Cervical mesonephric adenocarcinoma: A case report of a rare gynecological tumor from embryological remains of the female genital tract / Adenocarcinoma mesonéfrico cervical: Relato de caso de um tumor ginecológico raro de restos embriológicos do trato genital feminino

Abstract Introduction Malignant mesonephric tumors are uncommon in the female genital tract, and they are usually located where embryonic remnants of Wolffian ducts are detected, such as the uterine cervix. The information about these tumors, their treatment protocol, and prognosis are scarce. Case report A 60-year-old woman with postmenopausal vaginal bleeding was initially diagnosed with endometrial carcinoma. After suspicion co-testing, the patient underwent a loop electrosurgical excision of the cervix and was eventually diagnosed with mesonephric adenocarcinoma. She was subjected to a radical hysterectomy, which revealed International Federation of Gynecology and Obstetrics (FIGO) IB1 stage, and adjuvant radiotherapy. The follow-up showed no evidence of recurrence after 60 months. Conclusion We present the case of a woman with cervical mesonephric adenocarcinoma. When compared with the literature, this case had the longest clinical follow-up without evidence of recurrence, which reinforces the concept that these tumors are associated with a favorable prognosis if managed according to the guidelines defined for the treatment of patients with cervical adenocarcinomas. Though a rare entity, it should be kept in mind as a differential diagnosis for other cervical cancers.

Cervical Mesonephric Adenocarcinoma: A Case Report of a Rare Gynecological Tumor from Embryological Remains of the Female Genital Tract.

INTRODUCTION: Malignant mesonephric tumors are uncommon in the female genital tract, and they are usually located where embryonic remnants of Wolffian ducts are detected, such as the uterine cervix. The information about these tumors, their treatment protocol, and prognosis are scarce. CASE REPORT: A 60-year-old woman with postmenopausal vaginal bleeding was initially diagnosed with endometrial carcinoma. After suspicion co-testing, the patient underwent a loop electrosurgical excision of the cervix and was eventually diagnosed with mesonephric adenocarcinoma. She was subjected to a radical hysterectomy, which revealed International Federation of Gynecology and Obstetrics (FIGO) IB1 stage, and adjuvant radiotherapy. The follow-up showed no evidence of recurrence after 60 months. CONCLUSION: We present the case of a woman with cervical mesonephric adenocarcinoma. When compared with the literature, this case had the longest clinical follow-up without evidence of recurrence, which reinforces the concept that these tumors are associated with a favorable prognosis if managed according to the guidelines defined for the treatment of patients with cervical adenocarcinomas. Though a rare entity, it should be kept in mind as a differential diagnosis for other cervical cancers.

Mesonephric adenocarcinoma of the cervix: a case report with a three-year follow-up, lung metastases, and next-generation sequencing analysis.

BACKGROUND: Mesonephric adenocarcinoma (MNAC) is a rare tumor of the female genital tract, which originates from mesonephric duct remnants. Its diagnosis is pathologically challenging, because MNAC may exhibit a mixture of morphological patterns that complicates the differential diagnosis. CASE PRESENTATION: The patient in this case was a 48-year-old woman with a polypoid mass protruding into the endocervical canal. The patient underwent a total hysterectomy outside the institution. During biopsy, the mass showed a cerebroid aspect. Histological study revealed a tumor with a predominantly tubular and ductal growth pattern. The immunoprofile showed negative staining for calretinin, carcinoembryonic antigen (CEAm), estrogen receptors (ER), and progesterone receptors (PR), and positive staining for CD10, p16, and PAX2. The Ki-67 score was 46%. Using a next-generation sequencing assay, we documented genomic alterations in KRAS and CTNNB1, low tumor mutation burden (TMB), and an absence of microsatellite instability. In addition, gain of the long arm of chromosome 1 (1q) was also documented using chomogenic in situ hybridization (CISH). Three years later, the patient presented pulmonary nodules in the lingula and left basal lobe that were resected by thoracotomy. The histopathologic study of the pulmonary nodules confirmed the presence of metastases. CONCLUSION: Carcinomas of mesonephric origin are among the rarest subtypes of cervical tumors. We report the first case of mesonephric adenocarcinoma of the cervix with lung metastases showing a CTNNB1 gene mutation.

Imunohistoquimica no diagnostico do disgerminoma e tumor do seio endodermico do ovario: expressao de citoceratina, alfa-fetoproteina e alfa-antitripsina / Immunohistochemistry in the diagnosis of dysgerminoma and endodermal sinus tumor of ovary: cytokeratin, alpha-fetoprotein and alpha-antitrypsin antibodies expression

Os autores estudaram sete casos de disgerminoma e tres de tumor do seio endodermico do ovario, no intuito de avaliar a utilidade da imunohistoquimica, empregando anticorpos anti-citoceratina, alfa-fetoproteina e alfa-1-antitripsina no diagnostico destes tumores. Os 10 tumores expressaram alfa-1-antitripsina. Nenhum disgerminoma expressou citoceratina enquanto todos os tumores do seio endodermico mostraram reacoes positivas. Os tres tumores do seio endodermico e um disgerminoma expressaram alfa-fetoproteina. Apos investigacao detalhada, este caso foi classificado como um tumor misto de celulas germinativas, tambem por corresponder a um mau prognostico e curta sobrevida, nao muito caracteristico de disgerminomas puros. Este estudo indica que a imunohistoquimica pode ser util no diagnostico destes tipos de tumor, principalmente quando ha areas suspeitas que podem levar a um diagnostico de um tumor misto de celulas germinativas.

A propósito de un caso de tumor del seno endodermal del mediastino y breve revisión de la literatura / A case of endodermal sinue tumor at the mediastinum literature revision

El tumor del Seno Endodermal (TSE) es una neoplasia de las células germinales, de baja presentación en la población general y extraordinariamente rara en el compartimiento mediastinal. En el presente informe se hace referencia de un paciente de 20 años de edad que presentó TSE del mediastino anterior de grandes dimensiones, localmente avanzado y con comportamiento muy agresivo. El diagnóstico se estableció mediante biopsia intratorácica percutánea por aspiración y el paciente recibió quimioterapia combinada con plantino y eptopósido, falleciendo antes de completar el primer curso de tratamiento

Endodermal sinus(yolk sac) tumour of the mediastinum.

An endodermal sinus tumour of the anterior mediastinum is described in a 19-year-old man. This very rare condition is reported for the first time in the Caribbean literature.

Endodermal sinus (Yolk Sac) tumour of the mediastinum

An endodermal sinus tumour of the anterior mediatinum is described in a19-year-old man. This very rare condition is reported for the first time in the Caribbean literature