Violência no futebol: a percepção de torcedores dos grandes clubes de Curitiba-PR / Violence in football: the perception of fans of the big clubs of Curitiba-PR

O presente estudo objetivou analisar a percepção de violência por parte dos torcedores da capital paranaense. A metodologia desta pesquisa conta com análise qualitativa e quantitativa dos dados adquiridos a partir de entrevistas semiestruturadas realizadas com torcedores do Club Athletico Paranaense, Coritiba Foot Ball Club e Paraná Clube e membros da Torcida Os Fanáticos (Athletico), Torcida Império Alviverde (Coritiba) e Torcida Fúria Independente (Paraná). A partir de referenciais teóricos específicos, foram fundamentadas questões referentes às torcidas organizadas, a violência e suas principais motivações. Para realizar a sistematização dos dados utilizou-se o software Nvivo 12. As entrevistas foram transcritas e inseridas no software. Posteriormente, foram estabelecidas categorias a partir das temáticas emergentes. A percepção dos torcedores acerca da temática manifestou-se de forma centralizada em questões referentes a agressões principalmente físicas e também verbais, além de apontar como fator motivador a rivalidade e o desrespeito através da intolerância. Ao tratarmos das formas de expressão da violência no futebol, novamente fica evidente a percepção reduzida a brigas, xingamentos e provocações. Tal perspectiva está diretamente r elacionada ao entendimento de violência de cada indivíduo, onde por vezes seu entendimento e as formas de manifestação se misturam e são utilizados como sinônimos. Com base nisto pode-se observar que a violência presente no esporte não pode ser analisada de maneira isolada, mas deve considerar variáveis importantes relacionadas a sociedade de forma geral e aos indivíduos nela inseridos. Fazem-se necessários mais estudos referentes à percepção de violência dos torcedores e as principais motivações para que se possa entender de forma mais concreta e clara tais questões, possibilitando a elaboração de estratégias para coibir a violência no futebol. (AU)

The present study aimed to analyze the perception of violence on the part of fans in the capital of Paraná. The methodology of this research relies on qualitative and quantitative analysis of the data acquired from semi-structured interviews conducted with fans of Club Athletico Paranaense, Coritiba Foot Ball Club and Paraná Clube and members of Torcida Os Fanaticos (Athletico), Torcida Império Alviverde (Coritiba) and Torcida Fúria Independente (Paraná). Based on specific theoretical references, questions were raised regarding organized fans, violence and its main motivations. To carry out the systematization of the data, the Nvivo 12 software was used. The interviews were transcribed and inserted in the software. Subsequently, categories were established based on emerging themes. The perception of the fans about the theme was manifested in a centralized way in issues related to mainly physical and also verbal aggressions, besides pointing out rivalry and disrespect through intolerance as a motivating factor. When dealing with the forms of expression of violence in football, the perception reduced to fights, curses and provocations is again evident. Such perspective is directly related to the understanding of violence of each individual, where sometimes their understanding and the forms of manifestation are mixed and are used as synonyms. Based on this, it can be observed that the violence present in sport cannot be analyzed in an isolated way, but must consider important variables related to society in general and to the individuals inserted in it. More studies are needed regarding fans' perception of violence and the main motivations so that these issues can be understood in a more concrete and clear way, enabling the development of strategies to curb violence in football. (AU)

"Grumpy" or "furious"? arousal of emotion labels influences judgments of facial expressions.

Whether language information influences recognition of emotion from facial expressions remains the subject of debate. The current studies investigate how variations in emotion labels that are paired with expressions influences participants' judgments of the emotion displayed. Static (Study 1) and dynamic (Study 2) facial expressions depicting eight emotion categories were paired with emotion labels that systematically varied in arousal (low and high). Participants rated the arousal, valence, and dominance of expressions paired with labels. Isolated faces and isolated labels were also rated. As predicted, the label presented influenced participants' judgments of the expressions. Across both studies, higher arousal labels were associated with: 1) higher ratings of arousal for sad, angry, and scared expressions, and 2) higher ratings of dominance for angry, proud, and disgust expressions. These results indicate that emotion labels influence judgments of facial expressions.

Zolpidem-Associated Consequences: An Updated Literature Review With Case Reports.

