RESUMEN
This review deals with the origin of the term "angiogenesis", with an attention to John Hunter who is credited with this neologism. A part of the literature refers to a Hunter's work dating 1787, and the other part claims the first use of the term "angiogenesis" in the Hunter's masterpiece published in 1794. Since we were unable to find the term "angiogenesis" in Hunter's works, this review attempts to bring a new contribution to the historical research of this important concept, moving from ancient times to the first decades of the twentieth century, when "angiogenesis" begun to appear on titles of scientific articles. The development of the knowledge on the cardiocirculatory system and the principal steps of this fascinating subject were examined, with particular regard to microvascular bed and vessel sprouting, and to the intriguing observations on blood vessel neoformation that have been also made in the premicroscopic era. In Hunter's works, the concept of angiogenesis indeed emerges, but not the term "angiogenesis". The scientific language occurring during Hunter's time was still old-fashioned, and the term "angiogenesis" was not one of those he used, rather a much later neologism that sounds too modern to appear in that context. Would the first appearance of the term "angiogenesis" occur in late nineteenth century in studies dealing with embryogenesis and organ vascularization? The present study aims to explore the scientific literature and to open a debate to better define this matter.
Asunto(s)
Neovascularización Patológica/historia , Historia del Siglo XIX , Historia del Siglo XX , Historia Antigua , HumanosRESUMEN
Twenty-five years ago marked the publication of the first report describing a functional contribution by the cytokine, macrophage migration inhibitory factor (MIF), to tumor-associated angiogenesis and growth. Since first appearing, this report has been cited 304 times (as of this writing), underscoring not only the importance of this landmark study but also the importance of MIF in tumor neovascularization. Perhaps more importantly, this first link between MIF and stromal cell-dependent tumor angiogenesis presaged the subsequent identification of MIF in mediating protumorigenic contributions to several solid tumor stromal cell types, including monocytes, macrophages, T lymphocytes, NK cells, fibroblasts, endothelial progenitors and mesenchymal stem cells. This retrospective review will broadly evaluate both past and present literature stemming from this initial publication, with an emphasis on cellular sources, cellular effectors, signal transduction mechanisms and the clinical importance of MIF-dependent tumor vascularization.
Asunto(s)
Carcinoma de Pulmón de Células no Pequeñas/genética , Regulación Neoplásica de la Expresión Génica , Oxidorreductasas Intramoleculares/genética , Neoplasias Pulmonares/genética , Factores Inhibidores de la Migración de Macrófagos/genética , Neovascularización Patológica/genética , Carcinoma de Pulmón de Células no Pequeñas/historia , Carcinoma de Pulmón de Células no Pequeñas/metabolismo , Carcinoma de Pulmón de Células no Pequeñas/patología , Células Endoteliales/metabolismo , Células Endoteliales/patología , Fibroblastos/metabolismo , Fibroblastos/patología , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Oxidorreductasas Intramoleculares/historia , Oxidorreductasas Intramoleculares/metabolismo , Células Asesinas Naturales/metabolismo , Células Asesinas Naturales/patología , Neoplasias Pulmonares/historia , Neoplasias Pulmonares/metabolismo , Neoplasias Pulmonares/patología , Factores Inhibidores de la Migración de Macrófagos/historia , Factores Inhibidores de la Migración de Macrófagos/metabolismo , Macrófagos/metabolismo , Macrófagos/patología , Células Madre Mesenquimatosas/metabolismo , Células Madre Mesenquimatosas/patología , Monocitos/metabolismo , Monocitos/patología , Neovascularización Patológica/historia , Neovascularización Patológica/metabolismo , Neovascularización Patológica/patología , Transducción de Señal , Linfocitos T/metabolismo , Linfocitos T/patologíaAsunto(s)
Oncología Médica/historia , Animales , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Neoplasias/historia , Neoplasias/metabolismo , Neoplasias/patología , Neovascularización Patológica/historia , Neovascularización Patológica/metabolismo , Neovascularización Patológica/patología , Retratos como AsuntoRESUMEN
Werner Risaus work had a decisive impact on defining the overall nature of neovascularization processes during development and had the capability to integrate different directions in the field of endothelial cell biology research. In particular, he had a special interest in understanding the development, differentiation and maintenance of the blood-brain barrier. Risau very successfully propagated the concept that the same factors, such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF), which are essential for the formation of blood vessels during embryonic development, also influence pathological angiogenesis during tumor growth. This review is dedicated to a retrospective analysis of the most important contributions of Risaus work in the field of angiogenesis during embryonic development and in post-natal life, in both physiological and pathological conditions.
