Asunto(s)
Carcinoma Adenoescamoso/diagnóstico por imagen , Neoplasias Esofágicas/diagnóstico por imagen , Esofagectomía/efectos adversos , Intubación Gastrointestinal/efectos adversos , Complicaciones Posoperatorias/diagnóstico por imagen , Adulto , Carcinoma Adenoescamoso/cirugía , Endoscopía Gastrointestinal , Neoplasias Esofágicas/cirugía , Humanos , Masculino , Complicaciones Posoperatorias/etiología , Membrana Serosa/diagnóstico por imagen , Microtomografía por Rayos XRESUMEN
Background/aim: This study aimed to investigate the relationship between the iodine concentration (IC) of perigastric fat tissue as assessed by dual-energy computed tomography (DECT) and serosal invasion of gastric cancer. Materials and methods: A total of 41 patients underwent preoperative staging evaluation for gastric cancer using DECT between July 2015 and March 2018. Patients were divided into 2 groups based on pathology results: serosal invasion (stage T4a) and intact serosa (stages T1T3). Cutoff values, the diagnostic efficacy of IC in the perigastric fat tissue, and the perigastric fat tissue/tumor (P/T) ratio were determined. Results: Among the 41 patients, 22 had stage T4a gastric cancer and 19 patients had gastric cancer with a stage lower than T4a. The mean IC of perigastric fat tissue and the P/T ratio were significantly higher in patients with serosal invasion than in those with intact serosa (P < 0.001). During the arterial phase, the area under the curve (AUC) was 0.915 and 0.854 for the IC of perigastric fat tissue and the P/T ratio, respectively. During the venous phase, the AUC was 0.890 and 0.876 for the IC of perigastric fat tissue and the P/T ratio, respectively. Conclusion: The IC in the perigastric fat tissue seems to be a reliable indicator for serosal invasion of gastric cancer.
Asunto(s)
Membrana Serosa/diagnóstico por imagen , Neoplasias Gástricas/diagnóstico por imagen , Tomografía Computarizada por Rayos X/métodos , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Grasa Intraabdominal/química , Grasa Intraabdominal/diagnóstico por imagen , Yodo/análisis , Yodo/química , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Estudios Prospectivos , Membrana Serosa/patología , Neoplasias Gástricas/patologíaAsunto(s)
Neovascularización Coroidal/complicaciones , Mácula Lútea/patología , Miopía/complicaciones , Desprendimiento de Retina/complicaciones , Neovascularización Coroidal/diagnóstico , Diagnóstico Diferencial , Femenino , Angiografía con Fluoresceína , Humanos , Mácula Lútea/diagnóstico por imagen , Persona de Mediana Edad , Miopía/diagnóstico , Miopía/patología , Tamaño de los Órganos/fisiología , Desprendimiento de Retina/diagnóstico , Desprendimiento de Retina/patología , Membrana Serosa/diagnóstico por imagen , Membrana Serosa/patología , Tomografía de Coherencia ÓpticaRESUMEN
BACKGROUND: Recognition of a non-viable bowel during colorectal surgery is a challenging task for surgeons. Identifying the turning point in serosal microcirculatory deterioration leading up to a non-viable bowel is crucial. The aim of the present study was to determine whether sidestream darkfield (SDF) imaging can detect subtle changes in serosal microcirculation of the sigmoid after vascular transection during colorectal surgery. METHODS: A prospective observational clinical study was performed at a single medical centre. All eligible participants underwent laparoscopic sigmoid resection and measurements were taken during the extra-abdominal phase. Microcirculation was measured at the transected bowel and 20 cm proximal to this point. Microcirculatory parameters such as Microvascular Flow Index (MFI), proportion of perfused vessels (PPV), perfused vessel density (PVD), total vessel density (TVD) and the Heterogeneity Index were determined. Data are presented as median (interquartile range) or mean ± standard deviation. RESULTS: A total of 60 SDF images were acquired for 10 patients. Perfusion parameters and perfused vessel density were significantly lower at the transected bowel compared with the non-transected measurements [MFI 2.29 (1.96-2.63) vs 2.96 (2.73-3.00), p = 0.007; PPV 74% (55-83) vs 94% (86-97), p = 0.007; and PVD 7.61 ± 2.99 mm/mm2 versus 10.67 ± 1.48 mm/mm2, p = 0.009]. Total vessel density was similar between the measurement locations. CONCLUSIONS: SDF imaging can identify changes of the bowel serosal microcirculation. Significantly lower serosal microcirculatory parameters of the vascular transected bowel was seen compared with the non-transected bowel. The ability of SDF imaging to detect subtle differences holds promise for future research on microvascular cut-off values leading to a non-viable bowel.
