[Recombinant human epithelial growth factor accelerates healing of cervical erosion].

OBJECTIVE: To observe the effect of recombinant human epithelial growth factor (rhEGF) in promoting the healing of cervical erosion. METHODS: Forty-eight patients with cervical erosion were treated with rhEGF and 30 with 500 kHz high-frequency electromagnetic wave, and the effects of the therapies were compared in terms of healing of the cervical wound, healing time, volume of vaginal discharge and bleeding and the lasting time. RESULTS: In comparison with radiofrequency therapy, the healing of the lesion took significantly shorter time with rhEGF therapy, which also resulted in less vaginal discharge that lasted for shorter time without causing vaginal bleeding. CONCLUSION: rhEGF can obviously accelerate the healing of cervical erosion.

Pharmacotherapeutic effects of toki-shakuyaku-san on leukorrhagia in young women.

Toki-shakuyaku-san is a traditional Chinese herbal prescriptions that is composed of 6 herbal plants, i.e., peony root, atractylodes lancea rhizome, alisma rhizome, hoelen, cnidium rhizome and Japanese angelica root. Administration with Toki-shakuyaku-san normalized irregular menstrual cycle, healed cervical pseudo-erosion and reduced leukorrhagia in young women who had insufficient luteal function.

[The clinico-morphological and cytological characteristics of the ecto- and endocervix with the use of the oral contraceptive triregol]. / Kliniko-morfologicheskie i tsitologicheskie osobennosti ékto- i éndotserviksa pri primenenii oral'nogo kontratseptiva triregol.

Cervix uteri status was examined in 55 young nulliparous women in the course of triphasic oral contraception. The status of the cervix uteri was assessed on the basis of clinical, colposcopic, cytologic, and morphofunctional examinations. Triphase oral contraception with triregol was found conducive to the formation of squamous-cell metaplasia in ectopic sites, this promoting epithelialization of the cervix uteri.

PIP: The objective of this investigation was the study of clinical-morphological characteristics of the ecto- and endocervix in young nulliparous women with pseudoerosions in the course of using the 3-phase oral contraceptive (OC) Triregol made by Gedeon Richter Inc. of Hungary, which contains ethinyl estradiol and levonorgestrel. 55 healthy women, 17-30 years old, were observed. In the anamnesis of these women there was 1 instance of induced abortion and 1 instance of self-induced abortion. 22 women were married, and the rest were not. 2 patients had a history of inflammatory disease of the uterus and of the adnexa. In addition to routine clinical examination, echographic and dilatational colposcopy was performed in all women before starting them on the preparation. The observation was performed every 3, 6, 9, and 12 months and in the course of 1-2 months after taking the OC. A piece of tissue was taken by biopsy from the cervix and scrapings from the mucous membrane of the cervical canal for morphological examination. In 11 patients (27.5%) ectopia of varying extent was diagnosed by colposcopy, and in 27 patients (67.5%) ectopia in the transformation phase was discovered. Leukoplakia occurred in 2 patients (5%). Cervical biopsies were taken from 40 patients, and glandular pseudoerosion was discovered in 36, of whom in 18 patients fulminating and/or diffusive infiltration of lymphocytes were found in the subepithelial tissues, whereas papillary pseudoerosion was found in 2 cases. After 3 months of OC use in 2 patients full epithelization of the cervix was detected with multilayered flat epithelia. In the 2 patients with leukoplakia neither positive nor negative changes were observed. In 2 out of 40 patients a section of ripe or not ripe flat celled metaplasia in the mucous of the cervical canal and in 1 patient hyperplasia of the reserve cells were discovered. It must be underlined that in none of the observations was there a progressive pathological process nor the genesis of dysplasia detected.