RESUMEN
This article provides a review with a focus on clinical updates in treating patients with surgical parathyroid or thyroid disease. Primary hyperparathyroidism is a common cause of hypercalcemia. Patients are older and often asymptomatic, and urinary stones and urinary tract infection are common. Surgical treatment is recommended with an excellent prognosis. Thyroid tumors in dogs are the most common endocrine neoplasm. Functional thyroid testing, laryngeal examinations, and regional lymphadenectomy should be considered during surgery, along with use of vessel-sealing devices to mitigate hemorrhage. Long-term outcomes for dogs with advanced disease can be reached, so surgical resection should be an option.
Asunto(s)
Enfermedades de los Perros , Hipercalcemia , Hiperparatiroidismo , Neoplasias de las Paratiroides , Animales , Enfermedades de los Perros/cirugía , Perros , Hipercalcemia/etiología , Hipercalcemia/veterinaria , Hiperparatiroidismo/etiología , Hiperparatiroidismo/cirugía , Hiperparatiroidismo/veterinaria , Neoplasias de las Paratiroides/complicaciones , Neoplasias de las Paratiroides/patología , Neoplasias de las Paratiroides/cirugía , Neoplasias de las Paratiroides/veterinaria , Paratiroidectomía/efectos adversos , Paratiroidectomía/veterinaria , Glándula Tiroides/patologíaRESUMEN
BACKGROUND: Primary hyperparathyroidism is uncommon in equids. OBJECTIVES: To describe the diagnostic findings and efficacy of treatment in equids with primary hyperparathyroidism. STUDY DESIGN: Retrospective case series describing 16 horses and one mule. METHODS: Cases were identified by retrospective review of records at Cornell University and via an ACVIM listserv query. Inclusion criteria were an equid with hypercalcemia, normal renal function and high parathyroid hormone (PTH) or histopathological diagnosis of a parathyroid adenoma. Equids with normal PTH and PTH-related protein (PTHrP) in the face of hypercalcemia were included as suspect cases. RESULTS: The most common presenting complaints were weight loss (12/17) and hypercalcemia (10/17). PTH was above reference range in 12/17 cases. Suspected parathyroid tumours were localised in 12/14 equids imaged using ultrasonography alone (2/3), technetium 99m Tc sestamibi scintigraphy alone (1/1) or both modalities (9/10). Three horses did not have imaging performed. Surgical exploration successfully excised tumours in six of 10 cases. Five were located at the thoracic inlet, and surgery resulted in complete cure. One tumour was excised from the thyroid lobe, and the horse remained hypercalcemic. Four other cases explored surgically, four treated medically and three that were not treated also remained hypercalcemic. MAIN LIMITATIONS: The small study size prohibited statistical analysis. CONCLUSIONS: Parathyroid adenomas in equids can be successfully localised with ultrasonography and scintigraphy. Surgical excision appears more likely to be successful for single gland disease at the thoracic inlet.
Asunto(s)
Adenoma/veterinaria , Equidae , Hiperparatiroidismo/veterinaria , Neoplasias de las Paratiroides/veterinaria , Adenoma/diagnóstico , Adenoma/cirugía , Animales , Calcio/sangre , Hiperparatiroidismo/diagnóstico , Hiperparatiroidismo/cirugía , Neoplasias de las Paratiroides/diagnóstico , Neoplasias de las Paratiroides/cirugía , Estudios RetrospectivosRESUMEN
Juvenile whooping cranes (Grus americana) raised for wild release were found to have an increased incidence of rib fractures at fledging in 2017 compared with the previous 16 years. Serum analysis showed 30-day-old juveniles in 2017 (n = 12) had significantly lower 25-hydroxyvitamin D3 and significantly higher parathyroid hormone concentrations than juveniles in 2010 (n = 6) with no history of rib fractures. Increased serum parathyroid hormone concentrations in the 2017 juveniles persisted to fledging age. Review of dietary and environmental management revealed that juveniles in 2017 were provided a commercial diet with a lower, and perhaps suboptimal, calcium:phosphorus ratio and experienced reduced time outdoors in the first month after hatch, presumably resulting in less ultraviolet B radiation exposure. Mild hyperparathyroidism in precocial whooping cranes may result when dietary constraints and/or outdoor access is compromised and manifest as rib fractures in the absence of traumatic injury.