Asunto(s)
Colon Sigmoide/cirugía , Técnicas de Diagnóstico Cardiovascular , Cuidados Intraoperatorios/métodos , Membrana Serosa/irrigación sanguínea , Membrana Serosa/diagnóstico por imagen , Anciano , Colon Sigmoide/irrigación sanguínea , Estudios de Factibilidad , Femenino , Humanos , Masculino , Microcirculación/fisiología , Persona de Mediana Edad , Estudios ProspectivosRESUMEN
BACKGROUND: The effect of thoracic epidural analgesia (TEA) on splanchnic blood flow during abdominal surgery remains unclear. The purpose of this study was to examine whether the hemodynamic effects of TEA resulted in microcirculatory alterations to the intestinal serosa, which was visualized using incident dark-field (IDF) videomicroscopy. METHODS: An observational cohort study was performed. In 18 patients, the microcirculation of the intestinal serosa was visualized with IDF. Microcirculatory and hemodynamic measurements were performed prior to (T1) and after administering a bolus of levobupivacaine (T2). If correction of blood pressure was indicated, a third measurement was performed (T3). The following microcirculatory parameters were calculated: microvascular flow index, proportion of perfused vessels, perfused vessel density and total vessel density. Data are presented as median [IQR]. RESULTS: Mean arterial pressure decreased from 73 mmHg (68-83) at T1 to 63 mmHg (±11) at T2 (p = 0.001) with a systolic blood pressure of 114 mmHg (98-128) and 87 (81-97), respectively (p = 0.001). The microcirculatory parameters of the bowel serosa, however, were unaltered. In seven patients, blood pressure was corrected to baseline values from a MAP of 56 mmHg (55-57), while microcirculatory parameters remained constant. CONCLUSION: We examined the effects of TEA on the intestinal serosal microcirculation during abdominal surgery using IDF imaging for the first time in patients. Regardless of a marked decrease in hemodynamics, microcirculatory parameters of the bowel serosa were not significantly affected. TRIAL REGISTRY NUMBER: ClinicalTrials.gov identifier NCT02688946.
Asunto(s)
Anestesia Epidural , Anestésicos Locales , Intestino Delgado/fisiopatología , Levobupivacaína , Microcirculación , Membrana Serosa/fisiopatología , Anciano , Anestésicos Locales/farmacología , Presión Arterial/efectos de los fármacos , Estudios de Cohortes , Femenino , Humanos , Intestino Delgado/irrigación sanguínea , Intestino Delgado/diagnóstico por imagen , Levobupivacaína/farmacología , Masculino , Microcirculación/efectos de los fármacos , Microscopía por Video , Persona de Mediana Edad , Membrana Serosa/irrigación sanguínea , Membrana Serosa/diagnóstico por imagen , Vértebras TorácicasRESUMEN
OBJECTIVE: Our study aimed to explore the prognostic influence of tumor-to-background ratios (TBRs) of the maximum standardized uptake value (SUVmax) in advanced high-grade serous ovarian cancer (HGSC) patients. PATIENTS AND METHODS: We retrospectively investigated 51 advanced HGSC patients who underwent PET/CT before primary surgery at our hospital between January 2010 and June 2015. None of these patients received neoadjuvant chemotherapy. SUVmax of ovarian tumor (SUVmax-P) and background (SUVmax-B) were measured using a PET/CT workstation. TBR was calculated by SUVmax-P/SUVmax-B. Backgrounds included the liver, mediastinum, and muscle, and TBRs were noted as TBR-L, TBR-Me, and TBR-Mu, respectively. The χ-test was used to analyze the relationships between PET/CT parameters and several clinical features. Progression-free survival and overall survival were analyzed using the Kaplan-Meier method and log-rank tests in univariate analyses. RESULTS: The median (range) follow-up duration was 27 (8-61) months. The median (range) PET/CT parameter values were as follows: SUVmax, 11.41 (3.24-24.14), TBR-L, 2.84 (2.08-11.93), TBL-Me, 2.09 (1.33-9.07), and TBR-Mu, 1.04 (0.56-14.02). The patients were categorized into low and high groups by the median values of these parameters above separately. A larger proportion of patients in the high TBR-Me group were chemoresistant compared with the low-value group (P=0.039). Neither the residual disease nor the ascites levels correlated with SUVmax or TBR values. There were no differences in progression-free survival and overall survival between the patients in the high and low TBR level groups. CONCLUSION: TBRs of SUVmax were not prognostic indicators for advanced HGSC patients.
