RESUMEN
Hydraulic fracturing is often criticized due in part to the potential degradation of ground and surface water quality by high-salinity produced water generated during well stimulation and production. This preliminary study evaluated the response of the freshwater mussel, Elliptio complanata, after exposure to produced water. A limited number of adult mussels were grown over an 8-week period in tanks dosed with produced water collected from a hydraulically fractured well. The fatty tissue and carbonate shells were assessed for accumulation of both inorganic and organic pollutants. Ba, Sr, and cyclic hydrocarbons indicated the potential to accumulate in the soft tissue of freshwater mussels following exposure to diluted oil and gas produced water. Exposed mussels showed accumulation of Ba in the soft tissue several hundred times above background water concentrations and increased concentrations of Sr. Cyclic hydrocarbons were detected in dosed mussels and principle component analysis of gas chromatograph time-of-flight mass spectrometer results could be a novel tool to help identify areas where aquatic organisms are impacted by oil and gas produced water, but larger studies with greater replication are necessary to confirm these results.
Asunto(s)
Bario/efectos adversos , Bivalvos/efectos de los fármacos , Agua Dulce/química , Hidrocarburos Cíclicos/efectos adversos , Estroncio/efectos adversos , Agua/química , Animales , Fracking Hidráulico/métodos , Alimentos Marinos , Contaminantes Químicos del Agua/efectos adversosRESUMEN
There are few established causes of leukemia, the most common type of cancer in children. Studies in adults suggest a role for specific environmental agents, but little is known about any effect from exposures in pregnancy to toxics in ambient air. In our case-control study, we ascertained 69 cases of acute lymphoblastic leukemia (ALL) and 46 cases of acute myeloid leukemia (AML) from California Cancer Registry records of children Asunto(s)
Contaminantes Atmosféricos/efectos adversos
, Exposición a Riesgos Ambientales/efectos adversos
, Leucemia Mieloide Aguda/etiología
, Leucemia-Linfoma Linfoblástico de Células Precursoras/etiología
, Arsénico/efectos adversos
, Butadienos/efectos adversos
, California
, Estudios de Casos y Controles
, Preescolar
, Cloroformo/efectos adversos
, Femenino
, Humanos
, Hidrocarburos Cíclicos/efectos adversos
, Lactante
, Modelos Logísticos
, Exposición Materna/efectos adversos
, Embarazo
, Factores de Riesgo
, Selenio/efectos adversos
, Emisiones de Vehículos/toxicidad
Asunto(s)
Contaminantes Ambientales/metabolismo , Hidrocarburos Cíclicos/sangre , Hidrocarburos Halogenados/sangre , Índice de Masa Corporal , Lactancia Materna/efectos adversos , Niño , Preescolar , Dieta , Humanos , Hidrocarburos Cíclicos/efectos adversos , Hidrocarburos Halogenados/efectos adversos , Lactante , Recién Nacido , Leche Humana/químicaRESUMEN
Exposure biomarkers, which have long been restricted to the framework of occupational hygiene, currently arouse increasing interest in the field of environmental pollution. To assess their validity, we propose here a conceptual framework that is based on their intrinsic characteristics and on properties related to the procedures for their analysis. The most important criteria are specificity for the toxic substance under consideration and sensitivity, that is, the ability to distinguish contrasted levels of exposure. Their analytic sensitivity and specificity are also important. Fulfilling these criteria is especially important in the context of environmental pollution, because the levels of exposure, and thus the contrasts, are low. This framework is used to assess the validity of some biomarkers for polycyclic aromatic hydrocarbons (1-hydroxypyrene and DNA adducts) and for benzene (urinary and serum benzene, trans,trans muconic acid, and S-phenylmercapturic acid). This evaluation shows that the most relevant biomarkers for estimating individual exposure to environmental pollution are 1-hydroxypyrene for polycyclic aromatic hydrocarbons and urinary benzene and S-phenylmercapturic for benzene.
Asunto(s)
Benceno/análisis , Salud Ambiental , Hidrocarburos Aromáticos/análisis , Hidrocarburos Cíclicos/análisis , Acetilcisteína/análogos & derivados , Acetilcisteína/análisis , Benceno/efectos adversos , Biomarcadores/análisis , Aductos de ADN/análisis , Exposición a Riesgos Ambientales/análisis , Humanos , Hidrocarburos Aromáticos/efectos adversos , Hidrocarburos Cíclicos/efectos adversos , Pirenos/análisis , Medición de Riesgo , Sensibilidad y Especificidad , Ácido Sórbico/análogos & derivados , Ácido Sórbico/análisisRESUMEN
Pyrene was chosen as a noncarcinogen model of polycyclic aromatic hydrocarbons (PAHs). Groups of male Wistar rats were dosed with pyrene and with mixture of pyrene and fluoranthene, pyrene and benz[a]anthracene, or pyrene, fluoranthene, and benz[a]anthracene at 20 mg/kg by intravenous or oral routes. Blood samples were taken at 0.25, 0.5, 1, 2, 3, 4, and 5 h after administration. The concentration of pyrene was determined by gas chromatography. The toxicokinetic parameters for pyrene were determined from the time course of blood concentration. A significant increase in the bioavailability of pyrene after treatment with other PAHs was observed. Urinary 1-hydroxypyrene excretion was analyzed after pretreatment with acenaphthene, naphthalene, chrysene, phenanthrene, benz[a]anthracene, and benzo[a]pyrene. The urine from rats was collected for 3 d and the concentration of 1-hydroxypyrene was determined using high-performance liquid chromatography (HPLC). Most compounds examined caused a decrease in the urinary excretion of the metabolite of pyrene.
