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1.
Rev Med Suisse ; 20(883): 1409-1413, 2024 Aug 21.
Artículo en Francés | MEDLINE | ID: mdl-39175290

RESUMEN

Point of care ultrasound (POCUS) is used daily to diagnose and treat patients in emergency medicine. This article aims to demonstrate its utility focusing on central and peripheric nervous system pathologies frequently encountered in the emergency department such as difficult lumbar puncture, pain relief for proximal fracture of the femur and the detection of intracranial hypertension. Taught by well trained professionals the learning curve for performing these interventions safely is quick. The developmental potential for peripheral nerve blocks in emergency departments is high, especially for the fascia iliaca block.


Le POCUS (point of care ultrasound) est utilisé quotidiennement dans les services d'urgences à des fins diagnostiques et thérapeutiques. Cet article a pour but de démontrer son utilité dans quelques situations cliniques rencontrées fréquemment aux urgences en lien avec les systèmes nerveux central et périphérique, à savoir la ponction lombaire difficile, l'antalgie lors de fracture du fémur proximal et la détection d'une hypertension intracrânienne. Au contact de personnes formées, la courbe d'apprentissage pour réaliser ces gestes en toute sécurité est rapide. Un fort potentiel de développement existe pour la réalisation des blocs nerveux périphériques dans les services d'urgences, en particulier pour le bloc iliofascial.


Asunto(s)
Servicio de Urgencia en Hospital , Ultrasonografía , Humanos , Servicio de Urgencia en Hospital/organización & administración , Ultrasonografía/métodos , Sistemas de Atención de Punto , Enfermedades del Sistema Nervioso/diagnóstico , Enfermedades del Sistema Nervioso/terapia , Hipertensión Intracraneal/diagnóstico , Hipertensión Intracraneal/terapia , Punción Espinal/métodos , Bloqueo Nervioso/métodos
2.
Pediatr Emerg Med Pract ; 21(Suppl 6): 1-48, 2024 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-38885364

RESUMEN

More than 1.7 million traumatic brain injuries occur in adults and children each year in the United States, with approximately 30% occurring in children aged <14 years. Traumatic brain injury is a significant cause of morbidity and mortality in pediatric trauma patients. The early management of severe traumatic brain injury is focused on mitigation and prevention of secondary injury, specifically by avoiding hypotension and hypoxia, which have been associated with poorer outcomes. This review discusses methods to maintain adequate oxygenation, maximize management of intracranial hypertension, and optimize blood pressure in the emergency department to improve neurologic outcomes following pediatric severe traumatic brain injury.


Asunto(s)
Lesiones Traumáticas del Encéfalo , Servicio de Urgencia en Hospital , Humanos , Lesiones Traumáticas del Encéfalo/terapia , Lesiones Traumáticas del Encéfalo/diagnóstico , Niño , Adolescente , Hipertensión Intracraneal/etiología , Hipertensión Intracraneal/terapia , Hipertensión Intracraneal/diagnóstico , Preescolar , Lactante , Medicina Basada en la Evidencia
3.
Eur J Emerg Med ; 31(4): 287-293, 2024 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-38691014

RESUMEN

BACKGROUND AND IMPORTANCE: Occurrence of mydriasis during the prehospital management of traumatic brain injury (TBI) may suggest severe intracranial hypertension (ICH) subsequent to brain herniation. The initiation of hyperosmolar therapy to reduce ICH and brain herniation is recommended. Whether mannitol or hypertonic saline solution (HSS) should be preferred is unknown. OBJECTIVES: The objective of this study is to assess whether HSS, compared with mannitol, is associated with improved survival in adult trauma patients with TBI and mydriasis. DESIGN/SETTING AND PARTICIPANTS: A retrospective observational cohort study using the French Traumabase national registry to compare the ICU mortality of patients receiving either HSS or mannitol. Patients aged 16 years or older with moderate to severe TBI who presented with mydriasis during prehospital management were included. OUTCOME MEASURES AND ANALYSIS: We performed propensity score matching on a priori selected variables [i.e. age, sex and initial Coma Glasgow Scale (GCS)] with a ratio of 1 : 3 to ensure comparability between the two groups. The primary outcome was ICU mortality. The secondary outcomes were regression of pupillary abnormality during prehospital management, pulsatility index and diastolic velocity on transcranial Doppler within 24 h after TBI, early ICU mortality (within 48 h), ICU and hospital length of stay. RESULTS: Of 31 579 patients recorded in the registry between 2011 and 2021, 1417 presented with prehospital mydriasis and were included: 1172 (82.7%) received mannitol and 245 (17.3%) received HSS. After propensity score matching, 720 in the mannitol group matched 240 patients in the HSS group. Median age was 41 years [interquartile ranges (IQR) 26-60], 1058 were men (73%) and median GCS was 4 (IQR 3-6). No significant difference was observed in terms of characteristics and prehospital management between the two groups. ICU mortality was lower in the HSS group (45%) than in the mannitol group (54%) after matching [odds ratio (OR) 0.68 (0.5-0.9), P  = 0.014]. No differences were identified between the groups in terms of secondary outcomes. CONCLUSION: In this propensity-matched observational study, the prehospital osmotherapy with HSS in TBI patients with prehospital mydriasis was associated with a lower ICU mortality compared to osmotherapy with mannitol.