Asunto(s)
Neoplasias Ováricas/diagnóstico , Neoplasias Ováricas/metabolismo , Membrana Serosa/patología , Adulto , Anciano , Transporte Biológico , Femenino , Fluorodesoxiglucosa F18/metabolismo , Humanos , Persona de Mediana Edad , Clasificación del Tumor , Neoplasias Ováricas/diagnóstico por imagen , Neoplasias Ováricas/patología , Tomografía Computarizada por Tomografía de Emisión de Positrones , Pronóstico , Estudios Retrospectivos , Membrana Serosa/diagnóstico por imagenRESUMEN
OBJECTIVE: To explore whether CT value is useful in identifying different disease in tumors of rhinosinus parenchyma.â© Methods: The data of preoperation noncontrast CT in 277 patients were retrospectively reviewed. The final diagnosis and classification were based on the result of surgical histopathological examination. The CT value range for different classification was calculated and was compared. All patients were re-diagnosed according to CT value range combined with pathological results by the same doctor team. The diagnosis rates according to CT value range were compared.â© Results: The CT value was (25.3±3.5) Hu in nasal polyp, (7.9±3.5) Hu in serous cyst, (42.2±4.7) Hu in mucocele, (40.7±5.3) Hu in papilloma, (112.3±10.9) Hu in fungus ball, (41.7±4.8) Hu in hemangioma, (51.2±9.9) Hu in malignant melanoma, and (47.1±9.9) Hu in squamous carcinoma. The CT value in nasal polyp is significantly higher than that in serous cyst, which was significantly lower than that in mucocele, papilloma, fungus ball, hemangioma, malignant melanoma and squamous carcinoma (all P<0.05); the CT value in serous cyst was significantly lower than that in other classification diseases (all P<0.05); the CT value in fungus ball was significantly higher than that in other classification diseases (all P<0.05); there was no significant difference in CT value among mucocele, papilloma, hemangioma, malignant melanoma, squamous carcinoma (all Pï¹¥0.05). The diagnosis rate was elevated (from 71.1% to 92.4%) according to CT value range, with significant difference (χ2=42.150, P<0.01).â© Conclusion: CT value in nasal polyp, serous cyst, fungus ball is different from other diseases, and the 3 diseases can be distinguished only by CT value range; the CT value in mucocele, papilloma, hemangioma, malignant melanoma and squamous carcinoma is similar, and their differential diagnosis should combine with imaging data and other clinical characters. The diagnosis rates can be improved when the CT value range is taken into account.
