RESUMEN
<b>Background and Objective:</b> Angiogenesis is a mechanism by which new blood vessels are developed in healing and tumour tissues, where it is necessary for regeneration growth, tumour cells survival and metastasis. This study aimed to assess the angiogenesis mechanism among Sudanese females with breast cancer using anti-CD34 and anti-CD105 markers. <b>Materials and Methods:</b> Three hundred female representative Formalin-Fixed Paraffin-Embedded (FFPE) breast tissue blocks were included in this study. Of the 300 representative tissue blocks, 200 were breast cancer patient's tissues (confirmed cases) and 100 were normal breast tissues (controls). Their ages mean±SD, 47.3±12.9 years. <b>Results:</b> The results showed the MVD of CD34 significantly increased in malignant lesions as compared to normal breast tissues. The mean of MVD CD34 and MVD CD105 showed statistical differences among different histologic types of breast cancer. Also, a strong positive correlation was detected between the manual and automated MVD counting methods. Also, the current study revealed no significant differences were observed in mean MVD counting for both markers and menopausal status or the age groups of the study population. <b>Conclusion:</b> The MVD is a good tool for assessing prognostic markers. The CD105 marker has a high specificity to the new evolving tumour vessels and is a useful predictor for angiogenesis and breast cancer metastasis.
Asunto(s)
Inductores de la Angiogénesis/normas , Antígenos CD34/análisis , Neoplasias de la Mama/tratamiento farmacológico , Endoglina/análisis , Adulto , Anciano , Inductores de la Angiogénesis/metabolismo , Antígenos CD34/uso terapéutico , Neoplasias de la Mama/epidemiología , Neoplasias de la Mama/fisiopatología , Endoglina/uso terapéutico , Femenino , Humanos , Persona de Mediana Edad , Sudán/epidemiologíaRESUMEN
En este trabajo se describen los pasos sucesivos que se observan en el proceso de inflamación y reparación de las lesiones con el objeto de poder identificar, en el estudio histopatológico, el estadio en que se encuentran. Los pasos que se siguen en este proceso son los mismos en todos los órganos, a excepción del sistema nervioso. Intentamos que la descripción de las características microscópicas tenga un sentido práctico y pueda ser aplicada y utilizada en el diagnóstico de la data de las lesiones. Las fotos microscópicas que se han elegido se corresponden con el proceso reparativo de los infartos agudos de miocardio con la finalidad de que mantengan una secuencia lógica; sin embargo, mantienen las mismas características histopatológicas que las que pueden apreciarse en la piel o en cualquier otro órgano (AU)
We describe the successive steps observed in the inflammatory and reparative process of injuries. The aim of this article is to describe the histopathological characteristics of succesive stages in a lesion appreciated in autopsy. The evolutive process of the inflammatory and reparative events are practically identical in all organs with the exception of nervous system due to its absence of connective tissue. We try a clear histopathological description and easy to apply in the microscopical observation of a injury with the purpose of to facilitate the correct diagnosis. The microscopical figures has been chosen of the reparative process in acute myocardial infarcts and maintain the same histopathological characteristics than in the skin or other organs (AU)
