RESUMEN
Primary leiomyosarcoma of bone is rare. We present the clinicopathological features of a case, the first documented from the Caribbean, seen recently at our institution.
Asunto(s)
Neoplasias Óseas/patología , Huesos/patología , Leiomiosarcoma/patología , Adulto , Neoplasias Óseas/diagnóstico , Neoplasias Óseas/ultraestructura , Huesos/ultraestructura , Resultado Fatal , Humanos , Leiomiosarcoma/diagnóstico , Leiomiosarcoma/ultraestructura , Masculino , Metástasis de la NeoplasiaRESUMEN
Silver stained nucleolar organizer regions (AgNOR) have revealed differences in the biological behavior of certain entities. This study involves a morphometric analysis of AgNOR in 6 central, classic osteosarcomas and 6 parosteal osteosarcomas. There was a statistically significant difference in the number of AgNOR per nucleus between central and parosteal osteosarcomas. Single AgNOR volume was smaller in central osteosarcomas as compared to parosteal osteosarcomas. However, this difference did not reach statistical significance. The parameter AgNOR number per nucleus revealed a cut off value such that 100% of central osteosarcoma cases lay above this value and 100% of parosteal osteosarcoma cases lay below this value. AgNOR demonstration involves a simple technique which can be performed on formalin fixed, paraffin embedded file material. Thus, it may be prudent to routinely assess AgNOR as a contributor to the determination of the pathophysiology of osteosarcomas.
Asunto(s)
Neoplasias Óseas/ultraestructura , Osteosarcoma Yuxtacortical/ultraestructura , Osteosarcoma/ultraestructura , Técnicas Citológicas , Humanos , Tinción con Nitrato de PlataAsunto(s)
Neoplasias Óseas/ultraestructura , Tumores de Células Gigantes/ultraestructura , Osteoclastos/fisiología , Fosfatasa Ácida/análisis , Neoplasias Óseas/enzimología , Línea Celular , Resistencia a Medicamentos , Tumores de Células Gigantes/enzimología , Histocitoquímica , Humanos , Microscopía Electrónica , Tartratos/farmacologíaRESUMEN
A skeletal myxoid chondrosarcoma of the femur was examined by light and electron microscopy. Light microscopic features were characteristic for myxoid chondrosarcoma or "chordoid sarcoma." Electron microscopy disclosed crystalline arrays of microtubules within dilated rough endoplasmic reticulum, a feature previously described in extraskeletal myxoid chondrosarcomas. Tumors with the histologic characteristics of extraskeletal myxoid chondrosarcoma ("chordoid sarcoma") occurring in bone have been rarely reported. We describe herein such a tumor and document the existence of distinct microtubules within the endoplasmic reticulum.