Intravenous Ceftriaxone for Syphilitic Uveitis.

PURPOSE: Report of clinical/multimodal imaging outcomes of patients with syphilitic uveitis alternatively treated with intravenous(IV) ceftriaxone, due to unavailability of penicillin G. METHODS: Chart review of all cases of syphilitic uveitis presenting to Hospital São Geraldo/HC-UFMG and treated with intravenous ceftriaxone, between January and August 2014. Clinical, serological and ophthalmological data were collected. RESULTS: Twelve consecutive patients with syphilitic uveitis receiving IV ceftriaxone were identified. All 24 eyes had active intraocular inflammation on clinical examination. All patients received IV ceftriaxone (2-4 g daily) for 14-21 days, supplemented with oral corticosteroid as needed in 9 patients (75%), after documented clinical response. Improvement in intraocular inflammation was seen in all 24 eyes, with median best-corrected visual acuity (BCVA) increasing from 20/50 to 20/20, after a mean follow-up of 5.3 months. CONCLUSION: IV ceftriaxone may be an effective alternative for treatment of syphilitic uveitis, in the setting of unavailability of penicillin G.

Endophthalmitis after pars plana vitrectomy: results of the Pan American Collaborative Retina Study Group.

PURPOSE: To determine the incidence of endophthalmitis after 20-, 23-, and 25-gauge pars plana vitrectomies (PPVs). METHODS: Retrospective comparative case series of consecutive patients who underwent 20-, 23-, or 25-gauge PPV at 11 centers from Latin America between 2005 to 2009. Pars plana vitrectomy cases were identified through a search of the billing records of each institution. Cases of PPV performed in the management of trauma, endophthalmitis, and combined PPV phacoemulsification cases were excluded. Endophthalmitis was diagnosed by clinical criteria regardless of the microbiologic results. The incidence of post-PPV endophthalmitis was compared between 20-, 23-, and 25-gauge PPVs. RESULTS: A total of 35,427 cases of PPV were identified during the study period (n = 19,865 for 20 gauge, n = 10,845 for 23 gauge, and n = 4,717 for 25 gauge). The 5-year post-PPV endophthalmitis incidence rates were 0.020% (4 of 19,865), 0.028% (3 of 10,845), and 0.021% (1 of 4,717) for 20 gauge, 23 gauge, and 25 gauge, respectively (P = 0.9685). CONCLUSION: Small-gauge transconjunctival PPV does not appear to increase the rates of post-PPV endophthalmitis.

A superfície ocular e a sua microbiota / iotaobiotaobiotaobiotaobiotaobiota

Microrganismos freqüentemente encontrados em vários locais da superfície corpórea de indivíduosnormais e saudáveis são descritos como microbiota indígena. A superfície ocular é rica em nutrientese, consequentemente, muitas bactérias são encontradas, as quais constituem a microbiota ocular comensal.O conhecimento da microbiota normal auxilia o clínico a avaliar melhor certos microrganismospotencialmente patogênicos na superfície ocular e, em casos de lesões oculares, particularmenteúlceras de córnea, iniciar medidas preventivas e terapêuticas com maior efetividade. A proposta destarevisão é ajudar a esclarecer a dinâmica interação que existe entre a superfície ocular e a sua microbiotaindígena(AU)

The microorganisms that are frequently found in various body sites in normal, healthy individualsare described as indigenous microbiota. The eye surface is rich in nutrients and, consequently, severalbacteria are often found, which constitute the commensal ocular microbiota. Knowledge of normalocular microbiota enables the clinician to evaluate the pathogenic potential of certain organisms onthe ocular surface and, in the event of ocular lesions, especially in corneal ulcer, to initiate preventiveand therapeutic measures with greater efficiency. The purpose of this review is help to clarify thisdynamic interaction between eye surface and its indigenous microbiota(AU)

A superfície ocular e a sua microbiota / iotaobiotaobiotaobiotaobiotaobiota

Microrganismos freqüentemente encontrados em vários locais da superfície corpórea de indivíduosnormais e saudáveis são descritos como microbiota indígena. A superfície ocular é rica em nutrientese, consequentemente, muitas bactérias são encontradas, as quais constituem a microbiota ocular comensal.O conhecimento da microbiota normal auxilia o clínico a avaliar melhor certos microrganismospotencialmente patogênicos na superfície ocular e, em casos de lesões oculares, particularmenteúlceras de córnea, iniciar medidas preventivas e terapêuticas com maior efetividade. A proposta destarevisão é ajudar a esclarecer a dinâmica interação que existe entre a superfície ocular e a sua microbiotaindígena

The microorganisms that are frequently found in various body sites in normal, healthy individualsare described as indigenous microbiota. The eye surface is rich in nutrients and, consequently, severalbacteria are often found, which constitute the commensal ocular microbiota. Knowledge of normalocular microbiota enables the clinician to evaluate the pathogenic potential of certain organisms onthe ocular surface and, in the event of ocular lesions, especially in corneal ulcer, to initiate preventiveand therapeutic measures with greater efficiency. The purpose of this review is help to clarify thisdynamic interaction between eye surface and its indigenous microbiota