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Ann Hepatol ; 2(1): 47-51, 2003.
Artículo en Inglés | MEDLINE | ID: mdl-15094707

RESUMEN

We report a 53-year old Mexican female who developed liver dysfunction following a seven-day course of treatment with terbinafine for onychomycosis. She presented with jaundice and abdominal pain. Her serum bilirubin levels showed a peak value of 23.2 mg/dL seven weeks after discontinuing the medication. Infectious causes (hepatitis viruses A, B and C) were excluded. Imaging studies of the abdomen did not reveal any abnormalities. Serum iron and ceruloplasmin levels were normal. Autoantibodies were negative. A liver biopsy revealed necrosis and mononuclear infiltration of the parenchyma, mainly along the sinusoids and surrounding the portal spaces and biliary ducts. Eosinophil infiltration of the portal spaces was also noted. Treatment with ursodeoxycholic acid and ademethionine was started. Her liver tests normalized in the sixth months after stopping terbinafine.


Asunto(s)
Antifúngicos/efectos adversos , Fallo Hepático Agudo/inducido químicamente , Hígado/patología , Naftalenos/efectos adversos , Onicomicosis/tratamiento farmacológico , Antifúngicos/uso terapéutico , Colagogos y Coleréticos/uso terapéutico , Femenino , Humanos , Ictericia/inducido químicamente , Ictericia/tratamiento farmacológico , Fallo Hepático Agudo/tratamiento farmacológico , Fallo Hepático Agudo/patología , Pruebas de Función Hepática , Persona de Mediana Edad , Naftalenos/uso terapéutico , Terbinafina , Ácido Ursodesoxicólico/uso terapéutico
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