RESUMEN
Congenital ichthyoses are a heterogeneous group of genetic skin disorders characterized by defects in the critical barrier function of the skin. These life-long conditions present a significant therapeutic challenge in dermatology. One important example is Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects, or CHILD syndrome. This is a rare congenital ichthyosis caused by mutations in cholesterol biosynthesis. With limited success, the cutaneous features of this condition have historically been managed symptomatically with emollients, topical keratolytics, and topical steroids. However, over the last decade, topical therapy directed at the pathogenesis of this condition has emerged as an effective treatment. Herein, we report a case of successful treatment of the cutaneous features of CHILD syndrome with compounded simvastatin and cholesterol gel and highlight the role of the compounding pharmacist in the care of patients with congenital ichthyosis.
Asunto(s)
Anomalías Múltiples/fisiopatología , Colesterol/farmacología , Enfermedades Genéticas Ligadas al Cromosoma X/fisiopatología , Eritrodermia Ictiosiforme Congénita/fisiopatología , Deformidades Congénitas de las Extremidades/fisiopatología , Adolescente , Humanos , SimvastatinaAsunto(s)
Anomalías Múltiples/fisiopatología , Enfermedades Genéticas Ligadas al Cromosoma X/fisiopatología , Eritrodermia Ictiosiforme Congénita/fisiopatología , Deformidades Congénitas de las Extremidades/fisiopatología , Xantomatosis/fisiopatología , 3-Hidroxiesteroide Deshidrogenasas/genética , Anomalías Múltiples/genética , Femenino , Enfermedades Genéticas Ligadas al Cromosoma X/genética , Humanos , Eritrodermia Ictiosiforme Congénita/genética , Deformidades Congénitas de las Extremidades/genética , Masculino , Mutación , Xantomatosis/genéticaRESUMEN
BACKGROUND: Chanarin-Dorfman syndrome (CDS) is a rare syndromic disease related to an accumulation of triacylglycerol in most organs. The aim of our study was to investigate various organs in a large series of CDS patients. RESULTS: We report for the first time thyroid function impairment in CDS. Among 12 investigated patients, 7 showed thyroid function impairment. All of them were over 30 of age. The 5 remaining investigated patients with normal thyroid function were under 30. Thyroid loss of function is an unknown clinical feature of CDS that could gradually develop with age. Thyroid ultrasound showed an abnormal aspect in all investigated patients (6 with thyroid impairment and 3 with normal thyroid function). Cervical MRI done in 2 patients with thyroid impairment showed fat infiltration of thyroid parenchyma. Audiogram carried out in 8 of our patients showed sensorineural hearing impairment in all patients, although only 2 patients suffered from clinical hypoacusia. We also demonstrated that kidney could be a more commonly involved organ than previously reported in the literature. A poorly differentiated kidney parenchyma is a common feature in our series. One patient showed cerebellar atrophy and T2 hypersignal of brain's white matter in MRI. All patients carried the same founder mutation c.773(- 1)G > A in the ABDH5 gene. DISCUSSION: Aside from the congenital ichthyosiform erythroderma, the most common symptom of CDS, in addition to other organs involvement frequently reported in the literature, we described thyroid dysfunction, an unreported feature, probably related to the lipid infiltration of the thyroid parenchyma. The association found between age and hypothyroidism in CDS patients could explain the gradually development of thyroid disease with age. CONCLUSION: We reported a thyroid dysfunction and unreported ultrasonographic aspects of kidneys and cerebral MRI in CDS patients. METHODS: We performed clinical analyses in 15 patients in whom thyroid, liver, ocular, kidney, skeletal muscle and neurological involvement were explored. Genetic and molecular explorations were performed by direct sequence analysis. Software SPSS, Fisher's exact test and ANOVA were used for statistical analyses.