Asunto(s)
Enfermedades de las Aves/patología , Aves , Hiperparatiroidismo/veterinaria , Envejecimiento , Animales , Enfermedades de las Aves/diagnóstico , Fracturas Espontáneas/veterinaria , Hiperparatiroidismo/diagnóstico , Hiperparatiroidismo/patología , Estudios Retrospectivos , Factores de RiesgoAsunto(s)
Enfermedades de los Gatos/etiología , Hiperparatiroidismo/veterinaria , Trastornos Nutricionales/veterinaria , Animales , Animales Recién Nacidos , Gatos , Dieta/efectos adversos , Dieta/veterinaria , Fracturas Óseas/etiología , Fracturas Óseas/veterinaria , Hiperparatiroidismo/etiología , Trastornos Nutricionales/complicaciones , Fracturas de la Columna Vertebral/etiología , Fracturas de la Columna Vertebral/veterinariaRESUMEN
OBJECTIVE: To describe outcomes for dogs with primary hyperparathyroidism following treatment with percutaneous ultrasound-guided ethanol ablation of presumed functional parathyroid nodules. DESIGN: Retrospective case series. ANIMALS: 24 dogs with primary hyperparathyroidism that underwent 27 ultrasound-guided ethanol ablation procedures of presumed functional parathyroid nodules identified by cervical ultrasonography. PROCEDURES: Dogs were anesthetized for each procedure. For each nodule, 95% ethanol was injected into the center with ultrasound guidance (volume injected calculated on the basis of ultrasonographic measurements). The interval from treatment to resolution of hypercalcemia, complications, and follow-up clinicopathologic data were recorded. RESULTS: 5 procedures involved simultaneous treatment of 2 nodules. Three dogs underwent a second treatment because of initial treatment failure or development of another nodule. Hypercalcemia resolved after 23 of 27 (85%) procedures. In those 23 treatments, 22 (96%) had resolution of hypercalcemia within 72 hours after treatment. Hypocalcemia was detected in 6 different dogs at 2 (1 dog), 7 (3 dogs), 14 (1 dog), and 21 (1 dog) days after treatment; 5 of these dogs had mild transient hypocalcemia and 1 developed clinical signs requiring calcium supplementation. Although there were no periprocedural adverse effects, 2 dogs had delayed adverse effects; the overall rate of complications (including delayed adverse events and clinical hypocalcemia) was 11.1%. Long-term follow-up data indicated sustained normocalcemia in 17 of 19 dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that percutaneous ultrasound-guided ethanol ablation of functional parathyroid nodules may be an effective treatment for primary hyperparathyroidism of dogs, with short duration of anesthesia, minimal complications, and low risk for hypocalcemia.
Asunto(s)
Técnicas de Ablación/veterinaria , Enfermedades de los Perros/terapia , Etanol/farmacología , Hiperparatiroidismo/veterinaria , Neoplasias de las Paratiroides/veterinaria , Animales , Perros , Femenino , Hiperparatiroidismo/terapia , Inyecciones Intralesiones/veterinaria , Masculino , Neoplasias de las Paratiroides/terapia , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
A 13-year-old dog exhibited dramatic, radiographic osteopenia consistent with fibrous osteodystrophy secondary to primary hyperparathyroidism. Following parathyroidectomy, the dog developed severe, prolonged hypocalcemia, but was successfully treated and discharged 32 d after surgery. A variety of factors may have contributed to this dog's hypocalcemia including hypoparathyroidism and hungry bone syndrome.
Ostéodystrophie fibreuse préopératoire et hypocalcémie grave, réfractaire postopératoire après une parathyroïdectomie chez un chien. Un chien âgé de 13 ans a manifesté une ostéopénie radiographique dramatique conforme à une ostéodystrophie fibreuse secondaire à un hyperparathyroïdisme primaire. Après une parathyroïdectomie, le chien a développé une hypocalcémie grave et prolongée, mais il a été traité avec succès et a reçu son congé 32 jours après la chirurgie. Divers facteurs peuvent avoir contribué à l'hypocalcémie de ce chien, y compris l'hypoparathyroïdisme et l'hypocalcémie par avidité osseuse.(Traduit par Isabelle Vallières).
