1.
Nat Clin Pract Oncol
; 5(4): 234-8, 2008 Apr.
Artículo
en Inglés
| MEDLINE
| ID: mdl-18285762
RESUMEN
BACKGROUND: A 75-year-old man on methotrexate immunosuppression for myasthenia gravis presented with a 2-month history of lymphocytosis and bilateral inguinal adenopathy. There were no constitutional symptoms of fever, night sweats, or weight loss. INVESTIGATIONS: Physical examination, blood tests, flow cytometry, fluorescent in situ hybridization, immunoglobulin gene sequencing, viral load quantification by real-time polymerase chain reaction, excisional lymph-node biopsy, bone-marrow biopsy, tumor morphology and immunohistochemistry, sequential CT and PET scans. DIAGNOSIS: Methotrexate-associated mantle-cell lymphoma. MANAGEMENT: Cessation of methotrexate, anthracycline-based combination chemo-immunotherapy, and maintenance rituximab.
Asunto(s)
Inmunosupresores/efectos adversos , Linfoma de Células del Manto/inducido químicamente , Metotrexato/efectos adversos , Miastenia Gravis/tratamiento farmacológico , Anciano , Diagnóstico Diferencial , Humanos , Inmunosupresores/administración & dosificación , Linfocitos , Linfocitosis/inducido químicamente , Linfoma de Células del Manto/diagnóstico , Linfoma de Células del Manto/etiología , Masculino , Metotrexato/administración & dosificación , Factores de Riesgo
2.
Leukemia
; 20(5): 891-3, 2006 May.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16525491