidad Ósea/fisiología , Trasplante Óseo/métodos , Cadáver , Fatiga/fisiopatología , Fémur/fisiología , Humanos , Masculino , Persona de Mediana Edad , Espectrometría Raman
5.
Pan Afr Med J ; 30: 231, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30574249

RESUMEN

Collagenous gastritis is a rare entity, characterized by the deposition of a subepithelial collagenous band with an inflammatory infiltrate in the mucosa. We report the first Tunisian case revealed by severe anemia. Lesions were limited to the stomach and remained unchanged on 3 series biopsies during a 24 month follow up despite treatment with corticosteroids. The cause of the disease remains unknown; our findings suggest that lesions of collagenous gastritis may result from a local immune process.


Asunto(s)
Anemia/etiología , Enfermedades del Colágeno/diagnóstico , Gastritis/diagnóstico , Biopsia , Colágeno/metabolismo , Enfermedades del Colágeno/tratamiento farmacológico , Enfermedades del Colágeno/fisiopatología , Estudios de Seguimiento , Gastritis/tratamiento farmacológico , Gastritis/fisiopatología , Glucocorticoides/uso terapéutico , Humanos , Masculino , Túnez , Adulto Joven
6.
Radiother Oncol ; 125(2): 301-309, 2017 11.
Artículo en Inglés | MEDLINE | ID: mdl-29102264

RESUMEN

BACKGROUND AND PURPOSE: There is concern that patients with collagen vascular disease (CVD) are at higher risk of developing radiation toxicity. We analyzed radiation toxicities in patients with intrathoracic malignancy and CVD treated using modern radiotherapy. MATERIALS AND METHODS: This single-institution retrospective study included 31 patients with CVD and 825 patients without CVD treated from 1998 to 2014. Radiation esophagitis (RE) and radiation pneumonitis (RP) were scored by RTOG scales. RE was analyzed with logistic regression and RP with Cox regression. RESULTS: CVD patients experienced similar grade ≥3 RE compared to control patients (23% vs. 19%, p = 0.64) but more grade ≥3 RP (26% vs. 10%, p = 0.01). There was no significant association between CVD subtype and toxicities. In multivariate analysis, CVD and lung V20 >30% were associated with grade ≥3 RP. We identified V20 ≤30%, V5 ≤50%, and MLD ≤18 Gy as dose thresholds in patients with CVD. CVD patients with mild severity disease and only 1 organ system involved were at low risk for RP. CONCLUSIONS: Patients with CVD may be at higher risk of RP. However, CVD patients may be offered curative thoracic RT with particular attention to risk-reduction strategies and maintaining recommended dose constraints as described in this study.


Asunto(s)
Carcinoma de Pulmón de Células no Pequeñas/radioterapia , Enfermedades del Colágeno/fisiopatología , Neoplasias Pulmonares/radioterapia , Neumonitis por Radiación/etiología , Enfermedades Vasculares/fisiopatología , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Pulmón/patología , Pulmón/efectos de la radiación , Masculino , Persona de Mediana Edad , Neumonitis por Radiación/patología , Radioterapia Conformacional/efectos adversos , Radioterapia de Intensidad Modulada/efectos adversos , Estudios Retrospectivos
7.
Placenta ; 36(8): 915-20, 2015 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-26149518