Asunto(s)
Enfermedades de los Senos Paranasales/diagnóstico por imagen , Enfermedades de los Senos Paranasales/patología , Tomografía Computarizada por Rayos X/métodos , Carcinoma de Células Escamosas/diagnóstico por imagen , Diagnóstico Diferencial , Femenino , Hemangioma/diagnóstico por imagen , Humanos , Masculino , Melanoma/diagnóstico por imagen , Mucocele/diagnóstico por imagen , Micosis/diagnóstico por imagen , Mucosa Nasal/diagnóstico por imagen , Mucosa Nasal/patología , Pólipos Nasales/diagnóstico por imagen , Neoplasias de los Senos Paranasales/diagnóstico por imagen , Senos Paranasales/diagnóstico por imagen , Senos Paranasales/patología , Estudios Retrospectivos , Membrana Serosa/diagnóstico por imagen , Membrana Serosa/patología , Neoplasias Cutáneas/diagnóstico por imagen , Melanoma Cutáneo MalignoRESUMEN
AIM: The study aimed to describe the serosal microcirculation of the human bowel using sidestream dark field imaging, a microscopic technique using polarized light to visualize erythrocytes through capillaries. We also compared its feasibility to the current practice of sublingual microcirculatory assessment. METHOD: In 17 patients sidestream dark field measurements were performed during gastrointestinal surgery. Microcirculatory parameters like microvascular flow index (MFI), proportion of perfused vessels (PPV), perfused vessel density (PVD) and total vessel density (TVD) were determined for every patient, sublingually and on the bowel serosa. RESULTS: Sixty measurements were done on the bowel of which eight (13%) were excluded, five owing to too much bowel peristalsis and three because of pressure artefacts. Image stability was in favour of sublingual measurements [pixel loss per image, bowel 145 (95% CI 126-164) vs sublingual 55 (95% CI 41-68); P < 0.001] and time to acquire a stable image [bowel 96 s (95% CI 63-129) vs. sublingual 46 s (95% CI 29-64); P = 0.013]. No difference in the MFI was observed [bowel 2.9 (interquartile range 2.87-2.95) vs sublingual 3.0 (interquartile range 2.91-3.0); P = 0.081]. There was a difference in the PPV [bowel 95% (95% CI 94-96) vs sublingual 97% (95% CI 97-99); P < 0.001], PVD [bowel 12.9 mm/mm2 (95% CI 11.1-14.8) vs sublingual 17.4 mm/mm2 (95% CI 15.6-19.1); P = 0.003] and the TVD [bowel 13.6 mm/mm2 (95% CI 11.6-15.6) vs sublingual 17.7 mm/mm2 (95% CI 16.0-19.4); P = 0.008]. CONCLUSION: Sidestream dark field imaging is a very promising technique for bowel microcirculatory visualization and assessment. It is comparable to sublingual assessment and the analysis produces a similar outcome with slightly differing anatomical features.
Asunto(s)
Procedimientos Quirúrgicos del Sistema Digestivo , Cuidados Intraoperatorios/métodos , Microcirculación/fisiología , Microscopía de Polarización/métodos , Membrana Serosa/irrigación sanguínea , Anciano , Anciano de 80 o más Años , Estudios de Factibilidad , Femenino , Humanos , Mucosa Intestinal/irrigación sanguínea , Mucosa Intestinal/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Países Bajos , Estudios Prospectivos , Membrana Serosa/diagnóstico por imagenRESUMEN
The muscularis layer of the canine colon has been reported to appear homogeneously hypoechoic on ultrasonography. A hyperechoic band in the muscularis layer paralleling the serosal surface has been observed by authors in routine canine abdominal ultrasound examinations. The purpose of this prospective and retrospective cross-sectional study was to determine the prevalence of this lesion, characterize its ultrasonographic and postmortem histologic features, and correlate its presence with clinical signs of gastrointestinal disease. In the prospective study, all dogs that underwent routine abdominal ultrasonography by one of two observers during a 4-week period were included without any exclusion criteria. One observer reviewed ultrasound images and recorded the presence or absence of this lesion and its distribution, e.g. focal (< 2 cm long) or diffuse (> 2 cm long). In the retrospective study, all dogs that had both abdominal ultrasonography and necropsy from January 2011 to December 2013 were included without any exclusion criteria. Histologic examinations were performed by two observers and Masson's trichrome stain was used to identify fibrous collagen. Prevalence for the hyperechoic band was 32% in the prospective and 4.8% in the retrospective sample populations, respectively. The hyperechoic band appeared as diffuse, focal, or a combination of both. Histologic sections were available for six dogs. In a few cases, the lesion corresponded to the presence of fibrous tissue in the myenteric plexus or in the tunica muscularis. None of the dogs had a history of diarrhea. Findings supported the hypothesis that a colonic muscularis hyperechoic band paralleling the serosal layer in dogs could be a normal variant rather than a marker of disease.
Asunto(s)
Colon/diagnóstico por imagen , Perros/anatomía & histología , Membrana Serosa/diagnóstico por imagen , Variación Anatómica , Animales , Colágeno/análisis , Colágeno/ultraestructura , Enfermedades del Colon/diagnóstico por imagen , Enfermedades del Colon/patología , Enfermedades del Colon/veterinaria , Estudios Transversales , Enfermedades de los Perros/diagnóstico por imagen , Enfermedades de los Perros/patología , Mucosa Intestinal/diagnóstico por imagen , Músculo Liso/diagnóstico por imagen , Estudios Prospectivos , Estudios Retrospectivos , UltrasonografíaRESUMEN
The subserous space is a large, anatomically continuous potential space that interconnects the chest, abdomen, and pelvis. The subserous space is formed from areolar and adipose tissue, and contains branches of the vascular, lymphatic, and nervous systems. As such, it provides one large continuous space in which many disease processes can spread between the chest, abdomen, and the pelvis.