Asunto(s)
Enfermedades Óseas Metabólicas/veterinaria , Enfermedades de los Perros/patología , Hiperparatiroidismo/veterinaria , Hipocalcemia/veterinaria , Paratiroidectomía/veterinaria , Hidróxido de Aluminio/uso terapéutico , Animales , Enfermedades Óseas Metabólicas/patología , Calcitriol/uso terapéutico , Calcio/metabolismo , Calcio/uso terapéutico , Enfermedades de los Perros/etiología , Perros , Femenino , Hiperparatiroidismo/tratamiento farmacológico , Hiperparatiroidismo/cirugía , Hipocalcemia/etiología , Paratiroidectomía/efectos adversosRESUMEN
Dogs with spontaneous disorders of glucocorticoid production often have marked disturbances in calcium homeostasis. For example, hypercalcaemia is frequently observed in dogs with hypoadrenocorticism and secondary hyperparathyroidism is a common feature of canine hyperadrenocorticism. The mechanism(s) by which glucocorticoids modulate calcium homeostasis in dogs remains ill-defined. The hypothesis of this study is that a marked increase in serum cortisol concentrations would lead to an immediate negative calcium balance state which would drive a compensatory increase in parathyroid hormone (PTH) concentrations. This hypothesis was investigated by measuring serum cortisol and plasma PTH concentration in 19 dogs before and after administration of adrenocorticotrophic (ACTH) hormone. Post ACTH administration, there was a significant increase in serum cortisol, but not PTH, concentrations. The results of this study do not support the hypothesis that an increase in endogenous glucocorticoids influences calcium balance sufficiently to cause an immediate, compensatory increase in parathyroid hormone concentration.
Asunto(s)
Hormona Adrenocorticotrópica/farmacología , Perros/metabolismo , Hidrocortisona/sangre , Hormona Paratiroidea/sangre , Hiperfunción de las Glándulas Suprarrenales/etiología , Hiperfunción de las Glándulas Suprarrenales/metabolismo , Hiperfunción de las Glándulas Suprarrenales/veterinaria , Animales , Calcio/metabolismo , Enfermedades de los Perros/metabolismo , Femenino , Homeostasis/efectos de los fármacos , Hiperparatiroidismo/etiología , Hiperparatiroidismo/metabolismo , Hiperparatiroidismo/veterinaria , MasculinoRESUMEN
A 12-year-old dachshund dog was presented for persistent hypercalcemia and hyperparathyroidism despite bilateral parathyroidectomy. Magnetic resonance imaging of the head, neck, and cranial mediastinum identified an increased number of cranial mediastinal lymph nodes with heterogeneous signal intensity. Hypercalcemia and hyperparathyroidism resolved after surgery to remove multiple cranial mediastinal lymph nodes, one of which contained presumed metastatic parathyroid tissue.
Adénocarcinome parathyroïdien métastatique fonctionnel chez un chien. Un chien Dachsund âgé de 12 ans a été présenté pour de l'hypercalcémie et de l'hyperparathyroïdie persistantes malgré une parathyroïdectomie bilatérale. Une imagerie par résonance magnétique de la tête, du cou et du médiastin crânien a identifié un nombre accru de ganglions lymphatiques médiastinaux avec une intensité hétérogène du signal. L'hypercalcémie et l'hyperparathyroïdie se sont résorbées après la chirurgie pour enlever les nombreux ganglions lymphatiques médiastinaux crâniens, dont l'un contenait du tissu parathyroïdien métastatique présumé.(Traduit par Isabelle Vallières).