RESUMEN

INTRODUCTION: Virtual touch tissue quantification (VTTQ) has been developed to evaluate tissue elasticity. Our previous study using delivered placentas showed increased elasticity in fetal growth restriction (FGR). Therefore, we investigated changes in placental elasticity during pregnancy, including complicated pregnancies. METHODS: Based on complications, 199 women were divided into 5 groups (normal, FGR, pregnancy induced hypertension (PIH), diabetes mellitus and collagen disease), and shear wave velocity (SWV) of the placenta, measured using VTTQ, was compared. A cross-sectional study was performed with the 143 normal cases to construct the reference range. The association between placental SWV and the expression ratio of collagen fibers in the placenta stained with Masson's trichrome was determined. RESULTS: The SWV was safely measured for all participants. The correlation between SWV and gestational weeks was not significant. The mean ± SD SWVs in the normal, FGR, and PIH groups were 0.98 ± 0.21, 1.28 ± 0.39, and 1.60 ± 0.45 m/sec, respectively. The FGR and PIH groups had significantly higher SWVs than that of the normal group. SWV and the expression ratio of collagen fibers were significantly correlated. DISCUSSION: Based on the present findings, changes in SWV during pregnancy were associated with placental fibrosis, and increased SWV in PIH and/or FGR cases might be influenced by infarction, ischemic changes, and inflammation, as well as fibrosis. In conclusion, the measurement of placental SWV is potentially useful to evaluate the condition of the placenta during pregnancy.


Asunto(s)
Enfermedades del Colágeno/fisiopatología , Diabetes Mellitus/fisiopatología , Diagnóstico por Imagen de Elasticidad/métodos , Hipertensión Inducida en el Embarazo/fisiopatología , Placenta/fisiología , Adulto , Estudios Transversales , Elasticidad , Femenino , Humanos , Persona de Mediana Edad , Embarazo , Adulto Joven
9.
J Stroke Cerebrovasc Dis ; 24(3): 530-6, 2015 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-25534370

RESUMEN

BACKGROUND: The aims of this study were to determine whether arterial hypertension could affect the venous system of brain and to find out the consequent pathologic changes of cerebral veins. METHODS: Thirty male Sprague-Dawley rats were divided into 2 groups: a sham-clipped group and a stroke-prone renovascular hypertensive rat group. A 2-kidney 2-clip rat model was used to induce renovascular hypertension in the hypertensive group. Systolic blood pressure was measured by tail cuff once each week. Susceptibility-weighted imaging (SWI) was performed at 12, 16, and 20 weeks after surgery. All the rats were sacrificed after the SWI examination at 20 weeks after surgery. The brains were extracted and embedded in paraffin for histologic examination. Masson trichrome staining was performed to identify venous collagenosis. RESULTS: The sham group demonstrated less prominence of cerebral veins compared with hypertensive groups (P < .01); the hypertensive group showed significant venous collagenosis in cerebral venous walls compared with the sham group (P < .01). CONCLUSIONS: The increased visibility of cerebral veins on SWI as a sign of venous hypertension and the thickened cerebral venous walls (venous collagenosis), which may play a role in cerebral ischemia and/or infarction, are both consequences of long-term hypertension in hypertensive rats.


Asunto(s)
Venas Cerebrales/patología , Trastornos Cerebrovasculares/etiología , Enfermedades del Colágeno/etiología , Colágeno/metabolismo , Hipertensión Renovascular/complicaciones , Remodelación Vascular , Animales , Presión Arterial , Biopsia , Venas Cerebrales/metabolismo , Venas Cerebrales/fisiopatología , Trastornos Cerebrovasculares/metabolismo , Trastornos Cerebrovasculares/patología , Trastornos Cerebrovasculares/fisiopatología , Enfermedades del Colágeno/metabolismo , Enfermedades del Colágeno/patología , Enfermedades del Colágeno/fisiopatología , Modelos Animales de Enfermedad , Hipertensión Renovascular/fisiopatología , Imagen por Resonancia Magnética , Masculino , Ratas Sprague-Dawley , Factores de Riesgo , Factores de Tiempo
10.
Lung ; 192(5): 729-37, 2014 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-25056241