Asunto(s)
Hidrocarburos Aromáticos/farmacocinética , Hidrocarburos Cíclicos/farmacocinética , Mutágenos/farmacocinética , Pirenos/farmacocinética , Administración Oral , Animales , Carga Corporal (Radioterapia) , Hidrocarburos Aromáticos/efectos adversos , Hidrocarburos Aromáticos/farmacología , Hidrocarburos Cíclicos/efectos adversos , Hidrocarburos Cíclicos/farmacología , Inyecciones Intravenosas , Cinética , Masculino , Mutágenos/efectos adversos , Pirenos/efectos adversos , Ratas , Ratas WistarRESUMEN
Occupational exposures to certain metals, hydrocarbons and ionizing radiation are associated with increased lung cancer in workers; because these exposures continue, lung cancer remains an important problem in industrialized nations. The gravity of the lung cancer, specifically the low cure rate associated with the disease, has forced researchers to focus efforts at developing biological indicators (biomarkers) of carcinogen exposure and early, reversible effects. This review examines critically the development of these biomarkers for occupational and environmenta exposures to polycyclic aromatic hydrocarbons (PAH), a ubiquitous class of lung carcinogens. Biomarkers of several different stages of the carcinogenic process have been proposed. Industrial hygiene and occupational health emphasize exposure and disease prevention. For this reason, biomarkers useful in industrial hygiene practice are those which measure events prior to the initiation phase of carcinogenesis; markers of later events which have a greater positive predictive value may measure irreversible effects and are more appropriate for disease screening and epidemiology. One of the strengths of biological monitoring is that exposures and effects can be measured regardless of route. Data indicates that the dermal route may be a significant pathway for delivery of PAH to the lung. This finding has important ramifications because as airborne exposure limits decrease the relative impact of dermal absorption is increased.
Asunto(s)
Humanos , Carcinógenos , Daño del ADN , Regulación de la Expresión Génica , Marcadores Genéticos , Neoplasias Pulmonares/inducido químicamente , Mutación , Enfermedades Profesionales/inducido químicamente , Oncogenes , Hidrocarburos Cíclicos/efectos adversosRESUMEN
The influence of outdoor pollution on indoor air quality was studied in downtown Santiago (Bandera street). Carbon monoxide (CO), nicotine, particulate matter, respirable fraction (PM5) and total and carcinogenic polyaromatic hydrocarbons (PAHs) were simultaneously monitores indoors and outdoors and indoors in restaurants, offices and other places. The levels of CO changed simultaneously outdoors and indoors (r=0.89) specially during traffic rush hours, demonstrating the importance of outdoor infiltration into the indoor air quality and masking the contribution of other CO indoor sources. The maximun CO concentrations were over 800 percent and over 1000 percent higher indoors and outdoors respectively than the 9 ppm CO National Ambient Air Quality. The PM5 concentrations were very high and showed no significant differences (p>0.05) from indoor to outdoors, or between indoor levels in restaurants, offices and other places. Total ans carcinogenic PAHs levels were also very high, outdoors and indoors, outodoor levels being generally higher than those indoors and no significant; differences (p>0.05) were found for the indoor levels between restaurants, offices and other places. Nicotine levels showed significant differences (p<0.05) between indoor and outdoor levels. In addition, great differences (p<0.05) in indoor levels, were found between offices and restaurants, and offices and other places. Among indoor sources cigarrete smoke seems to be a minor source since nicotine concentrations, bieng 2.3 times higher in restaurants and other places than in offices, do not contribute to enhance significantly PM5 and total and carcinogenic HAPs in the first ones. These results suggest that in downtown Santiago, infiltration might be the main source of indoor pollution. This is supported by 2 evidences: a) coronene, a tracer of vehicle emissions was found in high concentraion indoors and b) in restaurants (in wich PAHs emissions might be higher indoor) a correlation coefficient of 0.987 for the indoor and outdoor concentrations of carcinogenic PAHs was found. Furthermore a survey asking for different symptoms and effects probably related to air pollution was made to people working in Bandera and in a rural area located 40 Km from Santiago. The results showed that excluding smoking as a confounded factor, people working in Bandera showed a significantly greater (p<0.05) risk of ill effects on their health than people working in the rural area