Asunto(s)
Sistema Cardiovascular/embriología , Neovascularización Patológica/historia , Fisiología/historia , Boston , Alemania , Alemania Oriental , Historia del Siglo XX , Neovascularización Patológica/embriologíaAsunto(s)
Neoplasias/irrigación sanguínea , Neovascularización Patológica/historia , Inhibidores de la Angiogénesis/uso terapéutico , Ojo/irrigación sanguínea , Ojo/fisiopatología , Oftalmopatías/tratamiento farmacológico , Oftalmopatías/fisiopatología , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Masculino , Neoplasias/tratamiento farmacológico , Neoplasias/fisiopatología , Neovascularización Patológica/tratamiento farmacológico , Oftalmología/historia , Factor A de Crecimiento Endotelial Vascular/fisiologíaAsunto(s)
Inhibidores de la Angiogénesis/historia , Investigación Biomédica/historia , Oncología Médica/historia , Neoplasias/historia , Distinciones y Premios , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Masculino , Neoplasias/tratamiento farmacológico , Neovascularización Patológica/historia , Sociedades Médicas/historia , Estados UnidosAsunto(s)
Inhibidores de la Angiogénesis/historia , Investigación/historia , Inhibidores de la Angiogénesis/uso terapéutico , Historia del Siglo XX , Historia del Siglo XXI , Neovascularización Patológica/tratamiento farmacológico , Neovascularización Patológica/historia , Neovascularización Fisiológica/efectos de los fármacos , Estados UnidosAsunto(s)
Investigación Biomédica/historia , Neoplasias/irrigación sanguínea , Neovascularización Patológica/historia , Inhibidores de la Angiogénesis/uso terapéutico , Animales , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Neoplasias/tratamiento farmacológico , Neoplasias/metabolismo , Neoplasias/patología , Neovascularización Patológica/tratamiento farmacológico , Neovascularización Patológica/metabolismo , Neovascularización Patológica/patologíaRESUMEN
Dr Judah Folkman was frequently described as a highly compassionate physician who served his patients not only by performing surgery and offering them comfort and reassurance, but also by working tirelessly in the laboratory to find new approaches to the treatment of disease. His dedication to understanding the role of angiogenesis, the formation of new blood vessels, in human disease has given rise to new treatments for several diseases, including inflammatory diseases, vision-threatening diseases of the eye and, as will be emphasized in this Perspective, cancer.
Asunto(s)
Inhibidores de la Angiogénesis/historia , Investigación Biomédica/historia , Oncología Médica/historia , Neoplasias/historia , Neovascularización Patológica/historia , Inhibidores de la Angiogénesis/farmacología , Animales , Historia del Siglo XX , Humanos , Neoplasias/irrigación sanguínea , Neoplasias/patología , Neovascularización Patológica/etiología , Neovascularización Patológica/prevención & controlAsunto(s)
Neoplasias/irrigación sanguínea , Neovascularización Patológica/historia , Neovascularización Fisiológica , Inhibidores de la Angiogénesis/historia , Inhibidores de la Angiogénesis/uso terapéutico , Animales , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Neoplasias/tratamiento farmacológico , Investigación/historiaAsunto(s)
Neoplasias/historia , Neovascularización Patológica/historia , Inhibidores de la Angiogénesis/uso terapéutico , Historia del Siglo XX , Historia del Siglo XXI , Neoplasias/irrigación sanguínea , Neovascularización Patológica/tratamiento farmacológico , Estados Unidos , Factores de Crecimiento Endotelial Vascular/antagonistas & inhibidoresAsunto(s)
Inductores de la Angiogénesis/sangre , Inhibidores de la Angiogénesis/uso terapéutico , Neoplasias/irrigación sanguínea , Neovascularización Patológica/tratamiento farmacológico , Inductores de la Angiogénesis/historia , Inhibidores de la Angiogénesis/historia , Docentes Médicos/historia , Factor 2 de Crecimiento de Fibroblastos/historia , Factor 2 de Crecimiento de Fibroblastos/metabolismo , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Neoplasias/tratamiento farmacológico , Neoplasias/historia , Neovascularización Patológica/historia , Factor Plaquetario 4/sangre , Estados Unidos , Factor A de Crecimiento Endotelial Vascular/historia , Factor A de Crecimiento Endotelial Vascular/metabolismoRESUMEN
More than 30 years ago, Judah Folkman found a revolutionary new way to think about cancer. He postulated that in order to survive and grow, tumors require blood vessels, and that by cutting off that blood supply, a cancer could be starved into remission. What began as a revolutionary approach to cancer has evolved into one of the most exciting areas of scientific inquiry today. Over the years, Folkman and a growing team of researchers have isolated the proteins and unraveled the processes that regulate angiogenesis. Meanwhile, a new generation of angiogenesis research has emerged as well, widening the field into new areas of human disease and deepening it to examine the underlying biological processes responsible for those diseases.