A post-2000 literature search reviewed prevalence of health consequences associated with zolpidem, plus two salient case reports. Common zolpidem-related harms encompassed accidents, falls, overdoses, delirium, and infections. Risks to others included assaults, vehicular accidents, various crimes, and civil actions that occurred during zolpidem-induced delirium, withdrawal, and other impediments. Remarkably, much harm occurred while patients were taking therapeutic doses of licitly prescribed zolpidem (10-30 mg). Zolpidem-associated health, behavioral, and social problems comprise an international pandemic of preventable heath misfortunes.

Misophonia is associated with altered brain activity in the auditory cortex and salience network.

Misophonia is characterized by intense rage and disgust provoked by hearing specific human sounds resulting in social isolation due to avoidance. We exposed patients with symptom provoking audiovisual stimuli to investigate brain activity of emotional responses. 21 patients with misophonia and 23 matched healthy controls were recruited at the psychiatry department of the Amsterdam UMC. Participants were presented with three different conditions, misophonia related cues (video clips with e.g. lip smacking and loud breathing), aversive cues (violent or disgusting clips from movies), and neutral cues (video clips of e.g. someone meditating) during fMRI. Electrocardiography was recorded to determine physiological changes and self-report measures were used to assess emotional changes. Misophonic cues elicited anger, disgust and sadness in patients compared to controls. Emotional changes were associated with increases in heart rate. The neuroimaging data revealed increased activation of the right insula, right anterior cingulate cortex and right superior temporal cortex during viewing of the misophonic video clips compared to neutral clips. Our results demonstrate that audiovisual stimuli trigger anger and physiological arousal in patients with misophonia, associated with activation of the auditory cortex and salience network.

Up-Regulation of MiR-1915 Inhibits Proliferation, Invasion, and Migration of Helicobacter pylori-Infected Gastric Cancer Cells via Targeting RAGE

PURPOSE: Helicobacter pylori (HP)-infected gastric cancer (GC) is known to be a fatal malignant tumor, but the molecular mechanisms underlying its proliferation, invasion, and migration remain far from being completely understood. Our aim in this study was to explore miR-1915 expression and its molecular mechanisms in regulating proliferation, invasion, and migration of HP-infected GC cells. MATERIALS AND METHODS: Quantitative real-time PCR and western blot analysis were performed to determine miR-1915 and receptor for advanced glycation end product (RAGE) expression in HP-infected GC tissues and gastritis tissues, as well as human gastric mucosal cell line GES-1 and human GC cell lines SGC-7901 and MKN45. CCK8 assay and transwell assay were performed to detect the proliferation, invasion, and migration capabilities. MiR-1915 mimics and miR-1915 inhibitor were transfected into GC cells to determine the target relationship between miR-1915 and RAGE. RESULTS: MiR-1915 was under-expressed, while RAGE was over-expressed in HP-infected GC tissues and GC cells. Over-expressed miR-1915 could attenuate cellular proliferation, invasion, and migration capacities. RAGE was confirmed to be the target gene of miR-1915 by bioinformatics analysis and luciferase reporter assay. Moreover, HP-infected GC cellular proliferation, invasion, and migration were inhibited after treatment with pcDNA-RAGE. CONCLUSION: MiR-1915 exerted tumor-suppressive effects on cellular proliferation, invasion, and migration of HP-infected GC cells via targeting RAGE, which provided an innovative target candidate for treatment of HP-infected GC.

CRISPR/Cas9 Edited sRAGE-MSCs Protect Neuronal Death in Parkinson's Disease Model

BACKGROUND AND OBJECTIVES: Parkinson’s disease (PD) is a fatal and progressive degenerative disease of the nervous system. Until recently, its promising treatment and underlying mechanisms for neuronal death are poorly understood. This study was investigated to identify the molecular mechanism of neuronal death in the substantia nigra and corpus striatum of PD. METHODS: The soluble RAGE (sRAGE) secreting Umbilical Cord Blood—derived Mesenchymal Stem Cell (UCB-MSC) was generated by gene editing method using clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9). These cells were transplanted into Corpus Striatum of rotenone-induced PD animal models then behavioral test, morphological analysis, and immunohistochemical experiments were performed to determine the neuronal cell death and recovery of movement. RESULTS: The neuronal cell death in Corpus Striatum and Substantia Nigra was dramatically reduced and the movement was improved after sRAGE secreting UCB-MSC treatment in PD mice by inhibition of RAGE in neuronal cells. CONCLUSIONS: We suggest that sRAGE secreting UCB-MSC based therapeutic approach could be a potential treatment strategy for neurodegenerative disease including PD.