Asunto(s)
Adenocarcinoma/veterinaria , Enfermedades de los Perros/patología , Ganglios Linfáticos/patología , Neoplasias de las Paratiroides/veterinaria , Adenocarcinoma/patología , Animales , Perros , Hipercalcemia/etiología , Hipercalcemia/veterinaria , Hiperparatiroidismo/etiología , Hiperparatiroidismo/veterinaria , Ganglios Linfáticos/cirugía , Metástasis Linfática , Masculino , Neoplasias de las Paratiroides/patologíaRESUMEN
Abnormal conditions of the thyroid and parathyroid in the guinea pig appear in the English-language scientific literature on an emerging basis. Although true descriptions of abnormal thyroid and parathyroid anatomy or morphology are not new findings, the clinical condition of abnormal thyroid or parathyroid function seems to be a more common observation by clinicians in recent years. This article is an overview of general clinical conditions and adequate diagnosis, and offers treatment options.
Asunto(s)
Cobayas , Hiperparatiroidismo/veterinaria , Hipertiroidismo/veterinaria , Enfermedades de los Roedores/diagnóstico , Animales , Diagnóstico Diferencial , Hiperparatiroidismo/diagnóstico , Hiperparatiroidismo/terapia , Hipertiroidismo/diagnóstico , Hipertiroidismo/terapia , Mascotas , Enfermedades de los Roedores/terapiaRESUMEN
OBJECTIVE: To identify preoperative variables associated with postoperative hypocalcemia in dogs with primary hyperparathyroidism undergoing parathyroidectomy. DESIGN: Retrospective case series. ANIMALS: 62 dogs. PROCEDURES: Medical records of dogs undergoing parathyroidectomy for treatment of primary hyperparathyroidism between January 2004 and January 2009 at 4 institutions were reviewed; data regarding various preoperative variables and postoperative serum total and ionized calcium concentrations were recorded. Preoperative ultrasonographic and surgical findings were compared regarding laterality (right, left, or bilateral) of parathyroid gland lesions. Data were analyzed via ANOVA, simple linear regression, and multiple linear regression to identify associations between preoperative variables and postoperative serum total and ionized calcium nadir concentrations. RESULTS: Preoperative variables significantly associated with low postoperative serum total calcium nadir concentrations included old age, history of weakness, lack of gastrointestinal tract signs, high serum parathyroid hormone concentration, and low serum calcium-phosphorus concentration product value. Preoperative variables significantly associated with low postoperative serum ionized calcium nadir concentrations included sexually intact status, low body weight, high serum urea nitrogen concentration, and lack of polyuria and polydipsia in the history. Age, body weight, serum calcium-phosphorus concentration product, and serum concentrations of parathyroid hormone and urea nitrogen were included in the final multiple linear regression model for prediction of postoperative serum calcium concentrations. Ultrasonography was performed in 58 dogs; results for 44 (75.9%) dogs agreed with surgical findings regarding laterality of parathyroid gland lesions. CONCLUSIONS AND CLINICAL RELEVANCE: Prediction of postoperative hypocalcemia in dogs in this study with primary hyperparathyroidism that underwent parathyroidectomy was difficult and depended on multiple (history, physical examination, and clinicopathologic) factors.
Asunto(s)
Enfermedades de los Perros/cirugía , Hiperparatiroidismo/veterinaria , Hipocalcemia/veterinaria , Paratiroidectomía/veterinaria , Complicaciones Posoperatorias/veterinaria , Envejecimiento , Animales , Peso Corporal , Perros , Femenino , Hiperparatiroidismo/cirugía , Hipocalcemia/etiología , Masculino , Paratiroidectomía/efectos adversos , Estudios Retrospectivos , Factores de Riesgo , Factores de TiempoRESUMEN
OBJECTIVE: To determine whether preoperative serum ionized calcium (iCa) or parathyroid hormone (PTH) concentrations help predict postoperative hypocalcemia following parathyroidectomy in dogs with primary hyperparathyroidism. DESIGN: Retrospective case series. ANIMALS: 17 dogs with primary hyperparathyroidism treated with parathyroidectomy. PROCEDURES: Medical records were evaluated from years 2001 to 2009. Data evaluated included age, breed, sex, clinical signs, diagnostic tests performed, preoperative and postoperative iCa concentrations, preoperative PTH concentrations, and whether calcium supplementation was provided following surgery. Two groups were identified on the basis of whether dogs became hypocalcemic (iCa < 1.2 mmol/L) following parathyroidectomy. RESULTS: 12 dogs developed hypocalcemia after surgery. Preoperative (within 24 hours before surgery) iCa concentrations for the hypocalcemic group (mean ± SD, 1.82 ± 0.22 mmol/L) and the nonhypocalcemic group (1.83 ± 0.29 mmol/L) were not significantly different. Calcium concentrations decreased in a linear fashion during the 24 hours following parathyroidectomy, and the slopes of the decrease over that time were not significantly different between the 2 groups. Preoperative PTH concentrations were not significantly different between the hypocalcemic and nonhypocalcemic groups. CONCLUSIONS AND CLINICAL RELEVANCE: Preoperative iCa and PTH concentrations were not predictive of postoperative hypocalcemia in dogs undergoing parathyroidectomy for primary hyperparathyroidism. Future studies to evaluate whether calcium supplementation should be provided on an individual basis with perhaps more emphasis on clinical signs than iCa concentrations after surgery may be warranted.