RESUMEN

PURPOSE: We retrospectively analyzed patients with clinically diagnosed interstitial pneumonia to investigate the factors which contribute to the difference in prognosis from the initiation of long-term oxygen therapy (LTOT) among subtypes. METHODS: Seventy-six patients with clinically diagnosed idiopathic interstitial pneumonia (IIP; n = 49) or interstitial pneumonia associated with collagen vascular disease (CVD-IP; n = 27) in whom LTOT was initiated in our facility from January 1999 to December 2012 were analyzed. RESULTS: Patients with CVD-IP had significantly longer survival time from the initiation of LTOT than those with IIP with the median survival of 51.7 months versus 18.8 months, respectively. The 1-year survival rate was 92.4% for patients with CVD-IP versus 76.5% for those with IIP, and 2-year survival was 88.6 versus 36.0%, respectively. The patterns classified with high-resolution computed tomography (HRCT) were not associated with prognosis. The association between pulmonary hypertension and prognosis was unclear. In results of the multivariate Cox analysis which included factors demonstrating p < 0.1 in the univariate Cox analysis, male gender, low body mass index, and the absence of collagen vascular disease (CVD) were significantly associated with poor prognosis. CONCLUSIONS: After the initiation of LTOT, patients with IIP had poor prognosis regardless of the patterns classified with HRCT, while those with CVD-IP survived longer. Male gender, low body mass index, and the absence of CVD were the independent negative prognostic factors in patients with interstitial pneumonia receiving LTOT.


Asunto(s)
Enfermedades del Colágeno/terapia , Enfermedades Pulmonares Intersticiales/terapia , Terapia por Inhalación de Oxígeno , Enfermedades Vasculares/terapia , Anciano , Índice de Masa Corporal , Enfermedades del Colágeno/diagnóstico , Enfermedades del Colágeno/mortalidad , Enfermedades del Colágeno/fisiopatología , Femenino , Humanos , Japón , Estimación de Kaplan-Meier , Pulmón/fisiopatología , Enfermedades Pulmonares Intersticiales/diagnóstico , Enfermedades Pulmonares Intersticiales/mortalidad , Enfermedades Pulmonares Intersticiales/fisiopatología , Masculino , Persona de Mediana Edad , Análisis Multivariante , Terapia por Inhalación de Oxígeno/efectos adversos , Terapia por Inhalación de Oxígeno/mortalidad , Modelos de Riesgos Proporcionales , Estudios Retrospectivos , Factores de Riesgo , Factores Sexuales , Factores de Tiempo , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Enfermedades Vasculares/diagnóstico , Enfermedades Vasculares/mortalidad , Enfermedades Vasculares/fisiopatología
11.
J Bone Joint Surg Am ; 95(19): e1391-6, 2013 Oct 02.
Artículo en Inglés | MEDLINE | ID: mdl-24088974

RESUMEN

BACKGROUND: Osteoporotic fractures commonly occur after low-energy trauma in postmenopausal women with reduced bone quantity documented by low bone mineral density (BMD). Low-energy fractures, however, have also been reported to occur in premenopausal women with normal or near-normal BMD, suggesting the existence of a bone quality abnormality. METHODS: Bone quality and quantity were evaluated in a cross-sectional study of three groups of premenopausal white females: (1) twenty-five subjects with low-energy fracture(s) and BMD in the normal range (t-scores > -2.0), (2) eighteen subjects with low-energy fracture(s) and BMD in the osteoporotic range (t-scores ≤ -2.5), and (3) fourteen healthy volunteers (controls). Bone quality was assessed with use of Fourier transform infrared spectroscopy and histomorphometry in iliac crest bone samples obtained from all subjects; bone quantity was assessed by dual x-ray absorptiometry and histomorphometry. RESULTS: The collagen crosslinking ratio in the non-low-BMD subjects with fractures was 13% greater than the ratio in the low-BMD subjects with fractures and 14% greater than the ratio in the controls (p < 0.001 for both). Cancellous bone volume was 29% greater (p < 0.01) and trabecular separation was 31% less (p < 0.01) in the non-low-BMD subjects with fractures than in the low-BMD subjects with fractures; the values in the non-low-BMD subjects did not differ from those in the controls. Bone turnover did not differ among the groups, and osteomalacia was not present in any subject. Thus, the non-low-BMD subjects with fractures maintained bone quantity, but the collagen crosslinking ratio, a parameter of bone quality, was abnormal. In contrast, the low-BMD subjects with fractures did not have this collagen crosslinking abnormality but did have abnormal bone quantity. CONCLUSIONS: This study highlights a collagen crosslinking abnormality in patients with low-energy fractures and nonosteoporotic t-scores. Reports have indicated that altered collagen crosslinking is associated with subnormal fracture resistance. A finding of nonosteoporotic bone mass in a patient with low-energy fractures would justify assessment of bone material quality, which currently requires a bone biopsy. Further studies are needed to search for possible noninvasive tests to diagnose abnormal crosslinking. Since no specific therapies for abnormal collagen crosslinking are currently available, studies are also needed to explore novel therapeutic modalities to reverse the underlying collagen crosslinking abnormality. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.