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Cavidad Abdominal/fisiopatología , Pelvis/fisiopatología , Peritoneo/fisiopatología , Membrana Serosa/fisiopatología , Cavidad Torácica/fisiopatología , Cavidad Abdominal/anatomía & histología , Cavidad Abdominal/diagnóstico por imagen , Cavidad Abdominal/fisiología , Humanos , Pelvis/anatomía & histología , Pelvis/diagnóstico por imagen , Pelvis/fisiología , Peritoneo/anatomía & histología , Peritoneo/diagnóstico por imagen , Peritoneo/fisiología , Radiografía Torácica , Membrana Serosa/anatomía & histología , Membrana Serosa/diagnóstico por imagen , Membrana Serosa/fisiología , Cavidad Torácica/anatomía & histología , Cavidad Torácica/fisiologíaRESUMEN
We undertook the present study to investigate the echographic characteristics of the uterus and cervix of female bonnet monkeys ( Macaca radiata ) during the proliferative and secretory phases of the menstrual cycle. The cervix was tortuous in shape and measured 2.74 ± 0.30 cm (mean ± SD) in width by 3.10 ± 0.32 cm in length. The cervical lumen contained 2 or 3 colliculi, which projected from the cervical canal. The echogenicity of cervix varied during proliferative and secretory phases. The uterus was pyriform in shape (2.46 ± 0.28 cm × 1.45 ± 0.19 cm) and consisted of serosa, myometrium, and endometrium. The endometrium generated a triple-line pattern; the outer and central lines were hyperechogenic, whereas the inner line was hypoechogenic. The endometrium was significantly thicker during the secretory phase (0.69 ± 0.12 cm) than during the proliferative phase (0.43 ± 0.15 cm). Knowledge of the echogenic changes in the female reproductive organs of bonnet monkeys during a regular menstrual cycle may facilitate understanding of other physiologic and pathophysiologic changes.
Asunto(s)
Proliferación Celular , Cuello del Útero/diagnóstico por imagen , Cuello del Útero/metabolismo , Endometrio/diagnóstico por imagen , Endometrio/metabolismo , Ciclo Menstrual/fisiología , Útero/diagnóstico por imagen , Animales , Cuello del Útero/fisiología , Endometrio/citología , Femenino , Humanos , Macaca radiata , Miometrio/citología , Miometrio/diagnóstico por imagen , Miometrio/metabolismo , Membrana Serosa/citología , Membrana Serosa/diagnóstico por imagen , Membrana Serosa/metabolismo , Ultrasonografía , Útero/fisiologíaAsunto(s)
Síndrome del Corazón Izquierdo Hipoplásico/diagnóstico por imagen , Síndrome del Corazón Izquierdo Hipoplásico/cirugía , Neumoperitoneo/diagnóstico por imagen , Membrana Serosa/diagnóstico por imagen , Diagnóstico Diferencial , Reacciones Falso Positivas , Femenino , Humanos , Recién Nacido , RadiografíaRESUMEN
OBJECTIVE: The purpose of our study was to evaluate CT findings to differentiate between T4a and less advanced gastric cancers. METHODS: The institutional review board approved this study and waived informed consent. This study included 228 retrospectively identified patients with surgically confirmed gastric cancer (138 T1, 25 T2, 24 T3 and 41 T4a) and who had also undergone pre-operative CT scan. Transverse and multiplanar reconstruction scans were reviewed in consensus by two other blinded radiologists. The following CT findings that differentiate T4a from less advanced cancers were evaluated: nodular or an irregular outer layer of the gastric wall, haziness of the perigastric fat and a hyperattenuating serosa sign. The CT features of T4a and less advanced gastric cancers were compared by means of univariate and multivariate analyses. RESULTS: In univariate analysis, nodular or an irregular outer layer of the gastric wall, haziness of the perigastric fat and the hyperattenuating serosa sign were significant in differentiation between T4a and less advanced gastric cancers. In addition, nodular or an irregular outer layer of the gastric wall and the hyperattenuating serosa sign were significant in differentiation between T3 and T4a. In multivariate logistic analysis, the hyperattenuating serosa sign was the most significant finding in differentiation between T3 and T4a (odds ratio, 4.210; 95% confidence intervals, 1.581-11.214; p=0.004). CONCLUSION: The hyperattenuating serosa sign may be a useful CT finding in differentiation between T4a and less-advanced gastric cancers. ADVANCES IN KNOWLEDGE: The hyperattenuating serosa sign is associated with gastric cancer with invading the serosa and can facilitate planning of the optimal pre-operative evaluation and treatment.
