Asunto(s)
Antibacterianos/uso terapéutico , Leprostáticos/uso terapéutico , Lepra/tratamiento farmacológico , Adulto , Animales , Antibacterianos/efectos adversos , Antibacterianos/clasificación , Antibacterianos/farmacología , Niño , Claritromicina/efectos adversos , Claritromicina/farmacología , Claritromicina/uso terapéutico , Contraindicaciones , Países en Desarrollo , Evaluación de Medicamentos , Evaluación Preclínica de Medicamentos , Femenino , Humanos , Recién Nacido , Leprostáticos/efectos adversos , Leprostáticos/clasificación , Leprostáticos/farmacología , Modelos Animales , Mycobacterium leprae/efectos de los fármacos , Ofloxacino/efectos adversos , Ofloxacino/farmacología , Ofloxacino/uso terapéutico , SeguridadAsunto(s)
Leprostáticos/uso terapéutico , Lepra/tratamiento farmacológico , Protocolos Clínicos , Ensayos Clínicos como Asunto , Quimioterapia Combinada , Predicción , Humanos , Leprostáticos/clasificación , Lepra/diagnóstico , Lepra/microbiología , Estudios Longitudinales , Recurrencia , Índice de Severidad de la Enfermedad , Factores de Tiempo , Resultado del Tratamiento , Organización Mundial de la SaludRESUMEN
The Memorandum reviews the considerable progress that has been made in research on the chemotherapy of leprosy during the last 10-15 years, as a result of which it is now possible to study the same topics in leprosy as are studied in other bacterial diseases. Thus drugs have been screened in mice for their activity against Mycobacteerium leprae. Those that have been found to have the greatest activity against M. leprae at acceptable dosages-dapsone, rifampicin, and clofazimine-have been characterized in terms of the minimal effective dosage and rate of bacterial kill. Similarly, their pharmacokinetics in man and in certain animals have been defined. The theoretical basis for drug trials in leprosy patients is discussed in terms of the number of viable and the number of dead M.leprae that remain of various stages of therapy