Asunto(s)
Densidad Ósea/fisiología , Matriz Ósea/fisiopatología , Enfermedades del Colágeno/fisiopatología , Osteoporosis/fisiopatología , Fracturas Osteoporóticas/fisiopatología , Premenopausia/fisiología , Adulto , Matriz Ósea/patología , Estudios de Casos y Controles , Colágeno/química , Enfermedades del Colágeno/etiología , Enfermedades del Colágeno/patología , Estudios Transversales , Femenino , Humanos , Osteoporosis/patología , Fracturas Osteoporóticas/etiología , Fracturas Osteoporóticas/patología
12.
Arch Bronconeumol ; 49(6): 249-60, 2013 Jun.
Artículo en Inglés, Español | MEDLINE | ID: mdl-23683373

RESUMEN

Collagen diseases are a large group of systemic inflammatory diseases of autoimmune etiology. The etiopathogenesis of collagen diseases is multifactorial. There is genetic susceptibility, as many connective tissue disorders show family history, and environmental factors may trigger the disease. Collagen diseases can affect almost all the organs of the body. The respiratory system is one of the most frequently affected, although the prevalence of pulmonary disease is not precisely known for the different collagen disorders. Any structure of the respiratory tract can be affected, but perhaps the most frequent is pulmonary parenchymal disease in the form of pneumonitis, which can be produced in any of the idiopathic interstitial pneumonitis patterns. The pleura, pulmonary vessels, airways and respiratory muscles may also be affected. The frequency of lung disease associated with collagen diseases is on the rise. This due in part to the better diagnostic methods that are available to us today (such as high-resolution computed tomography) and also to the appearance of new forms of pneumonitis associated with the new treatments that are currently used. The objective of this article is to offer a global vision of how collagen diseases can affect the lungs according to the latest scientific evidence.


Asunto(s)
Enfermedades del Colágeno/complicaciones , Enfermedades Pulmonares/etiología , Bronquiectasia/etiología , Bronquiolitis Obliterante/etiología , Síndrome de Caplan/etiología , Enfermedades del Colágeno/fisiopatología , Humanos , Hipertensión Pulmonar/etiología , Hipertensión Pulmonar/fisiopatología , Enfermedades Pulmonares/fisiopatología , Enfermedades Pulmonares Intersticiales/etiología , Enfermedades Pulmonares Intersticiales/fisiopatología , Trastornos Linfoproliferativos/etiología , Derrame Pleural/etiología , Neumonía/etiología , Esclerodermia Sistémica/complicaciones , Esclerodermia Sistémica/fisiopatología
13.
Curr Pain Headache Rep ; 17(3): 320, 2013 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-23338772

RESUMEN

Although headaches are common in the general population and have many causes, headaches secondary to inflammatory processes in the blood vessels in the Central Nervous System (CNS) are not so common. The most common types of vasculitis that are associated with headaches include primary CNS vasculitis, systemic necrotizing arteritis, granulomatous vasculitis, and systemic collagen diseases. It is important to differentiate between "true" vasculitides and a condition known and reversible cerebral vasoconstriction syndrome (RCVS). While treatment for many of the vasculitides consists of anti-inflammatory medications, this approach may produce significant complications in RCVS. It is up to the clinician to judiciously use imaging and laboratory data to reach the proper diagnosis and therefore offer the correct treatment to these patients.