Asunto(s)
Tomografía Computarizada Multidetector , Neoplasias Gástricas/diagnóstico por imagen , Tejido Adiposo/diagnóstico por imagen , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Estudios Retrospectivos , Membrana Serosa/diagnóstico por imagen , Neoplasias Gástricas/patología , Neoplasias Gástricas/cirugíaRESUMEN
OBJECTIVE: To explore the value of multidetector CT on aiding intraoperative judgement of serosal invasion of gastric cancer. METHODS: Clinical data of 206 cases of gastric cancer undergoing radical surgery in the First Hosptial of China Medical University from August 2009 to June 2011 were analyzed retrospectively. Preoperative CT findings and intraoperative judgement of serosal invasion in gastric cancer were compared with pathological results in order to investigate their values. RESULTS: The sensitivity and specificity of preoperative CT findings and intraoperative judgement of serosal invasion were 88.5%, 81.5% and 98.9%, 61.3%, respectively. The accuracy of preoperative CT in diagnosing serosal invasion was higher than that of intraoperative judgement, while the difference was not statistically significant (84.5% vs. 77.2%, P=0.060). The rates of serosal invasion of normal type, reactive type, nodular type, tendonoid type and color-diffused type were 0 (0/29), 2.5% (1/40), 40.5% (15/37), 59.2% (29/49), and 82.4% (42/51) respectively. The accuracy of preoperative CT in diagnosing serosal invasion of gastric cancer with tendonoid type was higher than that of intraoperative judgement, and the difference was statistically significant (61.2% vs. 87.8%, P=0.002). CONCLUSIONS: Multidetector CT plays an important role in aiding intraoperation judgement of serosal invasion of gastric cancer. For gastric cancer with tendonoid and color-diffused macroscopic serosal appearance, surgeons should pay attention to the value of preoperative CT findings.
Asunto(s)
Membrana Serosa/patología , Neoplasias Gástricas/patología , Tomografía Computarizada Espiral/métodos , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Cuidados Intraoperatorios , Masculino , Persona de Mediana Edad , Invasividad Neoplásica/diagnóstico por imagen , Estudios Retrospectivos , Sensibilidad y Especificidad , Membrana Serosa/diagnóstico por imagen , Neoplasias Gástricas/diagnóstico por imagenRESUMEN
Emaciated human patients have changes in the fat content in medullary bone that are consistent with serous atrophy of the bone marrow histologically. Serous atrophy has been identified at postmortem examination in horses; however, the magnetic resonance (MR) characteristics have not been documented. Herein we describe the abnormalities of the bone marrow and medullary bone detected by low-field and high-field MR imaging of the distal limbs of three emaciated horses. These low- and high-field MR imaging abnormalities are characterized by a decrease in signal intensity on T1-weighted images in combination with an increase in signal intensity on short tau inversion recovery images in all areas of trabecular bone in the distal limbs, in the absence of lameness. Serous atrophy was confirmed microscopically in two horses. Appreciating the sensitivity of MR imaging for detection of bone marrow changes may assist in assessment of fat atrophy in welfare cases where starvation is suspected.