Asunto(s)
Lesiones Traumáticas del Encéfalo , Servicios Médicos de Urgencia , Manitol , Humanos , Manitol/uso terapéutico , Manitol/administración & dosificación , Solución Salina Hipertónica/uso terapéutico , Solución Salina Hipertónica/administración & dosificación , Lesiones Traumáticas del Encéfalo/complicaciones , Lesiones Traumáticas del Encéfalo/mortalidad , Lesiones Traumáticas del Encéfalo/terapia , Femenino , Masculino , Estudios Retrospectivos , Persona de Mediana Edad , Adulto , Servicios Médicos de Urgencia/métodos , Francia , Escala de Coma de Glasgow , Sistema de Registros , Puntaje de Propensión , Estudios de Cohortes , Hipertensión Intracraneal/etiología , Hipertensión Intracraneal/tratamiento farmacológico , Hipertensión Intracraneal/terapia , Anciano , Diuréticos Osmóticos/uso terapéutico
4.
Neurosurg Clin N Am ; 35(3): 287-291, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38782521

RESUMEN

Idiopathic intracranial hypertension is defined by headaches and a decline in visual acuity due to increased intracranial pressure. Treatment options historically included weight loss, acetazolamide, and/or cerebrospinal fluid diversion surgery. Recent understanding of the contributions of dural venous sinus hypertension and stenosis has led to venous sinus stenting as a treatment option.


Asunto(s)
Seudotumor Cerebral , Humanos , Acetazolamida/uso terapéutico , Senos Craneales/cirugía , Hipertensión Intracraneal/terapia , Seudotumor Cerebral/cirugía , Seudotumor Cerebral/terapia , Stents
6.
Curr Pain Headache Rep ; 28(5): 395-401, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38430310

RESUMEN

PURPOSE OF REVIEW: Rebound intracranial hypertension (RIH) is a post-procedural treatment complication in patients with spontaneous intracranial hypotension (SIH) characterized by transient high-pressure headache symptoms. This article reviews the epidemiology, clinical features, risk factors, and treatment options for RIH. RECENT FINDINGS: This article discusses how changes in underlying venous pressure and craniospinal elastance can explain symptoms of RIH, idiopathic intracranial hypertension (IIH), and SIH. The pathophysiology of RIH provides a clue for how high and low intracranial pressure disorders, such as IIH and SIH, are connected on a shared spectrum.


Asunto(s)
Hipertensión Intracraneal , Hipotensión Intracraneal , Humanos , Hipertensión Intracraneal/fisiopatología , Hipertensión Intracraneal/terapia , Hipertensión Intracraneal/complicaciones , Hipotensión Intracraneal/terapia , Hipotensión Intracraneal/fisiopatología , Hipotensión Intracraneal/diagnóstico , Factores de Riesgo , Seudotumor Cerebral/fisiopatología , Seudotumor Cerebral/terapia , Seudotumor Cerebral/diagnóstico , Seudotumor Cerebral/complicaciones , Cefalea/fisiopatología , Cefalea/etiología , Cefalea/terapia
7.
BMJ Case Rep ; 17(3)2024 Mar 15.
Artículo en Inglés | MEDLINE | ID: mdl-38490699

RESUMEN

Spontaneous intracranial hypotension (SIH) is a condition characterised by postural headaches due to low cerebrospinal fluid (CSF) pressure, often stemming from CSF leakage. Diagnosis poses a significant challenge, and the therapeutic approach encompasses both conservative measures and operative interventions, such as the epidural blood patch (EBP). However, EBP carries the potential risk of inducing rebound intracranial hypertension (RIH), subsequently leading to high-pressure headaches. We present a case wherein RIH following EBP was effectively managed through the implementation of an external ventricular drain (EVD) aimed at reducing CSF pressure. The patient improved significantly, underscoring the potential utility, if not necessity, of EVD in carefully selected cases, highlighting the imperative for further research to enhance the management of SIH and optimise EBP-related complications.


Asunto(s)
Hipertensión Intracraneal , Hipotensión Intracraneal , Humanos , Pérdida de Líquido Cefalorraquídeo/terapia , Pérdida de Líquido Cefalorraquídeo/complicaciones , Hipotensión Intracraneal/terapia , Hipotensión Intracraneal/complicaciones , Parche de Sangre Epidural , Cefalea/terapia , Drenaje , Hipertensión Intracraneal/terapia , Hipertensión Intracraneal/complicaciones
8.
Pediatr Neurol ; 153: 92-95, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38354628