Oncologic, Perioperative Outcomes of Female Radical Cystectomy: Results from a Multicenter Study in Korea / Journal of the Korean Cancer Association, 대한암학회지

PURPOSE: The lower incidence of bladder cancer among women has led to a lack of information on female radical cystectomy (RC). This study aimed to analyze the characteristics related with female RC in a cohort from multiple academic institutions. MATERIALS AND METHODS: This was a retrospective review of 384 female patients who underwent RC for bladder cancer. Epidemiologic, perioperative variables including urologic referral periodwith consequent pathologic stage distributions were assessed. The changes in surgical techniques over time were illustrated. Also, we evaluated recurrence-free survival (RFS) at 2 and 5 years and overall survival (OS) at 5 years with stage-specific analyses using the Kaplan-Meier method. RESULTS: The mean follow-up time was 35 months (interquartile rage [IQR], 9 to 55). The average time to urologic referral with initial symptoms was 5.5 (IQR, 1 to 6) months and over 20% of patients visited clinics after 6 months. In subsequent stage distributions according to referral period, T2 or higher stage distributions were abruptly increased after 1 year. Overall 2-year/5-year RFS rates were 0.72/0.57 and 5-year OS was 0.61. Notable surgical descriptions were as follows: 91% of patients underwent open RC; 80% of patients underwent an ileal conduit; and 83% of patients received anterior exenteration. However, the proportions of robotic surgery, orthotopic neobladder and organ sparing cystectomy have increased recently. CONCLUSION: We identified the general characteristics and changes in pattern of female RC. Our results also suggest that women are susceptible to delays in referral to an urologist and are at greater risk for worse prognosis.

A questionnaire survey on road rage and anger-provoking situations in China.

This paper surveys the reactions of Chinese drivers when encountering anger-provoking situations, including traffic congestion, pedestrians crossing the street illegally, being flashed by the high beams of cars traveling in the opposite direction, aberrant overtaking by other cars and when the car ahead drives slowly. A questionnaire survey found that 69.4% of participants wait when encountering traffic congestion and that 71% of drivers tolerate pedestrians crossing the street illegally; moreover, 61.3% of drivers are "angry but tolerant" when encountering aberrant overtaking. However, 51.3% of drivers become enraged when flashed by the high beams of cars traveling in the opposite direction, and 34.1% of participants turn on their own high beams to fight back. Moreover, 61.4% of participants are dissatisfied when the car ahead drives slowly or fails to move when a traffic light turns green, and 53% of participants honk or flash their lights to prompt the driver of the car ahead. The results show that males become irritated more easily than females in all situations, except those in which pedestrians cross the street illegally. Age is a factor only when drivers are flashed by high beams or overtaken by other cars illegally. Driving experience has an effect when drivers encounter traffic congestion, are flashed by high beams, or are overtaken by other cars illegally or when the car ahead drives slowly; novices with fewer than two years of driving experience display greater tolerance for these events. The occupation of a driver acts on his/her responses when he/she is overtaken by other cars illegally or flashed by high beams or when pedestrians cross the street illegally. For the most effective measures to prevent road rage, 53.64% of participants chose "plan the trip in advance", 57.14% chose "strengthen law enforcement", and 71.5% chose "improve public transportation". Females, young people, and novices pay more attention to these measures.

Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages

BACKGROUND: Anti-Mullerian hormone (AMH) in women is secreted by granulosa cells of antral follicles. AMH appears to be a very stable marker for ovarian function. It may be used to diagnosis cases of premature ovarian failure, polycystic ovary syndrome (PCOS), and ovarian tumors. It has been suggested that cadmium exposure can reduce female fecundity. The purpose of this study was to investigate whether environmental exposure to cadmium was associated with alterations in AMH with regards to age. METHODS: In a cross-sectional study, the data of premenopausal women living in Seoul, ranging from 30 to 45 of age was collected. The study included a total of 283 women who completed serum AMH and whole blood cadmium assessments. Linear regression analyses were used in order to examine the association between cadmium and AMH. Given that age was the strongest confounder in both cadmium and AMH concentrations, we stratified subjects by 5 years old and analyzed their data. RESULTS: Geometric mean concentrations of blood cadmium and AMH were 0.97 μg/L and 3.02 ng/ml, respectively. Total association between cadmium and AMH was statistically significant (adjusted coefficient = − 0.34 (0.15), p = 0.02). After stratification, the only age group with a negative association between cadmium and AMH were the women raging between 30 and 35 years (adjusted coefficient = − 0.43 (0.18), p = 0.01). CONCLUSIONS: The results of this study suggest that environmental exposure to cadmium may alter the AMH level of premenopausal women, depending on their age group.