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1-Acilglicerol-3-Fosfato O-Aciltransferasa/genética , Eritrodermia Ictiosiforme Congénita/metabolismo , Eritrodermia Ictiosiforme Congénita/fisiopatología , Errores Innatos del Metabolismo Lipídico/metabolismo , Errores Innatos del Metabolismo Lipídico/fisiopatología , Enfermedades Musculares/metabolismo , Enfermedades Musculares/fisiopatología , Glándula Tiroides/metabolismo , Glándula Tiroides/fisiopatología , Adulto , Exones/genética , Femenino , Homocigoto , Humanos , Intrones/genética , Masculino , Persona de Mediana Edad , Músculo Esquelético/metabolismo , Músculo Esquelético/fisiopatología , Mutación/genética , Estudios RetrospectivosAsunto(s)
Eritrodermia Ictiosiforme Congénita/tratamiento farmacológico , Ictiosis Lamelar/tratamiento farmacológico , Queratolíticos/uso terapéutico , Errores Innatos del Metabolismo Lipídico/tratamiento farmacológico , Enfermedades Musculares/tratamiento farmacológico , Ácidos Nicotínicos/uso terapéutico , Adolescente , Femenino , Humanos , Eritrodermia Ictiosiforme Congénita/fisiopatología , Ictiosis Lamelar/fisiopatología , Errores Innatos del Metabolismo Lipídico/fisiopatología , Enfermedades Musculares/fisiopatología , Crema para la Piel/uso terapéutico , Tomografía de Coherencia Óptica , Pérdida Insensible de AguaRESUMEN
Hepatitis C virus (HCV) particles closely mimic human very-low-density lipoproteins (VLDL) to evade humoral immunity and to facilitate cell entry. However, the principles that govern HCV association with VLDL components are poorly defined. Using an siRNA screen, we identified ABHD5 (α/ß hydrolase domain containing protein 5, also known as CGI-58) as a new host factor promoting both virus assembly and release. ABHD5 associated with lipid droplets and triggered their hydrolysis. Importantly, ABHD5 Chanarin-Dorfman syndrome mutants responsible for a rare lipid storage disorder in humans were mislocalised, and unable to consume lipid droplets or support HCV production. Additional ABHD5 mutagenesis revealed a novel tribasic motif that does not influence subcellular localization but determines both ABHD5 lipolytic and proviral properties. These results indicate that HCV taps into the lipid droplet triglyceride reservoir usurping ABHD5 lipase cofactor function. They also suggest that the resulting lipid flux, normally devoted to VLDL synthesis, also participates in the assembly and release of the HCV lipo-viro-particle. Altogether, our study provides the first association between the Chanarin-Dorfman syndrome protein and an infectious disease and sheds light on the hepatic manifestations of this rare genetic disorder as well as on HCV morphogenesis.
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1-Acilglicerol-3-Fosfato O-Aciltransferasa/metabolismo , Hepacivirus/fisiología , Hepatitis C/metabolismo , Ensamble de Virus/fisiología , Western Blotting , Citometría de Flujo , Técnica del Anticuerpo Fluorescente , Técnicas de Silenciamiento del Gen , Humanos , Eritrodermia Ictiosiforme Congénita/metabolismo , Eritrodermia Ictiosiforme Congénita/fisiopatología , Errores Innatos del Metabolismo Lipídico/metabolismo , Errores Innatos del Metabolismo Lipídico/fisiopatología , Microscopía Confocal , Enfermedades Musculares/metabolismo , Enfermedades Musculares/fisiopatología , Reacción en Cadena en Tiempo Real de la Polimerasa , Triglicéridos/metabolismoRESUMEN
IMPORTANCE: Ichthyosis with confetti (IWC) is a genodermatosis caused by dominant negative mutations in the gene encoding keratin 10 (KRT10). We investigated clinical and genetic details of a substantial number of patients with IWC in order to define major and minor criteria for diagnosis of this rare disorder. OBSERVATIONS: Parallel clinical investigation of 6 patients with IWC revealed a novel spectrum of phenotypes. We found several features that qualify as major criteria for diagnosis, which are clearly and consistently associated with the condition. These included malformation of ears, hypoplasia of mammillae, and dorsal acral hypertrichosis. Genetic analysis of patients revealed several different frameshift mutations in intron 6 or exon 7 of KRT10. Analysis of this locus in 17 unrelated control individuals revealed 2 novel polymorphisms of KRT10. CONCLUSIONS AND RELEVANCE: We present for the first time to our knowledge the spectrum of clinical variability of IWC in 6 patients with confirmed mutations in KRT10. From this, we have extracted major and minor criteria to aid early and correct clinical diagnosis. Ectodermal malformations, present in all patients, suggest a novel classification of IWC as a syndrome. There is remarkable genetic variation at the IWC disease locus within control individuals from the general population.