RESUMEN

BACKGROUND: Currently no guidelines for repeating a lumbar puncture to guide management in primary intracranial hypertension (PIH) exist. METHODS: An institutional database of patients 18 years and younger followed in the institution's pediatric intracranial hypertension clinic was examined for opening pressure changes in PIH at diagnosis, before medication wean, and following medication wean, as well as to examine whether measurements at the time of diagnosis differed between those with and without disease recurrence. RESULTS: Forty-two patients were included in this study; 36% were male and the mean age at diagnosis was 11.01 years. Treatment duration averaged 9.68 months in those without recurrence and 8.5 months in those with recurrence. Average body mass index percentile of patients with disease recurrence was 83.7 and 72.1 in those without recurrence (P = 0.16). Average opening pressure values of all patients at diagnosis, prewean, and postwean was 36.53 cm H2O, 30.7 cm H2O, and 31.1 cm H2O, respectively. There was no statistically significant difference in opening pressures across these time points (P = 0.14). The change in opening pressure from diagnosis to postwean was statistically significant with a reduction of 5.18 cm H2O (P = 0.04). There was no statistical difference between change in opening pressure at diagnosis versus postwean between those with and without recurrence (P = 0.17). CONCLUSIONS: This clinical observational study suggests that mean opening pressure measurements in patients with PIH remain elevated both before and after medication wean despite papilledema resolution and patient-reported PIH symptoms. Clinically, this suggests that other features such as signs of optic disc edema and symptoms should be used to inform a clinical determination of disease recurrence and treatment course.


Asunto(s)
Hipertensión Intracraneal , Papiledema , Seudotumor Cerebral , Humanos , Masculino , Niño , Femenino , Seudotumor Cerebral/complicaciones , Seudotumor Cerebral/diagnóstico , Seudotumor Cerebral/terapia , Presión del Líquido Cefalorraquídeo , Estudios Retrospectivos , Hipertensión Intracraneal/diagnóstico , Hipertensión Intracraneal/etiología , Hipertensión Intracraneal/terapia , Papiledema/diagnóstico , Presión Intracraneal
9.
Neurol Neurochir Pol ; 58(1): 31-37, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38393958

RESUMEN

INTRODUCTION: Spontaneous CSF leak is a known complication of idiopathic intracranial hypertension (IIH). Patients with CSF rhinorrhea present a unique challenge within the IIH population, as the occurrence of a leak can mask the typical IIH symptoms and signs, complicating the diagnosis. Treatment of leaks in this population can also be challenging, with the risk of rhinorrhea recurrence if intracranial hypertension is not adequately treated. OBJECTIVE: The aim of this narrative review was to examine current literature on the association between spontaneous CSF rhinorrhea leaks and IIH, focusing on key clinical features, diagnostic approaches, management strategies, and outcomes. MATERIAL AND METHODS: A literature search was executed using the PubMed and Scopus databases. The search was confined to articles published between January 1985 and August 2023; extracted data was then analysed to form the foundation of the narrative review. RESULTS: This search yielded 26 articles, comprising 943 patients. Average age was 46.8 ± 6.5 years, and average body mass index was 35.8 ± 4.8. Most of the patients were female (74.33%). Presenting symptoms were rhinorrhea, headaches and meningitis. The most common imaging findings were empty sella and encephalocele. The standard treatment approach was endoscopic endonasal approach for correction of CSF rhinorrhea leak, and shunt placement was also performed in 128 (13%) patients. Recurrences were observed in 10% of cases. CONCLUSIONS: The complex relationship between spontaneous CSF leaks and IIH is a challenge that benefits from multidisciplinary evaluation and management for successful treatment. Treatments such as endoscopic repair, acetazolamide, and VP/ /LP shunts reduce complications and recurrence. Personalised plans addressing elevated intracranial pressure are crucial for successful outcomes.


Asunto(s)
Rinorrea de Líquido Cefalorraquídeo , Hipertensión Intracraneal , Seudotumor Cerebral , Humanos , Femenino , Adulto , Persona de Mediana Edad , Masculino , Seudotumor Cerebral/complicaciones , Seudotumor Cerebral/diagnóstico , Seudotumor Cerebral/terapia , Rinorrea de Líquido Cefalorraquídeo/diagnóstico por imagen , Rinorrea de Líquido Cefalorraquídeo/etiología , Rinorrea de Líquido Cefalorraquídeo/cirugía , Hipertensión Intracraneal/complicaciones , Hipertensión Intracraneal/terapia , Acetazolamida , Endoscopía/efectos adversos , Pérdida de Líquido Cefalorraquídeo/complicaciones , Estudios Retrospectivos
10.
Neurocrit Care ; 41(1): 228-243, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38356077

RESUMEN

Acute bacterial meningitis (ABM) is associated with severe morbidity and mortality. The most prevalent pathogens in community-acquired ABM are Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Other pathogens may affect specific patient groups, such as newborns, older patients, or immunocompromised patients. It is well established that ABM is associated with elevated intracranial pressure (ICP). However, the role of ICP monitoring and management in the treatment of ABM has been poorly described.An electronic search was performed in four electronic databases: PubMed, Web of Science, Embase, and the Cochrane Library. The search strategy chosen for this review used the following terms: Intracranial Pressure AND (management OR monitoring) AND bacterial meningitis. The search yielded a total of 403 studies, of which 18 were selected for inclusion. Eighteen studies were finally included in this review. Only one study was a randomized controlled trial. All studies employed invasive ICP monitoring techniques, whereas some also relied on assessment of ICP-based on clinical and/or radiological observations. The most commonly used invasive tools were external ventricular drains, which were used both to monitor and treat elevated ICP. Results from the included studies revealed a clear association between elevated ICP and mortality, and possibly improved outcomes when invasive ICP monitoring and management were used. Finally, the review highlights the absence of clear standardized protocols for the monitoring and management of ICP in patients with ABM. This review provides an insight into the role of invasive ICP monitoring and ICP-based management in the treatment of ABM. Despite weak evidence certainty, the present literature points toward enhanced patient outcomes in ABM with the use of treatment strategies aiming to normalize ICP using continuous invasive monitoring and cerebrospinal fluid diversion techniques. Continued research is needed to define when and how to employ these strategies to best improve outcomes in ABM.