Rage against the machine? Google's self-driving cars versus human drivers.

INTRODUCTION: Automated driving represents both challenges and opportunities in highway safety. Google has been developing self-driving cars and testing them under employee supervision on public roads since 2009. These vehicles have been involved in several crashes, and it is of interest how this testing program compares to human drivers in terms of safety. METHODS: Google car crashes were coded by type and severity based on narratives released by Google. Crash rates per million vehicle miles traveled (VMT) were computed for crashes deemed severe enough to be reportable to police. These were compared with police-reported crash rates for human drivers. Crash types also were compared. RESULTS: Google cars had a much lower rate of police-reportable crashes per million VMT than human drivers in Mountain View, Calif., during 2009-2015 (2.19 vs 6.06), but the difference was not statistically significant. The most common type of collision involving Google cars was when they got rear-ended by another (human-driven) vehicle. Google cars shared responsibility for only one crash. CONCLUSIONS: These results suggest Google self-driving cars, while a test program, are safer than conventional human-driven passenger vehicles; however, currently there is insufficient information to fully examine the extent to which disengagements affected these results. PRACTICAL APPLICATION: Results suggest that highly-automated vehicles can perform more safely than human drivers in certain conditions, but will continue to be involved in crashes with conventionally-driven vehicles.

Fuming with rage! Do members of low status groups signal anger more than members of high status groups?

Owuamalam, Weerabangsa, Karunagharan and Rubin found that Malaysians associate people in low status groups with anger more than their higher status counterparts: the hunchback heuristic. But is this belief accurate? Here, we propose the alternative possibility that members of low-status groups might deliberately suppress anger to counter this stigma, while members of high-status groups might disinhibit their anger to assert their superiority. To test these propositions, we manipulated undergraduate students' relative group status by leading them to believe that provocative comments about their undergraduate social identity came from a professor (low-status condition) or a junior foundation year student (high-status condition). Using eye-tracking, we then measured their gaze durations on the comments, which we used as a physiological signal of anger: dwelling (Experiment 1). Results revealed that dwelling was significantly greater in the high-status condition than in the low-status condition. Experiment 2 conceptually replicated this pattern using a self-report method and found that the suppression-disinhibition effect occurred only when reputational concerns were strong.

Editorial Commentary: Is Anterolateral Ligament Reconstruction of the Knee Needed? The Debate Rages on.

A recent systematic review on the techniques, biomechanics, and clinical outcomes of anterolateral ligament reconstruction of the knee summarizes our current understanding of this hotly debated topic. In 2017, it is not clear if an anterolateral ligament reconstruction is needed in the setting of primary anterior cruciate ligament reconstruction.

Shame as a compromise for humiliation and rage in the internal representation of abuse by loved ones: Processes, motivations, and the role of dissociation.

This paper examines one particular way a person abused may come to internally position themselves and the abuser to understand their abuse experience. It is based on a differentiation and exploration of the dynamic relationship between shame and humiliation associated with complex feelings the abused has to the abuser. Humiliation is described as denoting the naked self exposed by another, while shame is described as denoting the naked self exposed to another. From this lens, abusive events are conceived as humiliating experiences that come to be represented as shame experiences. Shame is argued to cover over humiliation in order to separate the abused from their internal representation of the abuser (i.e., conceal the self-other object-relationship). This process is facilitated by dissociation and serves several functions, including cloaking hostile feelings (e.g., humiliation fury) toward the abusive (though loved) object. Shame, with the assistance of dissociation, becomes a compromise formation. It punishes the self for the initial humiliation rage directed at the object, protects the object from further attack and blame for the abuse, and obscures awareness of the rage felt toward the object as well as the reparatory guilt possible from it. Dissociation maintains this position by isolating the interpersonal field, the self and object, from the narrative of abuse events. The potential for freedom comes from eroding dissociation, leaving the shame bubble, entertaining the abusive (though loved) object as etiologically significant, and facing the humiliation and humiliation rage that provides the path to reparatory guilt.

Anger Rumination Scale: Validation in Mexico.