Asunto(s)
Calcio/sangre , Enfermedades de los Perros/sangre , Hiperparatiroidismo/veterinaria , Hormona Paratiroidea/sangre , Paratiroidectomía/veterinaria , Animales , Biomarcadores/sangre , Calcio/química , Enfermedades de los Perros/cirugía , Perros , Femenino , Hiperparatiroidismo/cirugía , Masculino , Paratiroidectomía/efectos adversosRESUMEN
OBJECTIVE: To determine (1) whether the intraoperative parathyroid hormone concentration ([PTH]) during parathyroidectomy (PTX) can be used to indicate cure in dogs with primary hyperparathyroidism and (2) the time taken for postoperative serum calcium concentration to normalise. DESIGN: Retrospective study (2005-10) from a private referral hospital in Sydney, New South Wales, Australia. PROCEDURE: Nine client-owned dogs underwent surgical PTX for naturally occurring primary hyperparathyroidism. [PTH] was measured from serum samples taken immediately post-induction (pre-PTX]) and at least 20 min after adenoma removal (post-PTX) for all dogs, and during parathyroid gland manipulation (intra-PTX) for six dogs. The concentration of ionised calcium (iCa) was measured at various time points postoperatively until it normalised, then stabilised or decreased below reference ranges. Statistical analysis compared the mean pre-, intra- and post-PTX [PTH] and the average rate of decline of iCa concentration postoperatively. RESULTS: All dogs demonstrated a significant decrease from mean pre-PTX [PTH] (168.51 pg/mL) to mean post-PTX [PTH] (29.20 pg/mL). There was a significant increase in mean intra-PTX [PTH] (279.78 pg/mL). The average rate of decline of iCa concentration postoperatively to within the reference range (1.12-1.40 mmol/L) occurred after 24 h. CONCLUSION: Intraoperative measurements of [PTH] can be used clinically to determine cure of primary hyperparathyroidism. Parathyroid hormone increases significantly during parathyroid gland manipulation. Plasma iCa concentration returns to within the reference range on average 24 h after successful PTX. Not all dogs require vitamin D or calcium supplementation pre- or postoperatively.
Asunto(s)
Enfermedades de los Perros/sangre , Hiperparatiroidismo/veterinaria , Cuidados Intraoperatorios/veterinaria , Hormona Paratiroidea/sangre , Paratiroidectomía/veterinaria , Animales , Calcio/sangre , Enfermedades de los Perros/cirugía , Perros , Femenino , Hiperparatiroidismo/sangre , Hiperparatiroidismo/cirugía , Cuidados Intraoperatorios/métodos , Masculino , Paratiroidectomía/métodos , Estudios RetrospectivosRESUMEN
Endocrine diseases that may cause hypercalcemia and hypocalcemia include hyperparathyroidism, hypoparathyroidism, thyroid disorders, hyperadrenocorticism, hypoadrenocorticism, and less commonly pheochromocytoma and multiple endocrine neoplasias. The differential diagnosis of hypercalcemia may include malignancy (lymphoma, anal sac carcinoma, and squamous cell carcinoma), hyperparathyroidism, vitamin D intoxication, chronic renal disease, hypoadrenocorticism, granulomatous disorders, osteolysis, or spurious causes. Hypocalcemia may be caused by puerperal tetany, pancreatitis, intestinal malabsorption, ethlyene glycol intoxication, acute renal failure, hypopararthyroidism, hypovitaminosis D, hypomagnesemia, and low albumin. This article focuses on the endocrine causes of calcium imbalance and provides diagnostic and therapeutic guidelines for identifying the cause of hypercalcemia and hypocalcemia in veterinary patients.