Asunto(s)
Infecciones Comunitarias Adquiridas , Hipertensión Intracraneal , Meningitis Bacterianas , Humanos , Meningitis Bacterianas/terapia , Meningitis Bacterianas/diagnóstico , Meningitis Bacterianas/fisiopatología , Hipertensión Intracraneal/terapia , Hipertensión Intracraneal/fisiopatología , Hipertensión Intracraneal/diagnóstico , Infecciones Comunitarias Adquiridas/terapia , Enfermedad Aguda , Presión Intracraneal/fisiología
11.
Neurocrit Care ; 41(1): 202-207, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38379103

RESUMEN

BACKGROUND: Elevated intracranial pressure (ICP) is a neurological emergency in patients with acute brain injuries. Such a state requires immediate and effective interventions to prevent potential neurological deterioration. Current clinical guidelines recommend hypertonic saline (HTS) and mannitol as first-line therapeutic agents. Notably, HTS is conventionally administered through central venous catheters (CVCs), which may introduce delays in treatment due to the complexities associated with CVC placement. These delays can critically affect patient outcomes, necessitating the exploration of more rapid therapeutic avenues. This study aimed to investigate the safety and effect on ICP of administering rapid boluses of 3% HTS via peripheral intravenous (PIV) catheters. METHODS: A retrospective cohort study was performed on patients admitted to Sisters of Saint Mary Health Saint Louis University Hospital from March 2019 to September 2022 who received at least one 3% HTS bolus via PIV at a rate of 999 mL/hour for neurological emergencies. Outcomes assessed included complications related to 3% HTS bolus and its effect on ICP. RESULTS: Of 216 3% HTS boluses administered in 124 patients, complications occurred in 8 administrations (3.7%). Pain at the injection site (4 administrations; 1.9%) and thrombophlebitis (3 administrations; 1.4%) were most common. The median ICP reduced by 6 mm Hg after 3% HTS bolus administration (p < 0.001). CONCLUSIONS: Rapid bolus administration of 3% HTS via PIV catheters presents itself as a relatively safe approach to treat neurological emergencies. Its implementation could provide an invaluable alternative to the traditional CVC-based administration, potentially minimizing CVC-associated complications and expediting life-saving interventions for patients with neurological emergencies, especially in the field and emergency department settings.


Asunto(s)
Cateterismo Periférico , Hipertensión Intracraneal , Humanos , Solución Salina Hipertónica/administración & dosificación , Femenino , Estudios Retrospectivos , Persona de Mediana Edad , Masculino , Hipertensión Intracraneal/tratamiento farmacológico , Hipertensión Intracraneal/etiología , Hipertensión Intracraneal/terapia , Adulto , Cateterismo Periférico/efectos adversos , Cateterismo Periférico/instrumentación , Cateterismo Periférico/métodos , Anciano , Presión Intracraneal/efectos de los fármacos , Urgencias Médicas , Lesiones Encefálicas/terapia
12.
BMJ Case Rep ; 16(12)2023 Dec 30.
Artículo en Inglés | MEDLINE | ID: mdl-38160032

RESUMEN

Dural arteriovenous fistulas (DAVFs) are intracranial vascular abnormalities in which one or more meningeal arteries shunt into a venous structure, either a cortical vein or a venous sinus, causing cerebral venous hypertension and risk of haemorrhage. Imaging diagnosis and characterisation are of paramount importance to grade the haemorrhagic risk and direct management. Non-invasive vascular neuroimaging might pose a diagnostic suspicion, but invasive catheter digital subtraction angiography (DSA) is usually required. We present the case of a patient with an atypical acute cerebral haemorrhage in which admission imaging with CT angiography (CTA) and MR angiography (MRA) was unremarkable, while advanced morphological MR with susceptibility-weighted imaging (SWI) revealed specific findings suggesting unilateral chronic venous hypertension. Successively, DSA detected a small DAVF that was treated with endovascular embolization. This case report raises awareness on subtle but important conventional imaging findings that suggest the presence of an AV shunt, to avoid misdiagnosis and delayed treatment.


Asunto(s)
Malformaciones Vasculares del Sistema Nervioso Central , Embolización Terapéutica , Hipertensión , Hipertensión Intracraneal , Humanos , Imagen por Resonancia Magnética , Angiografía por Resonancia Magnética/métodos , Malformaciones Vasculares del Sistema Nervioso Central/complicaciones , Malformaciones Vasculares del Sistema Nervioso Central/diagnóstico por imagen , Malformaciones Vasculares del Sistema Nervioso Central/terapia , Neuroimagen , Hipertensión Intracraneal/terapia , Hipertensión/terapia
13.
Braz. J. Anesth. (Impr.) ; 72(6): 790-794, Nov.-Dec. 2022. tab
Artículo en Inglés | LILACS | ID: biblio-1420610

RESUMEN

Abstract Idiopathic intracranial hypertension (IIH) is a neurological condition characterized by raised intracranial pressure of unknown etiology with normal cerebrospinal fluid (CSF) composition and no brain lesions. It occurs in pregnant patients at approximately the same frequency as in general population, but obstetric and anesthetic management of the pregnancy and labor remains controversial. In this article we provide a multidisciplinary review of the main aspects of IIH in pregnancy including treatment options, mode of delivery and anesthetic techniques. Additionally, we report three cases of pregnant women diagnosed with IIH between 2012 and 2019 in our institution.