Asunto(s)
Enfermedades del Colágeno/diagnóstico , Cefaleas Primarias/diagnóstico , Poliarteritis Nudosa/diagnóstico , Vasculitis del Sistema Nervioso Central/diagnóstico , Angiografía Cerebral , Enfermedades del Colágeno/fisiopatología , Diagnóstico Diferencial , Femenino , Cefaleas Primarias/fisiopatología , Humanos , Masculino , Poliarteritis Nudosa/fisiopatología , Vasculitis del Sistema Nervioso Central/fisiopatología
14.
Curr Aging Sci ; 5(2): 157-67, 2012 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-22894741

RESUMEN

The recent concept of pulse wave encephalopathy helps understanding the cerebral venous remodeling in aging. This so-called periventricular venous collagenosis is an expected mechanical consequence of the age-related changes in arterial pulsations and the mechanical fatigue of vascular smooth muscles. Unlike arteriolar mechanical stress, venular mechanical stress depends on both the blood pulse wave amplitude and the mechanical properties of the environment tissue. Thereby, there is a preferential periventricular location of venous collagenosis and a mechanistic link between venous collagenosis and foci of white matter rarefaction or leukoaraiosis. The recent concept of pulse wave encephalopathy also helps understanding the widening of retinal venules, the "mirror" of cerebral venules, in various manifestations of pulse wave encephalopathy, including progressive leukoara�osis, lacunar and hemorrhagic "pulse wave" strokes, and dementia. Indeed, the age-related chronic increase in arterial pulsations explains subsequent arteriolar myogenic "fatigue", marked attenuation in the arteriolar myogenic tone and abnormal penetration of the insufficiently dampened arterial pulse wave into the venules. Thus, retinal venular widening, a biomarker of advanced pulse wave encephalopathy, is also increasingly recognized as a biomarker for high cardiovascular risk. All these data support a shift in the concept of chronic cerebrovascular disease, from the classical model which is restricted to steno-occlusive cerebrovascular diseases to an enlarged model which would include the pulse wave encephalopathy concept. Thereby, preventing damage to the cerebral microvasculature by an undampened arterial pulse wave will become a logical target for the prevention and treatment of late-onset cognitive decline.


Asunto(s)
Envejecimiento/patología , Encéfalo/irrigación sanguínea , Capilares/patología , Venas Cerebrales/patología , Circulación Cerebrovascular , Trastornos Cerebrovasculares/patología , Enfermedades del Colágeno/patología , Flujo Pulsátil , Factores de Edad , Envejecimiento/psicología , Animales , Presión Arterial , Capilares/fisiopatología , Venas Cerebrales/fisiopatología , Trastornos Cerebrovasculares/etiología , Trastornos Cerebrovasculares/fisiopatología , Trastornos Cerebrovasculares/psicología , Enfermedad Crónica , Cognición , Enfermedades del Colágeno/etiología , Enfermedades del Colágeno/fisiopatología , Enfermedades del Colágeno/psicología , Dilatación Patológica , Elasticidad , Humanos , Análisis de la Onda del Pulso , Estrés Mecánico
15.
Clin Exp Rheumatol ; 30(5): 693-9, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22704071

RESUMEN

OBJECTIVES: Pulmonary involvement of varying etiology is common in collagen vascular diseases (CVDs). Bronchoalveolar lavage fluid (BALF) cell differentials reveal information on the immune mechanisms involved in the CVDs. The aim of the present study was to evaluate BALF cell populations in CVD-associated ILD and to investigate possible correlation with pulmonary function. METHODS: Fifty-seven patients (26 male and 31 female, mean age ± SD: 54.68±12.18 years) with CVD-associated interstitial lung disease were studied. Patients were divided into 6 groups based on underlying CVD. The study population also included a group of 10 healthy controls. BALF was examined in all individuals. Cell density, total cell number and differential cell count were recorded. BALF lymphocyte subsets were analysed by dual flow cytometry. Pulmonary function was assessed in all patients. RESULTS: BALF differential cell count did not differ significantly among the different groups. Scleroderma patients showed the highest percentage of CD19 cells (p<0.001). The NK and NKT cell percentages were significantly higher in systemic lupus erythematosus and in Sjögren, respectively, compared to other CVDs and controls (p=0.001 and p<0.001). Also BALF neutrophil percentage correlated negatively with FVC (r=-0.356, p=0.011) and FEV1 (r=-0.336, p=0.017) and BALF NKT cell percentage correlated negatively with pO2 (r=-0.415, p=0.003). CONCLUSIONS: Important variations observed in BALF cell populations suggest the implication of NK and NKT cells in the pathogenesis of lung involvement in CVDs.