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Médula Ósea/diagnóstico por imagen , Médula Ósea/patología , Emaciación/veterinaria , Enfermedades de los Caballos/diagnóstico , Enfermedades de los Caballos/etiología , Imagen por Resonancia Magnética/veterinaria , Tejido Adiposo/diagnóstico por imagen , Tejido Adiposo/patología , Animales , Atrofia/diagnóstico , Atrofia/veterinaria , Emaciación/diagnóstico , Emaciación/patología , Eutanasia Animal , Extremidades , Enfermedades de los Caballos/patología , Caballos , Imagen por Resonancia Magnética/métodos , Masculino , Radiografía , Membrana Serosa/diagnóstico por imagenRESUMEN
OBJECTIVE: To demonstrate the safety of magnetic resonance-guided focused ultrasound surgery (MRgFUS) treatments regardless of the distance between the treatment region and the uterine serosa. STUDY DESIGN: 83 pre-menopausal women with symptomatic uterine fibroids were treated with MRgFUS in 88 treatments. Treatment data was analyzed, measuring the distance between the treatment spots (sonications) and the serosa. Patients were followed up for 1 year and adverse events were collected. RESULTS: 79% and 37% of the sonications were less than 15 mm and 10 mm from the serosa, respectively. Treatment was always confined to the fibroid capsule. There were no unexpected or serious adverse events. CONCLUSION: Reducing the margin between the fibroid treatment area and the uterine serosa, when possible, enables MRgFUS treatment of greater fibroid volume, while maintaining a high safety profile. Special attention should be paid when the uterus lies adjacent to other sensitive organs to avoid unintentional heating of these organs, using the planning and real-time MR images.
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Leiomioma/diagnóstico por imagen , Leiomioma/cirugía , Imagen por Resonancia Magnética Intervencional/métodos , Neoplasias Uterinas/diagnóstico por imagen , Neoplasias Uterinas/cirugía , Femenino , Humanos , Membrana Serosa/diagnóstico por imagen , Membrana Serosa/cirugía , Terapia por Ultrasonido/métodos , Ultrasonografía , Útero/cirugíaRESUMEN
Computed tomography (CT) is an important imaging modality for diagnosis and follow-up of neoplastic or nonneoplastic conditions of the serosal membrane. The characteristic CT findings of malignant pleural mesothelioma include unilateral pleural effusion, thickening of the mediastinal pleura, and circumferential and nodular pleural thickening of greater than 1 cm. Malignant peritoneal mesothelioma manifests as a large mass or diffuse peritoneal thickening without a definable mass and is difficult to differentiate from peritoneal carcinomatosis or tuberculosis. The imaging features of primary serous papillary carcinoma of the peritoneum resemble those of peritoneal carcinomatosis; however, the ovary is usually of normal size. The possibility of desmoplastic small round cell tumor should be considered in children or young adults with multiple peritoneal masses and no identifiable primary malignancy. The CT findings of secondary tumors include a variable amount of fluid in the serosal cavity, thickening of the serosal lining (irregular and nodular), and serosal implants. Nonneoplastic conditions manifest as focal or diffuse thickening of the serosal membrane, a variable amount of fluid in the serosal cavity, and a soft-tissue mass at CT. Although the CT findings of some of the conditions overlap, knowledge of the typical findings is helpful in narrowing the differential diagnosis.
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Enfermedades del Tejido Conjuntivo/diagnóstico por imagen , Membrana Serosa/diagnóstico por imagen , Neoplasias de los Tejidos Blandos/diagnóstico por imagen , Tomografía Computarizada por Rayos X/métodos , Adulto , Anciano , Tejido Conectivo , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
BACKGROUND: Endoscopic ultrasonography (EUS) is considered valuable for preoperative staging of gastric cancer and defining patient eligibility for enrollment in neoadjuvant protocols. The aim of this study was to correlate EUS staging with pathologic evaluation and outcome in patients undergoing curative R0 resection for gastric cancer. METHODS: All patients who underwent preoperative clinical assessment of T/N stage with EUS and subsequent R0 resection for gastric adenocarcinoma between 1993 and 2003 were identified from a prospective database. Patients who received neoadjuvant chemotherapy were excluded. Clinical staging results from preoperative EUS were compared with postoperative pathologic staging results and correlated with clinical outcome. RESULTS: Two hundred twenty-five patients with gastric cancer underwent EUS followed by R0 resection, without preoperative chemotherapy. The accuracy of the individual EUS T stage was 57% (127 of 223) and was 50% for N stage (110 of 218). Although EUS was less able to predict outcome according to individual T stage, patients with lesions Asunto(s)