Asunto(s)
Humanos , Femenino , Embarazo , Complicaciones del Embarazo/terapia , Seudotumor Cerebral/complicaciones , Seudotumor Cerebral/diagnóstico , Seudotumor Cerebral/terapia , Trabajo de Parto , Hipertensión Intracraneal/terapia
14.
Rev. méd. Chile ; 150(1): 78-87, ene. 2022. ilus, tab
Artículo en Español | LILACS | ID: biblio-1389621

RESUMEN

Elevated intracranial pressure (ICP) is a devastating complication, with great impact on neurological status and high morbidity and mortality. Intracranial hypertension (ICH) has multiple etiologies. The natural history of this condition can lead to brain death. The successful management of patients with elevated ICP (> 20-25 mmHg) requires fast and timely recognition, judicious use of invasive monitoring and therapies aimed to reversing its underlying cause. Therefore, it must be managed as a neurological emergency. The objective of this review is to present in a friendly way the diagnostic approach and the management of ICH, focused on general practitioners.


Asunto(s)
Humanos , Hipertensión Intracraneal/diagnóstico , Hipertensión Intracraneal/etiología , Hipertensión Intracraneal/fisiopatología , Hipertensión Intracraneal/terapia , Muerte Encefálica , Presión Intracraneal , Progresión de la Enfermedad , Medicina General
15.
Med. intensiva (Madr., Ed. impr.) ; 45(7): 421-430, Octubre 2021. tab, graf
Artículo en Español | IBECS | ID: ibc-224144

RESUMEN

Objetivo Evaluar el impacto de la infusión de lactato de sodio 0,5M sobre variables del medio interno y sobre la presión intracraneana en pacientes críticos. Diseño Estudio prospectivo experimental de cohorte única. Ámbito Unidad de cuidados intensivos de un hospital universitario. Pacientes Pacientes con shock y neurocríticos con hipertensión intracraneana. Intervenciones Se infundió una carga de 500 cc de infusión de lactato de sodio 0,5M en 15 min y se midió el nivel plasmático de sodio, potasio, magnesio, calcio, cloro, lactato, bicarbonato, PaCO2 arterial, pH, fosfato y albúmina en 3 tiempos: T0 preinfusión; T1 a los 30 min y T2 a los 60 min postinfusión. Se midieron la presión arterial media y presión intracraneana en T0 y T2. Resultados Recibieron el fluido N=41: n=19 como osmoagente y 22 como expansor. Se constató alcalosis metabólica: T0 vs. T1 (p=0,007); T1 vs. T2 (p=0,003). La natremia aumentó en los 3 tiempos (T0 vs. T1; p<0,0001; T1 vs. T2; p=0,0001). Se demostró un descenso de la presión intracraneana (T0: 24,83±5,4 vs. T2: 15,06±5,8; p <0,001). El lactato aumentó inicialmente (T1) con un rápido descenso (T2) (p <0,0001), incluso en aquellos pacientes con hiperlactatemia basal (p=0,002). Conclusiones La infusión de lactato de sodio 0,5M genera alcalosis metabólica, hipernatremia, disminución de la cloremia y un cambio bifásico del lactato, y muestra eficacia en el descenso de la presión intracraneana en pacientes con daño encefálico agudo. (AU)


Objective To evaluate the impact of the infusion of sodium lactate 500ml upon different biochemical variables and intracranial pressure in patients admitted to the intensive care unit. Design A prospective experimental single cohort study was carried out. Scope Polyvalent intensive care unit of a university hospital. Patients Critical patients with shock and intracranial hypertension. Procedure A 500ml sodium lactate bolus was infused in 15min. Plasma levels of sodium, potassium, magnesium, calcium, chloride, lactate, bicarbonate, PaCO2, pH, phosphate and albumin were recorded at 3timepoints: T0 pre-infusion; T1 at 30minutes, and T2 at 60minutes post-infusion. Mean arterial pressure and intracranial pressure were measured at T0 and T2. Results Forty-one patients received sodium lactate: 19 as an osmotically active agent and 22 as a volume expander. Metabolic alkalosis was observed: T0 vs. T1 (P=0.007); T1 vs. T2 (P=0.003). Sodium increased at the 3time points (T0 vs. T1, P<0.0001; T1 vs. T2, P=0.0001). In addition, sodium lactate decreased intracranial pressure (T0: 24.83±5.4 vs. T2: 15.06±5.8; P<0.001). Likewise, plasma lactate showed a biphasic effect, with a rapid decrease at T2 (P<0.0001), including in those with previous hyperlactatemia (P=0.002). Conclusions The infusion of sodium lactate is associated to metabolic alkalosis, hypernatremia, reduced chloremia, and a biphasic change in plasma lactate levels. Moreover, a decrease in intracranial pressure was observed in patients with acute brain injury. (AU)