Asunto(s)
Hipercalcemia/veterinaria , Hiperparatiroidismo/veterinaria , Hipertiroidismo/veterinaria , Hipocalcemia/veterinaria , Animales , Calcio/metabolismo , Enfermedades de los Gatos/diagnóstico , Gatos , Diagnóstico Diferencial , Enfermedades de los Perros/diagnóstico , Perros , Neoplasias de las Glándulas Endocrinas/complicaciones , Neoplasias de las Glándulas Endocrinas/diagnóstico , Neoplasias de las Glándulas Endocrinas/veterinaria , Hipercalcemia/diagnóstico , Hipercalcemia/etiología , Hiperparatiroidismo/complicaciones , Hiperparatiroidismo/diagnóstico , Hipertiroidismo/complicaciones , Hipertiroidismo/diagnóstico , Hipocalcemia/diagnóstico , Hipocalcemia/etiología , Fósforo/metabolismo , Vitamina D/metabolismoRESUMEN
Seven out of 25 goats from a southern Brazilian flock developed nutritional fibrous osteodystrophy. Affected animals were younger than 1 year of age and were confined in stalls and fed a concentrate ration containing 1:6 calcium:phosphorus ratio. The remaining flock (35 goats) was managed at pasture and showed no disease. Clinical signs were characterized by mandibular and maxillary enlargements, varying degrees of mouth opening and protruding tongue, dyspnea, apart of abnormalities of prehension and mastication. Affected animals had increased seric levels of phosphorus and parathormone, as well as higher alkaline phosphatase activity. Postmortem examination on three succumbed goats revealed bilateral enlargement of the maxilla and mandibula, and loose teeth, apart of multiple incomplete rib fractures in one of them. Severe diffuse proliferation of loose connective tissue surrounded the osteoid trabeculae, many of which were partially or completely non-mineralized. Mineralized osteoid trabeculae showed osteoclasts in the Howship's lacunae.
Sete de um total de 25 caprinos jovens (menos de um ano de idade) de um rebanho no sul do Brasil desenvolveram osteodistrofia fibrosa nutricional. Os animais afetados eram confinados em baias e alimentados com concentrado, cuja relação Ca:P era 1:6. O restante do rebanho (35 cabras) era mantido na pastagem e não desenvolveu a doença. Os sinais clínicos se caracterizaram por aumento de volume da mandibula e maxila, vários graus de abertura de boca com protrusão da língua, em associação com dispneia e anormalidades de apreensão de alimento e mastigação. Os animais afetados apresentaram os níveis séricos de fósforo e paratormônio aumentados, bem como maior atividade de fosfatase alcalina. Três caprinos foram necropsiados e os achados de necropsia incluíram aumento bilateral da maxi-la e mandíbula, dentes frouxos, além de múltiplas fraturas incompletas de costelas em um caprino. Microscopicamente, havia intensa proliferação de tecido conjuntivo frouxo ao redor de trabéculas ósseas, muitas das quais estavam parcial ou completamente não mineralizadas. Trabéculas ósseas mineralizadas apresentaram osteoclastos em lacunas de Howship.
Asunto(s)
Animales , Hiperfosfatemia/veterinaria , Hiperparatiroidismo/veterinaria , Autopsia , OsteoclastosRESUMEN
Metabolic complications of endocrine surgery occur commonly and precautions should be taken to avoid potentially life-threatening situations and to lessen expense associated with a more extended hospital stay. Common complications of endocrine surgery as well as prevention strategies will be reviewed for pancreatic, parathyroid, and adrenal surgery.