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Variación Genética , Eritrodermia Ictiosiforme Congénita/fisiopatología , Ictiosis/genética , Queratina-10/genética , Adulto , Niño , Exones/genética , Femenino , Genotipo , Humanos , Eritrodermia Ictiosiforme Congénita/diagnóstico , Eritrodermia Ictiosiforme Congénita/genética , Intrones/genética , Masculino , Mutación , Fenotipo , Polimorfismo Genético , Síndrome , Adulto JovenRESUMEN
In the last decades, nine inherited errors of the distal part of cholesterol biosynthesis have been recognized. Affected patients present complex malformation syndromes involving different organs and systems with variable degrees of severity. We report on the phenotype evolution of three patients with enzymatic defects at three distinct steps of such pathway: Smith-Lemli-Opitz syndrome, X-linked dominant chondrodysplasia punctata type 2 and congenital hemidysplasia with ichthyosiform erythroderma and limb defects syndrome. The patients' natural history, from childhood to adulthood, is thoroughly described in order to contribute for a better knowledge of these diseases. Our ultimate goals are to contribute for a better characterization of the long-term course of these metabolic disorders and for the recognition of such diseases in older patients.
Asunto(s)
Anomalías Múltiples/fisiopatología , Condrodisplasia Punctata/fisiopatología , Enfermedades Genéticas Ligadas al Cromosoma X/fisiopatología , Eritrodermia Ictiosiforme Congénita/fisiopatología , Deformidades Congénitas de las Extremidades/fisiopatología , Fenotipo , Síndrome de Smith-Lemli-Opitz/fisiopatología , Adolescente , Adulto , Niño , Preescolar , Colesterol/biosíntesis , Progresión de la Enfermedad , Femenino , Humanos , Recién Nacido , MasculinoRESUMEN
Neutral lipid storage disease is caused by mutations in the CGI-58 or the PNPLA2 genes. Lipid storage can be detected in various cell types including blood granulocytes. While CGI-58 mutations are associated with Chanarin-Dorfman syndrome, a condition characterized by lipid storage and skin involvement (ichthyosis), mutations in the patatin-like phospholipase domain-containing protein 2 gene (PNPLA2) were reported with skeletal and cardiac muscle disease only. We describe clinical, myopathological, magnetic resonance imaging (MRI), and genetic findings of six patients carrying different recessive PNPLA2 mutations. Pulse-chase labeling of control and patient cells with supplementation of clenbuterol, salmeterol, and dexamethasone was performed in vitro. The patients share a recognizable phenotype with prominent shoulder girdle weakness and mild pelvic girdle and distal muscle weakness, with highly elevated creatine kinase (CK) and cardiomyopathy developing at later stages. Muscle histology invariably reveals massive accumulation of lipid droplets. New muscle or whole-body MRI techniques may assist diagnosis and may become a useful tool to quantify intramuscular lipid storage. Four novel and two previously reported mutations were detected, affecting different parts of the PNPLA2 gene. Activation of hormone-sensitive lipase by beta-adrenergic substances such as clenbuterol appears to bypass the enzymatic block in PNPLA2-deficient patient cells in vitro. PNPLA2 deficiency is a slowly progressive myopathy with onset around the third decade. Cardiac involvement is relatively common at a later stage. Muscle MRI may detect increased lipid in a characteristic distribution, which could be used for monitoring disease progression. Beta-adrenergic agents may be beneficial in improving triacylglycerol breakdown in patients with PNPLA2 mutations.
Asunto(s)
Eritrodermia Ictiosiforme Congénita/genética , Eritrodermia Ictiosiforme Congénita/fisiopatología , Lipasa/genética , Errores Innatos del Metabolismo Lipídico/genética , Errores Innatos del Metabolismo Lipídico/fisiopatología , Enfermedades Musculares/genética , Enfermedades Musculares/fisiopatología , Mutación , Adulto , Análisis Mutacional de ADN , Femenino , Humanos , Eritrodermia Ictiosiforme Congénita/diagnóstico , Errores Innatos del Metabolismo Lipídico/diagnóstico , Imagen por Resonancia Magnética , Masculino , Músculo Esquelético/patología , Enfermedades Musculares/diagnóstico , FenotipoRESUMEN
Lipid storage myopathy (LSM) is pathologically characterized by prominent lipid accumulation in muscle fibers due to lipid dysmetabolism. Although extensive molecular studies have been performed, there are only four types of genetically diagnosable LSMs: primary carnitine deficiency (PCD), multiple acyl-coenzyme A dehydrogenase deficiency (MADD), neutral lipid storage disease with ichthyosis, and neutral lipid storage disease with myopathy. Making an accurate diagnosis, by specific laboratory tests including genetic analyses, is important for LSM as some of the patients are treatable: individuals with PCD show dramatic improvement with high-dose oral L-carnitine supplementation and increasing evidence indicates that MADD due to ETFDH mutations is riboflavin responsive.