Asunto(s)
Humanos , Lactato de Sodio/administración & dosificación , Lactato de Sodio/uso terapéutico , Fluidoterapia/instrumentación , Alcalosis/metabolismo , Hipertensión Intracraneal/terapia , Enfermedad Crítica , Unidades de Cuidados Intensivos
16.
Arq. bras. neurocir ; 39(3): 161-169, 15/09/2020.
Artículo en Inglés | LILACS | ID: biblio-1362437

RESUMEN

Objectives External ventricular drainage (EVD) is extensively used in the neurosurgical practice with the purpose of monitoring the intracranial pressure and draining the cerebrospinal fluid (CSF). Despite its remarkable benefits, the technique is not devoid of risks, notably infections, which have been reported in up to 45% of the cases. Methods A retrospective analysis of the main risk factors for CSF infection in neurosurgical patients submitted to EVD at a single institution. We recorded and submitted to statistical comparison every risk factor for CSF infection present or absent in each of the 110 EVD patients enrolled, 53 males and 57 females, with an average age of 52.9 years, with different underlying neurosurgical conditions. Results Infection of the CSF occurred in 32 patients (29%). The rate of mortality related to CSF infection was of 18.7% (6 of 32). The risk factors that showed statistical significance for CSF infection in this series were: emergency surgery; length of stay at the intensive care unit (UCI); duration of the EVD; parenchymal and/or intraventricular hemorrhage; simultaneous infections; time of bladder catheterization; and the use of non-disposable adhesive drapes as part of the preparation of the wound area. Conclusions Infection of the CSF in patients submitted to EVD is multifactorial and a challenge in terms of prevention. Further studies proposing scores with blended risk factors may be useful to prevent and reduce the morbidity and mortality associated with CSF infection.


Asunto(s)
Infecciones del Sistema Nervioso Central/complicaciones , Infecciones del Sistema Nervioso Central/líquido cefalorraquídeo , Derivación Ventriculoperitoneal/efectos adversos , Pérdida de Líquido Cefalorraquídeo/complicaciones , Perfil de Salud , Distribución de Chi-Cuadrado , Registros Médicos , Estudios Retrospectivos , Factores de Riesgo , Estadísticas no Paramétricas , Hipertensión Intracraneal/terapia
17.
Artículo en Inglés, Portugués | LILACS | ID: biblio-1057224

RESUMEN

ABSTRACT Objective: To determine the events associated with the occurrence of intracranial hypertension (ICH) in pediatric patients with severe cranioencephalic trauma. Methods: This was a prospective cohort study of patients 18 years old and younger with cranioencephalic trauma, scores below nine on the Glasgow Coma Scale, and intracranial pressure monitoring. They were admitted between September, 2005 and March, 2014 into a Pediatric Intensive Care Unit. ICH was defined as an episode of intracranial pressure above 20 mmHg for more than five minutes that needed treatment. Results: A total of 198 children and adolescents were included in the study, of which 70.2% were males and there was a median age of nine years old. ICH occurred in 135 (68.2%) patients and maximum intracranial pressure was 36.3 mmHg, with a median of 34 mmHg. A total of 133 (97.8%) patients with ICH received sedation and analgesia for treatment of the condition, 108 (79.4%) received neuromuscular blockers, 7 (5.2%) had cerebrospinal fluid drainage, 105 (77.2%) received mannitol, 96 (70.6%) received hyperventilation, 64 (47.1%) received 3% saline solution, 20 (14.7%) received barbiturates, and 43 (31.9%) underwent a decompressive craniectomy. The events associated with the occurrence of ICH were tomographic findings at the time of admission of diffuse or hemispheric swelling (edema plus engorgement). The odds ratio for ICH in patients with Marshall III (diffuse swelling) tomography was 14 (95%CI 2.8-113; p<0.003), and for those with Marshall IV (hemispherical swelling) was 24.9 (95%CI 2.4-676, p<0.018). Mortality was 22.2%. Conclusions: Pediatric patients with severe cranioencephalic trauma and tomographic alterations of Marshall III and IV presented a high chance of developing ICH.


RESUMO Objetivo: Determinar eventos associados à ocorrência de hipertensão intracraniana (HIC) em pacientes pediátricos com traumatismo cranioencefálico grave. Métodos: Trata-se de coorte prospectiva de pacientes de até 18 anos, com traumatismo cranioencefálico, pontuação abaixo de nove na Escala de Coma de Glasgow e monitoração da pressão intracraniana, admitidos entre setembro de 2005 e março de 2014 em unidade de terapia intensiva pediátrica. A HIC foi definida como episódio de pressão intracraniana acima de 20 mmHg por mais de cinco minutos e com necessidade de tratamento. Resultados: Incluídas 198 crianças e adolescentes, 70,2% masculinos, mediana de idade de nove anos. A HIC ocorreu em 135 (68,2%) pacientes; valor máximo de pressão intracraniana de 36,3; mediana 34 mmHg. Receberam sedação e analgesia para tratamento da HIC 133 (97,8%) pacientes, 108 (79,4%) receberam bloqueadores neuromusculares, 7 (5,2%) drenagem de líquor, 105 (77,2%) manitol, 96 (70,6%) hiperventilação, 64 (47,1%) solução salina a 3%, 20 (14,7%) barbitúricos e 43 (31,9%) foram submetidos à craniectomia descompressiva. Os eventos associados à ocorrência de HIC foram os achados tomográficos à admissão de swelling (edema mais ingurgitamento) difuso ou hemisférico. A razão de chance para que pacientes com classificação tomográfica Marshall III (swelling difuso) apresentassem HIC foi 14 (IC95% 2,8-113; p<0,003) e para aqueles com Marshall IV (hemisférico) foi 24,9 (IC95% 2,4-676; p<0,018). A mortalidade foi de 22,2%. Conclusões: Pacientes pediátricos com traumatismo cranioencefálico grave e alterações tomográficas tipo Marshall III e IV apresentaram grande chance de desenvolver HIC.


