Congenital cutaneous hemangioma in a newborn lamb

Background: Hemangioma is a benign dermal or subcutaneous endothelial cell tumor composed of vascular spaces of varying sizes filled with erythrocytes and lined with a single layer of uniform endothelial cells. Although the pathogenesis is not well defined, these tumors are considered to result from an imbalance in angiogenesis, leading to uncontrolled proliferation of vascular elements. To the best of our knowledge, there are no reports of congenital cutaneous hemangioma in sheep. This report describes the clinical, laboratory, and pathological findings of a case of congenital hemangioma affecting a newborn lamb. Case: A 5-day-old crossbred (Dorper x Santa Inês) lamb presenting with an ear nodule that expanded in the right ear was necropsied. An expansive subcutaneous nodule was observed macroscopically; it occupied approximately 90% of the right ear and had a crusty, irregular surface. The cut surface had multiple cavitations delimited by firm fibrous tissue and a light yellow-to-translucent content. Microscopically, it showed focally extensive subcutaneous neoplastic proliferation and moderate cellularity; it was formed of vascular beds of varied sizes and supported by moderate fibrocollagenous stroma. Suppurative inflammation was observed in the neoplastic vascular beds with large amounts of free basophilic coccoid bacteria inside macrophages. Immunohistochemistry analysis was performed to confirm the diagnosis. Strong cytoplasmic labeling was observed in neoplastic endothelial cells for CD31 and factor VIII. The Ki67 proliferation marker was positive in approximately 5% of neoplastic cells. The cells did not express smooth muscle actin (1A4) or pan-cytokeratin (AE1AE3). Histological characteristics and immunohistochemistry findings were consistent with those of congenital cutaneous hemangioma, a rare neoplasm in sheep. Discussion: The association of clinical, anatomopathological, and immunohistochemical data enabled the diagnosis of congenital cutaneous hemangioma in the 5-day-old lamb. Reports of vascular tumors in sheep are not frequent in literature and usually involve adult animals with no anatomical site predilection. In sheep, the occurrence of nasotracheal hemangioma in a 2-year-old ewe and gingival hemangioma in a 5-year-old sheep have already been described. A cutaneous extra-neural hemangioblastoma was diagnosed in the ear of a 1-month-old lamb. IHC was also used to confirm the diagnosis of hemangioblastoma. Macroscopically, hemangiomas can present as well-delimited and encapsulated masses that when cut, show a reticulated pattern similar to honeycombs that separate the blood-filled cavities. The present case showed a similar conformation but without enough erythrocytes to result in a bloody appearance. Tumor drainage and the predominance of blood serum in the content possibly made it macroscopically translucent. Microscopically, the hemangioma was classified as cavernous. This morphological variation forms large channels separated by fibrous connective tissue stroma, which may contain inflammatory cells. IHC confirmed the endothelial lining of the cystic cavities and was crucial in excluding differential diagnoses. Thus, factor VIII-related antigen was used as a marker for normal and neoplastic cells, as well as for tumoral and reactive neovascularization, in which neoplastic cells were immuno-expressed for CD31 and Factor VIII. In domestic animals, the association between CD31 and Factor VIII is considered more specific for vascular endothelial cells, differentiating them from cells of lymphatic origin. Congenital cutaneous hemangioma occurs in sheep, and its diagnosis and differentiation can be based on histopathology associated with conventional immunohistochemical panels for vascular neoformation.

Aural Hematoma Secondary to Hemangiosarcoma in a Domestic Cat-Case Report.

A 7-year-old, white, domestic short hair, female cat was presented with an aural hematoma of the right pinna, which had been partially resected a year previously. A 3 × 4 cm mass, macroscopically similar to an auricular hematoma, was visible on the convex surface and a smaller vascular lesion was present on the ear margin. Cytological examination of the smaller mass was suggestive of hemangiosarcoma, and a diagnosis confirmed by histopathologic and immunohistochemical tests. Complete pinnectomy with a wide margin was performed and during the 3-year follow-up, the cat had no local recurrence or metastasis. We conclude that hemangiosarcoma should be considered as a potential differential diagnosis in white-coated cats with an unusual clinical presentation of aural hematoma.

Carcinoma de células escamosas em um gato: relato de caso / Squamous cell carcinoma in cat: case report / Carcinoma de células escamosas en el gato: informe del caso

O carcinoma de células escamosas é uma neoplasia maligna que ocorre em cães e gatos, a exposição ao sol é um fator significante para o aparecimento das lesões, que podem surgir principalmente em regiões do corpo onde não tenha muito pelo, tais como orelha e plano nasal. Esse tipo de neoplasia é comum em animais idosos, clinicamente ela apresenta-se como uma lesão que nunca cicatriza, seu diagnóstico pode ser baseado no exame clínico, citologia aspirativa, mas sua definição é feita através do exame histopatológico. Existe uma variedade de tratamentos, dentre eles a cirurgia, criocirurgia, quimioterapia, radioterapia. O prognóstico vai depender do grau da lesão, do tratamento utilizado e da ocorrência ou não de metástase.

