Missing diagnosis: gingival hypertrophy due to amlodipine.

Gingival hypertrophy (GH) is a well-known physical manifestation due to inflammatory conditions, pregnancy, vitamin C deficiency, systemic diseases like leukemia, Wegners granulomatosis, and various drugs like anticonvulsants, immunosuppresant, and calcium channel blockers (CCBs).We present here a case of a 45-year-old woman, who has been taking Amlodipine 10mg once a day together with Atenelol 50mg per day for one and half years, and has subsequently developed gum hypertrophy. This manifestation was reversed after stopping of Amlodipine. Though this case presentation is described in literature, we hereby present it in a pictorial form, to sensitize the treating physician toward it.

Diagnosis of acute myeloid leukemia in a dental hospital; report of a case with severe gingival hypertrophy.

Acute myeloid leukemias (AMLs) are aggressive hematopoietic neoplasms that, if untreated, can lead to death within days. Owing to its high morbidity rate, early diagnosis and appropriate medical therapy is essential. Oral lesions may be the presenting feature of acute leukemias and are, therefore, important diagnostic indicators of the disease. Erythematous or cyanotic gingival hyperplasia with or without necrosis is reported to be the most consistent symptom leading to a diagnosis of acute leukemia that directs the patient to seek early dental consultation. This report refers to a patient with AML that was provisionally diagnosed in the dental hospital due to severe gingival enlargements.

Planejamento protético pré-cirúrgico em Implantodontia: caso clínico com correção de sorriso gengival / Pre-surgical prosthetic planning in implant dentistry: case repart oi gummy smile

O presente artigo descreve a reabilitação de arco superior por meio de prótese total fixada a implantes em um caso clínico de sorriso gengival associado a perdas dentárias. Para a obtenção de um resultado previsível, estética e funcionalmente, foi realizado extenso planejamento protético pré-cirúrgico em modelos e simulações digitais do sorriso. Baseado nesse planejamento foi realizada uma osteotomia maxilar com instalação imediata dos implantes. Aguardou-se o tempo de osseointegração dos implantes, para em seguida reabilitá-Ios com a prótese total fixa metaloplástica parafusada. A descrição desse caso objetiva ressaltar a importância do planejamento protético pré-cirúrgico minimizando assim, possíveis erros e prejuízos no resultado final estético e funcional da reabilitação.

The present study describes the rehabilitation of the upper arch with fixed full arch prosthesis screw retained to implants in a gummy smile case report. In order to obtain predictable results, esthetically and functionally, an extensive pre-surgical prosthetic planning and smile digital simulations were done. Based on this planning a maxillary osteotomy was done and immediate implants were installed. After the osseointegration period, the patient received a full fixed metaloplastic prosthesis, screw retained. This case report aims to highlight the importance of pre-surgical prosthetic planning to minimize errors and to achieve esthetic and functional results.

Juvenile hyaline fibromatosis: a case report.

Juvenile hyaline fibromatosis is a rare, hereditary disease with distinct clinical and histopathological features. Clinically, it presents with gingival hypertrophy, pappulonodular skin lesions and joint contractures. Bone involvement is usually an uncommon finding. We report a case of a 2-year-old patient, daughter of consanguineous parents, who presented since the age of 2 months with impairment of mental development, multiple joint contractures, motion limitation and nodules on the scalp. The calvarian lesions were surgically removed, and histopathological examination concluded to juvenile hyaline fibromatosis.

O papel da Ortodontia no diagnóstico e tratamento do sorriso gengival / The role of Orthodontics in the diagnosis and treatment of gingival smile

A exposição exagerada da gengiva é um dos problemas que afeta, negativamente, a estética do sorriso. Apresentando-se em diversos graus de extensão, sua etiologia pode estar relacionada com excesso vertical maxilar, protrusão dentoalveolar superior, extrusão e/ou erupção passiva alterada dos dentes anaterossuperiores, e hiperatividade dos músculos elevados do lábio superior. Em grande parte dos casos, porém, alguns desses fatores ou mesmo todos eles encontram-se associados. O Ortodontista parece ser o profissional mais indicado a diagnosticar e planejar o tratamento desses pacientes, por ter condições de avaliar a participação de cada um dos fatores etiológicos no problema e, numa proposta de abordagem transdisciplinar, encaminhá-los para profissionais das áreas afins.