Asunto(s)
Humanos , Masculino , Femenino , Preescolar , Niño , Adolescente , Presión Intracraneal/fisiología , Hipertensión Intracraneal/terapia , Hipertensión Intracraneal/epidemiología , Traumatismos Craneocerebrales/complicaciones , Índice de Severidad de la Enfermedad , Unidades de Cuidado Intensivo Pediátrico/estadística & datos numéricos , Tomografía Computarizada por Rayos X/métodos , Escala de Coma de Glasgow , Prevalencia , Estudios Prospectivos , Hipertensión Intracraneal/diagnóstico por imagen , Craniectomía Descompresiva/métodos , Pérdida de Líquido Cefalorraquídeo , Traumatismos Craneocerebrales/mortalidad , Traumatismos Craneocerebrales/epidemiología , Bloqueantes Neuromusculares/uso terapéutico
18.
J. bras. nefrol ; 41(3): 436-439, July-Sept. 2019. graf
Artículo en Inglés | LILACS | ID: biblio-1040244

RESUMEN

Abstract Introduction: The posterior reversible encephalopathy (PRES) syndrome encompasses a set of clinical-radiological findings associated with severe systemic arterial hypertension. This case report proposes to discuss the identification, diagnosis, and management of PRES in the pediatric population. Case presentation: Female patient, 10 years old, admitted to the emergency room with complaint of oliguria and generalized edema. At the initial physical exam, the only alteration present was anasarca. The diagnostic investigation revealed nephrotic syndrome, and clinical treatment was started. She evolved on the 8th day of hospitalization with peak hypertension, sudden visual loss, reduced level of consciousness, nystagmus, and focal seizures requiring intubation. She was transferred to the Intensive Care Unit, with neurological improvement, after the established therapy. CT scan revealed a discrete hypodense area in the white matter of the occipital lobe and anteroposterior groove asymmetry, compatible with PRES. Discussion: PRES is due to vasogenic cerebral edema of acute or subacute installation. Symptoms include headache and altered consciousness, stupor, coma, neurological deficits, seizures and cortical blindness. Nephropathies are the main cause of PRES in pediatrics. Magnetic resonance imaging with diffusion of molecules is the gold standard for diagnosis. The initial treatment objectives are the reduction of blood pressure, antiepileptic therapy, correction of hydroelectrolytic and acid-base disorders and management of intracranial hypertension. Conclusion: PRES is associated with acute hypertension. Early diagnosis and proper management may determine a better prognosis and minimize the severity of the clinical course.


Resumo Introdução: A Síndrome de Encefalopatia Posterior Reversível (SEPR) engloba um conjunto de achados clínico-radiológicos, associados a hipertensão arterial sistêmica grave. Este relato de caso propõe discutir a identificação, o diagnóstico e o manejo de SEPR na população pediátrica. Apresentação do caso: Paciente do sexo feminino, 10 anos, admitida em pronto-atendimento com queixa de oligúria e edema generalizado. Ao exame físico inicial, a única alteração presente era anasarca. A investigação diagnóstica revelou síndrome nefrótica, iniciando-se tratamento clínico. Evoluiu no 8º dia de internação com pico hipertensivo, perda visual súbita, redução do nível de consciência, nistagmo e crises convulsivas focais, demandando intubação. Foi transferida para Unidade de Terapia Intensiva, com melhora neurológica, após a terapêutica instituída. Tomografia de crânio evidenciou área de hipodensidade discreta em substância branca do lobo occipital e assimetria anteroposterior de sulcos, compatível com SEPR. Discussão: A SEPR decorre de edema cerebral vasogênico de instalação aguda ou subaguda. Sintomas descritos incluem cefaleia e alteração de consciência, estupor, coma, déficits neurológicos, convulsões e cegueira cortical. As nefropatias constituem as principais causas de SEPR em pediatria. A ressonância magnética com difusão de moléculas é o padrão-ouro para o diagnóstico. Os objetivos iniciais são a redução dos níveis pressóricos, terapia antiepiléptica, correção de distúrbios hidroeletrolíticos e do equilíbrio ácido-básico, e manejo da hipertensão intracraniana. Conclusão: A SEPR ocorre associada à hipertensão aguda. O diagnóstico precoce e manejo adequado podem determinar melhor prognóstico e minimizar a gravidade do curso clínico.