Asunto(s)
Enfermedades de los Gatos/cirugía , Enfermedades de los Perros/cirugía , Procedimientos Quirúrgicos Endocrinos/veterinaria , Complicaciones Posoperatorias/veterinaria , Neoplasias de las Glándulas Suprarrenales/patología , Neoplasias de las Glándulas Suprarrenales/cirugía , Neoplasias de las Glándulas Suprarrenales/veterinaria , Animales , Gatos , Perros , Procedimientos Quirúrgicos Endocrinos/efectos adversos , Hipercalcemia/prevención & control , Hipercalcemia/veterinaria , Hiperparatiroidismo/prevención & control , Hiperparatiroidismo/veterinaria , Hipertensión/prevención & control , Hipertensión/veterinaria , Insulinoma/patología , Insulinoma/cirugía , Insulinoma/veterinaria , Metástasis de la Neoplasia , Enfermedades Pancreáticas/patología , Enfermedades Pancreáticas/cirugía , Enfermedades Pancreáticas/veterinaria , Complicaciones Posoperatorias/prevención & control , Tromboembolia/prevención & control , Tromboembolia/veterinariaRESUMEN
An 18-yr-old male bobcat (Lynx rufus) presented with chronic moderate weight loss and acute onset of anorexia and lethargy. Hypercalcemia and azotemia were present on the serum chemistry panel. Abdominal ultrasound revealed hyperechoic renal cortices, but no evidence of neoplasia. Ionized calcium and 25-hydroxyvitamin D were mildly elevated, intact parathyroid hormone was severely elevated, and parathormone-related protein was undetected, suggesting primary hyperparathyroidism with possible renal dysfunction. Azotemia lessened in severity following diuresis, but hypercalcemia persisted; thus primary hyperparathyroidism was considered the most probable differential diagnosis. A second ultrasound including the cervical region revealed a solitary intraparenchymal left thyroid nodule. The nodule was surgically excised; histopathology confirmed a parathyroid adenoma. Although primary hyperparathyroidism was suspected, diagnosis was not achieved from serum chemistry values alone. This case emphasizes the importance of diagnostic imaging and histopathology in the investigation of persistently abnormal laboratory values.
Asunto(s)
Hiperparatiroidismo/veterinaria , Lynx , Adenoma/diagnóstico , Adenoma/cirugía , Adenoma/veterinaria , Animales , Hipercalcemia/sangre , Hipercalcemia/etiología , Hipercalcemia/veterinaria , Hiperparatiroidismo/complicaciones , Hiperparatiroidismo/diagnóstico , Hiperparatiroidismo/terapia , Masculino , Neoplasias de las Paratiroides/diagnóstico , Neoplasias de las Paratiroides/cirugía , Neoplasias de las Paratiroides/veterinariaRESUMEN
The purpose of this study is to characterize the sonographic appearance of canine parathyroid glands using high-resolution ultrasonography. Ten cadaver dogs were studied after euthanasia for reasons not relating to the parathyroid. The cervical region was examined using a 13-5 MHz linear transducer in right and left recumbency. Ultrasonographic features of the parathyroid and thyroid glands were compared with the gross and histopathologic findings. Thirty-five structures were identified sonographically as parathyroid glands but only 26 of 35 glands (74% positive predictive value) were proven to be normal parathyroid glands histopathologically. Of the nine false positives, five (14%) were proven to be lobular thyroid tissue. The remaining four (11%) structures were visible grossly or found histopathologically. There were no statistical differences between ultrasonographic and gross measurements of the parathyroid glands. The average size as seen sonographically was 3.3 x 2.2 x 1.7 mm and the average gross size was 3.7 x 2.6 x 1.6 mm (length, width, height). The average size of the thyroid lobules assessed sonographically was 2.3 x1.6 x 0.8 mm (length, width, height). Normal parathyroid glands can be identified using high-resolution ultrasonography. But some thyroid lobules will be misinterpreted as parathyroid glands; this will result in false positives when identifying parathyroid glands with ultrasonography.