[Cowden syndrome]. / Le syndrome de Cowden.

INTRODUCTION: Cowden syndrome is rare; oral symptoms are not always diagnosed. This case of Cowden syndrome was revealed by gingival hypertrophy. OBSERVATION: A 21-year-old female patient consulted for gingival hypertrophy and multiple papules in the mouth. She had a history of thyroid lobectomy due to a goiter. The gingival papillomatosis and the goiter suggested a Cowden syndrome. The diagnosis was confirmed clinically by facial skin papules. DISCUSSION: Cutaneous and oral lesions are usually the first symptoms of the syndrome. Diffuse gingival papillomatosis may suggest a Cowden syndrome and should lead to screen for associated symptoms. A high-risk diagnosis of breast and thyroid cancer is associated to Cowden syndrome and the patient should have a yearly follow-up.

A new finding in a patient with Mowat Wilson syndrome: peripupillary atrophy and gingival hypertrophy.

Mowat-Wilson syndrome is a genetic disease characterized by typical facial features, Hirschsprung disease and multiple congenital abnormalities. MWS is a single gene disorder. One of the most specific clinical signs in MWS is the distinctive face. We report a two-year-old boy with multiple congenital anomalies. He had peripupillary atrophy and gingival hypertrophy different from the literature. The patient was also diagnosed with his clinical findings. These features may be important in Mowat-Wilson syndrome and clinicians should keep these findings in mind.

Sorriso gengival: diagnóstico e tratamento / Gingival smile: diagnosis and treatment

A procura pela excelência estética é atualmente, uma realidade em nossa sociedade. Nesse context5o, a busca pelo sorriso perfeito tem siso constante. Uma queixa bastante comum é a presença do sorriso gengival, condição caracterizada pela aparência de mais de 2mm de gengiva durante o sorriso. O presente trabalho tem por objetivo apresentar um caso clínico de sorriso gengival em que a paciente era portadora de erupção passiva alterada do tipo I-A. A queixa estética se tornou mais evidente após o fim do tratamento ortodôntico. Os fatores etiológicos envolvidos são: o crescimento vertical da maxila, a extrusão dentoalveolar, a hiperatividade dos músculos labiais e/ou lábio superior curto, erupção passiva alterada e o uso de medicamentos cujo efeito colateral é o crescimento gengival. Dentro do ramo de atuaação da Ortodontia encontra-se a intrusão dentoalveolar, associada ou não à cirurgia ortognática. A Periodontia trata os casos em que são necessárias correções cirúrgicas no tecido gengival; já a Cirurgia Plástica e a Dermatologia corrigem as alterações musculares. /quando existem diferenças nas proporções dentárias, são requeridos tratamentos restauradores cocmplementares. Existem casos em que se torna necessa´ria a atuação multidisciplinar, pois podem coexistir dois ou mais fatores etiológicos. Foi realizada a ccirurgia periodontal indicada e a paciente mostrou bastante satisfação com o resulstado final, conformando que o correto diagnóstico, alaiado a técnicas consagradas, é a melhor forma de se alcançar metas estipuladas.

Reliability of two measurement indices for gingival enlargement.