The aim of the study was to assess the validity of the Anger Rumination Scale (ARS; Sukhodolsky, Golub, & Cromwell, 2001) in a Mexican sample (n = 700, M age = 38.6, SD = 12.42). Through confirmatory factor analysis and using modification indices, the four-factor structure of the original scale was replicated: angry afterthoughts, thoughts of revenge, angry memories, and understanding of causes. In addition, the four-factor model had better goodness of fit indices than rival models with three and two factors. Alpha reliabilities were acceptable (.72 -.89). ARS results correlated with measures of state anger, trait anger, anger expression, and anger control (negatively); correlations were significant (ps < .001) ARS outcomes also correlated (ps < .001) with physical and verbal aggression, hostility, anger, and emotion suppression, suggesting convergent validity. Men reported more thoughts of revenge than women (p < .001; Eta squared = .026), but there was no evidence of gender differences on the other anger rumination scales, or in total scores.

Ameliorative Effects of Nilotinib on CCl4 Induced Liver Fibrosis Via Attenuation of RAGE/HMGB1 Gene Expression and Oxidative Stress in Rat / 전남의대학술지

Nilotinib as a tyrosine kinase inhibitor has been recently used to improve the liver fibrosis process, but the exact mechanisms still require further clarification. In this study, we investigated the anti-fibrotic effects of Nilotinib via RAGE/HMGB1axis and antioxidant mechanisms. This experimental study was performed in the Hamadan University of Medical Sciences, Iran, from May 2015 to December 2016. Liver fibrosis was induced in Wistar male rats by CCL₄. Rats were gavaged daily with Nilotinib (10 mg/kg). RAGE, HMGB1, TNF-α and TGF-β mRNA expression were evaluated by quantitative RT-PCR. TNF-α protein levels were measured using the immunoassay method. Thiol groups, carbonyl groups, nitric oxide levels and glutathione peroxidase activity were measured by spectrophotometric methods.The results showed that Nilotinib decreased TNF-α, TGF-β, RAGE and HMGB1 mRNA expression (p<0.001) in the liver tissues of the fibrosis group. Nilotinib also decreased carbonyl groups and nitric oxide levels and increased thiol groups and glutathione peroxidase activity in the fibrosis groups. The histopathological changes were found to be attenuated by Nilotinib. In conclusion, Nilotinib can improve liver fibrosis and open new mechanisms of the anti-fibrotic properties of Nilotinib.

Anger Rumiation Scale: validation in Mexico

The aim of the study was to assess the validity of the Anger Rumination Scale (ARS; Sukhodolsky, Golub, & Cromwell, 2001) in a Mexican sample (n = 700, Mage = 38.6, SD = 12.42). Through confirmatory factor analysis and using modification indices, the four-factor structure of the original scale was replicated: angry afterthoughts, thoughts of revenge, angry memories, and understanding of causes. In addition, the four-factor model had better goodness of fit indices than rival models with three and two factors. Alpha reliabilities were acceptable (.72 -.89). ARS results correlated with measures of state anger, trait anger, anger expression, and anger control (negatively); correlations were significant (ps < .001) ARS outcomes also correlated (ps < .001) with physical and verbal aggression, hostility, anger, and emotion suppression, suggesting convergent validity. Men reported more thoughts of revenge than women (p < .001; Eta squared = .026), but there was no evidence of gender differences on the other anger rumination scales, or in total scores (AU)

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Ameliorative Effects of Nilotinib on CCl4 Induced Liver Fibrosis Via Attenuation of RAGE/HMGB1 Gene Expression and Oxidative Stress in Rat / 전남의대학술지

Nilotinib as a tyrosine kinase inhibitor has been recently used to improve the liver fibrosis process, but the exact mechanisms still require further clarification. In this study, we investigated the anti-fibrotic effects of Nilotinib via RAGE/HMGB1axis and antioxidant mechanisms. This experimental study was performed in the Hamadan University of Medical Sciences, Iran, from May 2015 to December 2016. Liver fibrosis was induced in Wistar male rats by CCL₄. Rats were gavaged daily with Nilotinib (10 mg/kg). RAGE, HMGB1, TNF-α and TGF-β mRNA expression were evaluated by quantitative RT-PCR. TNF-α protein levels were measured using the immunoassay method. Thiol groups, carbonyl groups, nitric oxide levels and glutathione peroxidase activity were measured by spectrophotometric methods.The results showed that Nilotinib decreased TNF-α, TGF-β, RAGE and HMGB1 mRNA expression (p<0.001) in the liver tissues of the fibrosis group. Nilotinib also decreased carbonyl groups and nitric oxide levels and increased thiol groups and glutathione peroxidase activity in the fibrosis groups. The histopathological changes were found to be attenuated by Nilotinib. In conclusion, Nilotinib can improve liver fibrosis and open new mechanisms of the anti-fibrotic properties of Nilotinib.