Cellular immune responses in Helicobacter heilmannii infection: evaluation of the role of the host and the bacterium.

We evaluated some aspects of the immune response to Helicobacter heilmannii in two mouse strains. Gastritis that was more severe in infected C57BL/6 mice. A proliferative response to H. pylori antigens was observed in splenocytes from H. heilmannii-positive and -negative mice, similar in the positive- and negative-BALB/c mice, but lower in the positive- than in the negative-C57BL/6 animals. A decrease in B cells and an increase in CD4+ cells after stimulation with type I H. pylori antigen and an increase in CD8+ cells after stimulation with type I and II antigens was observed in infected C57BL/6 mice. Conversely, the percentage of CD4+, CD8+, and B cells was similar in positive- and negative-BALB/c mice. These results demonstrated that the immune response is similar in H. heilmannii and H. pylori infection and strengthened the importance of host and bacterial virulence markers in the immune response to gastric Helicobacter infections.

Gastrite crônica associada a infecçäo "Gastrospirillum hominis" / Chronic gastritis associated with infection by \"Gastrospirillum hominis\"

Além da reconhecida gastrite infecciosa causada pelo Helicobacter pylori, outras bactérias podem colonizar a mucosa gástrica e induzir resposta inflamatória. Sao apresentados os dados clínicos, endoscópicos e histopatológicos de um paciente portador de gastrite crônica associada à infecçao por Gastrospirillum hominis.