Squamous cell carcinoma is a malignant neoplasm that affects dogs and cats; exposure to the sun is a significant factor for the appearance of lesions, which may appear mainly in regions of the body where it does not have much by such as ear and nasal plane. This type of neoplasia is common in elderly animals, clinically it presents as an injury that never heals, its diagnosis can be based on clinical examination, aspiration cytology, but its definition is made through histopathological examination. There are a variety of treatments, among them surgery, cryosurgery, chemotherapy, radiotherapy. The prognosis will depend on the degree of the lesion, the treatment whether metastasis is present or not.

El carcinoma de células escamosas es una neoplasia maligna que afecta a los perros y gatos, la exposición al sol es un factor significante para la aparición de las lesiones, que pueden aparecer principalmente en regiones del cuerpo donde no tiene mucho por tales como oreja y plano nasal. Este tipo de neoplasia es común en animales ancianos, clínicamente se presenta como una lesión que nunca cicatriza, su diagnóstico puede ser basado en el examen clínico, citología aspirativa, pero su definición es hecha a través del examen histopatológico. Hay una variedad de tratamientos, entre ellos la cirugía, criocirugía, quimioterapia, radioterapia. El pronóstico dependerá del grado de lesión, del tratamiento utilizado y de la ocurrencia o no de metástases.

Carcinoma de células escamosas em um gato: relato de caso / Squamous cell carcinoma in cat: case report / Carcinoma de células escamosas en el gato: informe del caso

O carcinoma de células escamosas é uma neoplasia maligna que ocorre em cães e gatos, a exposição ao sol é um fator significante para o aparecimento das lesões, que podem surgir principalmente em regiões do corpo onde não tenha muito pelo, tais como orelha e plano nasal. Esse tipo de neoplasia é comum em animais idosos, clinicamente ela apresenta-se como uma lesão que nunca cicatriza, seu diagnóstico pode ser baseado no exame clínico, citologia aspirativa, mas sua definição é feita através do exame histopatológico. Existe uma variedade de tratamentos, dentre eles a cirurgia, criocirurgia, quimioterapia, radioterapia. O prognóstico vai depender do grau da lesão, do tratamento utilizado e da ocorrência ou não de metástase.(AU)

Squamous cell carcinoma is a malignant neoplasm that affects dogs and cats; exposure to the sun is a significant factor for the appearance of lesions, which may appear mainly in regions of the body where it does not have much by such as ear and nasal plane. This type of neoplasia is common in elderly animals, clinically it presents as an injury that never heals, its diagnosis can be based on clinical examination, aspiration cytology, but its definition is made through histopathological examination. There are a variety of treatments, among them surgery, cryosurgery, chemotherapy, radiotherapy. The prognosis will depend on the degree of the lesion, the treatment whether metastasis is present or not.(AU)

El carcinoma de células escamosas es una neoplasia maligna que afecta a los perros y gatos, la exposición al sol es un factor significante para la aparición de las lesiones, que pueden aparecer principalmente en regiones del cuerpo donde no tiene mucho por tales como oreja y plano nasal. Este tipo de neoplasia es común en animales ancianos, clínicamente se presenta como una lesión que nunca cicatriza, su diagnóstico puede ser basado en el examen clínico, citología aspirativa, pero su definición es hecha a través del examen histopatológico. Hay una variedad de tratamientos, entre ellos la cirugía, criocirugía, quimioterapia, radioterapia. El pronóstico dependerá del grado de lesión, del tratamiento utilizado y de la ocurrencia o no de metástases.(AU)

Adenocarcinoma em pavilhão auricular de uma felina / Adenocarcinoma in a feline auricular pavilion

Um felino não definido foi admitido no HOVET / UFRA com desidratação e extenso traumatismo craniano próximo à aurícula esquerda. Foi observada uma massa localizada próxima à base das orelhas. Após verificar que o animal não melhorou a cicatrização, foi escolhida uma técnica de excisão por conchectomia. O material foi enviado para exame histopatológico, que mostrava diagnóstico morfológico de adenocarcinoma de provável origem apócrina grau II / III. A radiação ultravioleta da luz solar é um fator que pode contribuir para a formação de carcinoma espinocelular nas extremidades das orelhas de gatos de vida livre com pelagem leve.(AU)

A no defined bred feline was admitted to the HOVET/UFRA with dehydration and extensive head injury near the left auricle. A mass located near the base of the ears was observed. After verifying that the animal did not improve healing, an excision by conchectomy technique was chosen. The material was sent for histopathological examination, which showed a morphological diagnosis of adenocarcinoma of probable grade II / III apocrine origin. Ultraviolet radiation from sunlight is a fator that can contribute to the formation of squamous cell carcinoma on the ends of the ears of free-living cats with light coat.(AU)