Asunto(s)
Enfermedades del Colágeno/inmunología , Células Asesinas Naturales/inmunología , Enfermedades Pulmonares Intersticiales/inmunología , Pulmón/inmunología , Enfermedades Vasculares/inmunología , Adulto , Anciano , Antígenos CD19/análisis , Biomarcadores/análisis , Líquido del Lavado Bronquioalveolar/citología , Líquido del Lavado Bronquioalveolar/inmunología , Enfermedades del Colágeno/fisiopatología , Femenino , Citometría de Flujo , Volumen Espiratorio Forzado , Humanos , Pulmón/fisiopatología , Enfermedades Pulmonares Intersticiales/fisiopatología , Masculino , Persona de Mediana Edad , Células T Asesinas Naturales/inmunología , Pruebas de Función Respiratoria , Enfermedades Vasculares/fisiopatología , Capacidad Vital
16.
Medicine (Baltimore) ; 90(2): 146-157, 2011 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-21358437

RESUMEN

Multisystem autoimmune diseases occurring after allogeneic hematopoietic stem cell transplantation are infrequent, late-onset manifestations that resemble well-defined collagen vascular disorders. Because the lung is frequently involved in the course of connective tissue disorders, we focused on lung manifestations occurring in autoimmune diseases following allogeneic stem cell transplantation. In the present series, we report 6 patients with systemic lupus erythematous, mixed connective tissue disease, Sjögren syndrome, polymyositis, and ANCA-positive vasculitis who presented with a spectrum of pulmonary manifestations affecting the airways, lung parenchyma, and probably respiratory muscles. We identified 3 different histopathologic patterns of interstitial pneumonia consistent with the underlying autoimmune disorder: lymphocytic interstitial pneumonia and non-specific interstitial pneumonia in 2 patients with Sjögren syndrome and diffuse alveolar damage in 1 patient with ANCA-positive vasculitis. These lung manifestations had poor prognoses. Further studies are needed to determine the optimal therapy for these complications.


Asunto(s)
Enfermedades Autoinmunes/terapia , Enfermedades del Colágeno/fisiopatología , Trasplante de Células Madre Hematopoyéticas/efectos adversos , Enfermedades Pulmonares Intersticiales/fisiopatología , Adulto , Enfermedades del Colágeno/etiología , Femenino , Humanos , Enfermedades Pulmonares Intersticiales/etiología , Lupus Eritematoso Sistémico/etiología , Lupus Eritematoso Sistémico/fisiopatología , Masculino , Persona de Mediana Edad , Enfermedad Mixta del Tejido Conjuntivo/etiología , Enfermedad Mixta del Tejido Conjuntivo/fisiopatología , Polimiositis/etiología , Polimiositis/fisiopatología , Síndrome de Sjögren/etiología , Síndrome de Sjögren/fisiopatología , Factores de Tiempo , Trasplante Homólogo
17.
Clin Orthop Relat Res ; 469(8): 2194-206, 2011 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-21107923