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Metabolismo de los Lípidos , Músculo Esquelético/patología , Acil-CoA Deshidrogenasa/deficiencia , Acil-CoA Deshidrogenasa/genética , Carnitina/deficiencia , Carnitina/genética , Diagnóstico Diferencial , Humanos , Eritrodermia Ictiosiforme Congénita/genética , Eritrodermia Ictiosiforme Congénita/patología , Eritrodermia Ictiosiforme Congénita/fisiopatología , Eritrodermia Ictiosiforme Congénita/terapia , Errores Innatos del Metabolismo Lipídico/genética , Errores Innatos del Metabolismo Lipídico/patología , Errores Innatos del Metabolismo Lipídico/fisiopatología , Errores Innatos del Metabolismo Lipídico/terapia , Músculo Esquelético/fisiopatología , Enfermedades Musculares/genética , Enfermedades Musculares/patología , Enfermedades Musculares/fisiopatología , Enfermedades Musculares/terapia , Enfermedades de la Piel/enzimología , Enfermedades de la Piel/genética , Enfermedades de la Piel/patología , Enfermedades de la Piel/fisiopatologíaRESUMEN
BACKGROUND: Chanarin-Dorfman syndrome (CDS) is a rare autosomal recessive disorder characterized by nonbullous congenital ichthyosiform erythroderma (NCIE) and an intracellular accumulation of triacylglycerol (TG) droplets in most tissues. The clinical phenotype involves multiple organs and systems, including liver, eyes, ears, skeletal muscle and central nervous system (CNS). Mutations in ABHD5/CGI58 gene are associated with CDS. METHODS: Eight CDS patients belonging to six different families from Mediterranean countries were enrolled for genetic study. Molecular analysis of the ABHD5 gene included the sequencing of the 7 coding exons and of the putative 5' regulatory regions, as well as reverse transcript-polymerase chain reaction analysis and sequencing of normal and aberrant ABHD5 cDNAs. RESULTS: Five different mutations were identified, four of which were novel, including two splice-site mutations (c.47+1G>A and c.960+5G>A) and two large deletions (c.898_*320del and c.662-1330_773+46del). All the reported mutations are predicted to be pathogenic because they lead to an early stop codon or a frameshift producing a premature termination of translation. While nonsense, missense, frameshift and splice-site mutations have been identified in CDS patients, large genomic deletions have not previously been described. CONCLUSIONS: These results emphasize the need for an efficient approach for genomic deletion screening to ensure an accurate molecular diagnosis of CDS. Moreover, in spite of intensive molecular screening, no mutations were identified in one patient with a confirmed clinical diagnosis of CDS, appointing to genetic heterogeneity of the syndrome.