Adenocarcinoma/diagnóstico por imagen
, Endosonografía
, Neoplasias Gástricas/diagnóstico por imagen
, Adenocarcinoma/patología
, Adenocarcinoma/secundario
, Adenocarcinoma/cirugía
, Biopsia
, Esofagoscopía
, Estudios de Seguimiento
, Mucosa Gástrica/diagnóstico por imagen
, Mucosa Gástrica/patología
, Gastroscopía
, Humanos
, Ganglios Linfáticos/patología
, Metástasis Linfática/patología
, Invasividad Neoplásica
, Estadificación de Neoplasias
, Estudios Prospectivos
, Estudios Retrospectivos
, Medición de Riesgo
, Membrana Serosa/diagnóstico por imagen
, Membrana Serosa/patología
, Neoplasias Gástricas/patología
, Neoplasias Gástricas/cirugía
, Resultado del Tratamiento
RESUMEN
PURPOSE: With advances in imaging studies, dose specification for uterine cancer can be defined at specific anatomical sites such as the myometrium or the serosal surface rather than at arbitrary points or milligram-hours. This report presents our experience with image-based brachytherapy for inoperable uterine cancer. METHODS AND MATERIALS: Eight patients with organ-confined uterine cancer (2 Stage I GI, 3 Stage I G2, 3 Stage I G3) underwent definitive radiation therapy because of poor medical condition. All the patients underwent a CT or MRI scan of the pelvis before intracavitary application. Based on the size of the uterine cavity, a single-channel intrauterine applicator was selected for a small uterus, and a multiple-channel intrauterine applicator was used for a large uterus. A CT (n=5) or MRI (n=3) scan of the pelvis was performed with the applicator in place in addition to orthogonal pelvic films. Individualized dose specification was 75Gy to the midmyometrium and limited to 50Gy to the serosal surface of the uterus based on imaging information. RESULTS: Four patients with Stage I G1-2 disease had intracavitary brachytherapy alone. Four patients with Stage I G2-3 disease were treated with a combination of external pelvic radiation and intracavitary brachytherapy. Six patients had low-dose-rate brachytherapy, and 2 patients had high-dose-rate brachytherapy. Five patients had single-channel intrauterine brachytherapy, and 3 patients had multiple-channel brachytherapy. Based on the measurements of the uterine wall thickness by the imaging studies, the dose specification was prescribed to 1.5 cm lateral to the central axis of the uterus in 4 patients, 2.0 cm in 3 patients, and 2.5 cm in 1 patient. The medium followup time after radiation treatment was 38 months. Six patients are alive without evidence of disease, and 2 patients died of other causes. All patients had local control without major side effects. CONCLUSIONS: Image-based brachytherapy based on individualized dose specification at specific anatomical sites can be done easily and provides excellent local control for inoperable uterine cancer.
Asunto(s)
Braquiterapia , Imagen por Resonancia Magnética , Tomografía Computarizada por Rayos X , Neoplasias Uterinas/patología , Neoplasias Uterinas/radioterapia , Anciano , Anciano de 80 o más Años , Braquiterapia/métodos , Fraccionamiento de la Dosis de Radiación , Endometrio/diagnóstico por imagen , Endometrio/patología , Femenino , Estudios de Seguimiento , Humanos , Persona de Mediana Edad , Miometrio/diagnóstico por imagen , Miometrio/patología , Estadificación de Neoplasias , Pelvis/diagnóstico por imagen , Membrana Serosa/diagnóstico por imagen , Membrana Serosa/patología , Resultado del Tratamiento , Neoplasias Uterinas/diagnóstico por imagenRESUMEN
A 44-year-old female presented with tenderness of her abdomen, vomiting, intestinal obstruction, hypoalbuminemia and blood eosinophilia. Gastroscopy was normal and colonoscopic biopsies showed only non-specific inflammation of the colonic mucosa and submucosa. CT revealed large amounts of ascites and bilateral pleural effusions but eosinophil counts in the ascites were normal. At CT the jejunum was dilated and showed marked prominence of the valvulae whereas the ileum and the colon presented with a diffuse and hypoattenuating bowel wall thickening. The bowel wall thickening was most pronounced in the colon which especially showed also an impressive thickening and hyperenhancement mainly of its outer bowel wall layers. Parasitic infection could be excluded as well as a specific allergic response. In context with the known blood eosinophilia the diagnosis of an eosinophilic enterocolitis was suspected already by CT but finally only surgical full thickness biopsies could confirm the rare diagnosis of an eosinophilic enterocolitis with predominantly serosal and muscular bowel wall infiltration.