RESUMEN

BACKGROUND: Bone quantity, quality, and turnover contribute to whole bone strength. Although bone mineral density, or bone quantity, is associated with increased fracture risk, less is known about bone quality. Various conditions, including disorders of mineral homeostasis, disorders in bone remodeling, collagen disorders, and drugs, affect bone quality. QUESTIONS/PURPOSES: The objectives of this review are to (1) identify the conditions and diseases that could adversely affect bone quality besides osteoporosis, and (2) evaluate how these conditions influence bone quality. METHODS: We searched PubMed using the keywords "causes" combined with "secondary osteoporosis" or "fragility fracture." After identifying 20 disorders/conditions, we subsequently searched each condition to evaluate its effect on bone quality. RESULTS: Many disorders or conditions have an effect on bone metabolism, leading to fragility fractures. These disorders include abnormalities that disrupt mineral homeostasis, lead to an alteration of the mineralization process, and ultimately reduce bone strength. The balance between bone formation and resorption is also essential to prevent microdamage accumulation and maintain proper material and structural integrity of the bone. As a result, diseases that alter the bone turnover process lead to a reduction of bone strength. Because Type I collagen is the most abundant protein found in bone, defects in Type I collagen can result in alterations of material property, ultimately leading to fragility fractures. Additionally, some medications can adversely affect bone. CONCLUSIONS: Recognizing these conditions and diseases and understanding their etiology and pathogenesis is crucial for patient care and maintaining overall bone health.


Asunto(s)
Densidad Ósea , Enfermedades Óseas/fisiopatología , Huesos/fisiopatología , Osteoporosis/fisiopatología , Antirreumáticos/uso terapéutico , Enfermedades Óseas/metabolismo , Resorción Ósea/fisiopatología , Huesos/efectos de los fármacos , Huesos/metabolismo , Enfermedades del Colágeno/fisiopatología , Fracturas Óseas/fisiopatología , Glucocorticoides/uso terapéutico , Homeostasis/fisiología , Humanos , Hiperparatiroidismo/fisiopatología , Osteopetrosis/fisiopatología
18.
Haemophilia ; 16 Suppl 5: 146-51, 2010 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-20590874

RESUMEN

SUMMARY: While the majority of this session will deal with selected inherited vascular abnormalities that may manifest as a haemorrhagic disorder, the initial discussion by Dr Key will focus on the interplay between the vessel wall and components of the coagulation system, with a focus on haemophilia A and B. Although it is generally accepted that physiological haemostasis is triggered by contact of blood with tissue factor (TF), there remains some controversy regarding the cellular origin of TF in vivo. In addition, the initiation and propagation of thrombin generation are highly dependent on the balance of pro- and anticoagulant functions of endothelium, a profile that varies significantly throughout the vasculature. Drs De Paepe and Malfait address heritable collagen disorders such as the Ehlers-Danlos syndromes (EDS), a heterogeneous group of diseases involving the skin, ligaments and joints, blood vessels and internal organs. Most EDS subtypes are caused by mutations in genes encoding fibrillar collagens, or in genes coding for enzymes involved in posttranslational modifications of collagens. Accurate biochemical and molecular testing is now available for most EDS subtypes and can direct genetic counselling and medical management for these disorders. Dr Shovlin reviews recent developments in hereditary haemorrhagic telengiectasia (HHT), a frequently undiagnosed disorder characterized by arteriovenous malformations in multiple organs. These abnormal blood vessels are the result of mutations in one of a number of genes whose protein products influence TGF-beta signalling in vascular endothelial cells. Several HHT management guidelines have been published and are discussed.


Asunto(s)
Enfermedades del Colágeno/fisiopatología , Síndrome de Ehlers-Danlos/fisiopatología , Hemofilia A/complicaciones , Hemofilia B/complicaciones , Hemostasis , Colágeno/metabolismo , Diagnóstico Diferencial , Síndrome de Ehlers-Danlos/diagnóstico , Células Endoteliales/fisiología , Endotelio/fisiología , Epistaxis/genética , Humanos
19.
Pulm Pharmacol Ther ; 23(2): 115-20, 2010 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-19878731