Asunto(s)
1-Acilglicerol-3-Fosfato O-Aciltransferasa/genética , Eliminación de Secuencia , Adolescente , Adulto , Niño , Femenino , Humanos , Eritrodermia Ictiosiforme Congénita/genética , Eritrodermia Ictiosiforme Congénita/fisiopatología , Ictiosis Lamelar/genética , Ictiosis Lamelar/fisiopatología , Lactante , Errores Innatos del Metabolismo Lipídico/genética , Errores Innatos del Metabolismo Lipídico/fisiopatología , Masculino , Enfermedades Musculares/genética , Enfermedades Musculares/fisiopatología , Mutación , Fenotipo , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Análisis de Secuencia de ADN , SíndromeAsunto(s)
Genes Recesivos , Eritrodermia Ictiosiforme Congénita , Errores Innatos del Metabolismo Lipídico , Preescolar , Diagnóstico Diferencial , Humanos , Eritrodermia Ictiosiforme Congénita/diagnóstico , Eritrodermia Ictiosiforme Congénita/genética , Eritrodermia Ictiosiforme Congénita/fisiopatología , Errores Innatos del Metabolismo Lipídico/diagnóstico , Errores Innatos del Metabolismo Lipídico/genética , Errores Innatos del Metabolismo Lipídico/fisiopatología , Masculino , Mutación , Factores de RiesgoRESUMEN
Congenital recessive ichthyoses (CRI) form a remarkably heterogeneous group of diseases, resulting from mutations in at least eight distinct genes, six of which have been identified so far. In the present study we ascertained two CRI families of Iranian and Druze origins. Exploiting the high degree of consanguinity characterizing these populations, we typed all family members for microsatellite markers spanning the major CRI chromosomal loci and used homozygosity mapping to identify candidate genes for subsequent mutational analysis. This strategy led to the rapid identification of two novel homozygous CRI-causing mutations in TGM1 (c.2058delC) and FLJ39501 (p.W521X). The present data demonstrate that the molecular analyses of CRI in consanguineous families can be readily completed in less than 96 h at relatively low costs.
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Sistema Enzimático del Citocromo P-450/genética , Análisis Mutacional de ADN/métodos , Eritrodermia Ictiosiforme Congénita/genética , Mutación , Transglutaminasas/genética , Consanguinidad , Dermatitis Exfoliativa/genética , Femenino , Predisposición Genética a la Enfermedad , Homocigoto , Humanos , Eritrodermia Ictiosiforme Congénita/etnología , Eritrodermia Ictiosiforme Congénita/fisiopatología , Lactante , Recién Nacido , Irán/etnología , Israel , Masculino , Repeticiones de Microsatélite/genética , Linaje , Sepsis/genéticaRESUMEN
Netherton syndrome is a rare disorder inherited in an autosomal recessive pattern consisting of ichthyosiform dermatosis, hair shaft abnormalities (trichorrhexis invaginata), and an atopic diathesis. Patients with Netherton syndrome have been found to have a mutation on chromosome 5q32 in a gene named SPINK5 (serine protease inhibitor, Kazal type-5), which encodes an inhibitor of serine proteases called LEKTI. We report a female patient with previously undiagnosed Netherton syndrome who presented to participate in a clinical research trial investigating the benefit of topical tacrolimus 0.03% ointment [Protopic (Fujisawa Pharmaceutical Co. Ltd., Japan)] for the treatment of atopic dermatitis. This patient was confirmed to have a gene mutation in SPINK5. Current literature suggests a relative contraindication for use of topical tacrolimus in patients with Netherton syndrome owing to concern for increased systemic absorption of the drug. Our patient was not able to tolerate topical tacrolimus owing to local irritation, and did not derive any benefit from therapy. Though rare, when evaluating patients with a possible diagnosis of atopic dermatitis, an index of suspicion for Netherton Syndrome must be maintained. History and overall clinical findings, especially in regards to examination of the hair, will aid in diagnosis.
Asunto(s)
Eritrodermia Ictiosiforme Congénita/tratamiento farmacológico , Preescolar , Dermatitis Atópica/diagnóstico , Femenino , Humanos , Eritrodermia Ictiosiforme Congénita/diagnóstico , Eritrodermia Ictiosiforme Congénita/fisiopatología , Inmunosupresores/uso terapéutico , Tacrolimus/uso terapéutico , Resultado del TratamientoAsunto(s)
Epidermis/fisiología , Cabello/anomalías , Eritrodermia Ictiosiforme Congénita/fisiopatología , Animales , Proteínas Portadoras , Epidermis/fisiopatología , Humanos , Ratones , Proteínas Inhibidoras de Proteinasas Secretoras , Inhibidor de Serinpeptidasas Tipo Kazal-5 , Inhibidores de Serina Proteinasa , SíndromeRESUMEN