BACKGROUND AND OBJECTIVE: The objective of this study was to analyze the concordance of the vertical gingival overgrowth index (GOi) and the horizontal Miranda & Brunet index (MBi) and to compare their reliability and reproducibility for an early diagnosis of gingival enlargement. A wide range of methods has been employed to determine the severity of drug-induced gingival enlargement (DIGE) that has resulted in uncertainty with regard to the prevalence of this side effect. In recent studies, different indices have been used to grade DIGE. The large variability observed between studies and the differences between vertical and horizontal gingival-enlargement measurements could be the result of the use of nonreliable indices during the measurement process. Some indices involve invasive procedures that require many measurements, or even a data-processing system, while others are less convenient and technically expensive and complex. In previous studies we used two complementary indices - the vertical GOi and the horizontal MBi. The results of these studies found some differences between both indices, with the MBi rendering higher estimates of DIGE prevalence that was attributed to its greater sensitivity for the detection of minimal changes in gingival thickness. To our knowledge, there are no studies comparing different measurement indices for gingival enlargement that are supported by statistical concordance analysis. MATERIAL AND METHODS: Twelve plaster casts from patients who had worn orthodontic brackets, and who had different degrees of chronic inflammatory gingival enlargement, were analyzed. Three previously trained examiners registered twice the degree of buccal overgrowth, using the GOi and MBi, in all cast models with a minimum interval of 7 d between the first and the second evaluation. In total, from each cast, measurements from 16 gingival sites were taken using the GOi, and from nine gingival units (mesial and distal sites measurements) using the MBi. Concordance analysis of the registered measurements (intra-examiner and among examiners) for each index and between indices was assessed using the nonweighted Kappa index with a confidence interval of 95%. RESULTS: We obtained 648 values for the GOi and the MBi. The overall score 0 (indicating absence of enlargement) was 32.7% and 19.8% for GOi and MBi, respectively, score 1 (light/moderate) was 39.7% and 48.1%, and score 2 (severe) was 27.6% and 32.1%. Concordance analysis for each index showed intra-examiner Kappa values of 0.820 for the GOi and 0.830 for the MBi. Interexaminer Kappa values were 0.720 for the GOi and 0.770 for the MBi. Concordance between indices showed Kappa values for the same examiner of 0.600, whereas concordance among different examiners was 0.550. Discrepancies between indices indicated a systematic skew, with 79-82.1% of discrepancy associated with a higher value for the MBi compared with the GOi. CONCLUSION: Both gingival enlargement indices analyzed are reliable, complementary and applicable for measuring gingival overgrowth. However, the MBi shows, with fewer measurements, a greater sensitivity than the GOi for the detection of the early stages of gingival enlargement, being adequate for the screening of large populations at risk.

Unilateral gingival enlargement in patient with neurofibromatosis type I.

Neurofibromatosis (NF) is a benign peripheral nerve sheath tumor. It is a neurocutaneous disorder with two defined entities: (1) Peripheral type I (NF1), described by von Recklinghausen; and (2) central type II, affecting mainly the central nervous system. NF1, the more common type, is an autosomal dominant, inherited disease, characterized by neural and cutaneous manifestations, as well as skeletal, oral and jaw expressions. All oral tissues have been reported to be affected with this tumoral disorder. Gingival neurofibroma in NF1 is uncommon. Diagnosis of NF1 is based upon a series of clinical criteria. The purpose of this report is to present a case of NF1 with a unilateral gingival neurofibroma in the buccal attached gingiva of the lower left molars, along with a review of the literature. Because NF1 is among the most common genetic diseases and its oral manifestations are commonplace, dentists should be aware of its different characteristics.

A rare case of generalized pyogenic granuloma: a case report.

Gingival enlargement is defined as an overgrowth or increase in size of the gingiva. Enlargement can be of many types depending on etiologic factors like inflammation, drug-induced effects, neoplasm, hormonal imbalance, and systemic involvement (leukemia, etc). Drugs and hormonal imbalance are the most common causes of gingival enlargement. Nonspecific conditioned enlargement, or pyogenic granuloma, is considered an exaggerated conditioned response to minor trauma or chronic irritation. Pyogenic granuloma occurring in the oral cavity is a common phenomenon. However, simultaneously occurring generalized pyogenic granuloma in the oral cavity is a rare entity. Generalized pyogenic granuloma on the back and skin have been reported. This is the first case report of generalized pyogenic granuloma in the oral cavity. A 19-year-old male patient reported with a complaint of difficulty in mastication and generalized swelling of the gingiva that developed within a span of 15 days. Family and systemic history were noncontributory. Based on the clinical findings, histopathology report, and immunohistochemistry result, the patient was diagnosed with generalized pyogenic granuloma. Scaling and root planing were performed as the first phase of therapy followed by external bevel gingivectomy. The patient was followed for 3 months. The patient was advised to visit the clinic for regular maintenance visits for 1 year, as pyogenic granuloma has a tendency to recur.