RESUMEN

OBJECTIVE: We speculated that distinct angiogenic profiles are involved in idiopathic interstitial pneumonias (IIPs) in comparison with interstitial pneumonias associated with collagen vascular disease (CVD-IPs). This hypothesis was investigated by measuring the expression of a cardinal biologic axis, the vascular endothelial growth factor (VEGF)-stromal derived growth factor [SDF-1alpha, transcripts 1 and 2 (TR1 and TR2)] and receptor, CXCR4 and the angiogenetic receptors CXCR2 and CXCR3 in bronchoalveolar lavage fluid (BALF) in both conditions. METHODS: We studied prospectively 25 patients with fibrotic IIPs (f-IIPs) [20 with idiopathic pulmonary fibrosis (IPF) and 5 with idiopathic non-specific interstitial pneumonia (NSIP)] and 16 patients with CVD-IPs. mRNA expression was measured by Real-Time RT-PCR and protein was evaluated by Western Blotting. RESULTS: A significantly greater value has been detected in SDF-1alpha-TR1 mRNA expression levels of CVD-IPs (p=0.05) in comparison with IPF group. A similar trend has been also detected in protein expression in favor of CVD-IP group. In addition, VEGF mRNA levels have been found significantly increased in CVD-IPs in comparison with the NSIP group (p=0.05). No significant difference has been found in SDF-1alpha-TR2-CXCR4 mRNA and CXCR2-CXCR3 between the two groups. CONCLUSION: These results showed increased expression of SDF-1alpha in CVD-IPs, suggesting different angiogenic procedures. Further studies are needed in order to better explore the angiogenetic pathway in these disorders.


Asunto(s)
Quimiocina CXCL12/genética , Fibrosis Pulmonar Idiopática/genética , Enfermedades Pulmonares Intersticiales/genética , Regulación hacia Arriba , Anciano , Western Blotting , Líquido del Lavado Bronquioalveolar/química , Enfermedades del Colágeno/genética , Enfermedades del Colágeno/fisiopatología , Femenino , Humanos , Fibrosis Pulmonar Idiopática/fisiopatología , Enfermedades Pulmonares Intersticiales/fisiopatología , Masculino , Persona de Mediana Edad , Estudios Prospectivos , ARN Mensajero/metabolismo , Receptores CXCR3/genética , Receptores CXCR4/genética , Receptores de Interleucina-8B/genética , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Enfermedades Vasculares/genética , Enfermedades Vasculares/fisiopatología , Factor A de Crecimiento Endotelial Vascular/genética
20.
J Biomech ; 43(2): 355-63, 2010 Jan 19.
Artículo en Inglés | MEDLINE | ID: mdl-19837410

RESUMEN

In this paper the mechanical response of soft collagenous tissues with regular fiber arrangement (RSCTs) is described by means of a nanoscale model and a two-step micro-macro homogenization technique. The non-linear collagen constitutive behavior is modeled at the nanoscale by a novel approach accounting for entropic mechanisms as well as stretching effects occurring in collagen molecules. Crimped fibers are reduced to equivalent straight ones at the microscale and the constitutive response of RSCTs at the macroscale is formulated by homogenizing a fiber reinforced material. This approach has been applied to different RSCTs (tendon, periodontal ligament and aortic media), resulting effective and accurate as proved by the excellent agreement with available experimental data. The model is based on few parameters, directly related to histological and morphological evidences and whose sensitivity has been widely investigated. Applications to simulation of some physiopathological mechanisms are also proposed, providing confirmation of clinical evidences and quantitative indications helpful for clinical practice.


Asunto(s)
Colágeno/fisiología , Tejido Conectivo/fisiología , Modelos Biológicos , Algoritmos , Aorta/fisiología , Aorta/ultraestructura , Fenómenos Biomecánicos , Colágeno/química , Colágeno/ultraestructura , Enfermedades del Colágeno/patología , Enfermedades del Colágeno/fisiopatología , Tejido Conectivo/ultraestructura , Elasticidad , Humanos , Nanoestructuras , Dinámicas no Lineales , Ligamento Periodontal/fisiología , Ligamento Periodontal/ultraestructura , Tendones/fisiología , Tendones/ultraestructura , Termodinámica , Túnica Media/fisiología , Túnica Media/ultraestructura
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