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2.
Acta cancerol ; 42(1): 34-38, ene.-jun. 2013. ilus
Artículo en Español | LILACS, LIPECS | ID: lil-712825

RESUMEN

Se describe el caso de un paciente varón de 39 años, natural y procedente de Cajamarca, agricultor, sin antecedentes de importancia, evaluado en el Instituto Nacional de Enfermedades Neoplásicas (INEN) con tiempo de enfermedad de 20 años caracterizado por lesiones eritematoescamosas, hiperqueratosicas, hiper e hipopigmentadas en cuello, tórax, abdomen, miembros superiores e inferiores, pabellon auricular izquierdo, cuero cabelludo y región frontal, clínicamente compatibles con Epidermodisplasia Verruciformis.


We describe the case of a male patient aged 39, from and natural of Cajamarca, farmer, no history of importance, which goes to National Institute of Neoplastic Diseases (INEN) with a disease duration of 20 years characterized by erythematous lesions, hyper- keratosis, hyper-and hypopigmented lesions in neck, chest, abdomen, arms and legs, left ear, scalp and frontal region, clinically compatible with epidermodysplasia verruciformis.


Asunto(s)
Humanos , Masculino , Adulto , Epidermodisplasia Verruciforme , Epidermodisplasia Verruciforme/terapia , Neoplasias Cutáneas
3.
Dermatol. peru ; 23(1): 52-55, ene.-mar. 2013. ilus
Artículo en Español | LILACS, LIPECS | ID: lil-765198

RESUMEN

La epidermodisplasia verruciforme (EV) es una genodermatosis rara y hereditaria que ocasiona una susceptibilidad incrementada a infecciones por serotipos espec¡ficas de papilomavirus humano, se manifiesta con lesiones cut neas similares a verrugas planas, pitiriasis versicolor y queratosis seborreicas. Existen dos fenotipos de EY, benigno y maligno, lo cual va a condicionar el pron¢stico de la enfermedad; hasta el momento sigue siendo una condici¢n de dif¡cil manejo que requiere un seguimiento de las lesiones por su riesgo de malignizacion.


Epidermodysplasia verruciformis is a rare, inherited genoderma-tosis resulting in increased susceptibility to infections by specific serotypes of HPY, manifesting with skin lesions similar to flat warts, pityriasis versicolor and seborrheic keratoses. There are two phenotypes, benign and malignant, which will condition the prognosis of the disease so far remains an unwieldy condition that requires monuoring of its risk lesions of malignant.


Asunto(s)
Humanos , Masculino , Adulto , Epidermodisplasia Verruciforme , Epidermodisplasia Verruciforme/diagnóstico , Epidermodisplasia Verruciforme/terapia , Ilustración Médica
4.
Folia dermatol. peru ; 23(2): 67-72, may.-ago.2012. ilus, tab
Artículo en Español | LILACS, LIPECS | ID: lil-786451

RESUMEN

La epidermodisplasia verruciforme es una genodermatosis rara que condiciona una susceptibilidad anormal a infecciones por el virus del papiloma humano, presentando lesiones cutáneas con potencial oncogénico. Objetivo: determinar la frecuencia de epidermodisplasia verruciforme y caracterizas los hallazgos demográficos, clínicos y terapéuticos de los pacientes que acudieron a la Cátedra de Dermatología del Hospital de Clínicas, entre los años 2003, 2012. Material y métodos: se realizó un estudio descriptico de pacientes con diagnóstico clínico e histopatológico de epidermodisplasia verruciforme. Resultados: se encontraron cinco casos. Todos los pacientes iniciaron el cuadro en la infancia y presentaron lesiones tipo pitiriasis versicolor y verrugas planas. Todos refirieron exposición solar crónica y familiares de primer grado con la misma enfermedad. La neoplasia más frecuente fue al enfermedad de Bowen, seguida del carcinoma epidermoide infiltrante. Los tratamientos incluyeron cirugía, crioterapia y 5-fluorouracilo tópico...


Epidermodysplasia verruciformis is a rare genodermatosis characterized by an abnormal susceptibility to human papiloma virus infection, developing cutaneous lesions with oncogenic potential. Objective: To determine the frequency, clinical demographic and therapeutic characteristics of patients who attend to the Dermatology Department of the Hospital de Clinicas between 2003 and 2012. Methods: A descriptive study of patients with clinical and histopathological diagnosis of epidermodysplasia verruciformis was carried out. Results: Five cases were found. Childhood-onset of disease, pityriasis versicolor-like lesions and flat warts were seen in all cases. All patients reported chronic sun exposure and first-degree relatives with the same disease. BowenÆs disease was the most frequent neoplasm, followed by invasive squamous cell carcinoma. Treatment modalities included surgery, cryotherapy and topical 5 fluorouracil. Discussion: Consistently to the infrequent nature of the disease, only five cases were diagnosed in the years. Unlike other studies, BowenÆs disease was the predominant neoplasm...


Asunto(s)
Humanos , Enfermedad de Bowen , Epidermodisplasia Verruciforme , Epidermodisplasia Verruciforme/cirugía , Epidermodisplasia Verruciforme/terapia , Infecciones por Papillomavirus , Neoplasias Cutáneas , Epidemiología Descriptiva
5.
J Cutan Med Surg ; 13(6): 317-20, 2009.
Artículo en Inglés | MEDLINE | ID: mdl-19919810

RESUMEN

BACKGROUND: Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by massive infection with human papillomaviruses (HPVs) and development of skin cancer. Myelodysplastic syndromes (MDSs) are a group of chronic conditions that involve dysplastic hematopoiesis, peripheral blood cytopenias, and a high incidence of progression into leukemia. METHODS: We describe the intriguing association of these two premalignant conditions (EV and MDS) in one patient. These diagnoses were confirmed by histopathologic examination and cytogenetic abnormalities of bone marrow cells. RESULTS: The patient presented initially with clinical features typical of EV and impairment of cell-mediated immunity. In the skin lesions, HPVs 23 and 25 were identified by nested polymerase chain reaction. Six years later, he had recurrent episodes of mucosal bleeding with fever, weakness, and fatigue. At this time, severe refractory anemia and neutropenia were observed, and bone marrow smears showed hypercellularity with abnormal dysplastic megakaryocytes. The cytogenetic pattern showed abnormalities involving trisomy of chromosomes 8 and 21. The patient received a diagnosis of the indolent subtype of MDS. CONCLUSIONS: Through the observation of our patient and review of the literature, we hypothesized that the pathomechanisms, including the role of oncogenes and cytokines, are connected to the progression to malignancy in these settings.


Asunto(s)
Epidermodisplasia Verruciforme/diagnóstico , Síndromes Mielodisplásicos/diagnóstico , Diagnóstico Diferencial , Epidermodisplasia Verruciforme/complicaciones , Epidermodisplasia Verruciforme/terapia , Humanos , Masculino , Síndromes Mielodisplásicos/complicaciones , Adulto Joven
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