Asunto(s)
Humanos , Femenino , Niño , Hipertensión Intracraneal/complicaciones , Síndrome de Leucoencefalopatía Posterior/etiología , Síndrome de Leucoencefalopatía Posterior/diagnóstico por imagen , Hipertensión/complicaciones , Síndrome Nefrótico/complicaciones , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Hipertensión Intracraneal/terapia , Imagen de Difusión por Resonancia Magnética , Síndrome de Leucoencefalopatía Posterior/tratamiento farmacológico , Hipertensión/tratamiento farmacológico , Anticonvulsivantes/uso terapéutico , Antihipertensivos/uso terapéutico
19.
Prensa méd. argent ; 105(1): 24-33, mar 2019. fig
Artículo en Español | LILACS, BINACIS | ID: biblio-1026329

RESUMEN

La presión intracraneal elevada es una complicación devastadora de la lesión neurológica, que puede complicar el trauma, los tumores del sistema nervioso central, la hidrocefalia, la encefalopatía hepática y el flujo venoso del SNC alterado. El adecuado tratamiento consta de un rápido reconocimiento, utilizar material de monitoreo neurológico invasivo y su manejo para reducir la hipertensión intracraneal y sus múltiples causas subyacente. A continuación presentamos una revisión de sus principales características y principios de abordaje diagnóstico-terapéutico


Intracranial pressure is a devastating complication of neurological damage, which can complicate trauma, central nervous system disorders, hydrocephalus, hepatic encephalopathy, and altered CNS venous flow. The appropriate treatment consists of a rapid recognition, the use of an invasive neurological system and its management to reduce intracranial hypertension and its multiple underlying causes. Below we present a review of its main characteristics and principles of diagnostic-therapeutic approach.


Asunto(s)
Humanos , Perfusión , Presión Intracraneal , Circulación Cerebrovascular , Ultrasonografía Doppler/métodos , Hipertensión Intracraneal/diagnóstico , Hipertensión Intracraneal/prevención & control , Hipertensión Intracraneal/terapia , Craneotomía , Tratamiento Conservador
20.
Rev. pesqui. cuid. fundam. (Online) ; 11(1): 255-262, jan.-mar. 2019. tab
Artículo en Inglés, Portugués | LILACS, BDENF - Enfermería | ID: biblio-968579

RESUMEN

Objetivo: Identificar a través de la literatura las intervenciones de enfermería en el monitoreo de la presión intracraneal en pacientes neurocríticos. Método: Revisión de la literatura integradora con búsqueda de artículos, SciELO, LILACS y PUBMED. Los artículos seleccionados fueron publicados entre los años 2007 y 2017. Resultados: Se encontraron 94 artículos y excluidos 78 como criterios de inclusión. Hasta 16 artículos fueron utilizados en esta revisión. Estos datos sugieren que la monitorización neurológica puede realizarse en una invasiva y no invasiva. Entre los métodos invasivos es el monitoreo de la presión intracraneal y la enfermera, que era directamente responsable de este cuidado. Por lo tanto, el cuidado y la elevación de la cabeza, cuidado con aspiración traqueal, cuidado con hipoxemia, coordinación y gestión en enfermería entre otros debe ser parte de la atención de enfermería. Conclusión: Cuidados de enfermería es esencial para el paciente neurocrítico. Este cuidado contribuir tanto positivos como negativos en estos pacientes


Objective: To identify through literature the nursing interventions in the intracranial pressure monitoring in patients neurocríticos. Method: Integrative review of literature with search of articles in SciELO, LILACS, and PUBMED. The selected articles were published between the years 2007 and 2017. Results: We found 94 articles and excluded 78 as inclusion criteria. So 16 articles were used in this review. These suggest that the neurological monitoring can be performed in a invasive and non invasive. Among the invasive methods is the monitoring of intracranial pressure, and the nurse, who was directly responsible for this care. Thus, care and the elevation of the head, care with tracheal aspiration, care with hypoxemia, coordination and management in nursing care among others must be part of nursing care. Conclusion: Nursing care is essential for the patient neurocrítico. This care contribute to both positive developments as negative in these patients


Objetivo: Identificar por meio da literatura as intervenções de enfermagem na monitorização da pressão intracraniana em pacientes neurocríticos. Método:Revisão integrativa da literatura com busca dos artigos nas bases de dados SciELO, LILACS e PUBMED. Os artigos selecionados foram publicados entre os anos de 2007 e 2017. Resultados: Foram encontrados 94 artigos e excluídos 78 conforme critérios de inclusão. Assim, 16 artigos foram usados nesta revisão. Estes apontaram que a monitorização neurológica pode ser realizada de maneira invasiva e não invasiva. Entre os métodos invasivos, está a monitorização da pressão intracraniana, sendo o enfermeiro, responsável direto neste cuidado. Assim, cuidados como a elevação da cabeceira, cuidados com aspiração traqueal, cuidados com hipoxemia, coordenação e gerenciamento nos cuidados de enfermagem, entre outros, devem fazer parte da assistência de enfermagem. Conclusão: Os cuidados de enfermagem são indispensáveis para o paciente neurocrítico. Estes cuidados contribuem tanto para evolução positiva quanto negativa desses pacientes


Asunto(s)
Humanos , Masculino , Femenino , Hipertensión Intracraneal/enfermería , Hipertensión Intracraneal/terapia , Unidades de Cuidados Intensivos
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