Asunto(s)
Enfermedades de los Perros/diagnóstico por imagen , Glándulas Paratiroides/diagnóstico por imagen , Neoplasias de las Paratiroides/veterinaria , Glándula Tiroides/diagnóstico por imagen , Neoplasias de la Tiroides/veterinaria , Ultrasonografía/veterinaria , Animales , Artefactos , Nitrógeno de la Urea Sanguínea , Cadáver , Perros , Femenino , Hiperparatiroidismo/diagnóstico por imagen , Hiperparatiroidismo/patología , Hiperparatiroidismo/veterinaria , Masculino , Ovariectomía , Glándulas Paratiroides/anatomía & histología , Glándulas Paratiroides/patología , Neoplasias de las Paratiroides/diagnóstico por imagen , Glándula Tiroides/anatomía & histología , Glándula Tiroides/patología , Neoplasias de la Tiroides/diagnóstico por imagen , Ultrasonografía/métodosAsunto(s)
Enfermedades de los Gatos/diagnóstico por imagen , Enfermedades Renales/veterinaria , Triazinas/efectos adversos , Alimentación Animal/análisis , Animales , Calcinosis/inducido químicamente , Calcinosis/veterinaria , Enfermedades de los Gatos/inducido químicamente , Gatos , Femenino , Contaminación de Alimentos , Hiperparatiroidismo/etiología , Hiperparatiroidismo/veterinaria , Enfermedades Renales/inducido químicamente , Enfermedades Renales/complicaciones , RadiografíaRESUMEN
A 13-year-old spayed Labrador Retriever cross dog presented for polyuria and polydipsia. Serum total calcium, free calcium, and intact parathyroid hormone concentrations were elevated. Surgical exploration of the ventral neck revealed a grossly enlarged right external parathyroid gland. The histopathological diagnosis for the excised right parathyroid gland was an incompletely resected parathyroid carcinoma. Parathyroid carcinoma in the dog is an infrequent cause of hypercalcemia and primary hyperparathyroidism.
Asunto(s)
Carcinoma/veterinaria , Enfermedades de los Perros/diagnóstico , Hipercalcemia/veterinaria , Hiperparatiroidismo/veterinaria , Neoplasias de las Paratiroides/veterinaria , Animales , Calcio/sangre , Calcio/metabolismo , Carcinoma/complicaciones , Carcinoma/cirugía , Enfermedades de los Perros/etiología , Enfermedades de los Perros/patología , Perros , Hipercalcemia/diagnóstico , Hipercalcemia/etiología , Hiperparatiroidismo/diagnóstico , Hiperparatiroidismo/etiología , Neoplasias de las Paratiroides/complicaciones , Neoplasias de las Paratiroides/cirugíaRESUMEN
BACKGROUND: Studies in dogs with experimental chronic kidney disease (CKD) have demonstrated that abnormalities of calcium-phosphorus (Ca-P) homeostasis occur frequently and have a negative effect on kidney function and survival. However, the prevalence of these alterations in dogs with naturally occurring CKD at different stages of severity has not yet been investigated. HYPOTHESIS: Abnormalities of Ca-P metabolism occur early in the course of CKD with an increased prevalence in more severe stages. ANIMALS: Fifty-four dogs with CKD and 22 healthy dogs. METHODS: Blood and urine samples were obtained for a CBC, biochemistry, determination of parathyroid hormone (PTH), calcitriol, and ionized calcium concentrations and urinalysis. Based on urine protein/creatinine ratio and serum creatinine concentration, dogs were grouped according to the IRIS classification for CKD. RESULTS: Hyperparathyroidism (HPTH) (PTH > or = 48 pg/mL) was diagnosed in 41 (75.9%) dogs with CKD. Its prevalence increased from 36.4% (stage 1) to 100% (stage 4). Hyperphosphatemia (P > 5.5 mg/dL) was present in 37 (68.5%) dogs; increasing in prevalence from 18% (stage 1) to 100% (stage 4). Receiver-operating characteristic curve analysis showed that serum phosphorus concentration in the 4.5-5.5 mg/dL range correctly identified the presence of HPTH in most dogs. Calcitriol concentration progressively decreased in dogs with CKD and differences became statistically significant by stage 3. CONCLUSION AND CLINICAL RELEVANCE: HPTH and hyperphosphatemia occur frequently in dogs with naturally occurring CKD, even at early stages of CKD in some dogs. These findings highlight the importance of monitoring these parameters early in the course of CKD.