La eritrodermia ictiosiforme congénita ampollosa (EICA) es una anomalía congénita de la queratinización que se presenta en el momento del nacimiento o poco después del mismo. Entre las características clínicas de esta dermatosis destaca el eritema, la descamación y la aparición de ampollas subcórneas que rápidamente se rompen, dejando áreas erosivas, especialmente en superficies de roce, donde estas lesiones se vuelven vegetantes y pueden sobreinfectarse. Se presenta un caso de EICA en un varón de 8 meses de edad sin antecedentes familiares (AU)
Congenital bullous ichthyosiform erythroderma (CBIE) is a keratinization congenital disorder that appear at the moment of the birth or in first months of life. Clinical features include erythema, desquamation, and subcorneous bulla formation. These bulla quickly break, leaving erosive areas, especially in friction surfaces where these lesions become vegetants and overinfected. A case of CBIE in a male of 8 months old without family antecedents was presented (AU)
Asunto(s)
Humanos , Masculino , Lactante , Eritrodermia Ictiosiforme Congénita/complicaciones , Eritrodermia Ictiosiforme Congénita/terapia , Eritrodermia Ictiosiforme Congénita/tratamiento farmacológico , Hiperqueratosis Epidermolítica/complicaciones , Hiperqueratosis Epidermolítica/diagnóstico , Hiperqueratosis Epidermolítica/genética , Emolientes/uso terapéutico , Eritrodermia Ictiosiforme Congénita/fisiopatología , Biopsia/métodos , Biopsia , Administración TópicaRESUMEN
Proteinase inhibitors are important negative regulators of proteinase action in vivo and are thus involved in several pathophysiological processes. Starting with the isolation of two new peptides from human blood filtrate, we succeeded in cloning a cDNA encoding the precursor protein for a novel 15-domain Kazal-type-related serine proteinase inhibitor. Two of the 15 domains almost exactly match the Kazal-type pattern, whereas the other 13 domains exhibit only four instead of six cysteine residues. Since the corresponding gene is expressed in several lympho-epithelial tissues, we termed this inhibitor lympho-epithelial Kazal-type-related inhibitor (LEKTI). For three of the 15 LEKTI domains, we demonstrated a significant trypsin-inhibiting activity. Recent results of another group show a relation between mutations within the LEKTI gene and the severe congenital disorder Netherton syndrome. In this review article, we give an overview of the already known data on the structure, processing, gene expression, and pathophysiological role of LEKTI.
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Proteínas Portadoras , Inhibidores de Serina Proteinasa , Secuencia de Aminoácidos , Secuencia Conservada , Expresión Génica , Humanos , Eritrodermia Ictiosiforme Congénita/fisiopatología , Datos de Secuencia Molecular , Péptidos/sangre , Estructura Terciaria de Proteína , Proteínas Inhibidoras de Proteinasas Secretoras , Inhibidor de Serinpeptidasas Tipo Kazal-5 , Inhibidores de Serina Proteinasa/química , Inhibidores de Serina Proteinasa/genética , Inhibidores de Serina Proteinasa/fisiología , SíndromeAsunto(s)
Anomalías Múltiples , Eritrodermia Ictiosiforme Congénita , Deformidades Congénitas de las Extremidades , Anomalías Múltiples/etiología , Anomalías Múltiples/fisiopatología , Encéfalo/anomalías , Diagnóstico Diferencial , Femenino , Ligamiento Genético/genética , Humanos , Eritrodermia Ictiosiforme Congénita/etiología , Eritrodermia Ictiosiforme Congénita/fisiopatología , Deformidades Congénitas de las Extremidades/etiología , Deformidades Congénitas de las Extremidades/fisiopatología , Pronóstico , Síndrome , Cromosoma X/genéticaAsunto(s)
Enfermedades del Cabello , Hipersensibilidad Inmediata , Eritrodermia Ictiosiforme Congénita , Diagnóstico Diferencial , Enfermedades del Cabello/diagnóstico , Enfermedades del Cabello/fisiopatología , Humanos , Hipersensibilidad Inmediata/diagnóstico , Hipersensibilidad Inmediata/fisiopatología , Eritrodermia Ictiosiforme Congénita/diagnóstico , Eritrodermia Ictiosiforme Congénita/fisiopatología , Pronóstico , SíndromeRESUMEN
La hiperqueratosis epidermolítica es una alteración hereditaria, con un patrón autosómico dominante. El espectro clínico es muy variable e incluye varias formas de presentación, que anteriormente se consideraban como una forma de ictiosis (ictiosis hystrix, eritrodermia ictiosis forme ampollosa congénita). Estudios recientes señalan mutaciones en los genes 12q y 17q que codifican las queratinas K1 y K10 respectivamente, como los posibles factores causales. Se comunican tres casos con formas clínicas diferentes