Hipertrofia gengival induzida por anlodipina: [revisão] / Amlodipine induced gingival overgrowth: [review]

JUSTIFICATIVA E OBJETIVOS: A hipertrofia gengival (HG) é reconhecidamente um grave efeito adverso a medicamentos, frequentemente encontrado em pacientes em uso de imunossupressores, anticonvulsivantes ou anti-hipertensivos. Nesta última classe, se destaca a nifedipina, porém tem sido crescente o númerode casos secundários ao uso da anlodipina. O objetivo deste estudo foi observar na literatura os dados existentes sobre a epidemiologia, características clínicas e histopatológicas, a prevenção e o tratamento da HG associada a este fármaco. CONTEÚDO: A coleta de dados foi realizada através dos Bancos de Dados BIREME, Pubmed e Medline. As palavras pesquisadas foram: aumento gengival, hipertrofia gengival, hiperplasia gengival, amlodipine induced gingival overgrowth, gingival overgrowth induced by calcium channel blockers, drug induced gingival overgrowth. No bando de dados BIREME foram encontrados 24 artigos referentes ao assunto pesquisado, na Pubmed e Medline foram encontrados 47 artigos pertinentes ao contexto enfocado. Do total, foram utilizados 34 artigos na revisão de literatura. CONCLUSÃO: A anlodipina é um fármaco que comprovadamente atua no tecido gengival causando o seu aumento. Sendo assim, a HG induzida por este fármaco tem aspectos clínicos característicos e é uma reação adversa individualizada devido à influência multifatorial. Em razão do atual aumento do uso deste bloqueador de canal de cálcio, a incidência da HG torna-se cada vez mais crescente. Desta forma, por gerar comprometimento funcional e estético ao indivíduo acometido, é de suma importância o conhecimento desta condição pelos profissionais de saúde para que ocorra a correta identificação do quadro e o estabelecimento precoce de uma conduta terapêutica adequada.

BACKGROUND AND OBJECTIVES: Gingival hyperplasia(GH) is admittedly a severe adverse effect of medications, frequently found in the immunosupressors, anticonvulsivants or antihypertensives users. Among this last class of medications, nifedipine is featured, but adverse effects due amlodipine using have been increasing. The aim of this study was to examine the existing data on the literature about epidemiology, clinical and histopathological features, prevention and treatment of GH due this medication. CONTENTS: The data collection was performed through BIREME, Pubmed and Medline databases. The words searched were: gingival enlargement, gingival hypertrophy, gingival hyperplasia, amlodipine induced gingival overgrowth, gingival overgrowth induced by calcium channel blockers, drug induced gingival overgrowth. In the BIREME databases were found 24 articles concerningon the topic searched, in Pubmed and Medline were found 47 relevant articles focused on the context. Totally, 34 articles ofthe literature review were used. CONCLUSION: Amlodipine is a drug that acts in the gingival tissue inducing its enlargement. Therefore, GH induced by thisdrug has typical clinical features and is an individualized adverse effect by the multifactorial influence. Due to the current increasein the use of calcium channel blocker, the incidence of GH becomes increasingly common. However, by the functional and esthetic commitment of the affected individual, is of high importance the knowledge about this condition by health professionals aiming the correct identification of this case and the early establishment of an appropriate treatment.

[Maxillary bone sarcoidosis]. / Sarcoïdose osseuse maxillaire.

INTRODUCTION: Sarcoidosis is an unexplained systemic granulomatosis. Bone localizations of the disease are rare. We report a maxillary localization. CASE: A 35-year-old patient consulted for facial dysmorphia first observed 2 years before. This swelling was associated to nodular panniculitis lesions and xerostomia. The facial asymmetry was due to maxillary gingival and alveolar swelling. It was associated with scarring in the legs and a purple nodular facial lesion. Lip and jaw biopsies revealed epithelioid and giant cell granulomas without caseous necrosis. The panoramic dental X-ray showed diffuse horizontal alveolar ridge lysis and CT scan revealed an osteolytic lesion of the right maxilla associated to a bone-condensing lesion of the left hemi-mandible. DISCUSSION: The diagnosis of sarcoidosis is made in case of epithelioid and giant cell granulomas without caseous necrosis and the ruling out of other possible diagnoses, including tuberculosis. Bone involvement is rare; face and maxillary localization are extremely rare. The recommended treatment is corticosteroids. Facial remodeling surgery is not recommended.